Julia Sero
@cellmorphosero.bsky.social
How cells stick to things and move around, microscopy, cats, garden bugs, forays into machine learning, occasional political snark. Asst Prof University of Bath, UK 🏳️🌈
Reposted by Julia Sero
Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social
November 25, 2025 at 1:36 AM
Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social
Reposted by Julia Sero
The interfacial geometry of the epithelium has direct mechanical effects on cancer
cells. In regions of higher tension, cancer cells acquire stem cell properties. This was
demonstrated in 3D cultures of multiples shapes using melanoma cells. @kriskilian.bsky.social
buff.ly/GYlyEBH
cells. In regions of higher tension, cancer cells acquire stem cell properties. This was
demonstrated in 3D cultures of multiples shapes using melanoma cells. @kriskilian.bsky.social
buff.ly/GYlyEBH
November 23, 2025 at 8:01 AM
The interfacial geometry of the epithelium has direct mechanical effects on cancer
cells. In regions of higher tension, cancer cells acquire stem cell properties. This was
demonstrated in 3D cultures of multiples shapes using melanoma cells. @kriskilian.bsky.social
buff.ly/GYlyEBH
cells. In regions of higher tension, cancer cells acquire stem cell properties. This was
demonstrated in 3D cultures of multiples shapes using melanoma cells. @kriskilian.bsky.social
buff.ly/GYlyEBH
Reposted by Julia Sero
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
November 23, 2025 at 8:01 AM
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
People having whole ass Teams meetings on trains with no headphones in should be forcibly ejected.
November 24, 2025 at 9:12 AM
People having whole ass Teams meetings on trains with no headphones in should be forcibly ejected.
Reposted by Julia Sero
Elon Musk donated $277 million to Trump so he could steal the federal government’s data, dismantle the nation’s infrastructure, and stop foreign aid from going to nonwhite people. It’s a quid pro quo breathtaking in scope, corruption, and damage, & completely unprecedented in American history.
Bye bye, “DOGE”.
It no longer exists as a “centralized entity”, according to the Office of Personnel Management.
@reuters.com
www.reuters.com/world/us/dog...
It no longer exists as a “centralized entity”, according to the Office of Personnel Management.
@reuters.com
www.reuters.com/world/us/dog...
November 23, 2025 at 3:29 PM
Elon Musk donated $277 million to Trump so he could steal the federal government’s data, dismantle the nation’s infrastructure, and stop foreign aid from going to nonwhite people. It’s a quid pro quo breathtaking in scope, corruption, and damage, & completely unprecedented in American history.
Reposted by Julia Sero
November 23, 2025 at 2:00 PM
Reposted by Julia Sero
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
Hearing news that Carl Dieffenbach, the Director of the Division of AIDS at #NIH (NIAID), has been removed from his position because he was "not aligned with HHS/OMB."
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
November 24, 2025 at 5:49 AM
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
Reposted by Julia Sero
Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Engineered chromatin readers track damaged chromatin dynamics in live cells and animals - Nature Communications
DNA damage threatens genome stability, but its dynamics in living systems remain difficult to track. Here, the authors engineer MCPH1-based protein probes that specifically recognize γH2AX, enabling r...
www.nature.com
November 22, 2025 at 12:13 PM
Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Julia Sero
So, I wouldn’t panic off the bat. These days archiving raw image & measurement data makes us way better off than the casual image standards of olde tymes, even with AI.
Strong, quantitative expt design does not have to be intimidating! There’s a book about that.
4/4
www.amazon.com/Heuristic-Gu...
Strong, quantitative expt design does not have to be intimidating! There’s a book about that.
4/4
www.amazon.com/Heuristic-Gu...
A Heuristic Guide to Quantitive Imaging
www.amazon.com
November 23, 2025 at 1:49 PM
So, I wouldn’t panic off the bat. These days archiving raw image & measurement data makes us way better off than the casual image standards of olde tymes, even with AI.
Strong, quantitative expt design does not have to be intimidating! There’s a book about that.
4/4
www.amazon.com/Heuristic-Gu...
Strong, quantitative expt design does not have to be intimidating! There’s a book about that.
4/4
www.amazon.com/Heuristic-Gu...
Reposted by Julia Sero
This Day in Labor History: November 22, 1909. Approximately 20,000 garment workers in New York City went on strike against the horrendous conditions of their sweatshops. This strike, known as the Uprising of the 20,000, was the largest strike led by women in American history to that time!!!
November 22, 2025 at 3:26 PM
This Day in Labor History: November 22, 1909. Approximately 20,000 garment workers in New York City went on strike against the horrendous conditions of their sweatshops. This strike, known as the Uprising of the 20,000, was the largest strike led by women in American history to that time!!!
