Researchers reported in Precision Clinical Medicine the results of a multicenter, randomized, double-blind clinical trial evaluating a traditional Chinese herbal formula for diabetic kidney disease with macroalbuminuria.
#DiabeticKidneyDisease
Details: doi.org/10.1093/pcmedi/pbaf031
#DiabeticKidneyDisease
Details: doi.org/10.1093/pcmedi/pbaf031
December 29, 2025 at 11:41 AM
Researchers reported in Precision Clinical Medicine the results of a multicenter, randomized, double-blind clinical trial evaluating a traditional Chinese herbal formula for diabetic kidney disease with macroalbuminuria.
#DiabeticKidneyDisease
Details: doi.org/10.1093/pcmedi/pbaf031
#DiabeticKidneyDisease
Details: doi.org/10.1093/pcmedi/pbaf031
This study explored the immune cell-related #Ferroptosis genes (ICRFGs) in #DiabeticKidneyDisease and identified ALOX5 as the most crucial ICRFG, which may serve as a reliable and prospective #Diagnostic #Biomarker. #medsky
Read here: doi.org/10.1007/s115...
Read here: doi.org/10.1007/s115...
December 4, 2025 at 9:00 AM
This study explored the immune cell-related #Ferroptosis genes (ICRFGs) in #DiabeticKidneyDisease and identified ALOX5 as the most crucial ICRFG, which may serve as a reliable and prospective #Diagnostic #Biomarker. #medsky
Read here: doi.org/10.1007/s115...
Read here: doi.org/10.1007/s115...
Mitochondrial protein TOMM7 alleviates diabetic kidney disease by regulating mitophagy via intracellular redistribution of phospholipase PLA2G6
doi.org/10.1016/j.kint.2025.10.009
#NephSky #MedSky #diabetickidneydisease #diabetesmellitus
doi.org/10.1016/j.kint.2025.10.009
#NephSky #MedSky #diabetickidneydisease #diabetesmellitus
December 1, 2025 at 4:50 PM
Mitochondrial protein TOMM7 alleviates diabetic kidney disease by regulating mitophagy via intracellular redistribution of phospholipase PLA2G6
doi.org/10.1016/j.kint.2025.10.009
#NephSky #MedSky #diabetickidneydisease #diabetesmellitus
doi.org/10.1016/j.kint.2025.10.009
#NephSky #MedSky #diabetickidneydisease #diabetesmellitus
The best way to slow or prevent diabetes-related kidney disease is to try to reach your blood glucose and blood pressure goals. Healthy lifestyle habits and taking your medicines as prescribed can help you achieve these goals and improve your health overall.
#diabetickidneydisease #kidneyhealth
#diabetickidneydisease #kidneyhealth
November 14, 2025 at 4:48 PM
The best way to slow or prevent diabetes-related kidney disease is to try to reach your blood glucose and blood pressure goals. Healthy lifestyle habits and taking your medicines as prescribed can help you achieve these goals and improve your health overall.
#diabetickidneydisease #kidneyhealth
#diabetickidneydisease #kidneyhealth
Ahead of #NationalDiabetesMonth, a PSA on diabetic kidney disease, which affects one-third of all patients with #diabetes.
Understand the clinical signs of #DiabeticKidneyDisease and how to prevent it -- guidance from Medical Director Adi Chandrasekhar, MD, MPH, FACP.
Understand the clinical signs of #DiabeticKidneyDisease and how to prevent it -- guidance from Medical Director Adi Chandrasekhar, MD, MPH, FACP.
October 30, 2025 at 4:03 PM
Ahead of #NationalDiabetesMonth, a PSA on diabetic kidney disease, which affects one-third of all patients with #diabetes.
Understand the clinical signs of #DiabeticKidneyDisease and how to prevent it -- guidance from Medical Director Adi Chandrasekhar, MD, MPH, FACP.
Understand the clinical signs of #DiabeticKidneyDisease and how to prevent it -- guidance from Medical Director Adi Chandrasekhar, MD, MPH, FACP.
