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zhaolabski.bsky.social
ZhaoLab
@zhaolabski.bsky.social
1.4K followers 1.2K following 4 posts
We study chromosomal replication & recombinational repair mechanisms, Smc5/6, SUMO-based controls using multidisciplinary approaches. Tweets are a group effort.
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Reposted by ZhaoLab
origichals.bsky.social
Aanchal @origichals.bsky.social · 11d
Cryo-EM captures the elusive moment when E1 hands off SUMO to E2- a molecular relay that’s been mostly guesswork until now. The structures reveal E1 doing dramatic shape-shifting to line up perfectly for the transfer, like enzyme origami in action.
natsmb.nature.com
Nature Structural & Molecular Biology @natsmb.nature.com · 14d
New online: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer
Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer
Nature Structural & Molecular Biology, Published online: 25 September 2025; doi:10.1038/s41594-025-01681-8This study reveals how human small ubiquitin-like modifier (SUMO) E1 recruits its E2 partner UBC9 and transfers SUMO1 through large structural changes, uncovering key mechanisms that ensure specificity and fidelity in SUMOylation, an essential protein modification pathway.
go.nature.com
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Reposted by ZhaoLab
axeldelamarre.bsky.social
Axel Delamarre @axeldelamarre.bsky.social · Jul 17
Our paper is now out in Molecular Cell!

Check the thread in this former post:

www.cell.com/molecular-ce...
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Reposted by ZhaoLab
axeldelamarre.bsky.social
Axel Delamarre @axeldelamarre.bsky.social · Nov 13
Interested in chromatin architecture?

Checkout our new method - PCP - that can map genome organization as multi-way interactions as well as nucleosome footprint and nucleosome spacing at very high resolution.
www.biorxiv.org/content/10.1...
Chromatin architecture mapping by multiplex proximity tagging
Chromatin plays a pivotal role in genome expression, maintenance, and replication. To better understand chromatin organization, we developed a novel proximity-tagging method which assigns unique DNA b...
www.biorxiv.org
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zhaolabski.bsky.social
ZhaoLab @zhaolabski.bsky.social · Mar 7
wonderful to see it in print, congratulations!🍻
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Reposted by ZhaoLab
dirkremus.bsky.social
Dirk Remus @dirkremus.bsky.social · Mar 6
How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...
www.science.org
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zhaolabski.bsky.social
ZhaoLab @zhaolabski.bsky.social · Jan 4
Happy to share a new work from the lab on how DNA damage checkpoint can be down-regulated. rdcu.be/d5o3E. Congrats to all authors at @mskcancercenter.bsky.social and our Weill BCMB student @tzippora.bsky.social. gradschool.weill.cornell.edu/bcmb-allied-...
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zhaolabski.bsky.social
ZhaoLab @zhaolabski.bsky.social · Dec 20
Congratulations!🍻
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Reposted by ZhaoLab
semirkin.bsky.social
semirkin.bsky.social @semirkin.bsky.social · Nov 25
Our latest paper showing that DNA nicks drive expansions of both normal and disease-size alleles. All credit goes to a fantastic graduate student Liangzi Li as well as to a terrific team of current and former undergraduate and graduate students in the lab.

www.pnas.org/doi/10.1073/pnas.2413298121
Recurrent DNA nicks drive massive expansions of (GAA)n repeats | PNAS
Over 50 hereditary degenerative disorders are caused by expansions of short tandem DNA repeats (STRs). (GAA)n repeat expansions are responsible for...
www.pnas.org
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Reposted by ZhaoLab
dirkremus.bsky.social
Dirk Remus @dirkremus.bsky.social · Nov 22
If you are interested in pursuing a PhD in biomedical sciences in New York City, it is still time to apply to the BCMB program run jointly by Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center ! Deadline: Dec 1, 2024.
Join the BCMB PhD program jointly run by Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center. Deadline December 1st, 2024.
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Reposted by ZhaoLab
rbdamgaard.bsky.social
Rune Busk Damgaard @rbdamgaard.bsky.social · Nov 15
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn
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zhaolabski.bsky.social
ZhaoLab @zhaolabski.bsky.social · Nov 14
thanks for making this pack. can you please add our lab? thanks.
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