Judi Simcox
@judisimcox.bsky.social
Associate Professor @UWBiochem studying lipid signaling and regulation | HHMI FHS| co-Director Biotechnology Training Program | opinions are my own and do not reflect those of my employer
Pinned
Judi Simcox
@judisimcox.bsky.social
· May 15
Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Davidson et al. demonstrated that liver lysosomes orchestrate the metabolic adaptation to cold by rewiring lipid processing. They show that phospholipase A2 group XV (PLA2G15) breaks down bis(monoacylglycerol)phosphate (BMP) lipids to shift lysosomal function and metabolism in response to direct transcription factor EB regulation.
dlvr.it
Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social
Reposted by Judi Simcox
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 4:15 PM
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
Reposted by Judi Simcox
☕ @mikelangelipid.bsky.social @olzmannlab.bsky.social & co identify a #LipidDroplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of #ferroptosis.
@berkeleymcb.bsky.social
bit.ly/49mTeyF
@berkeleymcb.bsky.social
bit.ly/49mTeyF
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
bit.ly
November 16, 2025 at 8:38 AM
☕ @mikelangelipid.bsky.social @olzmannlab.bsky.social & co identify a #LipidDroplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of #ferroptosis.
@berkeleymcb.bsky.social
bit.ly/49mTeyF
@berkeleymcb.bsky.social
bit.ly/49mTeyF
Reposted by Judi Simcox
Here the authors propose that inhibition of the serine threonine kinase FAM20C in adipocytes may serve as a potential therapy for #T2D by restoring adipocyte health www.jci.org/articles/vie...
October 28, 2025 at 4:27 PM
Here the authors propose that inhibition of the serine threonine kinase FAM20C in adipocytes may serve as a potential therapy for #T2D by restoring adipocyte health www.jci.org/articles/vie...
Reposted by Judi Simcox
Here the authors further support the link between #leptin signaling and tissue #fibrosis demonstrating that a leptin-neutralizing antibody may be a promising therapeutic approach for reducing fibrosis in the kidney, liver, lung, heart, and blood vessels www.science.org/doi/10.1126/...
Leptin as a key driver for organ fibrogenesis
Neutralizing leptin reduces inflammation and fibrosis in mice, suggesting a potential treatment for fibrotic diseases.
www.science.org
October 22, 2025 at 6:11 PM
Here the authors further support the link between #leptin signaling and tissue #fibrosis demonstrating that a leptin-neutralizing antibody may be a promising therapeutic approach for reducing fibrosis in the kidney, liver, lung, heart, and blood vessels www.science.org/doi/10.1126/...
Reposted by Judi Simcox
Familial hypercholesterolaemia is still inadequately diagnosed and undertreated, with many affected people remaining at high risk of early cardiovascular disease www.thelancet.com/journals/lan...
#familial #hypercholesterolaemia #ASCVD
#MedSky #EndoSky #CardioSky
#familial #hypercholesterolaemia #ASCVD
#MedSky #EndoSky #CardioSky
October 23, 2025 at 11:08 AM
Familial hypercholesterolaemia is still inadequately diagnosed and undertreated, with many affected people remaining at high risk of early cardiovascular disease www.thelancet.com/journals/lan...
#familial #hypercholesterolaemia #ASCVD
#MedSky #EndoSky #CardioSky
#familial #hypercholesterolaemia #ASCVD
#MedSky #EndoSky #CardioSky
Reposted by Judi Simcox
Are you attending SACNAS NDiSTEM 2025!? Don't miss this awesome session about "How to Identify the Right Mentor for You" hosted by @greisha-ortiz.bsky.social @neuro-explorer-lc.bsky.social @luisci22.bsky.social and @joele-r.bsky.social. #NDiSTEM2025 #SACNAS #STEMResearch #PLI @sacnas.bsky.social 🧪🔬🥼
October 9, 2025 at 4:14 AM
Are you attending SACNAS NDiSTEM 2025!? Don't miss this awesome session about "How to Identify the Right Mentor for You" hosted by @greisha-ortiz.bsky.social @neuro-explorer-lc.bsky.social @luisci22.bsky.social and @joele-r.bsky.social. #NDiSTEM2025 #SACNAS #STEMResearch #PLI @sacnas.bsky.social 🧪🔬🥼
Reposted by Judi Simcox
Published in @lancetgh.bsky.social
Classifying a distinct form of #diabetes in lean individuals with a history of undernutrition: an international consensus statement www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
Classifying a distinct form of #diabetes in lean individuals with a history of undernutrition: an international consensus statement www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
Classifying a distinct form of diabetes in lean individuals with a history of undernutrition: an international consensus statement
Since 1955, a form of diabetes in lean, young (BMI <18·5 kg/m2, age <30 years) individuals
with a history suggestive of undernutrition from before birth and throughout childhood
has been described in ...
