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Yardena Samuels @yardenasamuels.bsky.social · Jun 16

Thanks Johanna

Johanna Joyce @johannajoyce.bsky.social · Jun 16

Opening of the EACR congress in Lisbon by our wonderful president, Yardena Samuels

#EACR2025
@helloeacr.bsky.social
@yardenasamuels.bsky.social

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Reposted by Yardena Samuels

EACR - European Association for Cancer Research @helloeacr.bsky.social · Jun 16

EACR President @yardenasamuels.bsky.social‬ delivers the #EACR2025 Opening Address!

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Yardena Samuels @yardenasamuels.bsky.social · Jun 16

Thanks Carlos!

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Reposted by Yardena Samuels

Carlos Caldas 🇵🇹🇮🇱🇪🇺🇬🇧🎗 @carloscaldas1960.bsky.social · Jun 16

@yardenasamuels.bsky.social opening #EACR2025! Amazing grace! @eacr.org is very lucky to have Yardena as its president!

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Reposted by Yardena Samuels

American Association for Cancer Research (AACR) @theaacr.bsky.social · May 14

Targeting the Cancer Ecosystem: Presenters addressed microenvironmental and host-level changes that accompany tumor progression during an #AACR25 Plenary Session. Read a recap in AACR Annual Meeting News: www.aacrmeetingnews.org/news/fourth-... @yardenasamuels.bsky.social

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Yardena Samuels @yardenasamuels.bsky.social · Apr 29

Thanks #AACR25 for the huge honor!

Samuels Lab @samuels-lab.bsky.social · Apr 29

Proud of @yardenasamuels.bsky.social for her fascinating plenary session at the @theaacr.bsky.social annual meeting in Chicago! A great thank you to the program committee chairs, Drs. Matthew Vander Heiden and Lillian Siu for this opportunity. @mvhlab.bsky.social @lilliansiu.bsky.social #AACR25

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Yardena Samuels @yardenasamuels.bsky.social · Apr 29

Thanks AACR25 this has been an amazing honor

Yardena Samuels @yardenasamuels.bsky.social · Apr 29

Thanks Liam!

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Reposted by Yardena Samuels

Liam Faller @liamfaller.bsky.social · Apr 29

Fantastic stuff by @yardenasamuels.bsky.social lab. The translational regulation of antigen presentation just gets more and more interesting! #RNAbiology #RNASky

www.sciencedirect.com/science/arti...

Translation dysregulation in cancer as a source for targetable antigens

Aberrant peptides presented by major histocompatibility complex (MHC) molecules are targets for tumor eradication, as these peptides can be recognized…

www.sciencedirect.com

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Yardena Samuels @yardenasamuels.bsky.social · Apr 29

Thanks @johannajoyce.bsky.social this is a huge honor!

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Yardena Samuels @yardenasamuels.bsky.social · Apr 29

Thanks Carlos!!

Yardena Samuels @yardenasamuels.bsky.social · Apr 29

Thank you #AACR for this huge honor!

Yardena Samuels @yardenasamuels.bsky.social · Apr 29

Thank you AACR25 for inviting me to give a plenary talk this morning! An absolute honor!

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Reposted by Yardena Samuels

ACIR @acir-org.bsky.social · Apr 2

Translation dysregulation may serve as a new source for identifying cancer-associated antigens, and may also help to predict responses to checkpoint blockade bit.ly/3E4OMY8 #CheckpointBlockade #CancerImmunotherapy @wellerchen.bsky.social @Samuels-lab.bsky.social @yardenasamuels.bsky.social

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Reposted by Yardena Samuels

Chris McGinnis @cmcginnis.bsky.social · Mar 29

With great collaborators @wellerchen.bsky.social @yardenasamuels.bsky.social and many others!

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Reposted by Yardena Samuels

Parker Institute for Cancer Immunotherapy (PICI) @parkerici.bsky.social · Mar 27

What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer.
🔗 www.cell.com/cancer-cell/...

Translation dysregulation in cancer as a source for targetable antigens

Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide MHC presentation, increasin...

www.cell.com

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Yardena Samuels @yardenasamuels.bsky.social · Mar 27

Thanks Chris! @cmcginnis.bsky.social‬
great working with you-looking forward to many more collaborations!

Chris McGinnis @cmcginnis.bsky.social · Mar 27

Thrilled to see our paper out today in @cp-cancercell.bsky.social — in collaboration with @yardenasamuels.bsky.social @wellerchen.bsky.social and many others, we show how perturbing translation fidelity causes aberrant peptide generation in tumors and anti-tumor immune responses in vivo — 🧵here

Yardena Samuels @yardenasamuels.bsky.social · Mar 27

www.cell.com/cancer-cell/...

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Yardena Samuels @yardenasamuels.bsky.social · Mar 27

thanks Carlos!!

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Yardena Samuels @yardenasamuels.bsky.social · Mar 27

thank you!

Yardena Samuels @yardenasamuels.bsky.social · Mar 27

thanks Panos!

Panos Poulis (currently in DE) @panos-poulis.bsky.social · Mar 27

Well, I live for these moments! A mutation in tRNA-modifying enzyme confuses the ribosome to synthesize aberrant and, most importantly, immunogenic peptides that enhance immune response against tumors! Amazing data in many different layers; from cell biology to clinical research! Congratulations!

Yardena Samuels @yardenasamuels.bsky.social · Mar 27

Thrilled to share our latest work in Cancer Cell! 🚨 Led by @chenweller, Osnat Bartok, with amazing collaborators @Chrismcginnis, @AnsumanSatpathy, Andreas Schlosser, @EytanRuppin & more, we reveal that impaired translation fidelity enhances anti-tumor immunity!🧵(1/7)

Yardena Samuels @yardenasamuels.bsky.social · Mar 27

and all our amazing collaborators H. Palashati, D. Malko, M.D. Shmueli, P. Poulis, M.J. Zemanek, M.M. Nielsen, A. Khatib, Y. Levin, Y. Pilpel, M. Rodnina, J. Cox, Y. Merbl, F. Erhard, T. Suzuki, A.R. Buskirk and whole team!

Yardena Samuels @yardenasamuels.bsky.social · Mar 27

✨ We are thankful to the @CancerCell editorial team and the reviewers for their constructive comments, and I am grateful to have such a wonderful team. (7/7)

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Yardena Samuels @yardenasamuels.bsky.social · Mar 27

🏥 Patient data completed the picture: Primary melanoma tumors with low TYW2 showed enhanced responses to ICB, even in patients with low TMB (@Tiangen). Translation fidelity defects may help predict immunotherapy responders, opening new paths for precision cancer treatment. (6/7)

Yardena Samuels @yardenasamuels.bsky.social · Mar 27

Together with Yaron Carmi, we identified FS peptides that triggered robust T cell responses. Moreover, these peptides elicited de novo T cell responses specifically in TYW2-KO tumor-bearing mice! (5/7)

Yardena Samuels @yardenasamuels.bsky.social · Mar 27

🐭 In mice, TYW2 loss increased tumor immunogenicity, specifically in immunocompetent mice. scRNA-seq revealed that TYW2-KO tumors were enriched for exhausted T cells. Indeed, TYW2-KO tumor-bearing mice were sensitive to immune checkpoint blockade (ICB) therapy.