Reposted by Julia Sero
I have posted about this before, but...
Researchers at Pitt School of Public Health (with NIH funding) developed Project Tycho where they digitized reportable disease data from across the country going back to ~1900.
graphics.wsj.com/infectious-d...
1/6
Researchers at Pitt School of Public Health (with NIH funding) developed Project Tycho where they digitized reportable disease data from across the country going back to ~1900.
graphics.wsj.com/infectious-d...
1/6
Battling Infectious Diseases in the 20th Century: The Impact of Vaccines
The number of infected people, measured over 70-some years and across all 50 states and the District of Columbia, generally declined after vaccines were introduced.
graphics.wsj.com
November 22, 2025 at 2:22 PM
I have posted about this before, but...
Researchers at Pitt School of Public Health (with NIH funding) developed Project Tycho where they digitized reportable disease data from across the country going back to ~1900.
graphics.wsj.com/infectious-d...
1/6
Researchers at Pitt School of Public Health (with NIH funding) developed Project Tycho where they digitized reportable disease data from across the country going back to ~1900.
graphics.wsj.com/infectious-d...
1/6
Reposted by Julia Sero
Dipshit is smashing out a car window with his gun, barrel first. Just rogue, cowboy stiff.
There were two US citizens in the car. They were apprehended and detained for “obstructing” ICE by honking their horn to let people know ICE was in the neighborhood.
There were two US citizens in the car. They were apprehended and detained for “obstructing” ICE by honking their horn to let people know ICE was in the neighborhood.
November 22, 2025 at 4:39 AM
Dipshit is smashing out a car window with his gun, barrel first. Just rogue, cowboy stiff.
There were two US citizens in the car. They were apprehended and detained for “obstructing” ICE by honking their horn to let people know ICE was in the neighborhood.
There were two US citizens in the car. They were apprehended and detained for “obstructing” ICE by honking their horn to let people know ICE was in the neighborhood.
Reposted by Julia Sero
I’m really surprised this isn’t bigger news. Just under 10 million people live in Tehran. Where can they go? Where else in Iran will have enough water? This will undoubtedly strain the country’s and the region’s politics, finances and governance capacity.
'Iran’s capital must be moved because the country “no longer has a choice,” President Masoud Pezeshkian said on Thursday in remarks carried by state media, warning that severe ecological strain has made Tehran impossible to sustain'
#Iran 🇮🇷
#Iran 🇮🇷
Iran president says capital move now a necessity as water crisis deepens
Iran’s capital must be moved because the country “no longer has a choice,” President Masoud Pezeshkian said on Thursday in remarks carried by state media, warning that severe ecological strain has mad...
www.iranintl.com
November 21, 2025 at 8:13 PM
I’m really surprised this isn’t bigger news. Just under 10 million people live in Tehran. Where can they go? Where else in Iran will have enough water? This will undoubtedly strain the country’s and the region’s politics, finances and governance capacity.
Reposted by Julia Sero
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
November 20, 2025 at 11:42 AM
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
"Openness is the heart of the matter. Britain flourishes when it is open and trading, and shrivels when it is not."
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
Rachel Reeves is studiously ignoring the cause of Britain’s woes: the Brexit-shaped hole in its roof | Jonathan Freedland
The autumn budget will mop up some damage, but the true source of the economic crisis is clear. The government should now fix it – tragically, it won’t, says Guardian columnist Jonathan Freedland
www.theguardian.com
November 22, 2025 at 11:35 AM
"Openness is the heart of the matter. Britain flourishes when it is open and trading, and shrivels when it is not."
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
I'm not sure how binging Netflix all weekend makes me extroverted and love being out and about, but it's a cute quiz anyway, and I learned about carbapenems. 🦠🧫
November 21, 2025 at 9:26 AM
I'm not sure how binging Netflix all weekend makes me extroverted and love being out and about, but it's a cute quiz anyway, and I learned about carbapenems. 🦠🧫
Reposted by Julia Sero
Many people have noted that the Primary / Social / Forums / Updates tabs are missing when you do this 👀. You can recreate these manually using the "Multiple Inbox" setup in settings. Basically, tell your inbox to include emails tagged "inbox" and exclude the social / forums / updates.
November 20, 2025 at 8:26 PM
Many people have noted that the Primary / Social / Forums / Updates tabs are missing when you do this 👀. You can recreate these manually using the "Multiple Inbox" setup in settings. Basically, tell your inbox to include emails tagged "inbox" and exclude the social / forums / updates.
Reposted by Julia Sero
If you use GMail, AI (Gemini) was turned on yesterday by default and now scans all of your content for machine learning. To turn off, go to Settings>General and scroll down. Uncheck the box for "Smart features."
