trentini-lab.bsky.social
Trentini Lab
@trentini-lab.bsky.social
200 followers 280 following 5 posts
Protein quality control and stress response lab at the Center for Molecular Medicine Cologne (CMMC) and CECAD research center https://www.trentini-lab.cmmc-uni-koeln.de/ (Icon made by Freepik from www.flaticon.com)
www.trentini-lab.cmmc-uni-koeln.de
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trentini-lab.bsky.social
Trentini Lab @trentini-lab.bsky.social · Aug 1
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
Principles of ribosome-associated protein quality control during the synthesis of CFTR
Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...
www.biorxiv.org
8 19
Reposted by Trentini Lab
cecad.bsky.social
CECAD Cologne @cecad.bsky.social · 23d
⏰🔬⏳What if we could prevent age-related diseases before they even start? At #CECAD Cologne, that’s exactly our #mission! In this new video, Prof. Dr. Carien Niessen shares our vision uncovering the biology of #aging to improve #health.

#HealthyAging @unicologne.bsky.social

youtu.be/9ALNLpG3oYc
CECAD: Our Scientific Mission
YouTube video by CECAD Cologne
youtu.be
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Reposted by Trentini Lab
crc1678.bsky.social
CRC1678 @crc1678.bsky.social · 29d
🚨 Speaker Alert! 🚨
We’re thrilled to announce the next #CRC1678 Seminar featuring @christinemayr.bsky.social !
Join us to dive into the fascinating role of mRNA 3′UTRs in chaperoning intrinsically disordered regions to regulate protein activity.
📅 September 16
📍 CECAD Lecture Hall
⏰ 2:00 PM
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Reposted by Trentini Lab
msuskiewicz.bsky.social
Marcin J. Suskiewicz @msuskiewicz.bsky.social · Sep 5
I supervise an excellent postdoc who's looking for a postdoc or associate position in < 1 yr. Highly skilled in chem biol and biochem (peptide synthesis, native chem ligation, bacterial expression, purification, intein-based splicing, crystallography, interaction assays). Contact me if interested.
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Reposted by Trentini Lab
crc1678.bsky.social
CRC1678 @crc1678.bsky.social · Sep 2
🚨Check out this brand new publication from the lab of our CRC 1678 project leader @thevilchezlab.bsky.social about how C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules! Congrationlations to this achievement!🥳
thevilchezlab.bsky.social
David Vilchez @thevilchezlab.bsky.social · Sep 2
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...
febs.onlinelibrary.wiley.com
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Reposted by Trentini Lab
inahuppertz.bsky.social
Ina Huppertz @inahuppertz.bsky.social · Aug 24
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...

#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells
Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...
doi.org
2 15 41
trentini-lab.bsky.social
Trentini Lab @trentini-lab.bsky.social · Aug 1
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
Principles of ribosome-associated protein quality control during the synthesis of CFTR
Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...
www.biorxiv.org
8 19
trentini-lab.bsky.social
Trentini Lab @trentini-lab.bsky.social · Jul 15
Cool work! Congrats Doris and team!
2
Reposted by Trentini Lab
hellerschmiedlab.bsky.social
Hellerschmied Lab @hellerschmiedlab.bsky.social · Jul 15
Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
natsmb.nature.com
Nature Structural & Molecular Biology @natsmb.nature.com · Jul 14
New online: Conformational plasticity of a BiP–GRP94 chaperone complex
Conformational plasticity of a BiP–GRP94 chaperone complex
Nature Structural & Molecular Biology, Published online: 14 July 2025; doi:10.1038/s41594-025-01619-0BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.
go.nature.com
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Reposted by Trentini Lab
crc1678.bsky.social
CRC1678 @crc1678.bsky.social · Jul 14
Today marks the first day of our very first CRC 1678 Early Career Researcher Retreat! We’re proud to have such an amazing group of scientists with us—full of curiosity, energy, and team spirit. 💥🧠 🥳💪 #CRC1678 #ECRetreat #ScienceCommunity
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Reposted by Trentini Lab
crc1678.bsky.social
CRC1678 @crc1678.bsky.social · Jul 11
Freshly launched! 🚀 Check out the new CRC 1678 website 🌐
👉 crc1678.uni-koeln.de
About CRC 1678 - CRC1678 - Collaborative Research Center
CRC 1678 investigates how age and stress-driven declines in the accuracy of mRNA and protein production affect cellular and organismal health. By taking an
crc1678.uni-koeln.de
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Reposted by Trentini Lab
davidbalchin.bsky.social
David Balchin @davidbalchin.bsky.social · Jun 2
New from our lab @crick.ac.uk, in collaboration with the Enchev and Bukau labs.
By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis.
www.biorxiv.org/content/10.1...
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trentini-lab.bsky.social
Trentini Lab @trentini-lab.bsky.social · May 15
Congratulations to PhD student Tom Eisenack for winning a poster prize at the #ubfriends2025 symposium! Many thanks to the organizers for putting together such a fantastic meeting!
sfb-tpd-vienna.bsky.social
SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · May 13
...AND THE #ubfriends2025 WINNERS ARE 👏

Best Short Talk:
@leokiss.bsky.social (@mpibiochem.bsky.social)

Best Posters:
Irene Schwartz (lab of @versteegga.bsky.social),
@julianvangerwen.bsky.social (@imsb-eth.bsky.social),
Tom Eisenack (lab @trentini-lab.bsky.social), and
@berndbauer.bsky.social!
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trentini-lab.bsky.social
Trentini Lab @trentini-lab.bsky.social · Mar 28
Congratulations Marcin and partners!
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trentini-lab.bsky.social
Trentini Lab @trentini-lab.bsky.social · Jan 31
I really enjoyed your talk! Thanks for visiting us and sharing the very cool work on protein quality control at the Golgi.
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Reposted by Trentini Lab
crc1678.bsky.social
CRC1678 @crc1678.bsky.social · Nov 28
This week, the @crc1678 kick-off retreat brought all the project leaders together! 🚀 A fantastic opportunity to dive into projects, spark collaborations, and lay the groundwork for an exciting journey ahead. On our way to innovation, teamwork and impactful discoveries! 💡👩‍🔬🧑‍🔬 #Research #Collaboration
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