Wonderful collaboration work from the GENIE consortium, focused on rare genetic variation and identified an EXD3 missense variant associated with #DiabeticKidneyDisease. @finndiane.bsky.social @folkhalsanresearch.bsky.social
#Exome-wide Analysis Identifies a Rare #EXD3 Missense Variant Associated With #Diabetic #Kidney Disease
#VisualAbstract by Stephanie Torres
https://www.kireports.org/article/S2468-0249(25)00649-7/fulltext
Niina Sandholm
#VisualAbstract by Stephanie Torres
https://www.kireports.org/article/S2468-0249(25)00649-7/fulltext
Niina Sandholm
October 29, 2025 at 6:57 PM
Wonderful collaboration work from the GENIE consortium, focused on rare genetic variation and identified an EXD3 missense variant associated with #DiabeticKidneyDisease. @finndiane.bsky.social @folkhalsanresearch.bsky.social
Shi et al identify defective leucine degradation in renal tubules of diabetic individuals and propose leucine as a causative factor for #DKD, highlighting its potential as a therapeutic target for further investigation #DiabeticKidneyDisease link.springer.com/article/10.1...
BCKDK accelerates the progression of diabetic kidney disease by regulating leucine-mediated metabolic remodelling in renal tubular cells - Diabetologia
Aims/hypothesis Kidney tubular cell injury is largely responsible for the pathophysiological features of diabetic kidney disease (DKD). Increased leucine levels in individuals with DKD have been assoc...
link.springer.com
August 28, 2025 at 7:59 AM
Shi et al identify defective leucine degradation in renal tubules of diabetic individuals and propose leucine as a causative factor for #DKD, highlighting its potential as a therapeutic target for further investigation #DiabeticKidneyDisease link.springer.com/article/10.1...
In a model of type 2 diabetic kidney disease, renal denervation lowered BP in early—but not late—stages, without improving blood sugar or kidney function. Timing may be key.
Read the research letter in The FASEB Journal: buff.ly/O6FxQQM
#DiabeticKidneyDisease #Nephrology #FASEBJournal
Read the research letter in The FASEB Journal: buff.ly/O6FxQQM
#DiabeticKidneyDisease #Nephrology #FASEBJournal
August 13, 2025 at 4:06 PM
In a model of type 2 diabetic kidney disease, renal denervation lowered BP in early—but not late—stages, without improving blood sugar or kidney function. Timing may be key.
Read the research letter in The FASEB Journal: buff.ly/O6FxQQM
#DiabeticKidneyDisease #Nephrology #FASEBJournal
Read the research letter in The FASEB Journal: buff.ly/O6FxQQM
#DiabeticKidneyDisease #Nephrology #FASEBJournal
Metabolic disorder–associated kidney disease and diabetic kidney disease in developing countries
doi.org/10.1016/j.kint.2025.03.034
#KIMiniReview #NephSky #MedSky #DKD #LMIC #diabetickidneydisease #MetabolicDisorder #kidneydisease #KidneyResearch
doi.org/10.1016/j.kint.2025.03.034
#KIMiniReview #NephSky #MedSky #DKD #LMIC #diabetickidneydisease #MetabolicDisorder #kidneydisease #KidneyResearch
July 29, 2025 at 3:59 PM
Metabolic disorder–associated kidney disease and diabetic kidney disease in developing countries
doi.org/10.1016/j.kint.2025.03.034
#KIMiniReview #NephSky #MedSky #DKD #LMIC #diabetickidneydisease #MetabolicDisorder #kidneydisease #KidneyResearch
doi.org/10.1016/j.kint.2025.03.034
#KIMiniReview #NephSky #MedSky #DKD #LMIC #diabetickidneydisease #MetabolicDisorder #kidneydisease #KidneyResearch
Genetic studies on metabolic disorder–associated kidney diseases
doi.org/10.1016/j.kint.2025.01.042
#KIMiniReview #diabetickidneydisease #obesity #metabolicdisorder #kidney #MedSky #NephSky
doi.org/10.1016/j.kint.2025.01.042
#KIMiniReview #diabetickidneydisease #obesity #metabolicdisorder #kidney #MedSky #NephSky
May 20, 2025 at 4:22 PM
Genetic studies on metabolic disorder–associated kidney diseases
doi.org/10.1016/j.kint.2025.01.042
#KIMiniReview #diabetickidneydisease #obesity #metabolicdisorder #kidney #MedSky #NephSky
doi.org/10.1016/j.kint.2025.01.042
#KIMiniReview #diabetickidneydisease #obesity #metabolicdisorder #kidney #MedSky #NephSky
A great Day 1 at EDNSG yesterday. So much wonderful research on diabetic kidney disease on display, topped off with a fab boat tour and dinner.
