Ryuzaburo Yuki
@zab-biology.bsky.social
Cancer biologist, Assistant professor@Kyoto pharmaceutical university🇯🇵←nms(JSPS PD)🇯🇵, Chiba univ🇯🇵
Reposted by Ryuzaburo Yuki
My lab website is now live! My lab feels a bit real now 🥺. Website: www.jasonzhanglab.com
November 29, 2025 at 4:54 AM
My lab website is now live! My lab feels a bit real now 🥺. Website: www.jasonzhanglab.com
Reposted by Ryuzaburo Yuki
デザインタンパク質による疾患治療へ
異常なナトリウムチャネルの機能を選択的に制御するde novoタンパク質をデザイン(正常なチャネルには影響が少ない)。異なるナトリウムチャネルに効果的で、てんかんや心不全のモデルで症状を改善
実際の薬ができるのも近そうです
www.cell.com/cell/fulltex...
異常なナトリウムチャネルの機能を選択的に制御するde novoタンパク質をデザイン(正常なチャネルには影響が少ない)。異なるナトリウムチャネルに効果的で、てんかんや心不全のモデルで症状を改善
実際の薬ができるのも近そうです
www.cell.com/cell/fulltex...
De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy
De novo protein design was used to engineer a peptide that reverses gain-of-function deficits in voltage-gated sodium channels linked to cardiac arrhythmia and epilepsy.
www.cell.com
November 1, 2025 at 10:00 AM
デザインタンパク質による疾患治療へ
異常なナトリウムチャネルの機能を選択的に制御するde novoタンパク質をデザイン(正常なチャネルには影響が少ない)。異なるナトリウムチャネルに効果的で、てんかんや心不全のモデルで症状を改善
実際の薬ができるのも近そうです
www.cell.com/cell/fulltex...
異常なナトリウムチャネルの機能を選択的に制御するde novoタンパク質をデザイン(正常なチャネルには影響が少ない)。異なるナトリウムチャネルに効果的で、てんかんや心不全のモデルで症状を改善
実際の薬ができるのも近そうです
www.cell.com/cell/fulltex...
Reposted by Ryuzaburo Yuki
Excited to share our latest work in expanding AI-based protein design into targeting PTMs! I’m particularly excited in this work as there is so much we don’t know about PTMs despite their central role in signaling and hopefully we can start to decode their rules and functions.
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
September 30, 2025 at 11:42 PM
Excited to share our latest work in expanding AI-based protein design into targeting PTMs! I’m particularly excited in this work as there is so much we don’t know about PTMs despite their central role in signaling and hopefully we can start to decode their rules and functions.
Reposted by Ryuzaburo Yuki
Our latest paper is finally published in @natcomms.nature.com (doi.org/10.1038/s414...) !! We successfully constructed synthetic multinuclear metal complexes using only proteins.
August 1, 2025 at 6:16 AM
Our latest paper is finally published in @natcomms.nature.com (doi.org/10.1038/s414...) !! We successfully constructed synthetic multinuclear metal complexes using only proteins.
Reposted by Ryuzaburo Yuki
Ep 17: Moonlighting Protein を公開しました！
open.spotify.com/show/1QHT8n1...
学会、ビザ更新、メンタリング、ChemDraw、Boltz on Chimera などについて雑談し、岡本の最新論文、多機能サイトカインで合成多核触媒構造を構築し、触媒活性をデザインした仕事について議論しました。
open.spotify.com/show/1QHT8n1...
学会、ビザ更新、メンタリング、ChemDraw、Boltz on Chimera などについて雑談し、岡本の最新論文、多機能サイトカインで合成多核触媒構造を構築し、触媒活性をデザインした仕事について議論しました。
Ep 17: Moonlighting Protein
open.spotify.com
September 7, 2025 at 12:34 AM
Ep 17: Moonlighting Protein を公開しました！
open.spotify.com/show/1QHT8n1...
学会、ビザ更新、メンタリング、ChemDraw、Boltz on Chimera などについて雑談し、岡本の最新論文、多機能サイトカインで合成多核触媒構造を構築し、触媒活性をデザインした仕事について議論しました。
open.spotify.com/show/1QHT8n1...
学会、ビザ更新、メンタリング、ChemDraw、Boltz on Chimera などについて雑談し、岡本の最新論文、多機能サイトカインで合成多核触媒構造を構築し、触媒活性をデザインした仕事について議論しました。
Reposted by Ryuzaburo Yuki
Excited to share that I’ll be joining UCLA Bioengineering as a tenure-track professor! My lab will focus on AI-driven molecular engineering to study cellular signaling. As someone 100% educated in US public schools, I’m proud to continue working in public education and inspiring future scientists!
July 16, 2025 at 6:22 PM
Excited to share that I’ll be joining UCLA Bioengineering as a tenure-track professor! My lab will focus on AI-driven molecular engineering to study cellular signaling. As someone 100% educated in US public schools, I’m proud to continue working in public education and inspiring future scientists!
Reposted by Ryuzaburo Yuki
My lab is opening in November 2025. If you are interested in working in my lab, please email me at: [email protected]. I am currently recruiting masters, PhD, and postdocs.
July 16, 2025 at 6:22 PM
My lab is opening in November 2025. If you are interested in working in my lab, please email me at: [email protected]. I am currently recruiting masters, PhD, and postdocs.