How does nutrient-responsive #mTORC1 sense the key amino acid #glutamine?
Gianluca Figlia, Aurelio Teleman et al @telemanlab.bsky.social identify a combination of GCN2-dependent processes triggered by secondary depletion of asparagine in glutamine-starved cells
www.embopress.org/doi/full/10....

Macrophages promote tumor growth by phagocytosis-mediated cytokine amplification in Drosophila: Current Biology www.cell.com/current-biol...

An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan
journals.plos.org/plosgenetics...

Online now - the Spotlight " #SAMcycle and #adenosine at the heart of immune conversations" from Tina Mukherjee and colleagues.

#macrophages #infection #immunometabolism #SAMtransmethylation

authors.elsevier.com/a/1lHcd3S6Gf...

Chen, J., Nouzova, M., Noriega, F. G., Tatar, M. (2024). Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin and juvenile hormone. Proc Natl Acad Sci www.pnas.org/doi/abs/10.1...

Recent study by the team of Tomáš Doležal @tomasdolezal.bsky.social on the role of adenosin molecule in immune response was highlighted by the Science journal (www.science.org/doi/10.1126/...).

Julius Lukeš (@czechacademy.bsky.social) is the only living scientist from the Czech Republic to become a member of National Academy of Sciences (@nasonline.org) a prestigious US institution. And he does it his own way. Congratulations!
(Photo courtesy - Biologické centrum AVČR)

In a new Science study, researchers describe a neural circuit underlying cachexia-related apathy in a mouse model of cancer.

Learn more: scim.ag/4iIQFbq #SciencePerspective

Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice. Liu, Dantas, Ferrer, Miao T, Qadiri, Liu, Comjean , Davidson, Perrier, Ahmed, Hu, Goncalves, Janowitz, Perrimon. Nat Metab. 2025 doi: 10.1038/s42255-025-01265-2. PMID: 40275022

When the fruit fly larva looses, an alien emerges. (parasitoid wasp Leptopilina boulardi, essential for our immunometabolic studies) #parasitoid #Drosophila

We are excited to announce the opening of registrations for the upcoming #EDRC2025 conference (25th-28th September 2025) in Alicante to showcase the latest advances in #Drosophila biology and technology edrc2025alicante.com

David Bilder @bilderlab.bsky.social is one of #EDRC2025 plenary speakers. He is full professor @ucberkeleyofficial.bsky.social where he runs a research lab focusing on the mechanisms that govern epithelial polarity, cell shape, and tissue morphogenesis using #Drosophila of course! 🪰🧪

Check this eLife Digest - elifesciences.org/digests/1050... of our new paper in eLife (@elife.bsky.social) if you want to learn how cells can use adenosine as a sensor of a balance between their activities and nutrient supply.

Have you ever wondered how a cell can measure its current activity? And if it is a privileged cell within an organism, how does it demand an adequate supply of nutrients from its environment? Check out our new article in eLife …

In @elife.bsky.social: SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response doi.org/10.7554/eLif...

"Science, both teaching and doing, is under attack."

Speak up. Act. And in the words of Dan Savage, keep dancing.

www.science.org/doi/10.1126/...