Our latest paper is online!
Here we report that a novel #Mediterranean diet-inspired supplement promotes a significant reduction in hippocampal #amyloid deposits and #neuroinflammation through the modulation of the #microbiota #gut-brain axis.
www.tandfonline.com/doi/full/10....
Here we report that a novel #Mediterranean diet-inspired supplement promotes a significant reduction in hippocampal #amyloid deposits and #neuroinflammation through the modulation of the #microbiota #gut-brain axis.
www.tandfonline.com/doi/full/10....
A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice
Alzheimer's disease (AD) is projected to increase in prevalence, heightening the need for strategies to alleviate its neuropathological burden. The bioactive constituents of a Mediterranean-style d...
www.tandfonline.com
January 14, 2026 at 12:13 PM
Our latest paper is online!
Here we report that a novel #Mediterranean diet-inspired supplement promotes a significant reduction in hippocampal #amyloid deposits and #neuroinflammation through the modulation of the #microbiota #gut-brain axis.
www.tandfonline.com/doi/full/10....
Here we report that a novel #Mediterranean diet-inspired supplement promotes a significant reduction in hippocampal #amyloid deposits and #neuroinflammation through the modulation of the #microbiota #gut-brain axis.
www.tandfonline.com/doi/full/10....
Non-invasive tracking of hippocampal theta oscillations https://www.biorxiv.org/content/10.64898/2026.01.13.699218v1
January 14, 2026 at 4:18 AM
Non-invasive tracking of hippocampal theta oscillations https://www.biorxiv.org/content/10.64898/2026.01.13.699218v1
Non-invasive tracking of hippocampal theta oscillations https://www.biorxiv.org/content/10.64898/2026.01.13.699218v1
January 14, 2026 at 4:18 AM
Non-invasive tracking of hippocampal theta oscillations https://www.biorxiv.org/content/10.64898/2026.01.13.699218v1
A hypothalamo-septo-hippocampal circuit for REM sleep-dependent consolidation of social memory https://www.biorxiv.org/content/10.64898/2026.01.13.699230v1
January 14, 2026 at 4:16 AM
A hypothalamo-septo-hippocampal circuit for REM sleep-dependent consolidation of social memory https://www.biorxiv.org/content/10.64898/2026.01.13.699230v1
A hypothalamo-septo-hippocampal circuit for REM sleep-dependent consolidation of social memory https://www.biorxiv.org/content/10.64898/2026.01.13.699230v1
January 14, 2026 at 4:16 AM
A hypothalamo-septo-hippocampal circuit for REM sleep-dependent consolidation of social memory https://www.biorxiv.org/content/10.64898/2026.01.13.699230v1
Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model https://www.biorxiv.org/content/10.64898/2026.01.12.699079v1
January 13, 2026 at 11:00 PM
Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model https://www.biorxiv.org/content/10.64898/2026.01.12.699079v1
Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model https://www.biorxiv.org/content/10.64898/2026.01.12.699079v1
January 13, 2026 at 11:00 PM
Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model https://www.biorxiv.org/content/10.64898/2026.01.12.699079v1
New #GWAS includes meta-analysis of eleven neuropathology endophenotypes from neuritic plaques and tau neurofibrillary to cerebral atherosclerosis and hippocampal sclerosis
#genetics #data
dss.niagads.org/datasets/ng...
#genetics #data
dss.niagads.org/datasets/ng...
NG00175-Genome-wide association study of neuropathology endophenotypes - Shade et al. 2024 - DSS NIAGADS
To access the full dataset, please log into DSS and submit an application.Within the application, add this dataset (accession NG00175) in the “Choose a Dataset” section.Once approved, you will be able to log in and access the data within the DARM por
dss.niagads.org
January 13, 2026 at 5:00 PM
New #GWAS includes meta-analysis of eleven neuropathology endophenotypes from neuritic plaques and tau neurofibrillary to cerebral atherosclerosis and hippocampal sclerosis
#genetics #data
dss.niagads.org/datasets/ng...
#genetics #data
dss.niagads.org/datasets/ng...
If there is a cell where microtubules are important for shaping and maintaining morphology and trafficking, it's the neuron. So we set up to assess microtubule turnover and the existence of in-lattice insertion in the best studied model of neuronal polarization - hippocampal neurons in culture 🧵 3/9
January 12, 2026 at 7:14 PM
If there is a cell where microtubules are important for shaping and maintaining morphology and trafficking, it's the neuron. So we set up to assess microtubule turnover and the existence of in-lattice insertion in the best studied model of neuronal polarization - hippocampal neurons in culture 🧵 3/9
🚨The Neurocyto lab is branching out in our latest preprint! We used tubulin microinjection to directly visualize microtubule turnover in developing hippocampal neurons, demonstrating the presence of in-lattice repair and a selective stabilization in the nascent axon. Check below, or read on 🧵 1/9
Direct labeling of microtubule turnover reveals in-lattice repair and stabilization patterns in developing neurons
The microtubule cytoskeleton is the backbone of neuronal morphogenesis, driving the development of the dendrites and axon, and supporting trafficking to distant compartments. How neuronal microtubules...
