MHC one–two punch knocks out #cancer. Amir Ghorbani and Jonathan Yewdell @niaidnews.bsky.social discuss new study by Zhang, Chamoto and colleagues @ccii-kyoto.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#TumorImmunology #Immunotherapy
#TumorImmunology #Immunotherapy
January 27, 2026 at 2:30 PM
MHC one–two punch knocks out #cancer. Amir Ghorbani and Jonathan Yewdell @niaidnews.bsky.social discuss new study by Zhang, Chamoto and colleagues @ccii-kyoto.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#TumorImmunology #Immunotherapy
#TumorImmunology #Immunotherapy
Please stop doing STING studies in vivo with LLC models and claiming it says something about human STING agonism #tumorimmunology
January 20, 2026 at 7:59 AM
Please stop doing STING studies in vivo with LLC models and claiming it says something about human STING agonism #tumorimmunology
Explore the 2025 𝘉𝘦𝘴𝘵 𝘰𝘧 𝘑𝘌𝘔 papers in basic #immunology, #immunotherapy and #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, and #inflammation 👉 rupress.org/jem/collecti...
THANK YOU to our authors, reviewers, and readers for your interest and continued support for JEM!
THANK YOU to our authors, reviewers, and readers for your interest and continued support for JEM!
January 16, 2026 at 2:31 PM
Explore the 2025 𝘉𝘦𝘴𝘵 𝘰𝘧 𝘑𝘌𝘔 papers in basic #immunology, #immunotherapy and #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, and #inflammation 👉 rupress.org/jem/collecti...
THANK YOU to our authors, reviewers, and readers for your interest and continued support for JEM!
THANK YOU to our authors, reviewers, and readers for your interest and continued support for JEM!
T cell engagers emerge as a compelling therapeutic modality. New review from Baeuerle, Grieshaber-Bouyer, Sauer, and Michaelson: rupress.org/jem/article/...
#CancerFocus #TumorImmunology #TcellEngagers
#CancerFocus #TumorImmunology #TcellEngagers
January 12, 2026 at 2:30 PM
T cell engagers emerge as a compelling therapeutic modality. New review from Baeuerle, Grieshaber-Bouyer, Sauer, and Michaelson: rupress.org/jem/article/...
#CancerFocus #TumorImmunology #TcellEngagers
#CancerFocus #TumorImmunology #TcellEngagers
Xiaoyun Li, Sofie Hedlund Møller, Ping-Chih Ho et al. show that tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor #macrophages 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#TumorImmunology
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#TumorImmunology
December 26, 2025 at 3:15 PM
Xiaoyun Li, Sofie Hedlund Møller, Ping-Chih Ho et al. show that tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor #macrophages 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#TumorImmunology
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#TumorImmunology
The ability to specifically engage tumor-reactive T cells for therapeutic benefit is the ultimate goal of cancer #immunotherapy. New review by Mirabile-Brightman and Butterfield discusses advances in the development of personalized neoantigen therapies. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
December 23, 2025 at 8:30 PM
The ability to specifically engage tumor-reactive T cells for therapeutic benefit is the ultimate goal of cancer #immunotherapy. New review by Mirabile-Brightman and Butterfield discusses advances in the development of personalized neoantigen therapies. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
New findings from Zhang, Honjo, Chamoto et al. @ccii-kyoto.bsky.social indicate that a subset of cancer cells expressing CTAs is sufficient to evoke overall antitumor immunity by broadening T cell responses to other neoantigens. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
December 19, 2025 at 4:15 PM
New findings from Zhang, Honjo, Chamoto et al. @ccii-kyoto.bsky.social indicate that a subset of cancer cells expressing CTAs is sufficient to evoke overall antitumor immunity by broadening T cell responses to other neoantigens. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
The 2025 𝘉𝘦𝘴𝘵 𝘰𝘧 𝘑𝘌𝘔 highlights research in basic #immunology, #immunotherapy & #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, & #inflammation. We remain grounded in our commitment to publishing studies that push the boundaries of our knowledge forward 👉 rupress.org/jem/collecti...
