'B cells from NOD mice are characterized by exaggerated glucose uptake and elevated IL-10 expression compared with non-autoimmune B6 B cells, despite reduced HIF-1α levels and attenuated induction of HIF-dependent glycolytic genes.'
academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv...
Altered B cell metabolic pathways characterize type 1 diabetes progression
Abstract. Type 1 diabetes (T1D) results from immune-mediated destruction of pancreatic beta cells. B cells serve as critical antigen-presenting cells whose
academic.oup.com
January 25, 2026 at 11:15 AM
'B cells from NOD mice are characterized by exaggerated glucose uptake and elevated IL-10 expression compared with non-autoimmune B6 B cells, despite reduced HIF-1α levels and attenuated induction of HIF-dependent glycolytic genes.'
academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv...
Leptin Regulates Intervertebral Disc Calcification and Ossification by Promoting Glycolysis Through OCN/HIF-1α Axis. Haoxi Li et al. J Cell Mol Med 2026 Jan shorturl.at/fYloj … first study showing the effects of leptin on the intervertebral disc and cartilage endplate cells in rat model
January 24, 2026 at 8:34 AM
Leptin Regulates Intervertebral Disc Calcification and Ossification by Promoting Glycolysis Through OCN/HIF-1α Axis. Haoxi Li et al. J Cell Mol Med 2026 Jan shorturl.at/fYloj … first study showing the effects of leptin on the intervertebral disc and cartilage endplate cells in rat model
Integrated omics analysis identifies mechanical irritation as a driver of #OSCC progression via the HIF-1α/ASC/ #NLRP3 pathway
www.sciencedirect.com/science/arti... #OpenAccess #MedSky
www.sciencedirect.com/science/arti... #OpenAccess #MedSky
January 21, 2026 at 10:29 AM
Integrated omics analysis identifies mechanical irritation as a driver of #OSCC progression via the HIF-1α/ASC/ #NLRP3 pathway
www.sciencedirect.com/science/arti... #OpenAccess #MedSky
www.sciencedirect.com/science/arti... #OpenAccess #MedSky
Protein degradation is often considered a final step in gene expression regulation, but it also regulates the first step: Transcription
Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥:
⬛️ It has a key advantage.
blog.slavovlab.net/2025/08/16/p...
Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥:
⬛️ It has a key advantage.
blog.slavovlab.net/2025/08/16/p...
Proteins made to die
Protein synthesis is among the most energy-demanding processes in a cell. Yet, some proteins are synthesized and immediately degraded. This may seem like a futile cycle, but it’s a remarkable…
blog.slavovlab.net
January 19, 2026 at 12:32 PM
Protein degradation is often considered a final step in gene expression regulation, but it also regulates the first step: Transcription
Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥:
⬛️ It has a key advantage.
blog.slavovlab.net/2025/08/16/p...
Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥:
⬛️ It has a key advantage.
blog.slavovlab.net/2025/08/16/p...
Iron Deficiency Drives Sarcopenia in the Elderly: HIF-1α-Mediated Fibro-Adipogenic Progenitor Differentiation Induces Fat Infiltration and Impairs Muscle Function https://www.biorxiv.org/content/10.64898/2026.01.15.699636v1
January 19, 2026 at 10:30 AM
Iron Deficiency Drives Sarcopenia in the Elderly: HIF-1α-Mediated Fibro-Adipogenic Progenitor Differentiation Induces Fat Infiltration and Impairs Muscle Function https://www.biorxiv.org/content/10.64898/2026.01.15.699636v1
Iron Deficiency Drives Sarcopenia in the Elderly: HIF-1α-Mediated Fibro-Adipogenic Progenitor Differentiation Induces Fat Infiltration and Impairs Muscle Function https://www.biorxiv.org/content/10.64898/2026.01.15.699636v1
January 19, 2026 at 10:30 AM
Iron Deficiency Drives Sarcopenia in the Elderly: HIF-1α-Mediated Fibro-Adipogenic Progenitor Differentiation Induces Fat Infiltration and Impairs Muscle Function https://www.biorxiv.org/content/10.64898/2026.01.15.699636v1
Ophthopedia Update: Resveratrol alleviated diabetic retinal neuronal ferroptosis induced by high glucose through inhibiting HIF-1α and HMOX1 pathway: Publication date: Available online 17 January 2026
Source: Experimental Eye Research
Author(s): Meng Ye, Yan Jiang, Hongya Gong, Chaowu Wu, Tao…
Source: Experimental Eye Research
Author(s): Meng Ye, Yan Jiang, Hongya Gong, Chaowu Wu, Tao…
Resveratrol alleviated diabetic retinal neuronal ferroptosis induced by high glucose through inhibiting HIF-1α and HMOX1 pathway
Publication date: Available online 17 January 2026
Source: Experimental Eye Research
Author(s): Meng Ye, Yan Jiang, Hongya Gong, Chaowu Wu, Tao Li, Xuhui Chen
dlvr.it
January 17, 2026 at 2:24 PM
Ophthopedia Update: Resveratrol alleviated diabetic retinal neuronal ferroptosis induced by high glucose through inhibiting HIF-1α and HMOX1 pathway: Publication date: Available online 17 January 2026
Source: Experimental Eye Research
Author(s): Meng Ye, Yan Jiang, Hongya Gong, Chaowu Wu, Tao…
Source: Experimental Eye Research
Author(s): Meng Ye, Yan Jiang, Hongya Gong, Chaowu Wu, Tao…
🦠 Gut–lung crosstalk in sepsis: Dysbiosis + barrier failure → LPS translocation, lung inflammation, NETs, ALI/ARDS. Immune shift to glycolysis (HIF-1α), ROS/mtDNA, gut metabolites worsen injury. Restoring the axis (probiotics/FMT, vagal activation, immunometabolic profiling) may improve outcomes.
