Tom Williams
@tweethinking.bsky.social
150 followers 79 following 14 posts
Computational evolutionary biologist - phylogenetics, molecular and microbial evolution
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Reposted by Tom Williams
lowlab.bsky.social
❗️ Exciting review alert❗️focussing on the evolution and mechanism of prokaryotic ESCRT-III-like systems.. fun collaboration with Tom Williams @tweethinking.bsky.social!

doi.org/10.1016/j.sb...
tweethinking.bsky.social
deemteam.bsky.social
📣 We are proud of the publication of the second paper of @bbaker24.bsky.social PhD thesis. In collaboration with friends in Halifax we have studied the difficult question of the phylogeny of the DPANN archaea, composed of several phyla of highly reduced, fast-evolving epiparasites 🧵

rdcu.be/erkkU
Phylogenomic analyses indicate the archaeal superphylum DPANN originated from free-living euryarchaeal-like ancestors
Nature Microbiology - Phylogenetic reconstructions with conserved protein markers from the 11 known DPANN phyla reveal their monophyletic placement within the Euryarchaeota.
rdcu.be
Reposted by Tom Williams
ssolo.bsky.social
Dating Bacteria is hard due to the lack of maxima. Assuming aerobes likely postdated the GOE gave us better resolved ages, but also surprised us, but not Dr Dayhoff, showing O2 use predated its atmospheric rise by 900 Mys and helped oxygenic photosynthesis to evolve. www.science.org/doi/10.1126/...
Reposted by Tom Williams
pilhoferlab.bsky.social
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)
tweethinking.bsky.social
Very interesting indeed for enthusiasts of symbiotic integration...
evanowack.bsky.social
Out today: Exciting intermediate between endosymbiont and organelle identified! Endosymbionts in Angomonas deanei lost nearly all bacterial cell division genes. Instead, we identified a host-encoded protein, ETP9, that became specialized for endosymbiont division. 1/2
www.science.org/doi/10.1126/...
Angomonas deanei with flourescent-labeled nucleus and endosymbiont. ETP9 localizes at the endosymbiont division site.
Reposted by Tom Williams
tweethinking.bsky.social
The position will involve developing pipelines and collaborating with other postdocs working on specific case studies of WGD across these different locations. See project website here www.rediploidisation.org. Feel free to contact James ([email protected]) or me for inquiries, or see the ad.
Project summary | rediploidisation.org
www.rediploidisation.org
tweethinking.bsky.social
The position will focus on phylogenomic and comparative genomic analyses of whole genome duplication and asynchronous rediploidization in eukaryotes. It's part of a wider large-scale grant (BBSRC sLOLA), with partners across the UK and further afield (e.g. Edinburgh, Oxford, Kew, Bristol, TCD, UCD).
tweethinking.bsky.social
Job announcement: a four-year postdoc position in phylogenomics at the Milner Centre for Evolution, Bath, with James Clark and me (I'm moving to Bath later in the year...). www.bath.ac.uk/jobs/Vacancy...
ED12442 Research Associate in Phylogenomics (fixed-term) - Jobs at Bath
www.bath.ac.uk
tweethinking.bsky.social
These are Asgard archaea that have evolved by genome reduction from a more complex ancestor, perhaps due to evolving a symbiotic lifestyle … not the only Asgards that have trodden that path…
Reposted by Tom Williams
mrclmb.bsky.social
New research on ancient Asgard archaeal ESCRT-III proteins reveals evolutionary secrets of membrane remodelling.
Diorge Souza, Javier Espadas and Sami Chaaban, investigated the ESCRT-III proteins with Buzz Baum and Aurelien Roux.
Read more: www2.mrc-lmb.cam.ac.uk/asgard-archa...
#LMBResearch (1/2)
Evolution, structure and membrane remodelling function of the ESCRT-III superfamily in eukaryotes and their closest relatives Asgard archaea. The two subfamilies, B-type and A-type, have distinct structural properties to perform sequential steps of the membrane remodelling pathway.
Reposted by Tom Williams
phil-donoghue.bsky.social
Yay! Our LUCA study shorturl.at/09YR8 made into @quantamagazine.bsky.social list of 2024's biggest breakthroughs! Thanks to @emoody.bsky.social @tweethinking.bsky.social Davide Pisani @bristolpalaeo.bsky.social and the rest of our amazing team!
emoody.bsky.social
Wow! A real honour to be included on this year's list, thanks @quantamagazine.bsky.social and of course all the vital collaborators involved in the work youtu.be/p9XHI_26cPE?...
2024's Biggest Breakthroughs in Biology and Neuroscience
YouTube video by Quanta Magazine
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