December 17, 2025 at 3:15 PM
The 2025 𝘉𝘦𝘴𝘵 𝘰𝘧 𝘑𝘌𝘔 highlights research in basic #immunology, #immunotherapy & #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, & #inflammation. We remain grounded in our commitment to publishing studies that push the boundaries of our knowledge forward 👉 rupress.org/jem/collecti...
Following the recommendation of the EFIS Gender & Diversity Task Force, #EFIS is pleased to announce that 2025 EJI Ita Askonas Prize is awarded to @obenaufa.bsky.social from the @impvienna.bsky.social!
🎉Our warm congratulations
🔗 www.efis.org/news/2025-ej...
#tumorimmunology
@eurjimmunol.bsky.social
🎉Our warm congratulations
🔗 www.efis.org/news/2025-ej...
#tumorimmunology
@eurjimmunol.bsky.social
December 17, 2025 at 9:45 AM
Following the recommendation of the EFIS Gender & Diversity Task Force, #EFIS is pleased to announce that 2025 EJI Ita Askonas Prize is awarded to @obenaufa.bsky.social from the @impvienna.bsky.social!
🎉Our warm congratulations
🔗 www.efis.org/news/2025-ej...
#tumorimmunology
@eurjimmunol.bsky.social
🎉Our warm congratulations
🔗 www.efis.org/news/2025-ej...
#tumorimmunology
@eurjimmunol.bsky.social
Advances in the development of personalized neoantigen therapies. New review from Spencer Mirabile-Brightman @lji.org and Lisa Butterfield (Merck Research Laboratories): rupress.org/jem/article/...
#JEMCancerFocus #TumorImmunology #SolidTumor
#JEMCancerFocus #TumorImmunology #SolidTumor
December 16, 2025 at 9:15 PM
Advances in the development of personalized neoantigen therapies. New review from Spencer Mirabile-Brightman @lji.org and Lisa Butterfield (Merck Research Laboratories): rupress.org/jem/article/...
#JEMCancerFocus #TumorImmunology #SolidTumor
#JEMCancerFocus #TumorImmunology #SolidTumor
Chimeric MHC class I and II-restricted non-self epitopes broaden anti-tumor T cell reactions. New study from Rongsheng Zhang, Tasuku Honjo, Kenji Chamoto and colleagues @ccii-kyoto.bsky.social: rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
December 12, 2025 at 8:15 PM
Chimeric MHC class I and II-restricted non-self epitopes broaden anti-tumor T cell reactions. New study from Rongsheng Zhang, Tasuku Honjo, Kenji Chamoto and colleagues @ccii-kyoto.bsky.social: rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
Mirabile–Brightman and Butterfield review the status of cancer vaccination. They focus on tumor-specific antigens, promotion of antitumor immunity, and optimal early stage clinical settings now allowing for improved outcomes for patients. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
December 9, 2025 at 6:30 PM
Mirabile–Brightman and Butterfield review the status of cancer vaccination. They focus on tumor-specific antigens, promotion of antitumor immunity, and optimal early stage clinical settings now allowing for improved outcomes for patients. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
In @jem.org, Zhang, Honjo, Chamoto et al. @ccii-kyoto.bsky.social identified peptide sequence principles that drive dendritic cell maturation and broaden tumor-reactive T cell clones, even with non-tumor sequences. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
December 5, 2025 at 6:30 PM
In @jem.org, Zhang, Honjo, Chamoto et al. @ccii-kyoto.bsky.social identified peptide sequence principles that drive dendritic cell maturation and broaden tumor-reactive T cell clones, even with non-tumor sequences. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
Zhang, Honjo, Chamoto et al. @ccii-kyoto.bsky.social identified peptide sequence principles that drive dendritic cell maturation and broaden tumor-reactive T cell clones, even with non-tumor sequences. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
December 5, 2025 at 5:45 PM
Zhang, Honjo, Chamoto et al. @ccii-kyoto.bsky.social identified peptide sequence principles that drive dendritic cell maturation and broaden tumor-reactive T cell clones, even with non-tumor sequences. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
