Kevin Mitchell
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wiringthebrain.bsky.social
Kevin Mitchell
@wiringthebrain.bsky.social
Neurogeneticist interested in the relations between genes, brains, and minds. Author of INNATE (2018) and FREE AGENTS (2023)
Reposted by Kevin Mitchell
Hard disagree. Although, yes, I think that psychedelic should be studied for medicinal and mental health purposes, I don't trust these magical thinking wellness grifter quacks to do the research responsibly, ethically or scientifically.
RFK Jr and "MAHA" is a losing proposition for all.
November 24, 2025 at 7:09 PM
Except for the influence of de novo mutations, which makes some clinical conditions completely genetic and not at all inherited.
November 24, 2025 at 7:54 PM
Thanks. Just to be clear, I wasn’t expressing skepticism with those questions - just looking for more info on other systems
November 24, 2025 at 4:22 PM
Reposted by Kevin Mitchell
Part of the problem is the way we teach about spiking: The HH model of a single squid axon. A single isolated neuron does not have these electric fields influences because there are no other neurons to provide them!
November 20, 2025 at 9:54 PM
Reposted by Kevin Mitchell
This paper shows that the whole cortex is structured around oscillations. Lower frequencies in deep layers, higher frequencies in superficial layers. If oscillations don't matter, why is the cortex built around them?
doi.org/10.1038/s415...
A ubiquitous spectrolaminar motif of local field potential power across the primate cortex - Nature Neuroscience
This study reports a motif of local field potentials that maps onto the anatomical layers of the cortex, is preserved across macaque cortical areas and across primates and may represent a ubiquitous l...
doi.org
November 24, 2025 at 2:22 PM
Is there something special about the organisation of cortex that tends to generate these large oscillations? What about hypothalamus or tectum or cerebellum? What about other species? Do insect brains have oscillations?
November 24, 2025 at 2:27 PM
Reposted by Kevin Mitchell
Sounds like there's a considerable amount of confusion even among the gurus! I'd love to see someone like @jmxpearson.bsky.social do a "what's what" on it, perhaps in @thetransmitter.bsky.social.

Here's what @marlenecohen.bsky.social and I had to say about it. /1

www.nature.com/articles/s41...
November 24, 2025 at 12:27 PM
Just because an observer observes them, doesn't mean they're not ALSO meaningful internal states of the system... 😉
November 24, 2025 at 11:17 AM
Reposted by Kevin Mitchell
So, yes, the conclusion differs. I don't look at that table (or other recent results) and conclude "there is one explanation, twin studies h2 estimates were inflated because the EEA was violated". I think different things explain different gaps, and I'm looking forward to understanding those better.
November 24, 2025 at 9:57 AM