HItoshi Sawa
@uncnondpy.bsky.social
Professor at NIG. Studying cell polarity and asymmetric division using C. elegans.
遺伝研教授です。C.elegansを使って受精卵や幹細胞から体が作られるしくみを研究してます。 投稿は個人的見解です。 論文ツイートまとめhttp://bit.ly/1AkPQiv、日本語X: @dpynonunc
Pinned
Differential functions of multiple Wnts and receptors in cell polarity regulation in C. elegans
Metazoan species possess multiple Wnt ligands and receptor genes that regulate diverse developmental processes. Because these genes often act redundantly, analysis of single-gene mutants does not nece...
www.biorxiv.org
In worms, polarity of somatic cells are controlled by 3 Wnt and 3 receptors. We comprehensively combined their mutations to uncover their specific functions.We also showed that Wnts have both instructive and permissive functions to control cell polarity orientation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
In worms, polarity of somatic cells are controlled by 3 Wnt and 3 receptors. We comprehensively combined their mutations to uncover their specific functions.We also showed that Wnts have both instructive and permissive functions to control cell polarity orientation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Differential functions of multiple Wnts and receptors in cell polarity regulation in C. elegans
Metazoan species possess multiple Wnt ligands and receptor genes that regulate diverse developmental processes. Because these genes often act redundantly, analysis of single-gene mutants does not nece...
www.biorxiv.org
November 30, 2025 at 8:28 AM
In worms, polarity of somatic cells are controlled by 3 Wnt and 3 receptors. We comprehensively combined their mutations to uncover their specific functions.We also showed that Wnts have both instructive and permissive functions to control cell polarity orientation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
It' getting cold.
November 25, 2025 at 11:33 PM
It' getting cold.
Reposted by HItoshi Sawa
New paper from the lab! Many animal cells exhibit chiral cell surface dynamics, which are proposed to drive left–right asymmetric patterning. However, the molecular mechanisms linking these events remain unclear. authors.elsevier.com/a/1l%7E7B3QW...
authors.elsevier.com
October 22, 2025 at 5:27 PM
New paper from the lab! Many animal cells exhibit chiral cell surface dynamics, which are proposed to drive left–right asymmetric patterning. However, the molecular mechanisms linking these events remain unclear. authors.elsevier.com/a/1l%7E7B3QW...
Reposted by HItoshi Sawa
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College
Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.
www.magd.cam.ac.uk
October 7, 2025 at 4:02 PM
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Colorful Mt. Fuji🗻
October 2, 2025 at 11:35 PM
Colorful Mt. Fuji🗻
Congratulation for the grand prize! #worm25 Art Show
As it’s my first time joining Worm Meeting, I was excited to participate in Worm Art show as well.
This year’s topic is resilience. In times of scarcity, worms gather holding one another to reach new grounds. Alone - they are fragile, together - they rise. Even the sky yields in unity. #worm25
This year’s topic is resilience. In times of scarcity, worms gather holding one another to reach new grounds. Alone - they are fragile, together - they rise. Even the sky yields in unity. #worm25
July 2, 2025 at 4:48 AM
Congratulation for the grand prize! #worm25 Art Show
Reposted by HItoshi Sawa
As it’s my first time joining Worm Meeting, I was excited to participate in Worm Art show as well.
This year’s topic is resilience. In times of scarcity, worms gather holding one another to reach new grounds. Alone - they are fragile, together - they rise. Even the sky yields in unity. #worm25
This year’s topic is resilience. In times of scarcity, worms gather holding one another to reach new grounds. Alone - they are fragile, together - they rise. Even the sky yields in unity. #worm25
June 27, 2025 at 4:20 AM
As it’s my first time joining Worm Meeting, I was excited to participate in Worm Art show as well.
This year’s topic is resilience. In times of scarcity, worms gather holding one another to reach new grounds. Alone - they are fragile, together - they rise. Even the sky yields in unity. #worm25
This year’s topic is resilience. In times of scarcity, worms gather holding one another to reach new grounds. Alone - they are fragile, together - they rise. Even the sky yields in unity. #worm25
June 2, 2025 at 12:01 PM
Our Institute preserve >200 cherry species. We have open house today.
April 5, 2025 at 1:57 AM
Our Institute preserve >200 cherry species. We have open house today.
Shidare-Zakura + MIshima Sakura ＠Sano museum
March 29, 2025 at 10:27 PM
Shidare-Zakura + MIshima Sakura ＠Sano museum
Reposted by HItoshi Sawa
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
openrxiv.org
March 11, 2025 at 1:20 PM
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
March 3rd is Hina-Matsuri (Doll's Festival?) day.
March 2, 2025 at 11:41 PM
March 3rd is Hina-Matsuri (Doll's Festival?) day.
Reposted by HItoshi Sawa
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 12, 2025 at 6:28 AM
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by HItoshi Sawa
Here’s a story about actual Nazis, the Original Gastruloid, and the lengths scientists will go for other scientists and for science itself. Welcome to Episode Two of the #LongBibliography
#DevBiol #SciHist 🧵. 1/13
#DevBiol #SciHist 🧵. 1/13
February 10, 2025 at 9:33 AM
Here’s a story about actual Nazis, the Original Gastruloid, and the lengths scientists will go for other scientists and for science itself. Welcome to Episode Two of the #LongBibliography
#DevBiol #SciHist 🧵. 1/13
#DevBiol #SciHist 🧵. 1/13
Reposted by HItoshi Sawa
I am thrilled that our paper, which is packed with our 10 years of data on the venom proteins of the parasitoid wasp Asobara japonica, has just been published!
Parasitoid wasp venoms degrade Drosophila imaginal discs for successful parasitism | Science Advances www.science.org/doi/10.1126/...
Parasitoid wasp venoms degrade Drosophila imaginal discs for successful parasitism | Science Advances www.science.org/doi/10.1126/...
Parasitoid wasp venoms degrade Drosophila imaginal discs for successful parasitism
Two parasitoid wasp venom proteins induce imaginal disc degradation of its host fly Drosophila larva, ensuring parasitism success.
www.science.org
January 29, 2025 at 8:30 PM
I am thrilled that our paper, which is packed with our 10 years of data on the venom proteins of the parasitoid wasp Asobara japonica, has just been published!
Parasitoid wasp venoms degrade Drosophila imaginal discs for successful parasitism | Science Advances www.science.org/doi/10.1126/...
Parasitoid wasp venoms degrade Drosophila imaginal discs for successful parasitism | Science Advances www.science.org/doi/10.1126/...
First 🌅 of the year
December 31, 2024 at 10:26 PM
First 🌅 of the year