Chen, Weichselbaum et al. @ludwigcancer.bsky.social discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy (RT), providing a clinically actionable strategy to overcome RT resistance and #metastasis. rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors
November 20, 2025 at 7:45 PM
Chen, Weichselbaum et al. @ludwigcancer.bsky.social discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy (RT), providing a clinically actionable strategy to overcome RT resistance and #metastasis. rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors
#Radiotherapy induces YTHDF2 in #DendriticCells impairing cross-presentation and T cell function, say Dapeng Chen, Chuan He, Hua Laura Liang, Ralph Weichselbaum @ludwigcancer.bsky.social and colleagues: rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors
November 13, 2025 at 3:30 PM
#Radiotherapy induces YTHDF2 in #DendriticCells impairing cross-presentation and T cell function, say Dapeng Chen, Chuan He, Hua Laura Liang, Ralph Weichselbaum @ludwigcancer.bsky.social and colleagues: rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors
This latest review examines the clinical relevance of #PRMT5 in various #Cancers, its role in #TumorImmunology, the trials involving PRMT5 #inhibitors, offering insights into future directions for PRMT5-targeted therapy. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
October 19, 2025 at 12:51 AM
This latest review examines the clinical relevance of #PRMT5 in various #Cancers, its role in #TumorImmunology, the trials involving PRMT5 #inhibitors, offering insights into future directions for PRMT5-targeted therapy. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity, say Xu et al. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity
This study demonstrates that the cGAS-TREX1 axis forms a critical negative feedback loop, enabling immune evasion in MSI-H/dMMR tumors. They revealed that
rupress.org
October 14, 2025 at 2:32 PM
Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity, say Xu et al. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
Reading list update! 📖
Dr. Zhian Chen dropped some fresh reviews covering inhibitory receptors, cell surface proximity tricks, and cholinergic T cells that apparently "revitalize" tumor environments.
Perfect weekend science reading material! buff.ly/xYeKUh9
#CytokineSociety #TumorImmunology
Dr. Zhian Chen dropped some fresh reviews covering inhibitory receptors, cell surface proximity tricks, and cholinergic T cells that apparently "revitalize" tumor environments.
Perfect weekend science reading material! buff.ly/xYeKUh9
#CytokineSociety #TumorImmunology
September 29, 2025 at 7:03 PM
Reading list update! 📖
Dr. Zhian Chen dropped some fresh reviews covering inhibitory receptors, cell surface proximity tricks, and cholinergic T cells that apparently "revitalize" tumor environments.
Perfect weekend science reading material! buff.ly/xYeKUh9
#CytokineSociety #TumorImmunology
Dr. Zhian Chen dropped some fresh reviews covering inhibitory receptors, cell surface proximity tricks, and cholinergic T cells that apparently "revitalize" tumor environments.
Perfect weekend science reading material! buff.ly/xYeKUh9
#CytokineSociety #TumorImmunology
Specific loading of oncolytic VSV on CAR enhances CAR-T cell signaling and anti-tumor activity, say Fan Xing, Hui Zhang and colleagues (Sun Yat-sen University): rupress.org/jem/article/...
#TumorImmunology #Immunotherapy
#TumorImmunology #Immunotherapy
September 19, 2025 at 2:03 PM
Specific loading of oncolytic VSV on CAR enhances CAR-T cell signaling and anti-tumor activity, say Fan Xing, Hui Zhang and colleagues (Sun Yat-sen University): rupress.org/jem/article/...
#TumorImmunology #Immunotherapy
#TumorImmunology #Immunotherapy
Job Alert
PhD Candidate for the Division of Personalized Immunotherapies
Deadline: 2025-09-30
Location: Germany, Mainz
www.academiceurope.com/ads/phd-cand...
#hiring #CancerResearch #tumorImmunology #PhD #molecularbiology #genetics #biochemistry #pharmaceuticalsciences #bioengineering
PhD Candidate for the Division of Personalized Immunotherapies
Deadline: 2025-09-30
Location: Germany, Mainz
www.academiceurope.com/ads/phd-cand...