Lovely to meet and chat with collaborators and make some new friends! 😀
#diabetes #DKD #DiabeticKidneyDisease
Lovely to meet and chat with collaborators and make some new friends! 😀
#diabetes #DKD #DiabeticKidneyDisease
May 17, 2025 at 11:28 AM
A great Day 1 at EDNSG yesterday. So much wonderful research on diabetic kidney disease on display, topped off with a fab boat tour and dinner.
Lovely to meet and chat with collaborators and make some new friends! 😀
#diabetes #DKD #DiabeticKidneyDisease
Lovely to meet and chat with collaborators and make some new friends! 😀
#diabetes #DKD #DiabeticKidneyDisease
New evidence links low #vitaminD levels to #diabetickidneydisease -sunlight could be more vital than we thought.☀️
The study suggests that while vitamin D supplements may help reduce #proteinuria, it has no significant impact on other measures of #kidney function. doi.org/10.1177/2042...
The study suggests that while vitamin D supplements may help reduce #proteinuria, it has no significant impact on other measures of #kidney function. doi.org/10.1177/2042...
Role of vitamin D in the development and progression of diabetic kidney disease: an overview of meta-analyses - Ashna Chackochan, Muhammed Rashid, Swetha R. Reghunath, Pooja Gopal Poojari, Girish Thun...
Background: The effectiveness of vitamin D supplementation in the progression of diabetic kidney disease (DKD) remains controversial. Our review tries to provid...
doi.org
May 8, 2025 at 10:51 AM
New evidence links low #vitaminD levels to #diabetickidneydisease -sunlight could be more vital than we thought.☀️
The study suggests that while vitamin D supplements may help reduce #proteinuria, it has no significant impact on other measures of #kidney function. doi.org/10.1177/2042...
The study suggests that while vitamin D supplements may help reduce #proteinuria, it has no significant impact on other measures of #kidney function. doi.org/10.1177/2042...
Join us on Friday, April 25, 2025, from 11 am - 12 pm PT for the #dkNET #webinar "Endothelial Cell Fates in #DiabeticKidneyDisease - Lessons from the #Kidney #PrecisionMedicine Project (#KPMP)"!
Presenter: Dr. Ricardo Melo Ferreira
Register here: dknet.org/about/blog/2...
#Omics #FAIRdata
Presenter: Dr. Ricardo Melo Ferreira
Register here: dknet.org/about/blog/2...
#Omics #FAIRdata
April 22, 2025 at 5:03 PM
Join us on Friday, April 25, 2025, from 11 am - 12 pm PT for the #dkNET #webinar "Endothelial Cell Fates in #DiabeticKidneyDisease - Lessons from the #Kidney #PrecisionMedicine Project (#KPMP)"!
Presenter: Dr. Ricardo Melo Ferreira
Register here: dknet.org/about/blog/2...
#Omics #FAIRdata
Presenter: Dr. Ricardo Melo Ferreira
Register here: dknet.org/about/blog/2...