There's other "Smart" add-ons as well, but that's the one that reads your content.
There's other "Smart" add-ons as well, but that's the one that reads your content.
November 20, 2025 at 5:32 PM
If you use GMail, AI (Gemini) was turned on yesterday by default and now scans all of your content for machine learning. To turn off, go to Settings>General and scroll down. Uncheck the box for "Smart features."
There's other "Smart" add-ons as well, but that's the one that reads your content.
There's other "Smart" add-ons as well, but that's the one that reads your content.
The Crackppt Index should be shared widely.
Joan Baez’s cousin wrote the rubric. You just have to apply it.
Crackpot index
math.ucr.edu
November 21, 2025 at 3:50 AM
The Crackppt Index should be shared widely.
Reposted by Julia Sero
Trackastra is part of the brand-new TrackMate v8.
It is the first deep-learning-based ("AI") drop-in replacement for TrackMate's regular LAP-Track algorithm.
Tracks out of the box for many types of datasets (bacteria, fluorescent nuclei, phase contrast cell culture etc), zero parameters to tune 🤖
It is the first deep-learning-based ("AI") drop-in replacement for TrackMate's regular LAP-Track algorithm.
Tracks out of the box for many types of datasets (bacteria, fluorescent nuclei, phase contrast cell culture etc), zero parameters to tune 🤖
November 20, 2025 at 8:18 PM
Trackastra is part of the brand-new TrackMate v8.
It is the first deep-learning-based ("AI") drop-in replacement for TrackMate's regular LAP-Track algorithm.
Tracks out of the box for many types of datasets (bacteria, fluorescent nuclei, phase contrast cell culture etc), zero parameters to tune 🤖
It is the first deep-learning-based ("AI") drop-in replacement for TrackMate's regular LAP-Track algorithm.
Tracks out of the box for many types of datasets (bacteria, fluorescent nuclei, phase contrast cell culture etc), zero parameters to tune 🤖
😟🤬😠
CDC has overhauled its website to assert that “the claim ‘vaccines do not cause autism’ is not an evidence-based claim”
November 20, 2025 at 10:23 PM
😟🤬😠
Reposted by Julia Sero
Brand new preprint from my lab, showing that TnpB, the ancestor of Cas12, acts as a gene drive in plasmids! And it turns out in conjugative plasmids that it acts as a primitive anti-self defense system, providing a potential link between its transposon effect and becoming CRISPR!
What is the best strategy to win any contest?
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
November 20, 2025 at 10:17 PM
Brand new preprint from my lab, showing that TnpB, the ancestor of Cas12, acts as a gene drive in plasmids! And it turns out in conjugative plasmids that it acts as a primitive anti-self defense system, providing a potential link between its transposon effect and becoming CRISPR!
Reposted by Julia Sero
Python notebook from a two year old paper:
Oh, no, I cannot run, there is a slight mismatch of a logging library.
ImageJ plugin from 2001 running on Quantum Java 51 in 2078:
Your 100 petabyte temporal hologram was successfully thresholded.
Oh, no, I cannot run, there is a slight mismatch of a logging library.
ImageJ plugin from 2001 running on Quantum Java 51 in 2078:
Your 100 petabyte temporal hologram was successfully thresholded.
November 20, 2025 at 5:42 PM
Python notebook from a two year old paper:
Oh, no, I cannot run, there is a slight mismatch of a logging library.
ImageJ plugin from 2001 running on Quantum Java 51 in 2078:
Your 100 petabyte temporal hologram was successfully thresholded.
Oh, no, I cannot run, there is a slight mismatch of a logging library.
ImageJ plugin from 2001 running on Quantum Java 51 in 2078:
Your 100 petabyte temporal hologram was successfully thresholded.
Reposted by Julia Sero
If you are interested in an interdisciplinary project connecting tissue mechanics, synthetic approaches and dev bio, this is the position for you! we are excited to get this colaboration started!!👇👇🤩🤓👇👇
🔬 PhD or Postdoc Position in Experimental Biophysics — University of Vienna
We are hiring for the WWTF-funded project MechanoSynth — focused on decoding and engineering multiscale mechanoresponses in synthetic and biological tissues.
PhD (48 months) or Postdoc (24 months). Vienna, Austria.
We are hiring for the WWTF-funded project MechanoSynth — focused on decoding and engineering multiscale mechanoresponses in synthetic and biological tissues.
PhD (48 months) or Postdoc (24 months). Vienna, Austria.
November 19, 2025 at 10:20 AM
If you are interested in an interdisciplinary project connecting tissue mechanics, synthetic approaches and dev bio, this is the position for you! we are excited to get this colaboration started!!👇👇🤩🤓👇👇