Lightnews — Scholar-powered news

Reposted by Catalina Vasilescu, PhD

Joseph Gordon @josephwgordon.bsky.social · 10h

www.cell.com/molecular-ce...

SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis

Dias et al. discover that the orphan solute carrier protein, SLC25A45, enables mitochondrial import of methylated amino acids. SLC25A45-dependent mitochondrial uptake of trimethyllysine drives carniti...

www.cell.com

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Reposted by Catalina Vasilescu, PhD

Christian Frezza @frezzalab.bsky.social · 1d

www.sciencedirect.com/science/arti...

... and congratulations to Kivanc Birsoy and his team too

SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis

Methylated amino acids accumulate upon the degradation of methylated proteins and are implicated in diverse metabolic and signaling pathways. Disturbe…

www.sciencedirect.com

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Reposted by Catalina Vasilescu, PhD

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · 1d

Online now - the Review "Interconnectivity of mitochondrial protein biogenesis and quality control" from @mitolab.bsky.social et al.

#ProteinImport #Proteaes #Proteolysis #Proteostasis

Read it here: authors.elsevier.com/sd/article/S...

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Reposted by Catalina Vasilescu, PhD

Sara Nowinski @saranowinski.bsky.social · 1d

Whoo hoo! The final version of our first paper is online! So proud of the team. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

Redirecting

kwnsfk27.r.eu-west-1.awstrack.me

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Reposted by Catalina Vasilescu, PhD

htw @heniek-htw.bsky.social · 16h

Mitochondrial translation impairment-triggered neuroinflammation mediates fluoride-induced cognitive deficits
www.sciencedirect.com/science/arti...

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 12h

Beautiful 👏👏

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Reposted by Catalina Vasilescu, PhD

Rachael Ott @rachaelott.bsky.social · 1d

For #FluorescenceFriday, α-spectrin (red) and lipid droplets (green) are shown in adipocytes 🔬 #Microscopy #CellBiology

α-spectrin (red), lipid droplets (green), and nuclei (blue) are shown in adipocytes. Scale bar is 20 μm.

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Reposted by Catalina Vasilescu, PhD

Anne Carpenter @drannecarpenter.bsky.social · 1d

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further

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Reposted by Catalina Vasilescu, PhD

Pluchino lab - Regenerative Neuroimmunology @pluchinolab.bsky.social · 1d

Delighted to see this out in @NeuroCellPress!!!

Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS

www.cell.com/neuron/fullt...

Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis

Park, Nicaise, Tsitsipatis, and colleagues discover transcriptional and epigenetic markers in human PMS iNSCs and fibroblasts that may underlie their senescent and inflammatory state. Novel DARGs with...

www.cell.com

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Reposted by Catalina Vasilescu, PhD

Christian Frezza @frezzalab.bsky.social · 1d

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging

Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

www.science.org

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Reposted by Catalina Vasilescu, PhD

Michele Frison @frisophagy.bsky.social · 1d

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?

This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.

www.science.org/doi/10.1126/...

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

www.science.org

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Reposted by Catalina Vasilescu, PhD

Nature @nature.com · 5d

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

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Reposted by Catalina Vasilescu, PhD

Michele Frison @frisophagy.bsky.social · 6d

In this week's mitophagy news 🪫🗑️

biomed.news/bims-tofagi/...

⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway

Thanks to @biomednews.bsky.social

PP2A-B55α activates TFEB upon mitochondrial damage to support Parkin-dependent mitophagy.

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 6d

Engineering Artificial Mitochondria with Self‐Amplifying Proton Generation for Autonomous Energy Supply and Metabolic Coupling in Artificial Cells - Fu - Angewandte Chemie International Edition - Wiley Online Library
onlinelibrary.wiley.com/doi/10.1002/...

Engineering Artificial Mitochondria with Self‐Amplifying Proton Generation for Autonomous Energy Supply and Metabolic Coupling in Artificial Cells

A mitochondria-mimicking ATP generator improves the enzyme instability of enzyme-based artificial mitochondria and eliminates the toxicity of H2O2 via quantitative enzyme co-compartmentalization. The....

onlinelibrary.wiley.com

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 6d

MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes | Nature Communications
www.nature.com/articles/s41...

MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes - Nature Communications

Increasing mitochondrial oxidative capacity and energy expenditure holds therapeutic potential for obesity and metabolic disorders. Here, the authors identify MTCH2 as a mitochondrial regulator of fatty acid oxidation via interaction with CPT1.

www.nature.com

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 6d

A mouse model of MEPAN demonstrates a role for mitochondrial fatty acid synthesis in iron–sulfur cluster and supercomplex formation | PNAS
www.pnas.org/doi/10.1073/...

A mouse model of MEPAN demonstrates a role for mitochondrial fatty acid synthesis in iron–sulfur cluster and supercomplex formation | PNAS

MEPAN (Mitochondrial Enoyl CoA Reductase Protein-Associated Neurodegeneration) is an early-onset movement disorder characterized by ataxia, dysarth...

www.pnas.org

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 6d

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 | Nature Communications
www.nature.com/articles/s41...

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 - Nature Communications

This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in Barth syndrome, impacts mitochondrial membrane-shaping mechanisms.

www.nature.com

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Reposted by Catalina Vasilescu, PhD

RyanLab_TCD @ryanlab.bsky.social · 6d

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Highlight:
Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 6d

#MitochondrialDisease papers from #week40! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A few highlights below! 👇

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function - Nature Metabolism

Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

www.nature.com

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Reposted by Catalina Vasilescu, PhD

Korolchuk Lab @korolchuklab.bsky.social · 6d

#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection engine. DM them if you want your own personalised feed.

biomed.news/bims-auttor/...

a woman in a red and white striped shirt is throwing papers into the air

ALT: a woman in a red and white striped shirt is throwing papers into the air

media.tenor.com

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Reposted by Catalina Vasilescu, PhD

Gabriele Zaffagnini @gzaffagnini.bsky.social · 6d

Happy Sunday egg-ficionados! Here come the latest papers on #oocyte cell biology:

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41027914/

Thanks @biomednews.bsky.social for preselecting! #cebooc

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Reposted by Catalina Vasilescu, PhD

Danielle Beckman @daniellebeckman.bsky.social · 8d

👻 "Dark Forest Within" 🧠
What if the brain is a creepy forest? Our neurons are the 🌲, old (as old as we are!), and without mobility. Suddenly, comes the microglia, our brain's immune cells. Everything lights up when they move around.
🟢microglia🟣neurons
#FluorescenceFriday 🎃

Confocal microscopy photo showing neurons and microglia

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Reposted by Catalina Vasilescu, PhD

Eric Chevet @ericchevet.bsky.social · 6d

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...

bims-proteo 2025-10-05 papers

biomed.news

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Reposted by Catalina Vasilescu, PhD

Christian Frezza @frezzalab.bsky.social · 6d

Good Sunday, all. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology ready for you! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

Without courage, wisdom bears no fruit. -Baltasar Gracián

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 7d

👉 Which of these lessons resonates most with you in your own work?