#Omics #FAIRdata
Podocyte aging and #diabetickidneydisease
doi.org/10.1016/j.kint.2025.01.011
Original article: doi.org/10.1016/j.kint.2024.12.013
#KICommentary #DKD #MedSky #NephSky
doi.org/10.1016/j.kint.2025.01.011
Original article: doi.org/10.1016/j.kint.2024.12.013
#KICommentary #DKD #MedSky #NephSky
March 31, 2025 at 3:34 PM
Podocyte aging and #diabetickidneydisease
doi.org/10.1016/j.kint.2025.01.011
Original article: doi.org/10.1016/j.kint.2024.12.013
#KICommentary #DKD #MedSky #NephSky
doi.org/10.1016/j.kint.2025.01.011
Original article: doi.org/10.1016/j.kint.2024.12.013
#KICommentary #DKD #MedSky #NephSky
Epigenetic alterations and memory: key players in the development/progression of chronic kidney disease promoted by #acutekidneyinjury and #diabetes
doi.org/10.1016/j.kint.2024.10.031
#OpenAccess #KIReview #CKD #AKI #chronickidneydisease #diabetickidneydisease #MedSky #NephSky
doi.org/10.1016/j.kint.2024.10.031
#OpenAccess #KIReview #CKD #AKI #chronickidneydisease #diabetickidneydisease #MedSky #NephSky
March 31, 2025 at 2:49 PM
Epigenetic alterations and memory: key players in the development/progression of chronic kidney disease promoted by #acutekidneyinjury and #diabetes
doi.org/10.1016/j.kint.2024.10.031
#OpenAccess #KIReview #CKD #AKI #chronickidneydisease #diabetickidneydisease #MedSky #NephSky
doi.org/10.1016/j.kint.2024.10.031
#OpenAccess #KIReview #CKD #AKI #chronickidneydisease #diabetickidneydisease #MedSky #NephSky
G-protein coupled receptor GPR124 protects against podocyte senescence and injury in diabetic kidney disease
doi.org/10.1016/j.kint.2024.12.013
#diabetickidneydisease #NephSky #MedSky
doi.org/10.1016/j.kint.2024.12.013
#diabetickidneydisease #NephSky #MedSky
March 18, 2025 at 4:40 PM
G-protein coupled receptor GPR124 protects against podocyte senescence and injury in diabetic kidney disease
doi.org/10.1016/j.kint.2024.12.013
#diabetickidneydisease #NephSky #MedSky
doi.org/10.1016/j.kint.2024.12.013
#diabetickidneydisease #NephSky #MedSky
Some key future research areas identified:
🔍 Understanding diabetic kidney disease mechanisms
🛑 Preventing diabetic kidney disease
⚖️ Tackling health inequalities
🔬 Enhancing diagnosis
🩺 Improving care
💪 Supporting self-management
#Diabetes #KidneyDisease
#Kidney
#DiabeticKidneyDisease
🔍 Understanding diabetic kidney disease mechanisms
🛑 Preventing diabetic kidney disease
⚖️ Tackling health inequalities
🔬 Enhancing diagnosis
🩺 Improving care
💪 Supporting self-management
#Diabetes #KidneyDisease
#Kidney
#DiabeticKidneyDisease
March 10, 2025 at 2:22 PM
Some key future research areas identified:
🔍 Understanding diabetic kidney disease mechanisms
🛑 Preventing diabetic kidney disease
⚖️ Tackling health inequalities
🔬 Enhancing diagnosis
🩺 Improving care
💪 Supporting self-management
#Diabetes #KidneyDisease
#Kidney
#DiabeticKidneyDisease
🔍 Understanding diabetic kidney disease mechanisms
🛑 Preventing diabetic kidney disease
⚖️ Tackling health inequalities
🔬 Enhancing diagnosis
🩺 Improving care
💪 Supporting self-management
#Diabetes #KidneyDisease
#Kidney
#DiabeticKidneyDisease
#SpatialTranscriptomics #Visium #Xenium
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
February 13, 2025 at 9:09 PM
#SpatialTranscriptomics #Visium #Xenium
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
A study of DKD drug monlunabant failed to meet its primary endpoint, but not all the kidney disease news in Novo Nordisk's 2024 financial report was bleak. #NovoNordisk #kidneydisease #diabetickidneydisease #drugdevelopment #nephrology #nephsky
Novo Nordisk Financial Report Reveals Monlunabant Failure But Several Bright Spots for Kidney Diseas | Docwire News
Monlunabant failed in a study of its use in diabetic kidney disease (DKD), but Novo Nordisk had positive news about other kidney treatments in its 2024 financial report.
buff.ly
February 7, 2025 at 5:15 PM
A study of DKD drug monlunabant failed to meet its primary endpoint, but not all the kidney disease news in Novo Nordisk's 2024 financial report was bleak. #NovoNordisk #kidneydisease #diabetickidneydisease #drugdevelopment #nephrology #nephsky
Glomerular Neovascularization
#DiabeticKidneyDisease #CaseReport
#SpatialTranscriptomics #Visium @10xGenomics
50-μm section multiplex IF
TEM▶️⏫Periglomerular Capillaries + de novo vascular anastomosis crossing Bowmen capsule
#KPMProject #CJASN 2024
journals.lww.com/cjasn/abstra...
