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Judi Simcox

@judisimcox.bsky.social

1.2K followers 750 following 45 posts

Associate Professor @UWBiochem studying lipid signaling and regulation | HHMI FHS| co-Director Biotechnology Training Program

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Judi Simcox @judisimcox.bsky.social · May 15

Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social

Cell Metabolism @cp-cellmetabolism.bsky.social · May 14

Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

Davidson et al. demonstrated that liver lysosomes orchestrate the metabolic adaptation to cold by rewiring lipid processing. They show that phospholipase A2 group XV (PLA2G15) breaks down bis(monoacylglycerol)phosphate (BMP) lipids to shift lysosomal function and metabolism in response to direct transcription factor EB regulation.

dlvr.it

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Reposted by Judi Simcox

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 11d

Published in @lancetgh.bsky.social
Classifying a distinct form of #diabetes in lean individuals with a history of undernutrition: an international consensus statement www.thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky

Classifying a distinct form of diabetes in lean individuals with a history of undernutrition: an international consensus statement

Since 1955, a form of diabetes in lean, young (BMI <18·5 kg/m2, age <30 years) individuals with a history suggestive of undernutrition from before birth and throughout childhood has been described in ...

www.thelancet.com

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Reposted by Judi Simcox

Daniel Drucker @danieljdrucker.bsky.social · 14d

Use of GLP-1 medicines in patients with HFrEF and implanted cardiac devices. Caution please www.jacc.org/doi/10.1016/...

Effects of Glucagon-Like Peptide 1 Receptor Agonist Initiation in Patients With Heart Failure With Reduced Ejection Fraction and Implantable Cardiac Devices:

www.jacc.org

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Reposted by Judi Simcox

Amy Weeks @amyweeks.bsky.social · Aug 13

New preprint: we developed a method that uses phosphoproteome-derived peptide libraries (PhosPropels) for deep specificity profiling of phosphatases and phospholyases www.biorxiv.org/content/10.1...

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Reposted by Judi Simcox

Jeff Martell @jeffmartell.bsky.social · Aug 14

Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr...
New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
1/n

DNA-Scaffolded Ultrahigh-Throughput Reaction Screening

Discovering and optimizing reactions is central to synthetic chemistry. However, chemical reactions are traditionally screened using relatively low-throughput methods, prohibiting exploration of diver...

chemrxiv.org

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Reposted by Judi Simcox

Maria Mihaylova @mihaylova.bsky.social · 16d

Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.

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Reposted by Judi Simcox

Maria Mihaylova @mihaylova.bsky.social · 16d

Special thanks to all co-authors and collaborators at OSU and Wisconsin, including @judisimcox.bsky.social , for their valuable contributions.

www.biorxiv.org/content/10.1...

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Reposted by Judi Simcox

Mark Huising @huisinglab.bsky.social · 22d

Very proud to see the main thesis work of the intrepid Dr. Mohammad Pourhosseinzadeh come out in @pnas.org today! In this paper, Mohammad assesses how crosstalk between insulin-secreting beta and somatostatin-secreting delta cells in the islet actually happens, in near real-time. A quick thread 1/10

a schematic of pancreatic beta and delta cells that explains how they turn glucose into activation and how these cell types signal to each other via gap junctions and G protein coupled receptors. The image has two stills of islet cells expressing fluorescent sensors for calcium and cAMP and of the same islet cells stained for the presence of the hormones insulin and somatostatin.

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Reposted by Judi Simcox

Rebecca Mosher @rm0sher.bsky.social · 24d

Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...

We are hiring! Oxford biology has three associate professorships available as we move to new state-of-the-art facilities

www.biology.ox.ac.uk

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Reposted by Judi Simcox

Lamming Lab @lamminglab.bsky.social · 27d

We have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti...

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Reposted by Judi Simcox

Muir Lab @muirlab.bsky.social · 29d

Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...

www.biorxiv.org

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Reposted by Judi Simcox

Alex Guseman @alexguseman.bsky.social · Aug 21

How the fuck am I supposed to plan my lab finances if my grants keep getting terminated and reinstated and terminated again?

End rant.

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Judi Simcox @judisimcox.bsky.social · Aug 21

Congratulations!!!!

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Reposted by Judi Simcox

Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

The Sinha Lab

The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.

sinha.biochem.utah.edu

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Judi Simcox @judisimcox.bsky.social · Aug 21

It was nice to see our lab’s retreat volunteer project be featured in the arboretum newsletter. We should all work to be stewards of the land we inhabit.

arboretum.wisc.edu/news/arboret...

