After pioneering xenotransplant research using gene-edited pig kidneys since 2021, NYU Langone Health performed the first surgery in an FDA-sanctioned clinical trial.

Read the full paper: Encouraging experience using multi-transgenic xenografts in a pig-to-baboon cardiac xenotransplantation model

Overcoming the mechanisms of rejection in pig-to-human organ transplants.

Nature Reviews Nephrology - Long-term results of pig-to-human decedent thymokidney xenotransplantation

Nature’s round-up of innovations that are poised to make a splash in the year ahead.

One year ago, Tim Andrews was among the world’s first recipients of a genetically modified pig kidney. Now, he is the first in that small group of pioneers to go on to receive a human kidney.

Here, we present a protocol for the small-molecule-driven derivation of dopaminergic and GABAergic neurons from neural progenitor cells (NPCs) differentiated from human induced pluripotent stem cells and for stereotactic xenotransplantation of NPCs into the mouse forebrain. We also describe steps for perfusion of xenografted mice and microdissection of grafts for single-nucleus RNA sequencing analysis. This protocol can be used for various assays, including drug screening and toxicity assays, or...

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Nature’s round-up of innovations that are poised to make a splash in the year ahead.

One year ago, Tim Andrews was among the world’s first recipients of a genetically modified pig kidney. Now, he is the first in that small group of pioneers to go on to receive a human kidney.