But if your elongase allows substitutions, you can change every biochemical charactistic you'd like. They're also synthetically quite useful enzymes and we made a few fun molecules with them.

Polyketide Synthase-Like Functionality Acquired by Plant Fatty Acid Elongase https://www.biorxiv.org/content/10.1101/2025.10.13.682109v1

Polyketide Synthase-Like Functionality Acquired by Plant Fatty Acid Elongase https://www.biorxiv.org/content/10.1101/2025.10.13.682109v1

In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation https://www.biorxiv.org/content/10.1101/2025.06.11.659216v1

In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation https://www.biorxiv.org/content/10.1101/2025.06.11.659216v1

Host fatty #acids enhance #dengue #virus #infectivity ...

| #flavivirus | #infections | #fattyacid | #mosquito | #elongase | #desaturase | Via @asbmb.bsky.social‬

🚨New #OpenAccess research in #BMCBiology 🚨Regulatory changes in the fatty acid elongase eloF underlie the evolution of sex-specific pheromone profiles in Drosophila prolongata 🪰❤️🪰
bmcbiol.biomedcentral.com/articles/10....

Molecular Characterization and Nutritional Regulation of Two Fatty Acid Elongase (elovl8) Genes in Chinese Perch (Siniperca chuatsi) https://pubmed.ncbi.nlm.nih.gov/40305290/

Regulatory changes in the fatty acid elongase eloF underlie the evolution of sex-specific pheromone profiles in Drosophila prolongata
#Drosophila

2️⃣ Why does this matter?
PDAC has a 12% survival rate, with poor responses to chemo. c-MYC reprograms tumor metabolism, making cancer cells more aggressive. We found that ELOVL6, a key fatty acid elongase, is directly regulated by c-MYC and could be a therapeutic target. 🔬

#PancreaticCancer 🧪

3/ ELOVL6 is an elongase enzyme involved in fatty acid synthesis. Our research reveals that c-MYC upregulates ELOVL6 in multiple PDAC models and cell lines, boosting lipid elongation to support cancer cell transformation

Regulatory Changes in the Fatty Acid Elongase eloF Underlie the Evolution of Sex-specific Pheromone Profiles in Drosophila prolongata https://www.biorxiv.org/content/10.1101/2024.10.09.617394v1

Regulatory Changes in the Fatty Acid Elongase eloF Underlie the Evolution of Sex-specific Pheromone Profiles in Drosophila prolongata https://www.biorxiv.org/content/10.1101/2024.10.09.617394v1

Delta-5 elongase knockout reduces DHA and TAG synthesis coupled with an increase of heat sensitivity in a marine diatom https://www.biorxiv.org/content/10.1101/2024.04.19.590303v1

Delta-5 elongase knockout reduces DHA and TAG synthesis coupled with an increase of heat sensitivity in a marine diatom https://www.biorxiv.org/content/10.1101/2024.04.19.590303v1

Wang, Z., Pu, J., Richards, C., Giannetti, E., Cong, H., Lin, Z., Chung, H. (2023). Evolution of a fatty acyl-CoA elongase underlies desert adaptation in Drosophila. Sci Adv, 9(35):eadg0328 www.science.org/doi/10.1126/...

Sato, M., Ota, R., Kobayashi, S., Yamakawa-Kobayashi, K., Miura, T., Ido, A. and Ohhara, Y. (2023). Bioproduction of n-3 polyunsaturated fatty acids by nematode fatty acid desaturases and elongase in Drosophila melanogaster. Transgenic Res. link.springer.com/article/10.1...