GastroAGI - AI Chat for Gastroenterology Students
Ask AI-powered questions about gastroenterology and enhance your academic learning.
gastroagi.com
January 13, 2026 at 12:55 PM
🦠 Gut–lung crosstalk in sepsis: Dysbiosis + barrier failure → LPS translocation, lung inflammation, NETs, ALI/ARDS. Immune shift to glycolysis (HIF-1α), ROS/mtDNA, gut metabolites worsen injury. Restoring the axis (probiotics/FMT, vagal activation, immunometabolic profiling) may improve outcomes.
HIF-1α under hypoxia
HIF-1α (a key player in oxygen sensing):
• mRNA levels stay high in normoxia.
• Protein is degraded under normoxia but stabilized under hypoxia, driving gene expression changes.
you might overlook hypoxia’s role in gene regulation without the context
HIF-1α (a key player in oxygen sensing):
• mRNA levels stay high in normoxia.
• Protein is degraded under normoxia but stabilized under hypoxia, driving gene expression changes.
you might overlook hypoxia’s role in gene regulation without the context
January 6, 2026 at 2:15 PM
HIF-1α under hypoxia
HIF-1α (a key player in oxygen sensing):
• mRNA levels stay high in normoxia.
• Protein is degraded under normoxia but stabilized under hypoxia, driving gene expression changes.
you might overlook hypoxia’s role in gene regulation without the context
HIF-1α (a key player in oxygen sensing):
• mRNA levels stay high in normoxia.
• Protein is degraded under normoxia but stabilized under hypoxia, driving gene expression changes.
you might overlook hypoxia’s role in gene regulation without the context
Nicotine exacerbates metabolic dysfunction-associated steatohepatitis by disrupting gut microbiota and impairing intestinal barrier integrity via HIF-1α suppression, while probiotic supplementation mitigates nicotine-induced liver injury.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Nicotine exacerbates MASH via inducing intestinal dysbiosis and barrier dysfunction - Communications Biology
Nicotine exacerbates MASH by disrupting gut microbiota and impairing intestinal barrier integrity via HIF-1α suppression, while probiotic supplementation mitigates nicotine-induced liver injury
www.nature.com
December 29, 2025 at 7:34 PM
Nicotine exacerbates metabolic dysfunction-associated steatohepatitis by disrupting gut microbiota and impairing intestinal barrier integrity via HIF-1α suppression, while probiotic supplementation mitigates nicotine-induced liver injury.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Regenerate Hyaluronan:
Prime tissue with HA precursors (UDP-sugars), then apply a brief HIF-2α–leaning pseudohypoxic pulse under low-ROS conditions without drifting into HIF-1α. Repeat.
Possible?
Prime tissue with HA precursors (UDP-sugars), then apply a brief HIF-2α–leaning pseudohypoxic pulse under low-ROS conditions without drifting into HIF-1α. Repeat.
Possible?
December 29, 2025 at 9:34 AM
Regenerate Hyaluronan:
Prime tissue with HA precursors (UDP-sugars), then apply a brief HIF-2α–leaning pseudohypoxic pulse under low-ROS conditions without drifting into HIF-1α. Repeat.
Possible?
