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Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 14d

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇

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Anaïs Bailles @anaisbailles.bsky.social · 26d

Thanks a lot to @elisecutts.bsky.social for nicely highlighting and putting in context our article! It was very interesting to discuss together, notably about the analogies between the emergence of order in Hydra and other physical phenomena.

Elise Cutts @elisecutts.bsky.social · 27d

Hydra are ~basically~ immortal.

Shred 50 of the lil guys to bits and pack their cells in a blob, and that blob will grow into a new Hydra... albeit with a few extra heads!

This week's post is a Q&A @anaisbailles.bsky.social @mpi-cbg.de about the physics of how Hydra coax order from chaos.🧪⚛️

Hydra are a cosmos in a cuvette

Anaïs Bailles on astrophysics and immortal animals

www.reviewertoo.com

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André Nadler @nadlerlab.bsky.social · Aug 22

Great work! Congratulations you all & especially to
@carldmodes.bsky.social who joined today after a lot of arm twisting by Caren...

NordenLab @nordenlab.bsky.social · Aug 22

The Friday second try: After intense work, especially in the last year, this work is finally ready to be seen by the public. Led by @apramos.bsky.social and great collaboration with @carldmodes.bsky.social group especially @liormoneta.bsky.social : www.biorxiv.org/content/10.1...

The Optic cup is actively shape programmed by independently patterned apical forces

During morphogenesis, initially flat tissues often must transition into complex 3D shapes, reminiscent of shape-programmable systems in physics and engineering. One key question in developmental biolo...

www.biorxiv.org

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André Nadler @nadlerlab.bsky.social · Aug 21

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

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Anaïs Bailles @anaisbailles.bsky.social · Aug 13

Our beautiful Hydra made the cover!!! 😍😍😍
An experiment performed by Pavel Mejstrik with a HCR protocol by @giuliaserafini.bsky.social, @paveltomancak.bsky.social lab @mpi-cbg.de
Actin fibers in blue, nuclei in orange.

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paveltomancak.bsky.social @paveltomancak.bsky.social · Aug 6

Our first #Hydra paper. @anaisbailles.bsky.social all the way, with crucial theory contributions from Carl Modes and @zechnerlab.bsky.social Hydra maintenance by Heino Andreas and HCR by Giulia Serafini. Teamwork. Many thanks to the generous Hydra research community.

Anaïs Bailles @anaisbailles.bsky.social · Aug 6

Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)

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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · Aug 5

Stretching the immortal Hydra. Publication by @paveltomancak.bsky.social group with Carl Modes @mpi-cbg.de & @zechnerlab.bsky.social shows how cells can create a new organism from scratch by coordinating their mechanical properties. @anaisbailles.bsky.social @pnas.org www.mpi-cbg.de/news-outreac...

Stretching the immortal Hydra

Dresden researchers show how cells can create a new organism from scratch by coordinating their mechanical properties.

www.mpi-cbg.de

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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · Jun 26

Novel Research in Biological Artificial Intelligence: Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence @mpi-cbg.de and @csbdresden.bsky.social. More information: www.mpi-cbg.de/news-outreac...

Novel Research in Biological Artificial Intelligence

Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence.

www.mpi-cbg.de

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Heather Harrington @haharrington.bsky.social · Jun 26

We are searching for an AI researcher in lab automation, statistical ML and (theoretical) physics AI for bio/med. Expression of interest and nominations welcome!!!

Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · Jun 26

Novel Research in Biological Artificial Intelligence: Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence @mpi-cbg.de and @csbdresden.bsky.social. More information: www.mpi-cbg.de/news-outreac...

Novel Research in Biological Artificial Intelligence

Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence.

www.mpi-cbg.de

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Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · Jun 26

We are looking for a research assistant to join our lab and support ongoing projects with genome engineering in mouse embryonic stem cells! Please get in touch if you are interested.
www.fmi.ch/education-ca...

