Christian Zierhut
@zierlab.bsky.social
Genome Stability and Innate Immunity Lab at the Institute of Cancer Research, London
https://www.zierhutlab.org/
https://www.zierhutlab.org/
Excited to announce a new review article that Andreas Villunger @villungerlab.bsky.social, Dario Rizzotto (not on bsky) and I wrote. In this article, we discuss mitosis as a central cell cycle stage for integrating DNA damage, cell death and inflammatory responses. www.nature.com/articles/s41...
Mitotic errors as triggers of cell death and inflammation - Nature Cell Biology
Rizzotto et al. discuss the causes and consequences of deregulated mitosis that allow cells arrested in mitosis to escape to the next interphase, where they can initiate inflammatory signalling or und...
www.nature.com
January 6, 2026 at 10:43 AM
Excited to announce a new review article that Andreas Villunger @villungerlab.bsky.social, Dario Rizzotto (not on bsky) and I wrote. In this article, we discuss mitosis as a central cell cycle stage for integrating DNA damage, cell death and inflammatory responses. www.nature.com/articles/s41...
Reposted by Christian Zierhut
Parkes lab pre-print alert! ‘TMEM33 deletion potentiates anti-tumor CD8⁺ T cell immunity.’ Led by mtjackson101.bsky.social. Full bluetutorial follows! 1/10 www.biorxiv.org/content/10.6...
January 5, 2026 at 3:30 PM
Parkes lab pre-print alert! ‘TMEM33 deletion potentiates anti-tumor CD8⁺ T cell immunity.’ Led by mtjackson101.bsky.social. Full bluetutorial follows! 1/10 www.biorxiv.org/content/10.6...
Reposted by Christian Zierhut
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 16, 2025 at 4:29 PM
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Christian Zierhut
We are pleased to present our manuscript on the annotation of clear cell Renal Cell Carcinoma #GWAS risk loci, recently published in @commsbio.nature.com
www.nature.com/articles/s42...
#ccRCC #cancer #genetics #genomics #KidneyCancer
www.nature.com/articles/s42...
#ccRCC #cancer #genetics #genomics #KidneyCancer
Deciphering genetic susceptibility to clear cell renal cell carcinoma - Communications Biology
Integration of genome-wide association data with epigenomic and chromatin interaction data identifies target genes mediating clear cell renal cell carcinoma risk, implicating disrupted hypoxia signall...
www.nature.com
December 16, 2025 at 5:27 PM
We are pleased to present our manuscript on the annotation of clear cell Renal Cell Carcinoma #GWAS risk loci, recently published in @commsbio.nature.com
www.nature.com/articles/s42...
#ccRCC #cancer #genetics #genomics #KidneyCancer
www.nature.com/articles/s42...
#ccRCC #cancer #genetics #genomics #KidneyCancer
Reposted by Christian Zierhut
The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris).
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
Epigenetics - 21st Course on Epigenetics 2026: Towards a quantitative understanding of nuclear dynamics during development and diseases | Institut Curie Advanced Training
The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involvin...
minilien.curie.fr
November 12, 2025 at 10:58 AM
The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris).
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
Reposted by Christian Zierhut
Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
International Symposium on Chromosome Dynamics from Structure to Cellular Function
www.fbs.osaka-u.ac.jp
November 21, 2025 at 6:33 PM
Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
Reposted by Christian Zierhut
My lab at the University of Birmingham have a fully funded 4 year PhD position available, focusing on the molecular mechanisms of the Alternative Lengthening of Telomeres (ALT).
Informal enquiries to [email protected]
APPLICATION LINK:
sits.bham.ac.uk/urd/sits.urd...
Informal enquiries to [email protected]
APPLICATION LINK:
sits.bham.ac.uk/urd/sits.urd...
IPP login screen
sits.bham.ac.uk
November 19, 2025 at 5:14 PM
My lab at the University of Birmingham have a fully funded 4 year PhD position available, focusing on the molecular mechanisms of the Alternative Lengthening of Telomeres (ALT).
Informal enquiries to [email protected]
APPLICATION LINK:
sits.bham.ac.uk/urd/sits.urd...
Informal enquiries to [email protected]
APPLICATION LINK:
sits.bham.ac.uk/urd/sits.urd...
Congratulations to Lauren Davies, the lab's first PhD student, who defended her thesis with flying colours yesterday! Special thanks to Lauren's examiners @eileenparkes.bsky.social and @mcclellandlab.bsky.social! Lauren will stay for a few months to finalise a manuscript - so watch this space!
November 19, 2025 at 2:18 PM
Congratulations to Lauren Davies, the lab's first PhD student, who defended her thesis with flying colours yesterday! Special thanks to Lauren's examiners @eileenparkes.bsky.social and @mcclellandlab.bsky.social! Lauren will stay for a few months to finalise a manuscript - so watch this space!
Deadline 18th Nov! Please write to express your support for continued funding for Jalview!
I just found this now. @jalview.bsky.social team needs your support for their BBSRC application. Deadline tomorrow!
discourse.jalview.org/t/write-a-le...
discourse.jalview.org/t/write-a-le...
Write a letter of support to help keep Jalview funded!
Jalview’s core funding from the Wellcome Trust ends in 2026, and we are now preparing an application to the UK’s BBSRC to support Jalview into the next decade. You can help us keep Jalview available ...
discourse.jalview.org
November 17, 2025 at 10:25 PM
Deadline 18th Nov! Please write to express your support for continued funding for Jalview!