www.thelancet.com
September 28, 2025 at 11:11 AM
Published in @lancetgh.bsky.social
Classifying a distinct form of #diabetes in lean individuals with a history of undernutrition: an international consensus statement www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
Classifying a distinct form of #diabetes in lean individuals with a history of undernutrition: an international consensus statement www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
Reposted by Judi Simcox
Use of GLP-1 medicines in patients with HFrEF and implanted cardiac devices. Caution please www.jacc.org/doi/10.1016/...
Effects of Glucagon-Like Peptide 1 Receptor Agonist Initiation in Patients With Heart Failure With Reduced Ejection Fraction and Implantable Cardiac Devices:
www.jacc.org
September 25, 2025 at 10:01 AM
Use of GLP-1 medicines in patients with HFrEF and implanted cardiac devices. Caution please www.jacc.org/doi/10.1016/...
Reposted by Judi Simcox
New preprint: we developed a method that uses phosphoproteome-derived peptide libraries (PhosPropels) for deep specificity profiling of phosphatases and phospholyases www.biorxiv.org/content/10.1...
August 13, 2025 at 5:20 PM
New preprint: we developed a method that uses phosphoproteome-derived peptide libraries (PhosPropels) for deep specificity profiling of phosphatases and phospholyases www.biorxiv.org/content/10.1...
Reposted by Judi Simcox
Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr...
New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
1/n
New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
1/n
DNA-Scaffolded Ultrahigh-Throughput Reaction Screening
Discovering and optimizing reactions is central to synthetic chemistry. However, chemical reactions are traditionally screened using relatively low-throughput methods, prohibiting exploration of diver...
chemrxiv.org
August 14, 2025 at 5:40 PM
Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr...
New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
1/n
New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
1/n
Reposted by Judi Simcox
Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.
September 23, 2025 at 12:55 PM
Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.
Reposted by Judi Simcox
Special thanks to all co-authors and collaborators at OSU and Wisconsin, including @judisimcox.bsky.social , for their valuable contributions.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 23, 2025 at 12:55 PM
Special thanks to all co-authors and collaborators at OSU and Wisconsin, including @judisimcox.bsky.social , for their valuable contributions.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Judi Simcox
Very proud to see the main thesis work of the intrepid Dr. Mohammad Pourhosseinzadeh come out in @pnas.org today! In this paper, Mohammad assesses how crosstalk between insulin-secreting beta and somatostatin-secreting delta cells in the islet actually happens, in near real-time. A quick thread 1/10
September 16, 2025 at 9:21 PM
Very proud to see the main thesis work of the intrepid Dr. Mohammad Pourhosseinzadeh come out in @pnas.org today! In this paper, Mohammad assesses how crosstalk between insulin-secreting beta and somatostatin-secreting delta cells in the islet actually happens, in near real-time. A quick thread 1/10
Reposted by Judi Simcox
Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...
We are hiring! Oxford biology has three associate professorships available as we move to new state-of-the-art facilities
www.biology.ox.ac.uk
September 15, 2025 at 11:22 AM
Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...
Reposted by Judi Simcox
We have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti...
September 12, 2025 at 2:23 PM
We have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti...
Reposted by Judi Simcox
Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer
Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...
www.biorxiv.org
September 9, 2025 at 9:38 PM
Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...
Reposted by Judi Simcox
How the fuck am I supposed to plan my lab finances if my grants keep getting terminated and reinstated and terminated again?