www.biorxiv.org
January 12, 2026 at 7:14 PM
🚨The Neurocyto lab is branching out in our latest preprint! We used tubulin microinjection to directly visualize microtubule turnover in developing hippocampal neurons, demonstrating the presence of in-lattice repair and a selective stabilization in the nascent axon. Check below, or read on 🧵 1/9
📃Scientific paper: The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking
Ref.: Springer Nature Singapore, 2024
➡️ Continued on ES/IODE
Ref.: Springer Nature Singapore, 2024
➡️ Continued on ES/IODE
January 12, 2026 at 11:00 AM
📃Scientific paper: The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking
Ref.: Springer Nature Singapore, 2024
➡️ Continued on ES/IODE
Ref.: Springer Nature Singapore, 2024
➡️ Continued on ES/IODE
Trishna Niraula: Hippocampal Atrophy Patterns Across the Alzheimer's Disease Spectrum: A Voxel-Based Morphometry Analysis https://arxiv.org/abs/2601.05494 https://arxiv.org/pdf/2601.05494 https://arxiv.org/html/2601.05494
January 12, 2026 at 6:30 AM
Trishna Niraula: Hippocampal Atrophy Patterns Across the Alzheimer's Disease Spectrum: A Voxel-Based Morphometry Analysis https://arxiv.org/abs/2601.05494 https://arxiv.org/pdf/2601.05494 https://arxiv.org/html/2601.05494
I urge you to look further into this, because no, you're wrong; hippocampal function *does* deteriorate when information is decoupled from spatial orientation and other sensory inputs. This is a major reason why mnemonic devices like the Memory Palace work so well.
Dig into the citations for more.
Dig into the citations for more.
January 12, 2026 at 12:06 AM
I urge you to look further into this, because no, you're wrong; hippocampal function *does* deteriorate when information is decoupled from spatial orientation and other sensory inputs. This is a major reason why mnemonic devices like the Memory Palace work so well.
Dig into the citations for more.
Dig into the citations for more.
However, @mmonzel.bsky.social et al. (2024) [see below] found reduced hippocampal activity during autobiographical memory retrival in aphantasics, which supports the memory impairment hypothesis. That should be the end of it, right? Well... 3/8
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
Hippocampal-occipital connectivity reflects autobiographical memory deficits in aphantasia
The autobiographical memory deficits seen in aphantasia are reflected by altered activation and connectivity patterns of the hippocampus and occipital cortex, corroborating the strong link between memory and mental imagery.
doi.org
January 11, 2026 at 11:31 AM
However, @mmonzel.bsky.social et al. (2024) [see below] found reduced hippocampal activity during autobiographical memory retrival in aphantasics, which supports the memory impairment hypothesis. That should be the end of it, right? Well... 3/8
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
-Pro-inflammatory cytokines interfere with synaptic plasticity, including long-term potentiation & long-term depression which are essential for learning and memory
- Chronic inflammation negatively affects hippocampal neurogenesis, further impairing cognitive processes across the lifespan
- Chronic inflammation negatively affects hippocampal neurogenesis, further impairing cognitive processes across the lifespan
January 11, 2026 at 5:29 AM
-Pro-inflammatory cytokines interfere with synaptic plasticity, including long-term potentiation & long-term depression which are essential for learning and memory
- Chronic inflammation negatively affects hippocampal neurogenesis, further impairing cognitive processes across the lifespan
- Chronic inflammation negatively affects hippocampal neurogenesis, further impairing cognitive processes across the lifespan
Can concur. I have severe hippocampal atrophy. SSA is denying applications for disability due to excessive numbers. Even with MRI proof from Mayo, I have to wait for a court hearing.
January 10, 2026 at 5:04 PM
Can concur. I have severe hippocampal atrophy. SSA is denying applications for disability due to excessive numbers. Even with MRI proof from Mayo, I have to wait for a court hearing.
GDF11/TGFBR1 Activation Is Essential for the Antidepressant-like Effect of H₂S: Role of Suppressing the hippocampal cascade of necroptosis-neuroinflammation-Kynurenine Pathway Disorder Phys&Beh
GDF11/TGFBR1 Activation Is Essential for the Antidepressant-like Effect of H₂S: Role of Suppressing the hippocampal cascade of necroptosis-neuroinflammation-Kynurenine Pathway Disorder
Publication date: Available online 10 January 2026
Source: Physiology & Behavior
Author(s): Xiang Chen, Bo Wang, Yu-Hui Tang, Yi-Li Yi, Wei Zou, Xiao-Qing Tang, San-Qiao Yang
dlvr.it
January 10, 2026 at 3:02 PM
GDF11/TGFBR1 Activation Is Essential for the Antidepressant-like Effect of H₂S: Role of Suppressing the hippocampal cascade of necroptosis-neuroinflammation-Kynurenine Pathway Disorder Phys&Beh
Chronic stress alters the brain: amygdala hyperactivity, hippocampal memory impairment, and reduced prefrontal regulation.