Reposted by Christian Zierhut
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 6, 2025 at 11:05 PM
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
For everyone interested in art, my incredibly talented girlfriend Lara is auctioning one of her paintings to support @freedomfromtorture.bsky.social. The current bid is a bargain for her art, so snatch it up, and still get an incredibly good deal!
artauction.freedomfromtorture.org/auction/item...
artauction.freedomfromtorture.org/auction/item...
November 7, 2025 at 12:18 PM
For everyone interested in art, my incredibly talented girlfriend Lara is auctioning one of her paintings to support @freedomfromtorture.bsky.social. The current bid is a bargain for her art, so snatch it up, and still get an incredibly good deal!
artauction.freedomfromtorture.org/auction/item...
artauction.freedomfromtorture.org/auction/item...
Reposted by Christian Zierhut
Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. Please checkout the job advert: www.jobs.ac.uk/job/DPH515/senior-research-technician
Senior Research Technician at University of Birmingham
An academic position as a Senior Research Technician is being advertised on jobs.ac.uk. Click now to find more details and explore additional academic job opportunities.
www.jobs.ac.uk
November 6, 2025 at 8:34 AM
Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. Please checkout the job advert: www.jobs.ac.uk/job/DPH515/senior-research-technician
Reposted by Christian Zierhut
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Senior Research Technician at University of Birmingham
Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
October 7, 2025 at 8:51 AM
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Reposted by Christian Zierhut
We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...
PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) in Chelsea | The Institute of Cancer Research
View details and apply for this PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) vacancy in Chelsea .
Salary: Dependent on relevant Postdoctoral exp...
jobs.icr.ac.uk
September 19, 2025 at 7:38 AM
We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...
Reposted by Christian Zierhut
#Jobalert 🚨: looking for a #computationalbiology expert with track record in analysis, integration and interpretation of #omics datasets, in particular #epigenomics, #singlecellgenomics, #proteomics data. uni-freiburg.de/stellenangeb... short deadline 30th September!
Universität Freiburg
uni-freiburg.de
September 19, 2025 at 8:08 AM
#Jobalert 🚨: looking for a #computationalbiology expert with track record in analysis, integration and interpretation of #omics datasets, in particular #epigenomics, #singlecellgenomics, #proteomics data. uni-freiburg.de/stellenangeb... short deadline 30th September!
Reposted by Christian Zierhut
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
September 18, 2025 at 8:02 PM
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Academic research generates almost all intellecutal innovation in the life sciences. With big pharma refusing to contribute, maybe it's time to stop giving them our research outputs cheaply, and instead having globally nationalised means of translating innovation?
www.theguardian.com/business/202...
www.theguardian.com/business/202...
US drugmaker Merck scraps £1bn London research centre and cuts 125 science jobs
New blow to UK’s key life science sector as industry body says country is losing ground on investment and research
www.theguardian.com
September 11, 2025 at 7:52 AM
Academic research generates almost all intellecutal innovation in the life sciences. With big pharma refusing to contribute, maybe it's time to stop giving them our research outputs cheaply, and instead having globally nationalised means of translating innovation?
www.theguardian.com/business/202...
www.theguardian.com/business/202...
Great story from our fantastic neighbour Jörg Mansfeld!
Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:
A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase controls its stability. Loss of C41 oxidation increases p21 stability, impairs proliferation, and promotes senescence after irradiation.
dlvr.it
August 26, 2025 at 10:38 PM
Great story from our fantastic neighbour Jörg Mansfeld!
Reposted by Christian Zierhut
Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:
A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase controls its stability. Loss of C41 oxidation increases p21 stability, impairs proliferation, and promotes senescence after irradiation.
dlvr.it
August 26, 2025 at 7:17 PM
Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:
Fantastic joint lab meeting day with @eileenparkes.bsky.social and Ben O'Leary plus our groups. Lots of cool science and discussions! And that fancy dinner at Lincoln College!
June 27, 2025 at 2:49 PM
Fantastic joint lab meeting day with @eileenparkes.bsky.social and Ben O'Leary plus our groups. Lots of cool science and discussions! And that fancy dinner at Lincoln College!
Reposted by Christian Zierhut
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
June 20, 2025 at 9:38 AM
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Reposted by Christian Zierhut
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Postdoctoral Research Associate in the Blackford Group
A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th
candidate.hr-manager.net
May 29, 2025 at 11:26 AM
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Reposted by Christian Zierhut
Nice work by the Kurumizaka Lab in @natcomms.nature.com
Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis
www.nature.com/articles/s41...
Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis
www.nature.com/articles/s41...
Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis - Nature Communications
The authors establish the ChIP-CryoEM method, which combines chromatin immunopurification coupled with cryo-electron microscopy, to visualize native human RNAPII elongation complexes in action, with a...
www.nature.com
May 29, 2025 at 7:09 AM
Nice work by the Kurumizaka Lab in @natcomms.nature.com
Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis
www.nature.com/articles/s41...
Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis
www.nature.com/articles/s41...
Reposted by Christian Zierhut
Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
DNA Repair | The replication stress response: mechanisms and functions | ScienceDirect.com by ElsevierScienceDirect
High-fidelity DNA replication is constantly challenged by a diverse range of obstacles, including endogenous lesions and secondary structures in the DNA template, tightly bound protein-DNA complexes, ...
www.sciencedirect.com
April 17, 2025 at 4:01 AM
Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
Reposted by Christian Zierhut
Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email [email protected] for info
March 12, 2025 at 2:51 PM
Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email [email protected] for info