#viralimmunology
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MedSky🧪#IDSky @cellpress #Viralimmunology There are the reason to #MaskUp 😷 and #Getboosted #COVID kills
#Viralimmunology #Molecularmedicine identify a spectrum of pathway dysregulations in #alveolarepithelium, #bronchialepithelium & #bloodvessels in severe #COVID patients vs non-#COVID19 controls,
A) Schematic workflow including cohort design, autopsy specimen collection, pathology-guided LMD, integrated sample preparation, MS-based deep proteome profiling, and bioinformatic analysis to analyze the ten regions of pulmonary tissues of severe COVID-19 patients and non-COVID-19 control individuals. (B) Representative H&E images of selected regions for spatial proteome profiling (scale bar represents 100 μm). Region names and their abbreviations are labeled above images. (C) Schematic human pulmonary structure. Case counts for each region are labeled including BE (n = 11), BMP (n = 7), AE (n = 10), HAT2 (n = 3), PF (n = 11), ASI (n = 10), VE (n = 11), N-BE (n = 2), N-AE (n = 3), and N-VE (n = 3). (D) Total number (as bar graph) and average number (as black dot) of identified protein groups for each region and project-specific spectral library. (E) Dynamic range of the proteome within ten regions based on average protein LFQ intensity. (F) Box-whisker plot of Pearson correlation coef
January 19, 2024 at 1:09 PM
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MedSky 🧪#IDSky #Viralimmunology An especially alarming complication of #COVID19 is abnormalities in #kidneyfunction & Potential Alternative Receptors for #SARSCoV2-Induced Kidney Damage .
Highlights
January 31, 2024 at 8:51 AM
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#MedSky🧪 #IDSky #Publichealth The truth in #LongCovid ,Not all symptoms are the same . #Publichealth #Viralimmunology @HeliyonJournal .The primary outcome is the #postacutesequelae of #COVID19 / #LongCovid in the #digestivesystem .
Symptoms incl
- general tiredness,
- fatigue,
- diarrhea,
September 23, 2024 at 5:55 PM
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MedSky🧪IDsky PedSky #viralimmunology Role of the #gutmicrobiota in the course of severe forms of #COVID19 .
Both the stay in #ICU & patient were significant factors affecting the microbiota composition. #SARSCoV2 #viralloads were higher in ICU than in non-ICU patients.
Comparison of the fecal microbiota in COVID-19 and non-COVID-19 patients. A, B The gut microbiota was compared between ventilated COVID-19 patients with antibiotics (COVID-19 group) to ventilated non-COVID-19 patients who were treated with antibiotics due to ventilation-associated pneumonia (pneumonia group) and those with neither pneumonia nor antibiotics (control group). A Chao1 and Shannon alpha diversity indexes in three groups at day 0 (inclusion) and day 7. Impact of COVID-19 severity on the taxa composition and longitudinal changes of the gut microbiota. A, B Differential abundance analysis and db-RDA analysis in ventilated and non-ventilated COVID-19 patients. A Genera differentially abundant among the two groups were identified by a complex model including ventilation, antibiotics and timepoint with longitudinal sampling correction Association of SARS-CoV-2 excretion with severity and microbiota composition Timeline of sampling with various information. Patients only day 0 samples are gathered on the left panel while those with multiple samples are shown on the right panel. Patients who died are labelled in red. The border of circles represents ventilated (red) and non-ventilated (blue) state, where SARS-CoV-2 PCR results in rectal swabs are written as positive ( +) and negative (-). The number of days after symptom onset is indicated at the left bottom side of day 0. One sample from P51 is lacking the PCR result. The gradient color inside (orange scale) and outside (green scale) circles show the number of treated antibiotics and Shannon index, respectively
October 3, 2023 at 6:28 PM
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#IDtwitter #Viralimmunology The question of how #SARSCoV2 persists in the body has refocused scientists on the question of where viruses persist in humans more generally @bmj_latest
https://www.bmj.com/content/382/bmj.p1156.short?rss=1
July 6, 2023 at 12:34 AM
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#MedSky🧪 #IDSky #publichealth #immunoSky #Viralimmunology #Kidney damages associated with #COVID from the acute to the chronic phase. Overview the mechanism in Long-term renal complications of #COVID19 & Kidney function decline #longCovid