End rant.
End rant.
August 21, 2025 at 10:01 PM
How the fuck am I supposed to plan my lab finances if my grants keep getting terminated and reinstated and terminated again?
End rant.
End rant.
Reposted by Judi Simcox
I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu
The Sinha Lab
The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.
sinha.biochem.utah.edu
August 21, 2025 at 7:09 PM
I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu
It was nice to see our lab’s retreat volunteer project be featured in the arboretum newsletter. We should all work to be stewards of the land we inhabit.
arboretum.wisc.edu/news/arboret...
arboretum.wisc.edu/news/arboret...
People Caring for the Land: Volunteers, Communities, and Connection | UW Arboretum
Spring brought abundant blossoms, greening of the prairie, songs of migratory birds, and many volunteer groups active on the land. In just thirteen weeks, nine different organizations carried out serv...
arboretum.wisc.edu
August 21, 2025 at 7:10 PM
It was nice to see our lab’s retreat volunteer project be featured in the arboretum newsletter. We should all work to be stewards of the land we inhabit.
arboretum.wisc.edu/news/arboret...
arboretum.wisc.edu/news/arboret...
Reposted by Judi Simcox
We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime
The Lipid Interactome Repository – Lipid Interactome Repository
lipidinteractome.org
August 5, 2025 at 1:06 PM
We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime
Congratulations to @uwbiochem.bsky.social Alumni Brian Carrick for receipt of the Shurl and Kay Curci Fellowship from the LSRF!! Well deserved!
Incredibly honored to be a Shurl and Kay Curci Fellow of the Life Sciences Research Foundation. Thanks to Marv and Judith for their support during my PhD and @lapassmore.bsky.social for her backing and mentorship in my postdoc work.
lsrf.org/current-fell...
lsrf.org/current-fell...
August 1, 2025 at 7:52 PM
Congratulations to @uwbiochem.bsky.social Alumni Brian Carrick for receipt of the Shurl and Kay Curci Fellowship from the LSRF!! Well deserved!
Great opportunity, the metabolism community in Utah is amazing. I miss my former colleagues daily! Killer research, collaborations, and investment in technology.
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social
Open Rank, Tenure Track Position – Metabolic Physiology - Salt Lake City, Utah job with University of Utah | 674355
The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...
jobs.sciencecareers.org
July 21, 2025 at 9:21 PM
Great opportunity, the metabolism community in Utah is amazing. I miss my former colleagues daily! Killer research, collaborations, and investment in technology.
Reposted by Judi Simcox
Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C
Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini
Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...
rdcu.be
July 18, 2025 at 2:40 PM
Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C
Reposted by Judi Simcox
Receiving an @endocrinesociety.bsky.social Early Career Investigator Award has been a highlight of my year. Thank you to the #Nicholaslab and all of my supporters, especially my gradschool and postdoc PIs. #ENDO2025 is my scientific home and I look forward to sharing our progress each year
July 13, 2025 at 6:49 PM
Receiving an @endocrinesociety.bsky.social Early Career Investigator Award has been a highlight of my year. Thank you to the #Nicholaslab and all of my supporters, especially my gradschool and postdoc PIs. #ENDO2025 is my scientific home and I look forward to sharing our progress each year
Reposted by Judi Simcox
Congratulations to Professor Alan Attie on being recognized as the Henry & Annrita Lardy Professor of Biochemistry, a @warfnews.bsky.social Named Professorship. Attie has devoted his career to advancing our knowledge of metabolism. Read more: biochem.wisc.edu/2025/06/26/a...
Attie Honored with WARF Named Professorship
Attie, a dedicated mentor and educator, has devoted his career to advancing our knowledge of diabetes and metabolism.
biochem.wisc.edu
July 1, 2025 at 4:00 PM
Congratulations to Professor Alan Attie on being recognized as the Henry & Annrita Lardy Professor of Biochemistry, a @warfnews.bsky.social Named Professorship. Attie has devoted his career to advancing our knowledge of metabolism. Read more: biochem.wisc.edu/2025/06/26/a...