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Tom Golde

@tomgolde.bsky.social

150 followers 260 following 7 posts

biophysics. post-doc @XavierTrepat lab barcelona. currently focused on intermediate filaments and epithelial tissues.

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Tom Golde @tomgolde.bsky.social · Sep 4

Thanks Nimesh! Lets hope that the reviewers are as excited about our papers as we are.

Tom Golde @tomgolde.bsky.social · Sep 2

Check out the preprint of my main work in the lab of @xaviertrepat.bsky.social @IBECBarcelona. Many thanks to all the people involved!

Xavier Trepat @xaviertrepat.bsky.social · Sep 1

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...

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Tom Golde @tomgolde.bsky.social · Jul 3

I'm proud to contributing to the development of the experimental system of this amazing study.

I heard @onenimesa.bsky.social will do a whole thread soon.

And maybe we have even more in the pipeline...

Xavier Trepat @xaviertrepat.bsky.social · Jul 3

🚨 Second preprint of the week!

We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.

We harness these mechanical instabilities for synthetic morphogenesis.

Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu

www.biorxiv.org/content/10.1...

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Reposted by Tom Golde

Pau Guillamat @pauguillamat.bsky.social · Jun 30

New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations.

The tissue morphogenesis logic, now engineered into living, programmable materials.

www.biorxiv.org/content/10.1...

#ActiveMatter #TissueEngineering

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Reposted by Tom Golde

epithelial mechanics fan club @epimechfc.bsky.social · Jun 8

What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations?

I'm @juliaeckert.bsky.social. Let's explore some analysis software!‬

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Tom Golde @tomgolde.bsky.social · Feb 7

Xavier Trepat @xaviertrepat.bsky.social · Feb 7

New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs).
www.nature.com/articles/s41...
@ibecbarcelona.eu

Tom Golde @tomgolde.bsky.social · Dec 13

Özge Özgüç @oozguc.bsky.social · Dec 13

🎄 𝗜𝘁’𝘀 𝗕𝗲𝗴𝗶𝗻𝗻𝗶𝗻𝗴 𝘁𝗼 𝗟𝗼𝗼𝗸 𝗮 𝗟𝗼𝘁 𝗟𝗶𝗸𝗲 𝗖𝗵𝗿𝗶𝘀𝘁𝗺𝗮𝘀... 𝗨𝗻𝗱𝗲𝗿 𝘁𝗵𝗲 𝗠𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝗲! 🔬

Why buy Christmas trees when you can "grow" one using micropatterning and @alleninstitute.bsky.social cells that come with their own LaminB1 "ornaments"?

Happy #FluorescenceFriday! ✨❄️

A colony of human induced pluripotent stem cells (hiPSCs) in a christmas tree-like shape. The cells' nuclear envelope appears in magenta in the image forming the ornaments. In green, we see the actin structures within the cells, giving the colony a tree like texture.

Tom Golde @tomgolde.bsky.social · Dec 4

Great stuff from our lab!

Xavier Trepat @xaviertrepat.bsky.social · Dec 3

🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1

Tom Golde @tomgolde.bsky.social · Nov 18

Hello world! I wrote something about intermediate filaments and epithelial mechanics back on twitter. But you can also find it here :)

epithelial mechanics fan club @epimechfc.bsky.social · Dec 10

But what about intermediate filaments? This question is often in my head when I see a talk about cell mechanics focused on actin or microtubules. I am @tom_golde and today I will give you a short overview about the role of intermediate filaments (IF) in #EpithelialMechanics

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