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Reposted by Tom Van Agtmael

sher12.bsky.social @sher12.bsky.social · 12d

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Tom Van Agtmael @tomvanagtmael.bsky.social · 20d

Thanks Shireen!

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Tom Van Agtmael @tomvanagtmael.bsky.social · 20d

New paper out from Markus Ruegg lab on gene therapy for muscular dystrophy due to laminin mutations:
Dual AAV gene therapy using laminin-linking proteins ameliorates muscle and nerve defects in LAMA2-related muscular dystrophy.
www.biorxiv.org/content/10.1...

Dual AAV gene therapy using laminin-linking proteins ameliorates muscle and nerve defects in LAMA2-related muscular dystrophy

Adeno-associated virus (AAV)-mediated gene replacement holds promise for treating genetic diseases but faces challenges due to AAV's limited packaging capacity and potential immune responses to transg...

www.biorxiv.org

Tom Van Agtmael @tomvanagtmael.bsky.social · 22d

This has been a great collaboration @fuller-lab.bsky.social @manuelsalmeron.bsky.social @marcocantini.bsky.social Joe Swift @uofglasgow.bsky.social @fabqu.bsky.social @uofgscmh.bsky.social @uofgmvls.bsky.social

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Tom Van Agtmael @tomvanagtmael.bsky.social · 22d

We explore shared molecular signatures between Col4a1 mutant hearts and common cardiac disease proteomics datasets, highlighting key overlapping mechanistic pathways enforcing the critical function of cardiac basement membranes.

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Tom Van Agtmael @tomvanagtmael.bsky.social · 22d

She describes a novel cardiac phenotype attributed to Col4a1 mutations underlined by the development of cardiac fibrosis, reduced contractile capacity and biomechanical alterations.
Proteomic analysis revealed several altered cardiac metabolism and sarcomere formation pathways 📉📈

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Tom Van Agtmael @tomvanagtmael.bsky.social · 22d

Really excited to tell you about our paper just out in the journal Matrix Biology.
@erinboland.bsky.social set out to investigate what the impact of basement membrane defects are on adult heart function/biology.
www.sciencedirect.com/science/arti...

Biomechanical and compositional basement membrane defects due to a Col4a1 mutation affect cardiac morphology and function

Collagen IV is a major constituent of basement membranes and mutations in the genes COL4A1 and COL4A2 present clinically as a variable, multi-system d…

www.sciencedirect.com

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Yoshi Ishikawa @collagenyoshi.bsky.social · Jul 10

"My" latest review is online now. We need your creativity! 😎
👇👇👇
Collagen Biosynthesis and Its Molecular Ensemble: What Remains Unexplored | Biochemistry pubs.acs.org/doi/10.1021/...

Collagen Biosynthesis and Its Molecular Ensemble: What Remains Unexplored

Collagen embodies an intriguing paradox in protein biology. Despite being one of the most abundant protein superfamilies in vertebrates and having a seemingly simple structural organization, its biosy...

pubs.acs.org

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Tom Van Agtmael @tomvanagtmael.bsky.social · Jul 13

Congrats Yoshi! Was good to see you last week at the collagen Gordon conference...

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Reposted by Tom Van Agtmael

Eric Topol @erictopol.bsky.social · Jul 12

Here's what it gets you

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Valerio Val Izzi @valerioizzi.bsky.social · Jul 11

Am I back from the best conference ever? Yes! But do I also see a crucial tool for the analysis of the #ECMatrix in scRNAseq? Also yes!! Another fantastic tool in collaboration with @nabalabuic.bsky.social 🔥🔥🔥

Naba Lab UIC @nabalabuic.bsky.social · Jul 11

Perfect timing on the last day of the 2025 #Collagen Gordon Research Conference! Our paper, in collaboration with @valerioizzi.bsky.social describing #MatriCom, a tool to infer ECM communication systems from scRNA-Seq datasets, is now published in @jcellsci.bsky.social!
doi.org/10.1242/jcs....

MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–extracellular matrix interactions

Highlighted Article: MatriCom is a web application devised to mine single-cell RNA-sequencing datasets to infer extracellular matrix (ECM)–ECM and cell–ECM communication systems across cell population...

doi.org

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Tom Van Agtmael @tomvanagtmael.bsky.social · Jul 13

Congrats Alex and @valerioizzi.bsky.social! Was great to see you both at the Collagen Gordon meeting and thank you for participating in the power hour

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Naba Lab UIC @nabalabuic.bsky.social · Jul 11

Perfect timing on the last day of the 2025 #Collagen Gordon Research Conference! Our paper, in collaboration with @valerioizzi.bsky.social describing #MatriCom, a tool to infer ECM communication systems from scRNA-Seq datasets, is now published in @jcellsci.bsky.social!
doi.org/10.1242/jcs....

MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–extracellular matrix interactions

Highlighted Article: MatriCom is a web application devised to mine single-cell RNA-sequencing datasets to infer extracellular matrix (ECM)–ECM and cell–ECM communication systems across cell population...

doi.org

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Tom Van Agtmael @tomvanagtmael.bsky.social · Jun 13

New data from the Deltas lab on targeting ER stress in Alport Syndrome.
Chemical chaperone 4-phenylbutyrate treatment alleviates the kidney phenotype in a mouse model of Alport syndrome with a pathogenic variant in Col4a3
www.sciencedirect.com/science/arti...

Chemical chaperone 4-phenylbutyrate treatment alleviates the kidney phenotype in a mouse model of Alport syndrome with a pathogenic variant in Col4a3

Alport Syndrome is a severe inherited glomerulopathy caused by pathogenic variants in genes encoding collagen-IV, the most abundant component of the g…

www.sciencedirect.com

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Tom Van Agtmael @tomvanagtmael.bsky.social · May 30

New paper in Nature Cell Biol from @johannaivaska.bsky.social and @ivaskalab.bsky.social

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells
rdcu.be/eoAUD

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells

Nature Cell Biology - Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST...

rdcu.be

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Tom Van Agtmael @tomvanagtmael.bsky.social · May 26

Really excited to work with the Ruggiero lab over the summer as visiting professor at the Institute Genomics Functional De Lyon, ENS de Lyon. #Collagen. #Matrix and #disease treatments. @uofgmvls.bsky.social @uofgscmh.bsky.social

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Tom Van Agtmael @tomvanagtmael.bsky.social · May 18

And how are you meant to drive away from here? Parking in Barcelona

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Melanie Simms @melaniesimms.bsky.social · Apr 28

And we recreated it 150 years later. www.gla.ac.uk/news/archive...

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Tom Van Agtmael @tomvanagtmael.bsky.social · Apr 29

20 degrees in Edinburgh. those of you who know Scottish tenement flats built in early 1900s (in which I live) know this means opening the windows to warm the house 😂

Tom Van Agtmael @tomvanagtmael.bsky.social · Apr 28

Another collagen IV paper on the "to read" list...
new review just out in the journal #matrix_biology
"The life cycle of type IV collagen" by David Sherwood
www.sciencedirect.com/science/arti...

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Doug Dyer @douglaspdyer.bsky.social · Apr 28

So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...

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Rachel Lennon @rachellennon.bsky.social · Apr 28

Curious about collagen??
There is an amazing program for the Collagen Gordon in New Hampshire this year.
We have ample speaker slots reserved for abstract submissions.

Come and join us!

www.grc.org/collagen-con...
July 6 - 11, 2025

www.grc.org/collagen-grs...
July 5 - 6, 2025

Doug,Rachel,Alex

2025 Collagen Conference GRC

The 2025 Gordon Research Conference on Collagen will be held in New London, New Hampshire. Apply today to reserve your spot.

www.grc.org

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Tom Van Agtmael @tomvanagtmael.bsky.social · Apr 28

To all our undergraduate student's at @uofglasgow.bsky.social ..good luck with your exams!

Reposted by Tom Van Agtmael

Steve Wang @stevewang251.bsky.social · Apr 26

Heard from a former (undergrad) student who just defended her PhD. Students: tell your old profs about your successes and achievements. It's not bragging, and we love to hear about it. It's one of the best parts of being an educator.
#academicsky

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Tom Van Agtmael @tomvanagtmael.bsky.social · Apr 26

Congratulations Yoshi! Nice to see this out. For mice at least, milder phenotype due to knockout is also what we saw for the Col4a2 gene.
www.thelancet.com/journals/ebi...

Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage

COL4A1/COL4A2 variants act in genetic and sporadic CSVD with ICH via dysregulated EDH, and altered vascular wall thickness and biomechanics due to lower collagen IV levels and/or mutant collagen IV se...

www.thelancet.com

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