@wjvalentine.bsky.social
Pinned
MBOAT2 limits the amounts of PUFA in phosphatidylcholine of neonatal and dystrophic skeletal muscle and promotes muscle regeneration https://www.biorxiv.org/content/10.1101/2025.11.02.686003v1
Excited to share our new preprint! MBOAT2 is known to replace PUFA with MUFA and suppress lipid peroxidation and #ferroptosis. We discovered novel activities of MBOAT2 to potently reduce PUFA in phosphatidylcholine of skeletal muscle relevant to #DMD, #aging, and #sarcopenia 💪
#lipids #lipidomics
#lipids #lipidomics
Reposted
Talks by:
Wei Zhang
Giulio Formenti
Gianni Castiglione
@magnushaughey.bsky.social
@peiwei-chen.bsky.social
Juan Vazquez
Sudhir Kumar
Stéphane Peyrégne
Laura Carrillo-Olivas
William (Bill) Sherwin
Wei Zhang
Giulio Formenti
Gianni Castiglione
@magnushaughey.bsky.social
@peiwei-chen.bsky.social
Juan Vazquez
Sudhir Kumar
Stéphane Peyrégne
Laura Carrillo-Olivas
William (Bill) Sherwin
July 5, 2025 at 4:19 PM
Talks by:
Wei Zhang
Giulio Formenti
Gianni Castiglione
@magnushaughey.bsky.social
@peiwei-chen.bsky.social
Juan Vazquez
Sudhir Kumar
Stéphane Peyrégne
Laura Carrillo-Olivas
William (Bill) Sherwin
Wei Zhang
Giulio Formenti
Gianni Castiglione
@magnushaughey.bsky.social
@peiwei-chen.bsky.social
Juan Vazquez
Sudhir Kumar
Stéphane Peyrégne
Laura Carrillo-Olivas
William (Bill) Sherwin
Excited to share our new preprint! MBOAT2 is known to replace PUFA with MUFA and suppress lipid peroxidation and #ferroptosis. We discovered novel activities of MBOAT2 to potently reduce PUFA in phosphatidylcholine of skeletal muscle relevant to #DMD, #aging, and #sarcopenia 💪
#lipids #lipidomics
#lipids #lipidomics
MBOAT2 limits the amounts of PUFA in phosphatidylcholine of neonatal and dystrophic skeletal muscle and promotes muscle regeneration https://www.biorxiv.org/content/10.1101/2025.11.02.686003v1
November 7, 2025 at 9:21 AM
Excited to share our new preprint! MBOAT2 is known to replace PUFA with MUFA and suppress lipid peroxidation and #ferroptosis. We discovered novel activities of MBOAT2 to potently reduce PUFA in phosphatidylcholine of skeletal muscle relevant to #DMD, #aging, and #sarcopenia 💪
#lipids #lipidomics
#lipids #lipidomics
Reposted
Membrane Biology: Nothing can replace polyunsaturated lipids
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
September 7, 2025 at 8:21 AM
Membrane Biology: Nothing can replace polyunsaturated lipids
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
Reposted
Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social
Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Davidson et al. demonstrated that liver lysosomes orchestrate the metabolic adaptation to cold by rewiring lipid processing. They show that phospholipase A2 group XV (PLA2G15) breaks down bis(monoacylglycerol)phosphate (BMP) lipids to shift lysosomal function and metabolism in response to direct transcription factor EB regulation.
dlvr.it
May 15, 2025 at 12:06 PM
Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social