The review examines the subventricular zone as a reservoir of #NeuralStemCells, emphasizing its importance in #Neurodegeneration, #Glioblastoma, and #NeuralRepair, and its potential for #RegenerativeTherapies. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
November 3, 2025 at 5:59 AM
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A new study reports brain immune cells can both fight and fuel inflammation in #Alzheimers and #Parkinsons. Source: #MedicalXpress
https://f.mtr.cool/obpslbbvso
#AccessPress #Neurodegeneration #BrainHealth
https://f.mtr.cool/obpslbbvso
#AccessPress #Neurodegeneration #BrainHealth
Role of brain inflammation in Alzheimer's and Parkinson's may depend on the behavior of microglia
Researchers from the Alzheimer's Center at Temple (ACT) provide new insights into how microglia, the brain's immune cells, exhibit an apparent dual function with the ability to both increase and decrease inflammation in the brain. Deeper understanding of this phenomenon could shape the potential for identifying the causes of, and possible treatment for neurodegenerative diseases including Alzheimer's disease and Parkinson's.
f.mtr.cool
November 2, 2025 at 6:02 PM
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Check out our #glymphatics preprint from the SWORD Lab (www.swordusuhs.org) and Uniformed Services University: www.biorxiv.org/content/10.1... a collaboration with Johns Hopkins Applied Physics Laboratory @jhuapl.bsky.social , @weegeecee.bsky.social #sleep #military #neuroscience #neurodegeneration
Sleep and Wearables Operational Research for Readiness and Defense
Explore innovative sleep and wearable research for military and civilian performance, focusing on biomarker development and sleep management solutions.
www.swordusuhs.org
November 1, 2025 at 11:30 PM
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⭐New Product!⭐
StressMarq now provides Human Tau (K18) P301L Mutant Pre-formed Fibrils generated without heparin, offering an improved model for #tauopathy and #neurodegeneration studies. These PFFs induce neurotoxicity in primary mouse cortical neurons.
🔬Learn more here: http://bit.ly/46UZ4V1
StressMarq now provides Human Tau (K18) P301L Mutant Pre-formed Fibrils generated without heparin, offering an improved model for #tauopathy and #neurodegeneration studies. These PFFs induce neurotoxicity in primary mouse cortical neurons.
🔬Learn more here: http://bit.ly/46UZ4V1
Human Tau (K18) P301L Mutant PFFs (SPR-523)
Order Human Tau (K18) P301L Mutant PFFs (SPR-523) from StressMarq. High-quality reagents for neurodegenerative disease research.
bit.ly
October 30, 2025 at 5:07 PM
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Excited to share our study on the function of the protein kinase TBK1, which is linked to ALS and dementia, in the regulation of selective autophagy and lysosomes. #neurodegeneration #ALS
Thank you to all collaborators and to the NIH iNDI.
www.sciencedirect.com/science/arti...
Thank you to all collaborators and to the NIH iNDI.
www.sciencedirect.com/science/arti...
Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks
Loss-of-function variants in TBK1, encoding a protein kinase, are strongly associated with familial amyotrophic lateral sclerosis (ALS) and frontotemp…
www.sciencedirect.com
October 30, 2025 at 4:41 AM
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Are you interested in the link between #polyglutamine and #neurodegeneration? E. Villavicencio & H. Zoghbi have just published a #review about it. @jem.org @bcmhouston.bsky.social #TexasChildrens @bcmgenetics.bsky.social @bcmneurosci.bsky.social rupress.org/jem/article/...
October 29, 2025 at 8:49 PM
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#Microglia sensing of #peripheral signals that bridge the brain and body
Claire E. Young & Melanie A. Samuel @bcmhouston.bsky.social #neurodegeneration
molecularneurodegeneration.biomedcentral.com/articles/10....
Claire E. Young & Melanie A. Samuel @bcmhouston.bsky.social #neurodegeneration
molecularneurodegeneration.biomedcentral.com/articles/10....
