Xiaojun Tian
@xiaojuntian.bsky.social
Associate Professor at @ASU, systems biology, synthetic biology, #NSFCareer 2022 Awardee, #NIH MIRA 2021 Awardee,
Check out the ASU News story highlighting our Cell paper， Using nature’s playbook to keep engineered cells on script news.asu.edu/20251110-sci...
Using nature’s playbook to keep engineered cells on script | ASU News
When it comes to organization, even cells have their own preferred system.While genetic engineers can design and assemble sophisticated gene circuits to program cells with new functions, as these cell...
news.asu.edu
November 11, 2025 at 3:21 PM
Check out the ASU News story highlighting our Cell paper， Using nature’s playbook to keep engineered cells on script news.asu.edu/20251110-sci...
Excited to share our new Cell paper!
Liquid–liquid phase separation (LLPS) provides a powerful way to stabilize synthetic gene circuits by buffering growth-mediated dilution—adding a spatial layer of control beyond network design.
Grateful to all collaborators! www.cell.com/cell/fulltex...
Liquid–liquid phase separation (LLPS) provides a powerful way to stabilize synthetic gene circuits by buffering growth-mediated dilution—adding a spatial layer of control beyond network design.
Grateful to all collaborators! www.cell.com/cell/fulltex...
Phase separation to buffer growth-mediated dilution in synthetic circuits
Phase separation stabilizes synthetic gene circuits and boosts production under dynamic
growth conditions. By locally concentrating transcription factors at promoters, it
protects gene expression from...
www.cell.com
November 7, 2025 at 5:03 PM
Excited to share our new Cell paper!
Liquid–liquid phase separation (LLPS) provides a powerful way to stabilize synthetic gene circuits by buffering growth-mediated dilution—adding a spatial layer of control beyond network design.
Grateful to all collaborators! www.cell.com/cell/fulltex...
Liquid–liquid phase separation (LLPS) provides a powerful way to stabilize synthetic gene circuits by buffering growth-mediated dilution—adding a spatial layer of control beyond network design.
Grateful to all collaborators! www.cell.com/cell/fulltex...
We’re Hiring Professor (all ranks) in Synthetic Biology and AI-Enabled Biodesign at the School of Biological and Health Systems Engineering, Arizona State University.📍 Tempe, Arizona
Apply here: apply.interfolio.com/175856
Apply here: apply.interfolio.com/175856
Apply - Interfolio
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apply.interfolio.com
October 24, 2025 at 4:11 PM
We’re Hiring Professor (all ranks) in Synthetic Biology and AI-Enabled Biodesign at the School of Biological and Health Systems Engineering, Arizona State University.📍 Tempe, Arizona
Apply here: apply.interfolio.com/175856
Apply here: apply.interfolio.com/175856
Our new NAR paper is out! We turned a recombinase-based negative feedback circuit into a combined feedback+feedforward controller with one promoter flip—tunable resource decoupling achieved. Congrats to our 3rd-year PhD student 🎉 academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Integrating recombinase-based feedback and feedforward control for optimal resource decoupling
Abstract. Resource competition disrupts circuit modularity by introducing unintended coupling between otherwise independent gene modules, thereby compromis
academic.oup.com
September 29, 2025 at 4:53 PM
Our new NAR paper is out! We turned a recombinase-based negative feedback circuit into a combined feedback+feedforward controller with one promoter flip—tunable resource decoupling achieved. Congrats to our 3rd-year PhD student 🎉 academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Now this is out at @ACS Synthetic Biology pubs.acs.org/doi/full/10....
CRISPRi-Linked Multimodule Negative Feedback Loops to Address Winner-Take-All Resource Competition
Cellular resource limitations create unintended interactions among synthetic gene circuit modules, compromising circuit modularity. This challenge is particularly pronounced in circuits with positive ...
pubs.acs.org
September 23, 2025 at 4:47 PM
Now this is out at @ACS Synthetic Biology pubs.acs.org/doi/full/10....
🆕 Another preprint!
CRISPRi-linked multi-module negative feedback loops to combat winner-take-all dynamics from resource competition in gene circuits.
📄 www.biorxiv.org/content/10.1...
#SynBio #CRISPRi #GeneCircuits #ResourceCompetition
CRISPRi-linked multi-module negative feedback loops to combat winner-take-all dynamics from resource competition in gene circuits.
📄 www.biorxiv.org/content/10.1...
#SynBio #CRISPRi #GeneCircuits #ResourceCompetition
CRISPRi-Linked Multi-Module Negative Feedback Loops to Address Winner-Take-All Resource Competition
Cellular resource limitations create unintended interactions among synthetic gene circuit modules, compromising circuit modularity. This challenge is particularly pronounced in circuits with positive ...
www.biorxiv.org
May 18, 2025 at 4:28 AM
🆕 Another preprint!
CRISPRi-linked multi-module negative feedback loops to combat winner-take-all dynamics from resource competition in gene circuits.
📄 www.biorxiv.org/content/10.1...
#SynBio #CRISPRi #GeneCircuits #ResourceCompetition
CRISPRi-linked multi-module negative feedback loops to combat winner-take-all dynamics from resource competition in gene circuits.
📄 www.biorxiv.org/content/10.1...