Prime tissue with HA precursors (UDP-sugars), then apply a brief HIF-2α–leaning pseudohypoxic pulse under low-ROS conditions without drifting into HIF-1α. Repeat.
Possible?
#BMP9 upregulates #SIRT5 to drive #osteogenic differentiation in #MSCs and promote #BoneDefect repair by reducing HIF‑1α acetylation/malonylation—expanding BMP9 mechanisms and identifying targets to boost #osteogenesis for #TissueEngineering.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 24, 2025 at 2:56 AM
#BMP9 upregulates #SIRT5 to drive #osteogenic differentiation in #MSCs and promote #BoneDefect repair by reducing HIF‑1α acetylation/malonylation—expanding BMP9 mechanisms and identifying targets to boost #osteogenesis for #TissueEngineering.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
This study compares the protective effects of barbastatin A and valproic acid on vascular endothelial glycocalyx shedding during hemorrhagic shock by inhibiting HIF-1α/MMP-9 signaling.
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
December 23, 2025 at 8:00 PM
This study compares the protective effects of barbastatin A and valproic acid on vascular endothelial glycocalyx shedding during hemorrhagic shock by inhibiting HIF-1α/MMP-9 signaling.
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
HIF-1α-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development#Drosophilaa
HIF-1α-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
December 22, 2025 at 9:23 AM
HIF-1α-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development#Drosophilaa
Cell Regen Research | α-Ketoglutarate boosts skin flap survival! 🩹 Enhances angiogenesis via PI3K/Akt/HIF-1α in ischemic flaps. #Angiogenesis #WoundHealing
🔗 Full paper at: doi.org/10.1186/s136...
🔗 Full paper at: doi.org/10.1186/s136...
December 22, 2025 at 9:16 AM
Cell Regen Research | α-Ketoglutarate boosts skin flap survival! 🩹 Enhances angiogenesis via PI3K/Akt/HIF-1α in ischemic flaps. #Angiogenesis #WoundHealing
🔗 Full paper at: doi.org/10.1186/s136...
🔗 Full paper at: doi.org/10.1186/s136...
HIF-1α-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development#Drosophilaa
HIF-1α-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
December 22, 2025 at 6:23 AM
HIF-1α-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development#Drosophilaa
- Shift to Aerobic Glycolysis (Warburg Effect): Viral infections induce a shift from oxidative phosphorylation to aerobic glycolysis in glial cells, often mediated by the stabilization of HIF-1α.
- Microglia: Shift to a pro-inflammatory phenotype,
- Microglia: Shift to a pro-inflammatory phenotype,
December 20, 2025 at 4:56 AM
- Shift to Aerobic Glycolysis (Warburg Effect): Viral infections induce a shift from oxidative phosphorylation to aerobic glycolysis in glial cells, often mediated by the stabilization of HIF-1α.
- Microglia: Shift to a pro-inflammatory phenotype,
- Microglia: Shift to a pro-inflammatory phenotype,
This study compares the protective effects of barbastatin A and valproic acid on vascular endothelial glycocalyx shedding during hemorrhagic shock by inhibiting HIF-1α/MMP-9 signaling.
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
December 16, 2025 at 8:00 PM
This study compares the protective effects of barbastatin A and valproic acid on vascular endothelial glycocalyx shedding during hemorrhagic shock by inhibiting HIF-1α/MMP-9 signaling.
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
In conclusion #SARSCoV2 N protein is associated with the induction of microglia senescence, which, through metabolic reprogramming involving glycolysis,leads to chronic neuroinflammation & cognitive impairment.This process is marked by increased ROS, HIF-1α stabilization & SASP cytokine production
December 16, 2025 at 4:53 AM
In conclusion #SARSCoV2 N protein is associated with the induction of microglia senescence, which, through metabolic reprogramming involving glycolysis,leads to chronic neuroinflammation & cognitive impairment.This process is marked by increased ROS, HIF-1α stabilization & SASP cytokine production
In conclusion #SARSCoV2 N protein is associated with the induction of microglia senescence, which, through metabolic reprogramming involving glycolysis, leads to chronic neuroinflammation & cognitive impairment.This process is marked by increased ROS,HIF-1α stabilization & SASP cytokine production
December 15, 2025 at 11:44 AM
In conclusion #SARSCoV2 N protein is associated with the induction of microglia senescence, which, through metabolic reprogramming involving glycolysis, leads to chronic neuroinflammation & cognitive impairment.This process is marked by increased ROS,HIF-1α stabilization & SASP cytokine production
#SARSCoV2 infection triggers metabolic reprogramming towards glycolysis via mitochondrial dysfunction, ROS production & HIF-1α stabilization
-Increased glycolysis in microglia & other brain cells sustains the inflammatory response & may promote further senescence & viral persistence.