People Caring for the Land: Volunteers, Communities, and Connection | UW Arboretum

Spring brought abundant blossoms, greening of the prairie, songs of migratory birds, and many volunteer groups active on the land. In just thirteen weeks, nine different organizations carried out serv...

arboretum.wisc.edu

Reposted by Judi Simcox

Jeremy Baskin @jeremybaskin.bsky.social · Aug 5

We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime

The Lipid Interactome Repository – Lipid Interactome Repository

lipidinteractome.org

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Judi Simcox @judisimcox.bsky.social · Aug 1

Congratulations to @uwbiochem.bsky.social Alumni Brian Carrick for receipt of the Shurl and Kay Curci Fellowship from the LSRF!! Well deserved!

Brian Carrick @bcarrick.bsky.social · Aug 1

Incredibly honored to be a Shurl and Kay Curci Fellow of the Life Sciences Research Foundation. Thanks to Marv and Judith for their support during my PhD and @lapassmore.bsky.social for her backing and mentorship in my postdoc work.

lsrf.org/current-fell...

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Judi Simcox @judisimcox.bsky.social · Jul 21

Great opportunity, the metabolism community in Utah is amazing. I miss my former colleagues daily! Killer research, collaborations, and investment in technology.

Katsu Funai @katsufunai.bsky.social · Jul 21

We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social

Open Rank, Tenure Track Position – Metabolic Physiology - Salt Lake City, Utah job with University of Utah | 674355

The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...

jobs.sciencecareers.org

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Reposted by Judi Simcox

Amy Weeks @amyweeks.bsky.social · Jul 18

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini

Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

rdcu.be

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Dequina Nicholas @quinascience.bsky.social · Jul 13

Receiving an @endocrinesociety.bsky.social Early Career Investigator Award has been a highlight of my year. Thank you to the #Nicholaslab and all of my supporters, especially my gradschool and postdoc PIs. #ENDO2025 is my scientific home and I look forward to sharing our progress each year

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Reposted by Judi Simcox

UW–Madison Department of Biochemistry @uwbiochem.bsky.social · Jul 1

Congratulations to Professor Alan Attie on being recognized as the Henry & Annrita Lardy Professor of Biochemistry, a @warfnews.bsky.social Named Professorship. Attie has devoted his career to advancing our knowledge of metabolism. Read more: biochem.wisc.edu/2025/06/26/a...

Attie Honored with WARF Named Professorship

Attie, a dedicated mentor and educator, has devoted his career to advancing our knowledge of diabetes and metabolism.

biochem.wisc.edu

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Judi Simcox @judisimcox.bsky.social · Jul 13

#ENDO2025 has been the renewal of hope I needed. I feel the joy in seeing mentors including @intmedabel.bsky.social and Barbara Kahn, meeting up with friends, and seeing the transformation of the metabolic disease space. Onward to new discoveries. Thanks to #NIDDK for organizing our session.

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Judi Simcox @judisimcox.bsky.social · Jul 10

Officially tenured. Thank you to all the mentors who guided me, and to the trainees who made this possible with your ideas, hard work, and scientific joy.

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Judi Simcox @judisimcox.bsky.social · Jul 9

Because acylcarnitines are known to regulate insulin sensitivity and energy expenditure, it will be exciting to explore these pathways with our various SCD models. It was an honor to co-correspond with James Ntambi, a leader in lipid signaling and metabolism.

pubmed.ncbi.nlm.nih.gov/40350036/

Stearoyl-CoA desaturase 1 deficiency drives saturated lipid accumulation and increases liver and plasma acylcarnitines - PubMed

Stearoyl-CoA desaturase-1 (SCD1) is a critical regulator of lipogenesis that catalyzes the synthesis of MUFAs, mainly oleate (18:1n-9) and palmitoleate (16:1n-7) from saturated fatty acids, stearoyl-C...

pubmed.ncbi.nlm.nih.gov

Judi Simcox @judisimcox.bsky.social · Jul 9

Great work by Mugagga, Lainy and Jess from the Simcox Lab! SCD1 is known to regulate the production of monounsaturated fatty acids and development of diabetes in response of high carbohydrate diet. We showed loss of SCD1 also controls acylcarnitine levels.

UW–Madison Department of Biochemistry @uwbiochem.bsky.social · Jul 8

Research from the James Ntambi and @judisimcox.bsky.social Labs reveals an enzyme’s important role in maintaining a healthy balance of lipids in our bodies. More on their latest research: biochem.wisc.edu/2025/07/02/r...

Research in Brief: The What, Why, and How

Research from the Ntambi and Simcox Labs reveals an enzyme’s important role in maintaining a healthy balance of lipids in our bodies.

biochem.wisc.edu

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Reposted by Judi Simcox

UW–Madison Department of Biochemistry @uwbiochem.bsky.social · Jul 8

Research in Brief: The What, Why, and How

Research from the Ntambi and Simcox Labs reveals an enzyme’s important role in maintaining a healthy balance of lipids in our bodies.

biochem.wisc.edu

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