#DiabeticKidneyDisease #CaseReport
#SpatialTranscriptomics #Visium @10xGenomics
50-μm section multiplex IF
TEM▶️⏫Periglomerular Capillaries + de novo vascular anastomosis crossing Bowmen capsule
#KPMProject #CJASN 2024
journals.lww.com/cjasn/abstra...
February 5, 2025 at 12:49 PM
Glomerular Neovascularization
#DiabeticKidneyDisease #CaseReport
#SpatialTranscriptomics #Visium @10xGenomics
50-μm section multiplex IF
TEM▶️⏫Periglomerular Capillaries + de novo vascular anastomosis crossing Bowmen capsule
#KPMProject #CJASN 2024
journals.lww.com/cjasn/abstra...
#DiabeticKidneyDisease #CaseReport
#SpatialTranscriptomics #Visium @10xGenomics
50-μm section multiplex IF
TEM▶️⏫Periglomerular Capillaries + de novo vascular anastomosis crossing Bowmen capsule
#KPMProject #CJASN 2024
journals.lww.com/cjasn/abstra...
A study assessed the efficacy of adding sodium zirconium cyclosilicate to allow patients with stage 3-4 DKD to maintain RAASi use. #kidneywk #nephrology #nephsky #raasi #diabetickidneydisease
Efficacy of SZC for Optimizing RAASi Treatment in DKD | Docwire News
A study examined the efficacy of adding sodium zirconium cyclosilicate (SZC) to allow patients with stage 3-4 diabetic kidney disease to maintain treatment with RAASi.
buff.ly
January 20, 2025 at 9:00 PM
A study assessed the efficacy of adding sodium zirconium cyclosilicate to allow patients with stage 3-4 DKD to maintain RAASi use. #kidneywk #nephrology #nephsky #raasi #diabetickidneydisease
Vascular endothelial growth factor B-mediated fatty acid flux in the adipose-kidney axis contributes to #lipotoxicity in #diabetickidneydisease
doi.org/10.1016/j.kint.2024.11.026
#OpenAccess #lipolysis #NephSky #MedSky
doi.org/10.1016/j.kint.2024.11.026
#OpenAccess #lipolysis #NephSky #MedSky
January 8, 2025 at 5:56 PM
Vascular endothelial growth factor B-mediated fatty acid flux in the adipose-kidney axis contributes to #lipotoxicity in #diabetickidneydisease
doi.org/10.1016/j.kint.2024.11.026
#OpenAccess #lipolysis #NephSky #MedSky
doi.org/10.1016/j.kint.2024.11.026
#OpenAccess #lipolysis #NephSky #MedSky
Just out for 2025- Protein handling in kidney tubules 👩🔬🧪🥼👨🔬 @natureportfolio.bsky.social ##NephSky #CardioSky #Nephropathy #kidney #kidneydisease #diabetickidneydisease 👇👇👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Protein handling in kidney tubules - Nature Reviews Nephrology
The kidney tubules have a crucial role in homeostasis as they modify and regulate the kidney filtrate. This Review examines current data on how filtered proteins are processed along the kidney tubule,...
www.nature.com
January 7, 2025 at 9:10 AM
Just out for 2025- Protein handling in kidney tubules 👩🔬🧪🥼👨🔬 @natureportfolio.bsky.social ##NephSky #CardioSky #Nephropathy #kidney #kidneydisease #diabetickidneydisease 👇👇👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TRAIL induces podocyte PANoptosis via death receptor 5 in diabetic kidney disease
doi.org/10.1016/j.kint.2024.10.026
#OpenAccess #diabetickidneydisease #podocytes #NephSky #MedSky
doi.org/10.1016/j.kint.2024.10.026
#OpenAccess #diabetickidneydisease #podocytes #NephSky #MedSky
January 1, 2025 at 11:47 PM
TRAIL induces podocyte PANoptosis via death receptor 5 in diabetic kidney disease
doi.org/10.1016/j.kint.2024.10.026
#OpenAccess #diabetickidneydisease #podocytes #NephSky #MedSky
doi.org/10.1016/j.kint.2024.10.026
#OpenAccess #diabetickidneydisease #podocytes #NephSky #MedSky