Cytosolic nucleic acid–sensing pathways are potential targets for cancer immunotherapy. Although stimulator of interferon genes (STING) agonists have shown substantial antitumor effects in animal mode...

Study shows clear link between Israeli restrictions on aid entering Gaza and levels of malnutrition among children Almost 55,000 children in Gaza are estimated to be acutely malnourished, far more than have so far been identified as victims of the potentially lethal condition, a study published in the Lancet, the respected international medical periodical, has revealed. The study, published on Wednesday, and led by the UN Relief and Works Agency for Palestine Refugees (Unrwa), offers a month-by-month breakdown through much of the two-year conflict, and shows for the first time a clear link between Israeli restrictions on supplies entering Gaza and levels of malnutrition among children. Continue reading...

Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance. This otherwise imperceptible immun...

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