#viralimmunology
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His work aims to advance tools for studying antiviral immunity and support the development of Lassa Fever countermeasures.

#ViralImmunology
#LassaFever
#AntibodyResearch
#StructuralBiology
#OxfordScience
July 30, 2025 at 8:55 AM
epivinf.bsky.social
Last week, our project hosted a seminar with Prof Jörn Walter for a deep dive into the world of epigenomics.
📖 Read more about it in our latest post

www.epivinf.eu/2025/06/25/e...

#Epigenetics #ViralImmunology #EpiAtlas #Genomics
Exploring the Human Epigenome: Insights from Professor Jörn Walter on IHEC and the EpiAtlas – EPIVINF
www.epivinf.eu
June 25, 2025 at 12:33 PM
castltrastondrs.bsky.social
#NeuroCovid #viralimmunology
Underestimated virus impaired cognition-more evidence and more work to do . Molecular mechanisms associated with viral infection-related #neurodegeneration
www.frontiersin.org/journals/imm...
Molecular mechanisms adapted by viruses in causing Nds.
May 31, 2025 at 4:03 AM
castltrastondrs.bsky.social
#MedSky🧪#IDSky #publichealth #Virology #viralimmunology The virological characteristics of #SARSCoV2 #XEC
To sum up
🦠 #XEC exhibited more robust #immuneresistance to KP.3.3 BTI sera than KP.3.1.1.
🦠XEC exhibited higher #pseudovirus infectivity and higher #immuneevasion than KP.3 .
October 18, 2024 at 4:38 AM
castltrastondrs.bsky.social
#MedSky🧪#IDSky #Publichealth #Viralimmunology Differential host response biomarker profiles associated with #COVID19 severity.

www.cell.com/iscience/ful...
PDF

www.cell.com/iscience/pdf...
Delineating sex-specific circulating host response signatures associated with COVID-19 severity and mortality.
Male SARS-CoV-2-infected patients have higher hospitalization rates, ICU admissions, and mortality compared to females, yet with unclear underlying mechanisms. We investigated the influence of biologi...
www.cell.com
October 16, 2024 at 1:46 PM
castltrastondrs.bsky.social
#MedSky🧪 #IDSky #Publichealth The truth in #LongCovid ,Not all symptoms are the same . #Publichealth #Viralimmunology @HeliyonJournal .The primary outcome is the #postacutesequelae of #COVID19 / #LongCovid in the #digestivesystem .
Symptoms incl
- general tiredness,
- fatigue,
- diarrhea,
September 23, 2024 at 5:55 PM
castltrastondrs.bsky.social
#MedSky🧪#IDSky #publichealth #Viralimmunology the impact of #antiviral treatment on the emergence of #SARSCoV2 resistance during persistent infections in immunocompromised patients

www.nature.com/articles/s41...
Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections - Nature Communications
Here, the authors isolate a SARS-CoV-2 mutant that has developed decreased sensitivity to Paxlovid and remdesivir from an immunocompromised patient, show that drug resistance can be overcome by simultaneous treatment with both drugs in vitro, and demonstrate that the drug resistant virus can efficiently transmit in the hamster model.
www.nature.com
September 18, 2024 at 4:50 PM
castltrastondrs.bsky.social
#MedSky🧪#IDSky #PublicHealth #ImmunoSky #Viralimmunology #Immunity acquired by vaccination following infection, termed #hybridimmunity, has been shown to confer enhanced protection against severe #COVID by enhancing the breadth & potency of #immuneresponses .
August 30, 2024 at 11:46 AM
castltrastondrs.bsky.social
#MedSky🧪 #IDSky #publichealth #immunoSky #Viralimmunology #Kidney damages associated with #COVID from the acute to the chronic phase. Overview the mechanism in Long-term renal complications of #COVID19 & Kidney function decline #longCovid

www.ncbi.nlm.nih.gov/pmc/articles...
Kidney damage associated with COVID & #LongCOVID : from the acute to the chronic phase.
August 12, 2024 at 11:30 AM
castltrastondrs.bsky.social
#MedSky🧪#IdSky #Publichealth #Viralimmunology @nejm A phase 2–3 double-blind trial to assess the efficacy and safety of #Paxlovix in asymptomatic, rapid antigen test–negative adults who had been exposed to a household contact with #COVID19 within 96 hours before randomization.
July 17, 2024 at 10:34 PM
castltrastondrs.bsky.social
#MedSky🧪 #IDSky #Publichealth #Publichealth #Viralimmunology A recent study analyzed data from more than 200,000 Americans who had #COVID19 twice, revealing that severe #COVID infections tend to predict similarly severe reinfections.
July 12, 2024 at 7:44 PM
castltrastondrs.bsky.social
#MedSky🧪#IDSky #Viralimmunology #ImmunoSky #Tlymphocytes play a primary role in the #Adaptiveimmunity .Both #lymphocytosis & #lymphopenia were found to be associated with severe #SARSCoV2
July 7, 2024 at 5:25 PM
castltrastondrs.bsky.social
#MedSky🧪#IDSky #NeuroSky #Neuroinflamation #Neuroimmunology #viralimmunology .This is the 1st #Casereport in 🇧🇬 of a patient with imported malaria in the course of #SARSCoV2 infection .
June 3, 2024 at 12:21 PM
castltrastondrs.bsky.social
#MedSky🧪 #IDSky #publichealth #Viralimmunology Individuals who completed #Paxlovid treatment for #COVID19 experienced fewer symptoms & lower #ViralLoad but rebound occured more often vs the untreated individuals. Providers should prescribe N/R, when indicated, & communicate rebound risk to patients.
May 30, 2024 at 5:27 PM
castltrastondrs.bsky.social
#MedSky🧪 #IDSky #NeuroSky #Viralimmunology #Immunology This study highlights the potential toxicity of the #SARSCoV2 Spike protein for mammalian cells & illustrates the central role for #alveolarmacrophage in pathogenic protein uptake.
April 28, 2024 at 12:39 PM
castltrastondrs.bsky.social
#MedSky🧪 #IDSky #Viralimmunology #Immunology Understanding 🔑 contributor to #COVID19 is #SarsCoV2 ’s utilization of “host shutoff” strategies, optimizing viral replication at the expense of host gene expression and delaying the #Innateimmune response.

