Wael Awad
@waelawad.bsky.social
Group leader | Metabolite Processing and Presentation
@MonashUni
Structural immunologist
@MonashUni
Structural immunologist
Pinned
Wael Awad
@waelawad.bsky.social
· Jan 23
Wael Awad, Jemma Mayall, Weijun Xu, Jamie Rossjohn and colleagues show that cigarette smoke contains a diverse mix of chemicals that bind the antigen-presenting protein MR1 and modulate MAIT cell function in the lung through diverse mechanisms. https://buff.ly/3PG6u6v
Finally, published
@JExpMed
after a decade of work.
Through multidisciplinary approaches, we found that components of #cigarrete & #vaping smoke (CS) modulate #MR1- #MAIT cells axis in the lung with a major implication for COPD, the third leading cause of death worldwide
See 🧵
@JExpMed
after a decade of work.
Through multidisciplinary approaches, we found that components of #cigarrete & #vaping smoke (CS) modulate #MR1- #MAIT cells axis in the lung with a major implication for COPD, the third leading cause of death worldwide
See 🧵
Reposted by Wael Awad
Abdelaal, Gherardin, Rossjohn, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...
November 26, 2025 at 6:45 PM
Abdelaal, Gherardin, Rossjohn, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...
Reposted by Wael Awad
In @jem.org, Abdelaal, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...
November 26, 2025 at 7:15 PM
In @jem.org, Abdelaal, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...
Reposted by Wael Awad
The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites @jem.org @waelawad.bsky.social @monashuniversity.bsky.social
rupress.org/jem/article/...
rupress.org/jem/article/...
November 26, 2025 at 8:39 PM
The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites @jem.org @waelawad.bsky.social @monashuniversity.bsky.social
rupress.org/jem/article/...
rupress.org/jem/article/...
Mitochondria produce nucleobase ligands for T cells.
Our recent paper was published today in PNAS.
Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells | PNAS www.pnas.org/doi/10.1073/...
Our recent paper was published today in PNAS.
Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells | PNAS www.pnas.org/doi/10.1073/...
Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells | PNAS
Mitochondria coordinate several metabolic pathways, producing metabolites that influence
the immune response in various ways. It remains unclear wh...
www.pnas.org
May 13, 2025 at 3:45 AM
Mitochondria produce nucleobase ligands for T cells.
Our recent paper was published today in PNAS.
Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells | PNAS www.pnas.org/doi/10.1073/...
Our recent paper was published today in PNAS.
Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells | PNAS www.pnas.org/doi/10.1073/...
Our recent review on MR1-MAIT axis
Molecular Insights Into MR1-Mediated T Cell Immunity: Lessons Learned and Unanswered Questions
onlinelibrary.wiley.com/doi/epdf/10....
Molecular Insights Into MR1-Mediated T Cell Immunity: Lessons Learned and Unanswered Questions
onlinelibrary.wiley.com/doi/epdf/10....
May 8, 2025 at 4:48 AM
Our recent review on MR1-MAIT axis
Molecular Insights Into MR1-Mediated T Cell Immunity: Lessons Learned and Unanswered Questions
onlinelibrary.wiley.com/doi/epdf/10....
Molecular Insights Into MR1-Mediated T Cell Immunity: Lessons Learned and Unanswered Questions
onlinelibrary.wiley.com/doi/epdf/10....
A follow up study to the Nature Immunology paper we published on the MR1-restricted T-cells (MC.7.G5) that respond to cancer! This time, cancer specific recognition of cancer cell lines through the use of a semi-invariant TCR containing a TRAJ42 segment and a CAXYGGSQGNLIF TCRα motif.