Friedrich Miescher Institute, open position

www.fmi.ch

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Anders Sejr Hansen @andersshansen.bsky.social · May 15

(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint

Q: how does chromatin move?

Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...

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Zechner Lab @zechnerlab.bsky.social · Mar 28

Many congratulations to Anne for defending her PhD this week…excellent results and presentation! We wish you all the best for your future career!

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Giovanni Bussi @bussigio.bsky.social · Mar 27

We are finalizing the program of the @cecamevents.bsky.social RNA modelling across scales www.cecam.org/workshop-det... at SISSA, Trieste, Italy, May 19-22. Please note that we still have a few slots for in person attendance. We will accept applications for the next few weeks, until fully booked!

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paveltomancak.bsky.social @paveltomancak.bsky.social · Mar 2

Come to #Prague for #Woodstock2025. What is it? A scientific conference unlike any other. Think #BurningMan or #MusicFestival but #science themed. It'll have two parts - decentralised sessions spread in #Prague (sightsee as you move around) & #campsite event to wrap it up (1/7)

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Max Planck Institute for the Physics of Complex Systems @mpipks.bsky.social · Jan 29

"Cacio e pepe" physics: In arxiv.org/abs/2501.00536v1, eight Italian scientists from the Max Planck Institute for the Physics of Complex Systems explain the physics behind a perfect dish of "cacio e pepe" and how to eschew the dreaded "mozzarella phase" - work featured @nytimes.com.

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Zechner Lab @zechnerlab.bsky.social · Feb 13

Congratulations Tommaso for an excellent PhD defense! Very well done!

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Zechner Lab @zechnerlab.bsky.social · Feb 12

3. Even "simple" systems with purely homotypic interactions lack a fixed c_sat in non-equilibrium conditions (e.g., cells)

4. Inferring solute interactions (homotypic vs. heterotypic) from changes of c_sat / partition coefficient is problematic in cells because of point 3.

Zechner Lab @zechnerlab.bsky.social · Feb 12

Key conclusions:

1. Noise reduction and concentration buffering are different concepts

2. Noise reduction does not depend on a fixed saturation concentration (c_sat)

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Zechner Lab @zechnerlab.bsky.social · Feb 12

Excited to share our new work with Frank Jülicher on noise control & concentration buffering in intracellular condensates! There has been confusion about these concepts, which we aim to address in this paper.

www.cell.com/cell-systems...

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Giovanni Bussi @bussigio.bsky.social · Feb 4

Starting the new season of seminars in Molecular and Statistical Biophysics at SISSA! Gareth Tribello today gave a talk with title “Reconnaissance Metadynamics Rides Again”

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Zechner Lab @zechnerlab.bsky.social · Jan 17

Please share! There are two postdoc opportunities at the Molecular and Statistical Biophysics group at SISSA. Join us in beautiful Trieste! More information at msb.sissa.it/join-us/

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Anders Sejr Hansen @andersshansen.bsky.social · Jan 16

Excited to share James Jusuf's preprint:

By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)

We quantify mESC 36k loops: are generally rare (2.3%)

www.biorxiv.org/content/10.1...

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Bussi Lab @bussilab.org · Jan 15

📢 Post-doc opportunity alert! Join the Molecular and Statistical Biophysics group at SISSA. Choose your mentor from Giovanni Bussi, Cristian Micheletti, or Angelo Rosa, or collaborate across these groups. www.bussilab.org/joinus#postd... #joinus Please reshare!

Join Us

RNA, molecular dynamics, and more

www.bussilab.org

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Zechner Lab @zechnerlab.bsky.social · Dec 3

Congrats Agnes!!

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Zechner Lab @zechnerlab.bsky.social · Dec 2

Exciting news! As of today, our group is part of SISSA in Trieste. Time to say THANK YOU to all current and past group members, collaborators and mentors and to @mpicbg.bsky.social for hosting us for 8 amazing years! If you are interested in working with us in Trieste, please get in touch!

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