www.ncbi.nlm.nih.gov/pmc/articles...
Kidney damage associated with COVID & #LongCOVID : from the acute to the chronic phase.
August 12, 2024 at 11:30 AM
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#Cancerimmunotherapy #Viralimmunology Clinical characteristics of #covid19vaccine in cancer patients with #Immunecheckpointinhibitors & Interaction between ICIs - #SarsCoV2 infection-#COVID19vaccines .
July 10, 2023 at 9:17 AM
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MedSky🧪#Immunology #Viralimmunology #NeuroCovid What #LongCOVID Prevention Strategies Suggest About Its #Pathophysiology @idsainfo

academic.oup.com/ofid/advance...

PDF
watermark.silverchair.com/ofad466.pdf?...
September 12, 2023 at 4:12 PM
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MedSky🧪 #IDsky #PublicHealth #Viralimmunology Whether pre-exposure prophylaxis (PrEP) with #tixagevimab/#cilgavimab 150mg/150 mg (T/C) in individuals with #hematologicaldiseases may lead to ⏬️risk of Breakthrough #SARSCoV2 infection/hospitalization or death in #Omicron era remains to be established…
April 12, 2024 at 3:21 PM
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MedSky🧪 #IDSky #Cellbiology #Clinical_ID #Viralimmunology This findings provide molecular insights into the mechanisms by which strong viral replication but scarce inflammatory response during the early (ACE2-dependent) infection stage,
Fig. 1: SARS-CoV-2 NSP14 facilitates the activation of NF-κB signalling and inflammatory response.
March 21, 2024 at 10:46 PM
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MedSky🧪#ViralImmunology #Immunology The HLA advantage: Why #COVID19 benched you but not your co-worker ? @sciimmunology

www.science.org/doi/full/10....

www.ncbi.nlm.nih.gov/pmc/articles...

www.news-medical.net/news/2023072...
September 5, 2023 at 9:28 PM
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MedSky🧪IDSky #Viralimmunology #Immunology #CovidIsNotOver #Getboosted ,#VaccinesWork & #MaskUp 😷 Similar to XBB.1.5, XBB.1.16 is immune evasive, especially against sera from those who received 3 doses of monovalent mRNA vaccine and in BA.4/5 convalescent individuals.
XBB.1.16 Infectivity of lentiviral pseudotype bearing the S protein of interest in HEK293T-ACE2 and CaLu-3 cells Neutralization of XBB.1.16 by bivalent-vaccinated, 3-dose-vaccinated, and BA.4/5 convalescent sera
October 2, 2023 at 6:25 PM
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#Viralimmunology #Immunology #publichealth Never to late to 😷up #CovidIsNotOver The mutation called HLA-B*15:01 was carried by about 20% of the people in the study and while it doesn’t prevent infection by #SARSCoV2 , it does prevent people from showing any symptoms @latrobe @ucsfmedicine @Nature
July 20, 2023 at 11:21 AM
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#MedSky🧪 #IDSky #ImmunoSky #Viralimmunology #Drugsdevelopment Overview the role of #interferons in host immunity & Viral infection : from virus-host crosstalk to prophylactic and therapeutic potential in #SARSCoV2 infection.
Schematic representation of the IFN receptors network.
January 15, 2024 at 7:08 AM
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MedSky🧪 #IDsky #Publichealth #Viralimmunology #Immunocardiology Severe lung infection during #COVID19 can cause damage to the heart .Study shows that 🦠 that causes #COVID19 can damage the heart without directly infecting heart tissue.