Microglia sensing of peripheral signals that bridge the brain and body - Molecular Neurodegeneration
Microglia are the resident immune cell of the brain, and alterations in microglia signaling have been implicated in many neurodegenerative disorders. While microglia responses to central cues and othe...
molecularneurodegeneration.biomedcentral.com
October 29, 2025 at 1:27 PM
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4/ These findings help us better understand what might go wrong in conditions like Alzheimer’s or Parkinson’s, where transport and cargo-sorting in neurons are disrupted. #Neurodegeneration #MolecularMotors
October 29, 2025 at 9:24 AM
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The Hypothalamic-Pituitary-Ovarian Axis, Ovarian Disorders, and Brain Aging. Read more in #Endocrinology: bit.ly/4hy3Dd2 #Gonadotropins #Neuroprotection #Neurodegeneration
The Hypothalamic-Pituitary-Ovarian Axis, Ovarian Disorders, and Brain Aging
Abstract. The hypothalamic-pituitary-ovarian (HPO) axis is a complex endocrine feedback mechanism controlling ovulation in female vertebrates. Balance of t
bit.ly
October 28, 2025 at 2:56 PM
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A bioengineered neural network (BENN) closely replicating brain physiology offers insights into the dynamics of axonal networks, with potential applications in the study of alcohol-induced #Neurodegeneration.
#IJEM #OpenAccess: doi.org/10.1088/2631...
#IJEM #OpenAccess: doi.org/10.1088/2631...
October 24, 2025 at 1:40 PM
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1 likes
⭐New Product!⭐
StressMarq now provides Human Tau (K18) P301L Mutant Pre-formed Fibrils generated without heparin, offering an improved model for #tauopathy and #neurodegeneration studies. These PFFs induce neurotoxicity in primary mouse cortical neurons.
🔬Learn more here: http://bit.ly/46UZ4V1
StressMarq now provides Human Tau (K18) P301L Mutant Pre-formed Fibrils generated without heparin, offering an improved model for #tauopathy and #neurodegeneration studies. These PFFs induce neurotoxicity in primary mouse cortical neurons.
🔬Learn more here: http://bit.ly/46UZ4V1
Human Tau (K18) P301L Mutant PFFs (SPR-523)
Order Human Tau (K18) P301L Mutant PFFs (SPR-523) from StressMarq. High-quality reagents for neurodegenerative disease research.
bit.ly
October 23, 2025 at 5:07 PM
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Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @plosbiology.org 🧪 plos.io/49mmzcm
October 23, 2025 at 8:05 AM
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It was a great pleasure to present our work on #epigenetics, #oligodendrocytes and #neurodegeneration at the "White Matter in Focus symposium" in Cambridge today. Lots of inspiring talks and networking. Thank you to the organisers and sponsors for this opportunity 😊!
October 22, 2025 at 8:14 PM
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Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @plosbiology.org 🧪 plos.io/49mmzcm
October 22, 2025 at 4:55 PM
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Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @plosbiology.org 🧪 plos.io/49mmzcm
October 22, 2025 at 1:24 PM
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I'm excited to be speaking about our work on #epigenetics #oligodendrocytes and #neurodegeneration at "White Matter in Focus" this week 👇
neuroscience.cam.ac.uk/event-posts/...
neuroscience.cam.ac.uk/event-posts/...
White matter in focus symposium: Exploring the role of myelin and oligodendrocytes in neurodegeneration
Current research is increasingly highlighting the role of oligodendrocytes in neurodegeneration and specifically in dementia. Explore this theme across disease areas in the upcoming symposium White…
neuroscience.cam.ac.uk
October 20, 2025 at 9:28 PM
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Mind-blowing: ALS & MS deaths follow the same map. 🤯
If Epstein–Barr virus helps cause MS, maybe it’s part of a bigger story—one that could link two devastating diseases.
#MS #ALS #EBV #Neurodegeneration #ScienceNews
#MedSky
If Epstein–Barr virus helps cause MS, maybe it’s part of a bigger story—one that could link two devastating diseases.
#MS #ALS #EBV #Neurodegeneration #ScienceNews
#MedSky
The geographic association of multiple sclerosis and amyotrophic lateral sclerosis - Scientific Reports
Scientific Reports - The geographic association of multiple sclerosis and amyotrophic lateral sclerosis
www.nature.com
October 19, 2025 at 10:50 AM
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⭐New Product!⭐
StressMarq now provides Human Tau (K18) P301L Mutant Pre-formed Fibrils generated without heparin, offering an improved model for #tauopathy and #neurodegeneration studies. These PFFs induce neurotoxicity in primary mouse cortical neurons.