#hiring #CancerResearch #tumorImmunology #PhD #molecularbiology #genetics #biochemistry #pharmaceuticalsciences #bioengineering
September 11, 2025 at 7:18 AM
Job Alert
PhD Candidate for the Division of Personalized Immunotherapies
Deadline: 2025-09-30
Location: Germany, Mainz
www.academiceurope.com/ads/phd-cand...
#hiring #CancerResearch #tumorImmunology #PhD #molecularbiology #genetics #biochemistry #pharmaceuticalsciences #bioengineering
PhD Candidate for the Division of Personalized Immunotherapies
Deadline: 2025-09-30
Location: Germany, Mainz
www.academiceurope.com/ads/phd-cand...
#hiring #CancerResearch #tumorImmunology #PhD #molecularbiology #genetics #biochemistry #pharmaceuticalsciences #bioengineering
our study on #gdTcells in pediatric neuroblastoma is out! In contrast to adult tumors, it is the gdTcells that not only expand, but that are the most tumor reactive #TILs.
#immunology #tumorimmunology
funded by KIKA, Sanquin and supported by Oncode
www.life-science-alliance.org/content/8/11...
#immunology #tumorimmunology
funded by KIKA, Sanquin and supported by Oncode
www.life-science-alliance.org/content/8/11...
γδ T cells are the prime antitumoral T cells in pediatric neuroblastoma
High-risk pediatric neuroblastoma patients have a dismal survival rate despite intensive treatment regimens. New treatment options are thus required. Even though HLA expression in neuroblastoma is low...
www.life-science-alliance.org
September 3, 2025 at 6:53 AM
our study on #gdTcells in pediatric neuroblastoma is out! In contrast to adult tumors, it is the gdTcells that not only expand, but that are the most tumor reactive #TILs.
#immunology #tumorimmunology
funded by KIKA, Sanquin and supported by Oncode
www.life-science-alliance.org/content/8/11...
#immunology #tumorimmunology
funded by KIKA, Sanquin and supported by Oncode
www.life-science-alliance.org/content/8/11...
Perturbation of Calreticulin potentiates CD8⁺ T cell-mediated anti-tumor immunity, say Kaiyang Tang, Lijian Wu, Zexian Zeng @pku1898.bsky.social, Deng Pan @tsinghuauniversity.bsky.social and colleagues: rupress.org/jem/article/...
#TumorImmunology #Immunotherapy
#TumorImmunology #Immunotherapy
August 27, 2025 at 2:45 PM
Perturbation of Calreticulin potentiates CD8⁺ T cell-mediated anti-tumor immunity, say Kaiyang Tang, Lijian Wu, Zexian Zeng @pku1898.bsky.social, Deng Pan @tsinghuauniversity.bsky.social and colleagues: rupress.org/jem/article/...
#TumorImmunology #Immunotherapy
#TumorImmunology #Immunotherapy
Heart of the matter: #Neutrophils, #cancer, and #CardiovascularDisease. New review from Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, and Jose Adrover @adrover.bsky.social @crick.ac.uk: rupress.org/jem/article/...
#TumorImmunology #CardiovascularBiology #InnateImmunity #inflammation
#TumorImmunology #CardiovascularBiology #InnateImmunity #inflammation
August 18, 2025 at 1:45 PM
Heart of the matter: #Neutrophils, #cancer, and #CardiovascularDisease. New review from Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, and Jose Adrover @adrover.bsky.social @crick.ac.uk: rupress.org/jem/article/...
#TumorImmunology #CardiovascularBiology #InnateImmunity #inflammation
#TumorImmunology #CardiovascularBiology #InnateImmunity #inflammation
CD4⁺ T cell dysfunction in #cancer. New review from Hrishi Venkatesh and Lawrence Fong @fredhutch.bsky.social: rupress.org/jem/article/...
#CancerFocus #TumorImmunology #Immunotherapy
#CancerFocus #TumorImmunology #Immunotherapy
August 14, 2025 at 3:16 PM
CD4⁺ T cell dysfunction in #cancer. New review from Hrishi Venkatesh and Lawrence Fong @fredhutch.bsky.social: rupress.org/jem/article/...
#CancerFocus #TumorImmunology #Immunotherapy
#CancerFocus #TumorImmunology #Immunotherapy