www.nih.gov/news-events/...
Photo
March 20, 2024 at 2:38 PM
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MedSky🧪#IDSky #Publichealth #Viralimmunology #NeuroCovid . People with #MyalgicEncephalomyelitis/#ChronicFatigueSyndrome May Have an “Exhausted” Immune System
A long-awaited study of people with ME/CFS revealed differences in their immune & nervous system.
February 24, 2024 at 11:14 AM
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MedSky🧪#IDSky #viralimmunology Virological characteristics of the #SARSCoV2 BA.2.86 variant , Antiviral effect of clinically available compounds against BA.2.86

www.biorxiv.org/content/10.1...
🧵 by @SystemsVirology
x.com/systemsvirol...
Pdf Pdf
November 4, 2023 at 6:15 AM
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MedSky🧪 #IDSky #viralimmunology #immunology #Mucosalimmunity Understanding mucosal #antibody responses from #SARSCoV2 infection and/or #COVID19vaccination is crucial to develop strategies for longer term immunity, especially against emerging viral variants.
The data highlight how preexisting immunity shapes mucosal SARS-CoV-2–specific antibody responses and has implications for long-term protection from COVID-19.
October 6, 2023 at 9:18 PM
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MedSky🧪#IDSky #PublicHealth #Viralimmunology #COVID19vaccines may mitigate dysregulation of IL-1/IL-18 & post-infection vaccination in patients with PCC/#LongCovid might be beneficial in a subgroup of individuals displaying gastrointestinal symptoms.

www.nature.com/articles/s41...
SARS-CoV-2 vaccination may mitigate dysregulation of IL-1/IL-18 and gastrointestinal symptoms of the post-COVID-19 condition - npj Vaccines
npj Vaccines - SARS-CoV-2 vaccination may mitigate dysregulation of IL-1/IL-18 and gastrointestinal symptoms of the post-COVID-19 condition
www.nature.com
February 11, 2024 at 6:00 PM
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MedSky🧪 IDSky ImmunoSky #Viralimmunology #SARSCoV2 infection leads to a prolonged alteration of the #geneexpression profile of circulating Tcells, Bcells , NK cells & #monocytes .
Low-dose IL-2 immunotherapy and SARS-CoV-2 infection induce opposite transcriptional changes in immune cells. A Overview of the DILfrequency, COMBAT and INCOV cohorts The IL-2-induced anti-inflammatory gene expression signature (IL2-AIS) score is progressively decreased after SARS-CoV-2 infection.
September 21, 2023 at 9:37 AM
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MedSky #ImmunoSky #Viralimmunology #SARSCoV2 infects a wide array of domestic & wild animals, raising concerns regarding its evolutionary dynamics in animals & potential for spillback transmission of emerging variants to humans. #SARSCoV2 infection in animals has significant #publichealth relevance.
January 22, 2024 at 6:47 AM
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MedSky🧪#IDSky #ImmunoSky #Viralimmunology In this #clinicalstudy indicated that sequential immunization of heterologous #COVID19 vaccinations could elicit cross-reactive broadly neutralizing #antibodies against #SARSCoV2, its variants, SARS-CoV, & even MERS-CoV
www.nature.com/articles/s41...
Abstract
February 8, 2024 at 7:05 AM
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MedSky🧪#IDSky #Viralimmunology we are not out of the woods yet despite of political imparing . #LongCovid are still messing with our head & our body for year to come
Understanding #DNA methylation in long COVID

www.frontiersin.org/articles/10....
DNA methylation in long COVID
Long COVID (also termed Post-acute sequelae of COVID-19 [PASC]) refers to the chronic symptoms that survivors may experience after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectio...
www.frontiersin.org
March 11, 2024 at 8:53 AM
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#MedSky🧪#IDSky #publichealth #Virology #viralimmunology The virological characteristics of #SARSCoV2 #XEC
To sum up
🦠 #XEC exhibited more robust #immuneresistance to KP.3.3 BTI sera than KP.3.1.1.
🦠XEC exhibited higher #pseudovirus infectivity and higher #immuneevasion than KP.3 .
October 18, 2024 at 4:38 AM
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#MedSky🧪#IDSky #Viralimmunology #ImmunoSky #Tlymphocytes play a primary role in the #Adaptiveimmunity .Both #lymphocytosis & #lymphopenia were found to be associated with severe #SARSCoV2
July 7, 2024 at 5:25 PM