Neuroplasticity allows recovery through mindfulness, therapy, exercise, rest, and social connection.
#Neuroscience #BrainHealth
Neuroplasticity allows recovery through mindfulness, therapy, exercise, rest, and social connection.
#Neuroscience #BrainHealth
January 9, 2026 at 7:49 PM
Chronic stress alters the brain: amygdala hyperactivity, hippocampal memory impairment, and reduced prefrontal regulation.
Neuroplasticity allows recovery through mindfulness, therapy, exercise, rest, and social connection.
#Neuroscience #BrainHealth
Neuroplasticity allows recovery through mindfulness, therapy, exercise, rest, and social connection.
#Neuroscience #BrainHealth
Fluorescence Friday- DIV21 hippocampal neurons imaged with 10x expansion microscopy.
Magenta- Bassoon
Cyan- PSD95
Magenta- Bassoon
Cyan- PSD95
January 9, 2026 at 7:31 PM
Fluorescence Friday- DIV21 hippocampal neurons imaged with 10x expansion microscopy.
Magenta- Bassoon
Cyan- PSD95
Magenta- Bassoon
Cyan- PSD95
This is very cool work!
Reminiscent of spatial vs. associative encodings in hippocampal research in cog neuro as well as differences in low-rank bias across different regions of the brain (e.g. www.jneurosci.org/content/38/4...)
Reminiscent of spatial vs. associative encodings in hippocampal research in cog neuro as well as differences in low-rank bias across different regions of the brain (e.g. www.jneurosci.org/content/38/4...)
January 9, 2026 at 9:20 AM
This is very cool work!
Reminiscent of spatial vs. associative encodings in hippocampal research in cog neuro as well as differences in low-rank bias across different regions of the brain (e.g. www.jneurosci.org/content/38/4...)
Reminiscent of spatial vs. associative encodings in hippocampal research in cog neuro as well as differences in low-rank bias across different regions of the brain (e.g. www.jneurosci.org/content/38/4...)
"Untreated and long term depression leads to hippocampal volume loss"
Ok I know I know but whenever this part of the brain is mentioned I do just imagine a very small hippo chilling - or not chilling - out in my skull. I must keep the hippo happy and plump.
Ok I know I know but whenever this part of the brain is mentioned I do just imagine a very small hippo chilling - or not chilling - out in my skull. I must keep the hippo happy and plump.
January 9, 2026 at 8:48 AM
"Untreated and long term depression leads to hippocampal volume loss"
Ok I know I know but whenever this part of the brain is mentioned I do just imagine a very small hippo chilling - or not chilling - out in my skull. I must keep the hippo happy and plump.
Ok I know I know but whenever this part of the brain is mentioned I do just imagine a very small hippo chilling - or not chilling - out in my skull. I must keep the hippo happy and plump.
Hippocampal Asymmetry Captures Non Amyloid Related Risk of Memory Decline and Clinical Progression #NeuroDegeneration 🧪🧠
https://www.medrxiv.org/content/10.64898/2026.01.06.26343553v1
https://www.medrxiv.org/content/10.64898/2026.01.06.26343553v1
January 9, 2026 at 8:02 AM
Hippocampal Asymmetry Captures Non Amyloid Related Risk of Memory Decline and Clinical Progression #NeuroDegeneration 🧪🧠
https://www.medrxiv.org/content/10.64898/2026.01.06.26343553v1
https://www.medrxiv.org/content/10.64898/2026.01.06.26343553v1
Hippocampal Asymmetry Captures Non Amyloid Related Risk of Memory Decline and Clinical Progression https://www.medrxiv.org/content/10.64898/2026.01.06.26343553v1
January 8, 2026 at 9:25 PM
Hippocampal Asymmetry Captures Non Amyloid Related Risk of Memory Decline and Clinical Progression https://www.medrxiv.org/content/10.64898/2026.01.06.26343553v1
Chronic elevation of IL-6 is an independent risk factor for the "brain fog," depression, and fatigue typical of LC. High IL-6 levels in the CSF are strongly associated with impaired hippocampal neurogenesis & altered synaptic function.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms - Molecular Psychiatry
Molecular Psychiatry - Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms
www.nature.com
January 8, 2026 at 7:32 AM
Chronic elevation of IL-6 is an independent risk factor for the "brain fog," depression, and fatigue typical of LC. High IL-6 levels in the CSF are strongly associated with impaired hippocampal neurogenesis & altered synaptic function.
www.nature.com/articles/s41...
www.nature.com/articles/s41...