JCI -
MHC-related protein 1–restricted recognition of cancer via a semi-invariant TCR-α chain
www.jci.org
February 6, 2025 at 7:52 PM
Reposted by Wael Awad
Great to see this work published! Congrats to Wael, Jamie and coauthors 🎉
Wael Awad, Jemma Mayall, Weijun Xu, Jamie Rossjohn and colleagues show that cigarette smoke contains a diverse mix of chemicals that bind the antigen-presenting protein MR1 and modulate MAIT cell function in the lung through diverse mechanisms. https://buff.ly/3PG6u6v
January 17, 2025 at 8:20 PM
Great to see this work published! Congrats to Wael, Jamie and coauthors 🎉
Reposted by Wael Awad
Wael Awad, Jemma Mayall, Weijun Xu, Jamie Rossjohn and colleagues show that cigarette smoke contains a diverse mix of chemicals that bind the antigen-presenting protein MR1 and modulate MAIT cell function in the lung through diverse mechanisms. https://buff.ly/3PG6u6v
January 17, 2025 at 5:20 PM
Wael Awad, Jemma Mayall, Weijun Xu, Jamie Rossjohn and colleagues show that cigarette smoke contains a diverse mix of chemicals that bind the antigen-presenting protein MR1 and modulate MAIT cell function in the lung through diverse mechanisms. https://buff.ly/3PG6u6v
Thanks Lauren and congratulations for you too
Great to see this work published! Congrats to Wael, Jamie and coauthors 🎉
Wael Awad, Jemma Mayall, Weijun Xu, Jamie Rossjohn and colleagues show that cigarette smoke contains a diverse mix of chemicals that bind the antigen-presenting protein MR1 and modulate MAIT cell function in the lung through diverse mechanisms. https://buff.ly/3PG6u6v
January 23, 2025 at 2:24 AM
Thanks Lauren and congratulations for you too
Finally, published
@JExpMed
after a decade of work.
Through multidisciplinary approaches, we found that components of #cigarrete & #vaping smoke (CS) modulate #MR1- #MAIT cells axis in the lung with a major implication for COPD, the third leading cause of death worldwide
See 🧵
@JExpMed
after a decade of work.
Through multidisciplinary approaches, we found that components of #cigarrete & #vaping smoke (CS) modulate #MR1- #MAIT cells axis in the lung with a major implication for COPD, the third leading cause of death worldwide
See 🧵
Wael Awad, Jemma Mayall, Weijun Xu, Jamie Rossjohn and colleagues show that cigarette smoke contains a diverse mix of chemicals that bind the antigen-presenting protein MR1 and modulate MAIT cell function in the lung through diverse mechanisms. https://buff.ly/3PG6u6v
January 23, 2025 at 2:16 AM
Finally, published
@JExpMed
after a decade of work.
Through multidisciplinary approaches, we found that components of #cigarrete & #vaping smoke (CS) modulate #MR1- #MAIT cells axis in the lung with a major implication for COPD, the third leading cause of death worldwide
See 🧵
@JExpMed
after a decade of work.
Through multidisciplinary approaches, we found that components of #cigarrete & #vaping smoke (CS) modulate #MR1- #MAIT cells axis in the lung with a major implication for COPD, the third leading cause of death worldwide
See 🧵
Reposted by Wael Awad
#PressRelease 📰 Australian researchers have discovered that multiple chemicals found in cigarette smoke & e-cigarettes alter the function of a key type of immune cell found in the lungs.
In our News Release: https://buff.ly/3C9kmmH
Original paper in JEM: https://buff.ly/3PG6u6v
In our News Release: https://buff.ly/3C9kmmH
Original paper in JEM: https://buff.ly/3PG6u6v
January 17, 2025 at 3:30 PM
#PressRelease 📰 Australian researchers have discovered that multiple chemicals found in cigarette smoke & e-cigarettes alter the function of a key type of immune cell found in the lungs.
In our News Release: https://buff.ly/3C9kmmH
Original paper in JEM: https://buff.ly/3PG6u6v
In our News Release: https://buff.ly/3C9kmmH
Original paper in JEM: https://buff.ly/3PG6u6v
Reposted by Wael Awad
Cigarette smoke chemicals bind MR1 and modulate MAIT cell function in the lung through diverse mechanisms, impacting their ability to respond to respiratory infections and potentially contributing to disease
doi.org/10.1084/jem....
doi.org/10.1084/jem....
January 20, 2025 at 8:53 PM
Cigarette smoke chemicals bind MR1 and modulate MAIT cell function in the lung through diverse mechanisms, impacting their ability to respond to respiratory infections and potentially contributing to disease
doi.org/10.1084/jem....
doi.org/10.1084/jem....