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Reposted by Wendy Bickmore

Gurdon Institute, University of Cambridge @gurdoninstitute.bsky.social · 11h

It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists.
🔗 www.gurdon.cam.ac.uk/nobel-laurea...

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Institute of Genetics and Cancer @uoe-igc.bsky.social · 12d

We're all ready for #DoorsOpenDays2025 tomorrow and looking forward to showing off a snapshot of the work we do at the Institute 🔬🧬🥼🧪 🧫
@cmvm-edinburghuni.bsky.social

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Marci Shore @marcishore.bsky.social · 16d

Dan's latest song, for Stephen Colbert, Jimmy Kimmel, and all the comedians out there--

Dan Shore - Nothing Hurts Me More

YouTube video by danshoremusic

www.youtube.com

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Wendy Bickmore @wbickmor.bsky.social · 27d

Honoured to be in Birmingham to mark Bryan Turner’s retirement- a gentleman and giant of epigenetics.

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Wendy Bickmore @wbickmor.bsky.social · 28d

Well, we survived our ERC Synergy interview. So exciting working with this great GeneMotors team of SMC experts @ceesdekker.bsky.social Benjamin Rowland, Leonid Mirny. Here's hoping we can continue working together for the next 6 years.

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Cees Dekker @ceesdekker.bsky.social · Sep 8

preparing for our ERC Synergy Grant interview tomorrow!

#rehearsingrehearsingrehearsing

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Wendy Bickmore @wbickmor.bsky.social · Sep 5

Working class women makes inadvertent mistake and resigns.
Posh bloke uses devious means to avoid paying income tax and stamp duty... and doesn't resign.

www.theguardian.com/politics/202...

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Andrew Wood @andrewwood.bsky.social · Aug 26

Our manuscript characterising tissue-specific consequences of tagged protein fusions in CRISPR-engineered mice is now online @PLOSGenetics. journals.plos.org/plosgenetics.... Thanks again to all coauthors, reviewers and editors for a smooth publication process. Brief summary below.

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Joe Marsh @jmarshlab.bsky.social · Aug 19

New paper out today in PLOS Comp Biol:
journals.plos.org/ploscompbiol...

Intrinsically disordered regions make variant prediction deceptively easy for benign changes but very hard for pathogenic ones. Our work shows why current tools struggle here, and why disorder-aware approaches are needed.

Assessing variant effect predictors and disease mechanisms in intrinsically disordered proteins

Author summary Some parts of proteins, known as intrinsically disordered regions, do not fold into fixed shapes. Instead, they stay flexible and play key roles in controlling how cells work, often by ...

journals.plos.org

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Wendy Bickmore @wbickmor.bsky.social · Jul 28

GWAS to mechanism: when non-coding is coding. Beautiful insightful science from @gweykopf.bsky.social @simonbiddie.bsky.social Joe Marsh and many colleagues. @uoe-igc.bsky.social @cmvm-edinburghuni.bsky.social www.biorxiv.org/content/10.1...

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Wendy Bickmore @wbickmor.bsky.social · Jul 26

www.crowdfunder.co.uk/p/saving-pet...

Saving Peter Womersley's Bernat Klein Studio

To save for the nation one of Scotland’s most significant buildings of the twentieth century.

www.crowdfunder.co.uk

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Wendy Bickmore @wbickmor.bsky.social · May 30

Great to see this published @genesdev.bsky.social. Evidence that enhancers can activate a bystander gene in an adjacent TAD, and that cohesin facilitates this. @uoe-igc.bsky.social.
pubmed.ncbi.nlm.nih.gov/40436628/

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Wendy Bickmore @wbickmor.bsky.social · May 28

Exquisite work. Well done to the whole team.

Daniel Ibrahim @danielibrahim.bsky.social · May 27

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances

Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

rdcu.be

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Richard Sever @richardsever.bsky.social · May 23

Non-profit journals are on the critical list.

The cause: academics obsession with the Nature brand, coupled with the APC $ model.

Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..

Seema Grewal @seemagrewal.bsky.social · May 22

Thanks @mitodynamics.bsky.social for the fun interview and for saying it like it is:

“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”

Journal of Cell Science @jcellsci.bsky.social · May 22

In our Special Issue: Cell Biology of Mitochondria we interview Guest Editor Heidi McBride @mitodynamics.bsky.social Heidi discusses her career path, the past, present & future of #mitochondria research & her role as guest editor at JCS.
journals.biologists.com/jcs/article/...
#JCSMitoSI

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Eimear Lagan @eimearlagan.bsky.social · May 21

Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).

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Jack Wallington @jackwallington.com · May 2

“I certainly do not let myself be underpaid as many women do. There are people who write to me and think because I am a woman I will ask less than a man. This I never do. I know my profession and charge accordingly, as all women should do.” I love this 💞 www.theguardian.com/society/2025...

‘She changed the face of London’: statue to be unveiled of suffragist gardener

Fanny Wilkinson designed 75 parks in the capital, the first UK female landscape gardener to be paid for her work

www.theguardian.com

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Institute of Genetics and Cancer @uoe-igc.bsky.social · Apr 30

Read more about this study by @jmarshlab.bsky.social 👇

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Wendy Bickmore @wbickmor.bsky.social · Apr 22

Nonsense mediated decay has taken hold.

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Wendy Bickmore @wbickmor.bsky.social · Apr 14

ZC3HC1 and TPR is not required for TPR localisation at the nuclear pore basket, and the two have different functions. wellcomeopenresearch.org/articles/10-...

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Wendy Bickmore @wbickmor.bsky.social · Apr 13

But ecDNA do not form hubs

pubmed.ncbi.nlm.nih.gov/36476408/

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells - PubMed

Extrachromosomal DNA (ecDNA) are frequently observed in human cancers and are responsible for high levels of oncogene expression. In glioblastoma (GBM), ecDNA copy number correlates with poor prognosi...

pubmed.ncbi.nlm.nih.gov

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Wendy Bickmore @wbickmor.bsky.social · Apr 11

Time for us all to re-read Orwell’s 1984.

Wendy Bickmore @wbickmor.bsky.social · Apr 8

So well deserved. Congratulations Cees.

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Wendy Bickmore @wbickmor.bsky.social · Apr 4

Eric Green is a giant of the Human Genome Project. His legacy of discoveries, enhancing human knowledge and humanity, is engraved in the scientific literature and cannot be erased. Something these philistines who have seized power will never understand.

www.deiwatchlist.com/dossier/eric...

Eric Green - DEI Watch List

www.deiwatchlist.com

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John Greally @greally.bsky.social · Mar 22

OK, I'm not going to say a word about this.

Go ahead and list what's wrong with this study. We need a generation of reviewers to be confident expressing their concerns, just as we need researchers not to perform these wasteful and damaging studies in the first place.

www.nature.com/articles/s41...

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Wendy Bickmore @wbickmor.bsky.social · Mar 29

The Review Commons system tries to partly address this by having one set of peer reviewer comments that you can take to different journals.