www.cell.com/cell-reports...
April 25, 2024 at 4:42 AM
castltrastondrs.bsky.social
MedSky🧪 #IDSky #Immunosky #NeuroimmunoSky #Viralimmunology This #Clinicalreviews the main #miRNAs studies & their associations with #cognitivedysfunction & physiopathological in molecular processes, other diseases and observations in #COVID19 Patients.
Schematic diagram providing a visual summary of the key findings, including the main miRNAs studied, and their associations with cognitive dysfunction and other diseases and co-existing factors. Parts of this image were derived from the free medical site http://smart.servier.com/ (accessed on November 15, 2023) by Servier, licensed under a Creative Commons Attribution 3.0 Unported Licence. miRNA/miR, microRNA; APOE, apolipoprotein E; CRH, corticotrophin-releasing hormone; AVP, arginine-vasopressin; LC, locus coeruleus; NE, norepinephrine; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. Schematic diagram of the main miRNAs studied and their associations with cognitive dysfunction and physiopathological and molecular processes, and other diseases and observations in patients with COVID-19; potential uses as of miRNAs as markers or therapeutic targets.
April 17, 2024 at 3:17 PM
castltrastondrs.bsky.social
MedSky🧪 #IDsky #ViralImmunology #Immunopharmacology Evaluate the efficacy of #antiviraltreatment for #COVID19 & to identify risk factors for severe #COVID19 in #kidneytransplantrecipients during the #Omicron subvariant-dominant period @BMC_series

link.springer.com/article/10.1...
Assessing antiviral treatment efficacy and risk factors for severe COVID-19 in kidney transplant recipients during the Omicron subvariant-dominant period: a retrospective study - BMC Nephrology
Background Kidney transplant recipients (KTRs) are at risk of severe coronavirus disease 2019 (COVID-19), and even now that Omicron subvariants have become dominant, cases of severe disease are certai...
link.springer.com
April 15, 2024 at 11:17 AM
castltrastondrs.bsky.social
MedSky🧪 #IDsky #PublicHealth #Viralimmunology Whether pre-exposure prophylaxis (PrEP) with #tixagevimab/#cilgavimab 150mg/150 mg (T/C) in individuals with #hematologicaldiseases may lead to ⏬️risk of Breakthrough #SARSCoV2 infection/hospitalization or death in #Omicron era remains to be established…
April 12, 2024 at 3:21 PM
castltrastondrs.bsky.social
MedSky🧪 #IDSky #Viralimmunology #Clinical_ID #Drugsdevelopment perspectives #publichealth @aaas Where do we go wrong ? Pfizer’s antiviral #Paxlovid may not help as many people as hoped. The combo drug was granted emergency use authorization in 2021 in 🇺🇸
April 9, 2024 at 1:21 PM
castltrastondrs.bsky.social
#Immunology #Viralimmunology #Publchealth Understanding #COVID19 Abzymes . #ACE2-like enzymatic activity is associated with #immunoglobulin in #COVID19 patients

journals.asm.org/doi/10.1128/...
Schematic diagram illustrating the hypothesis underlying the study. The SARS-CoV-2 spike protein RBD binds ACE2 on the surface of potential host cells. The RBD has a partial negative image of ACE2. Some antibodies against the RBD may then have a conformation sufficiently like ACE2 to have proteolytic activity similar to the proteolytic activity of ACE2. The hypothesis further suggests that the catalytic activity of some antibodies will have a substrate specificity like ACE2, but because the negative image of RBD present antibodies is imperfect, some antibodies with proteolytic activity will have an altered substrate specificity, potentially affecting multiple proteolytic regulatory cascades.
March 29, 2024 at 4:16 PM
castltrastondrs.bsky.social
MedSky🧪 #IDSky #Viralimmunology #Immunolgy #Evolutionbiology #Microbiology Following the path of #SARSCoV2 infection from the immune response impairment in #PASC / #LongCovid individuals & the potential contribution of different #COVID19pandemic waves & the consequent effects found after infection :
Abstract
March 25, 2024 at 6:06 PM
castltrastondrs.bsky.social
MedSky🧪 #IDSky #PublicHealth #Covidheart #Viralimmunology Understanding Pathogenesis of long COVID myocarditis: A comprehensive review
🫀#Myocarditis, a long-term complication of #COVID19 an inflammatory condition involving the myocardium of the heart.
March 22, 2024 at 6:46 PM
castltrastondrs.bsky.social
MedSky🧪 #IDSky #Cellbiology #Clinical_ID #Viralimmunology This findings provide molecular insights into the mechanisms by which strong viral replication but scarce inflammatory response during the early (ACE2-dependent) infection stage,
Fig. 1: SARS-CoV-2 NSP14 facilitates the activation of NF-κB signalling and inflammatory response.
March 21, 2024 at 10:46 PM
castltrastondrs.bsky.social
MedSky🧪 #IDSky #PublicHealth #Viralimmunology Scientists believe they may have found cause of #longCovid.
Two new studies based on an analysis of blood samples of infected people may pave the way for new treatments…

inews.co.uk/news/health/...

@ImperialImmuno 🔗

x.com/imperialimmu...
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March 21, 2024 at 6:23 PM