De rechtbank van eerste aanleg Oost-Vlaanderen heeft 15 mensen veroordeeld voor drugshandel in Gent. 2 leiders krijgen een gevangenisstraf van 5 jaar, terwijl verschillende koeriers gunstmaatregelen krijgen. De organisatie gebruikte schuilnamen om koeriers aan te sturen.

Nucleotide excision repair (NER) removes bulky adducts from genomic DNA and prevents the ultraviolet light-sensitivity disease xeroderma pigmentosum, cancer and premature ageing1. After initial lesion recognition by XPC in global genome repair or by stalled RNA polymerases in transcription-coupled repair, a lesion and surrounding DNA duplex are unwound by TFIIH, which includes the ATPases XPB and XPD, and additional NER factors XPA, XPF, XPG and RPA, to form a DNA bubble2 comprising around 27 nucleotides. The double strand–single strand (ds-ss) junction-specific endonucleases XPF and XPG cleave DNA on the 5′ and 3′ sides of the lesion, respectively. Here we report the functional steps and atomic structures of the ATPase-driven and lesion-dependent DNA bubble formation and arrangement of the complete NER factors for dual incision. The unwinding of nearly 30 base pairs of DNA depends mainly on the double strand DNA translocase XPB and the duplex dividers XPA and XPF. XPD binds the lesion strand with XPF at the 5′ ds-ss junction. XPF cuts the lesion strand only after XPG binds the 3′ ds-ss junction. The ERCC1 subunit of XPF facilitates DNA strand separation and recruitment of RPA to the non-lesion strand. These findings provide insights on the causes of human diseases and potential targets for enhancing chemotherapeutic efficacy. Cryo-electron microscopy structures of nucleotide excision repair complexes reveal the roles of the constituent proteins XPA, XPB, XPC, XPD, XPF, XPG and RPA in DNA bubble formation and excision of the lesion strand.

Ukraine fights with Challenger 2 main battle tanks. The British Army has 140 Challenger 2 tanks that will not be upgraded to Challenger 3 standard. There is a risk they will be dismanted and stored. Ukraine is a logical candidate, since it's already using them and is under attack.

De migratiedeal die Italië met Albanië heeft gesloten over asielopvang buiten EU-grenzen wordt met grote bewondering gevolgd door andere landen. Ook door Nederland. Maar deze deal biedt geen oplossing...

Listen to Franck, Boulanger, Debussy & Vermeulen: Works for Cello and Piano by Lidy Blijdorp, Tobias Borsboom, César Franck, Nadia Boulanger, Claude Debussy, Matthijs Vermeulen. Stream now on IDAGIO

VAL DI FIEMME (Nettavisen): – Fy faen! Det er kult, bryter Mika Vermeulen ut når Nettavisen viser han resultatlista fra søndagens 20 km skiathlon i OL.

De Tilburgse Ilse Vermeulen was veelgevraagd als kostuumontwerper en textielkunstenaar. Ze slaagde erin om richting haar omgeving altijd het positieve te brengen, wat gezien haar achtergrond niet vanzelfsprekend was.