🔬Learn more here: http://bit.ly/46UZ4V1
StressMarq now provides Human Tau (K18) P301L Mutant Pre-formed Fibrils generated without heparin, offering an improved model for #tauopathy and #neurodegeneration studies. These PFFs induce neurotoxicity in primary mouse cortical neurons.
🔬Learn more here: http://bit.ly/46UZ4V1
Human Tau (K18) P301L Mutant PFFs (SPR-523)
Order Human Tau (K18) P301L Mutant PFFs (SPR-523) from StressMarq. High-quality reagents for neurodegenerative disease research.
bit.ly
October 16, 2025 at 5:07 PM
Everybody can reply
🧬 New in NARMME: RNA splicing tweaks rescue tau toxicity in C. elegans. Modifying tri-snRNP proteins rescues tau-induced deficits in transgenic C. elegans, restoring behaviour, neurodegeneration and extending lifespan.
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
October 16, 2025 at 3:41 PM
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Join us at the #ALSTDI Summit in Boston, MA tomorrow to learn more about how we're bringing #AI and unprecedented data to the fight against #ALS, the most common form of motor neurone disease ( #MND).
#LouGehrig #AIforGood #DrugDiscovery #HealthInnovation #Neurodegeneration
#LouGehrig #AIforGood #DrugDiscovery #HealthInnovation #Neurodegeneration
Summit day is almost here! 🙌 Join us this Friday for the ALS TDI Summit — a free conference sharing the latest breakthroughs in ALS research.
There’s still time to register to attend virtually 🌍
👉 fundraise.als.net/alssummit
There’s still time to register to attend virtually 🌍
👉 fundraise.als.net/alssummit
October 16, 2025 at 11:13 AM
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#drugdevelopment #Clinicaltrials #RandD #clinicalresearch #neurodegeneration #regenerativemedicine #clinicaltrialdevelopments #orphandrugdesignation #preclinicaldata #fasttrackdesignation #expandedaccess #FDApriorityreview #clinicalprogress #strategicfunding
zurl.co/jmZiW
zurl.co/jmZiW
Q3 Clinical trials round-up: July to September 2025
As the third quarter of 2025 draws to a close, the clinical research landscape has been marked by a surge of promising data and regulatory milestones.
zurl.co
October 15, 2025 at 11:15 AM
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🚬 New insight: smoking may accelerate symptom progression in Huntington’s disease, with smokers experiencing a faster decline. Lifestyle counselling could be key to slowing neurological deterioration.
www.emjreviews.com/en-us/amj/ne...
#AMJNeurology #HuntingtonsDisease #Neurodegeneration
www.emjreviews.com/en-us/amj/ne...
#AMJNeurology #HuntingtonsDisease #Neurodegeneration
Smoking Tied to Faster Huntington’s Decline
Analysis of Enroll-HD shows smoking is linked to earlier Huntington’s disease onset in women and faster motor and cognitive decline, supporting cessation advice for HD gene carriers.In Enroll-HD, smok...
www.emjreviews.com
October 14, 2025 at 1:19 PM
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Delighted to see this out in @NeuroCellPress!!!
Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS
www.cell.com/neuron/fullt...
Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS
www.cell.com/neuron/fullt...
Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis
Park, Nicaise, Tsitsipatis, and colleagues discover transcriptional and epigenetic
markers in human PMS iNSCs and fibroblasts that may underlie their senescent and inflammatory
state. Novel DARGs with...
www.cell.com
October 10, 2025 at 2:59 PM
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🔥 #Neurodegeneration won’t wait!⏳ Smarter #IT systems could transform millions of lives!❤️Read our review 📖 & spark the #NeuroRevolution 🌟@mdpiopenaccess.bsky.social #FutureMedicine #BrainHealth
👉
doi.org/10.3390/biom...
👉
doi.org/10.3390/biom...
October 10, 2025 at 5:42 AM
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