Geming Lu
@brian98er.bsky.social
97 followers
120 following
27 posts
Immunologist and islets biologist, dedicated to the autoimmune and Metabolism research of T1D, T2D, colitis, and multiple sclerosis.
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Geming Lu
@brian98er.bsky.social
· Sep 3
A vascular-associated fibroblastic cell controls pancreatic islet immunity
Clarke et al. reveal that non-hematopoietic cells, fibroblastic in nature, located
outside the islet of Langerhans, spontaneously present β cell antigens. These cells,
associated with the post-capilla...
www.cell.com
Geming Lu
@brian98er.bsky.social
· May 28
Improving cellular fitness of human stem cell-derived islets under hypoxia - Nature Communications
Hypoxia impairs the efficacy of stem cell-derived islet cell therapy, making it a potential barrier for treatment of type 1 diabetes. Wang et al. identify EDN3 as a key factor that preserves β cell id...
www.nature.com
Geming Lu
@brian98er.bsky.social
· May 26
Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses
Pregnancy is associated with physiological adaptations that affect virtually all organs,
enabling the mother to support the growing fetus and placenta while withstanding the
demands of pregnancy. As a...
www.cell.com
Geming Lu
@brian98er.bsky.social
· Apr 29
Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation - Nature Communications
Xenotransplantation is a promising option when allogeneic donors are unavailable but hampered by a more stringent immunological barrier. Here authors show that hypoimmune cells engineered to overcome ...
www.nature.com
Geming Lu
@brian98er.bsky.social
· Apr 26
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms
Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen,
Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring
T1D. Their creative and r...
www.cell.com
Geming Lu
@brian98er.bsky.social
· Apr 24
Distinct adipose progenitor cells emerging with age drive active adipogenesis
Starting at middle age, adults often suffer from visceral adiposity and associated adverse metabolic disorders. Lineage tracing in mice revealed that adipose progenitor cells (APCs) in visceral fat un...
www.science.org
Reposted by Geming Lu
Reposted by Geming Lu
Liora Katz
@likatz.bsky.social
· Mar 2
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity - Nature Communications
Targeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, s...
www.nature.com
Geming Lu
@brian98er.bsky.social
· Mar 1
Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes - Nature Communications
The pancreatic vasculature displays significant heterogeneity, with the islets perfused by a specialized microcirculation with greater density than the surrounding acinar tissue. Using single-cell RNA...
www.nature.com
Reposted by Geming Lu
Geming Lu
@brian98er.bsky.social
· Feb 23
Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants
Arthur and Nguyen et al. leverage iPSCORE, a large collection of three early developmental-like
tissues with corresponding molecular datasets (RNA-seq, ATAC-seq, H3K27ac ChIP-seq),
to map over 70,000 ...
www.cell.com
Reposted by Geming Lu
Diabetologia
@diabetologiajnl.bsky.social
· Feb 11
High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4+ T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response - Diabetologia
Aims/hypothesis Diabetic kidney disease (DKD) features intrarenal inflammation, in which T cells play a part. Hypoxia-inducible factor-1α (HIF-1α), a key transcription factor regulating cellular respo...
tinyurl.com
Reposted by Geming Lu
Klaus Kaestner
@kkaestner.bsky.social
· Feb 20
Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas
Spontaneous transdifferentiation of pancreatic glucagon-producing alpha to insulin secreting beta cells has been observed in mouse but not in human islets1. Here, we analyzed the largest single cell d...
www.biorxiv.org
Geming Lu
@brian98er.bsky.social
· Feb 8
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues
Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the consequences of compromised mitochondria in metabolic tissues are often unclear. Here, we report that dysfunctiona...
www.science.org
Geming Lu
@brian98er.bsky.social
· Jan 30
MDA5 variants trade antiviral activity for protection from autoimmune disease
Loss-of-function variants in MDA5, a key sensor of double-stranded RNA from viruses and retroelements, have been associated with protection from type 1 diabetes (T1D) in genome-wide association studie...
www.medrxiv.org