#SynBio #CRISPRi #GeneCircuits #ResourceCompetition
🚨 New preprint!
We present Re-NF-FF-Controller—a compact strategy that integrates negative feedback and feedforward control via a single promoter flip to optimally decouple resource competition.
📄 www.biorxiv.org/content/10.1...
#SynBio #GeneCircuits #ResourceCompetition
We present Re-NF-FF-Controller—a compact strategy that integrates negative feedback and feedforward control via a single promoter flip to optimally decouple resource competition.
📄 www.biorxiv.org/content/10.1...
#SynBio #GeneCircuits #ResourceCompetition
Integrating Recombinase-Based Feedback and Feedforward Control for Optimal Resource Decoupling
Resource competition disrupts circuit modularity by introducing unintended coupling between otherwise independent gene modules, thereby compromising genetic circuit function. While various control str...
www.biorxiv.org
May 16, 2025 at 7:55 PM
🚨 New preprint!
We present Re-NF-FF-Controller—a compact strategy that integrates negative feedback and feedforward control via a single promoter flip to optimally decouple resource competition.
📄 www.biorxiv.org/content/10.1...
#SynBio #GeneCircuits #ResourceCompetition
We present Re-NF-FF-Controller—a compact strategy that integrates negative feedback and feedforward control via a single promoter flip to optimally decouple resource competition.
📄 www.biorxiv.org/content/10.1...
#SynBio #GeneCircuits #ResourceCompetition
Reposted by Xiaojun Tian
Latest report from a highly credible source. An SRO issuing study section guidance to not address the Diversity Plan or include it in the impact score for a mechanism that required the plan to be included.
January 22, 2025 at 7:52 PM
Latest report from a highly credible source. An SRO issuing study section guidance to not address the Diversity Plan or include it in the impact score for a mechanism that required the plan to be included.
Reposted by Xiaojun Tian
If you’ve been directly impacted by a pause or cancellation of an NIH study session, we @forbes.com would like to talk to you
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 10:59 PM
If you’ve been directly impacted by a pause or cancellation of an NIH study session, we @forbes.com would like to talk to you
Reposted by Xiaojun Tian
Reposted by Xiaojun Tian
Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg.
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...
November 13, 2024 at 9:21 PM
Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg.
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...
Our new work demonstrated the idea of using a supplementary repressive link to enhance the synthetic gene circuit stability under growth feedback.
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
January 15, 2024 at 5:28 PM
Our new work demonstrated the idea of using a supplementary repressive link to enhance the synthetic gene circuit stability under growth feedback.
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Reposted by Xiaojun Tian
Open position for a molecular biologist in a brand new sequencing lab at Achilles Therapeutics, a London-based biotech SME working on cancer immune therapies. If interested please get in touch! 👇
apply.workable.com/achilles-the...
apply.workable.com/achilles-the...
Research Associate/ Senior Research Associate - Sequencing - Achilles Therapeutics
Achilles is a fast paced, trail blazing company focused on the development of the next generation of personalised T cell therapies to treat cancer. We are breaking new ground with our science - there...
apply.workable.com
October 26, 2023 at 1:47 PM
Open position for a molecular biologist in a brand new sequencing lab at Achilles Therapeutics, a London-based biotech SME working on cancer immune therapies. If interested please get in touch! 👇
apply.workable.com/achilles-the...
apply.workable.com/achilles-the...
Reposted by Xiaojun Tian
Light-driven synchronization of optogenetic clocks https://www.biorxiv.org/content/10.1101/2023.10.24.563722v1
Light-driven synchronization of optogenetic clocks https://www.biorxiv.org/content/10.1101/2023.10.24.563722v1
Synthetic genetic oscillators can serve as internal clocks within engineered cells to program period
www.biorxiv.org
October 25, 2023 at 7:05 AM
Light-driven synchronization of optogenetic clocks https://www.biorxiv.org/content/10.1101/2023.10.24.563722v1
Reposted by Xiaojun Tian
Our Holobiont Research centre has 2 bioengineering postdoc places on offer, inc. a synthetic biology one in my group. Interested in engineering microbes to live within native communities and sense and record inputs? Then this job could be for you👇
www.jobs.ac.uk/job/DDO637/r...
www.jobs.ac.uk/job/DDO637/r...
October 23, 2023 at 2:25 PM
Our Holobiont Research centre has 2 bioengineering postdoc places on offer, inc. a synthetic biology one in my group. Interested in engineering microbes to live within native communities and sense and record inputs? Then this job could be for you👇
www.jobs.ac.uk/job/DDO637/r...
www.jobs.ac.uk/job/DDO637/r...
Reposted by Xiaojun Tian
A three-node Turing gene circuit forms periodic spatial patterns in bacteria https://www.biorxiv.org/content/10.1101/2023.10.19.563112v1
A three-node Turing gene circuit forms periodic spatial patterns in bacteria https://www.biorxiv.org/content/10.1101/2023.10.19.563112v1
Turing patterns1 are well-known self-organising systems that can form spots, stripes, or labyrinths.
www.biorxiv.org
October 20, 2023 at 4:07 AM
A three-node Turing gene circuit forms periodic spatial patterns in bacteria https://www.biorxiv.org/content/10.1101/2023.10.19.563112v1