-Increased glycolysis in microglia & other brain cells sustains the inflammatory response & may promote further senescence & viral persistence.
December 15, 2025 at 11:11 AM
#SARSCoV2 infection triggers metabolic reprogramming towards glycolysis via mitochondrial dysfunction, ROS production & HIF-1α stabilization
-Increased glycolysis in microglia & other brain cells sustains the inflammatory response & may promote further senescence & viral persistence.
-Increased glycolysis in microglia & other brain cells sustains the inflammatory response & may promote further senescence & viral persistence.
potentially through the activation of acid-sensing ion channels and disruption of water homeostasis.
. Moreover, age-related hyperglycemia & mitochondrial dysfunction can exacerbate this process, further ⏫️ ROS and HIF-1α levels & promoting both glycolysis & the expression of inflammatory cytokines
. Moreover, age-related hyperglycemia & mitochondrial dysfunction can exacerbate this process, further ⏫️ ROS and HIF-1α levels & promoting both glycolysis & the expression of inflammatory cytokines
December 15, 2025 at 10:44 AM
potentially through the activation of acid-sensing ion channels and disruption of water homeostasis.
. Moreover, age-related hyperglycemia & mitochondrial dysfunction can exacerbate this process, further ⏫️ ROS and HIF-1α levels & promoting both glycolysis & the expression of inflammatory cytokines
. Moreover, age-related hyperglycemia & mitochondrial dysfunction can exacerbate this process, further ⏫️ ROS and HIF-1α levels & promoting both glycolysis & the expression of inflammatory cytokines
🧨 Role of #Glycolysis in #SARSCoV2 Induced Microglia Senescence
- ⏫️ in glycolysis in immune cells, incl monocytes & potentially microglia ➡️ induces mitochondrial dysfunction & ROS production, which stabilizes hypoxia-inducible factor-1α (HIF-1α) 🔑 regulator of #glycolysis
- ⏫️ in glycolysis in immune cells, incl monocytes & potentially microglia ➡️ induces mitochondrial dysfunction & ROS production, which stabilizes hypoxia-inducible factor-1α (HIF-1α) 🔑 regulator of #glycolysis
December 15, 2025 at 10:37 AM
🧨 Role of #Glycolysis in #SARSCoV2 Induced Microglia Senescence
- ⏫️ in glycolysis in immune cells, incl monocytes & potentially microglia ➡️ induces mitochondrial dysfunction & ROS production, which stabilizes hypoxia-inducible factor-1α (HIF-1α) 🔑 regulator of #glycolysis
- ⏫️ in glycolysis in immune cells, incl monocytes & potentially microglia ➡️ induces mitochondrial dysfunction & ROS production, which stabilizes hypoxia-inducible factor-1α (HIF-1α) 🔑 regulator of #glycolysis
This study compares the protective effects of barbastatin A and valproic acid on vascular endothelial glycocalyx shedding during hemorrhagic shock by inhibiting HIF-1α/MMP-9 signaling.
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
December 9, 2025 at 8:01 PM
This study compares the protective effects of barbastatin A and valproic acid on vascular endothelial glycocalyx shedding during hemorrhagic shock by inhibiting HIF-1α/MMP-9 signaling.
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
https://journals.lww.com/jtrauma/abstract/2025/12000/histone_deacetylase_inhibitors_protect_endothelial.15.aspx
This research reveals how SIRT5 can enhance the bone-forming effects of BMP9 by protecting HIF-1α from degradation in mouse embryonic fibroblasts suggesting a novel regulatory axis for improving osteogenesis.
#BoneRegeneration #RegenerativeMedicine #SIRT5
www.sciencedirect.com/science/arti...
#BoneRegeneration #RegenerativeMedicine #SIRT5
www.sciencedirect.com/science/arti...
December 8, 2025 at 3:38 PM
This research reveals how SIRT5 can enhance the bone-forming effects of BMP9 by protecting HIF-1α from degradation in mouse embryonic fibroblasts suggesting a novel regulatory axis for improving osteogenesis.
#BoneRegeneration #RegenerativeMedicine #SIRT5
www.sciencedirect.com/science/arti...
#BoneRegeneration #RegenerativeMedicine #SIRT5
www.sciencedirect.com/science/arti...