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Journal of Clinical Epidemiology @jclinepi.bsky.social · 12d

Reusing clinical trial data to consolidate and advance medical knowledge - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Reusing clinical trial data to consolidate and advance medical knowledge

While data sharing holds great potential to maximize the value of research and reduce waste, these benefits can only be fully realized if shared data are also effectively reused. Yet data reuse remain...

www.jclinepi.com

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Jack Wilkinson @jdwilko.bsky.social · Sep 5

www.medrxiv.org/content/10.1...

INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.

INSPECT-SR: a tool for assessing trustworthiness of randomised controlled trials

The integrity of evidence synthesis is threatened by problematic randomised controlled trials (RCTs). These are RCTs where there are serious concerns about the trustworthiness of the data or findings....

www.medrxiv.org

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Mike Galsworthy @mikegalsworthy.bsky.social · Dec 2

"The South Downs National Park is the newest and most visited of all England's national parks. Its stunning views must be protected" 🦋

Celebrating the South Downs National Park

The South Downs National Park is the newest and most visited of all England's national parks. Its stunning views must be protected

sussexbylines.co.uk

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Richard Hooper @richardhooper.bsky.social · Nov 29

J Clin EPi @jclinepi.bsky.social has a unique focus on meta-research. I've co-led a November editorial reflecting on the variety its content, and how an even richer balance might be achieved. Methodologists assemble! www.jclinepi.com/article/S089... @davidit.bsky.social @andreatricco.bsky.social

What advice can we offer to authors? Reflections from the statisticians’ bench

What are the statistical issues on which the Journal of Clinical Epidemiology editorial team should be offering advice to authors? Lists of statistical bugbears and elephant traps in health research r...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Jan 30

Incomplete reporting of adverse events in duloxetine trials: a meta-research survey of randomized controlled trials versus placebo - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Incomplete reporting of adverse events in duloxetine trials: a meta-research survey of randomized controlled trials versus placebo

Relying on published data alone might be insufficient for meta-analyses to be reliable and trustworthy since selective outcome reporting is common, especially for adverse events. We investigated the e...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 22

Epidemiology and reporting characteristics of systematic reviews of clinical prediction models:a scoping review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Epidemiology and reporting characteristics of systematic reviews of clinical prediction models:a scoping review

This study aimed to explore research trends and areas of interest in systematic reviews (SRs) and meta-analyses of clinical prediction models (CPMs), while summarizing their conduct and reporting char...

www.jclinepi.com

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Lex Bouter @lexbouter.bsky.social · May 8

@jclinepi.bsky.social kindly invited me to express my thoughts on handling #ConflictsOfInterest of authors of scholarly publications. bit.ly/431UYIQ
@nrin-integrity.bsky.social @opensciencenl.bsky.social @peerreviewcongress.bsky.social @davidit.bsky.social @lseimpactblog.bsky.social

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David Tovey @davidit.bsky.social · May 14

Thanks for such a brilliant commentary. Transparency is necessary but not sufficient in many circumstances

Lex Bouter @lexbouter.bsky.social · May 8

@jclinepi.bsky.social kindly invited me to express my thoughts on handling #ConflictsOfInterest of authors of scholarly publications. bit.ly/431UYIQ
@nrin-integrity.bsky.social @opensciencenl.bsky.social @peerreviewcongress.bsky.social @davidit.bsky.social @lseimpactblog.bsky.social

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David Tovey @davidit.bsky.social · Mar 24

Disappointing but perhaps not surprising

Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 22

Epidemiology and reporting characteristics of systematic reviews of clinical prediction models:a scoping review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Epidemiology and reporting characteristics of systematic reviews of clinical prediction models:a scoping review

This study aimed to explore research trends and areas of interest in systematic reviews (SRs) and meta-analyses of clinical prediction models (CPMs), while summarizing their conduct and reporting char...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 22

Priority-setting criteria for clinical practice guideline development on rare genetic neurodevelopmental disorders: a Delphi study within the European Reference Network (ERN) ITHACA - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Priority-setting criteria for clinical practice guideline development on rare genetic neurodevelopmental disorders: a Delphi study within the European Reference Network (ERN) ITHACA

The prioritization of clinical practice guideline (CPG) efforts is particularly challenging for rare genetic neurodevelopmental disorders given the large number of (ultra)rare conditions and limited r...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 22

A scoping review identifies comments suggesting modifications to PRISMA-P 2015 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

A scoping review identifies comments suggesting modifications to PRISMA-P 2015

To identify, summarise, and analyse published comments relevant to the PRISMA-P (Preferred Items for Reporting Systematic reviews and Meta-Analyses Protocols) 2015 reporting guideline for systematic r...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 22

Methods resources for authors new to conducting systematic reviews with network meta-analysis: A Scoping Review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Methods resources for authors new to conducting systematic reviews with network meta-analysis: A Scoping Review

To support systematic reviewers new to network meta-analysis (NMA), we (i) identified and described published methods resources for conducting systematic reviews (SRs) with NMA of randomized controlle...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 20

Our message is one of hope, and we see this as a time of opportunity for leaders in the field to stand up for sound methods and high-quality science.

Editorial, April 2025
www.jclinepi.com/article/S089...

Editorial, April 2025

Drafting the monthly round-up of noteworthy manuscripts to be published in the corresponding issue of the Journal of Clinical Epidemiology (JCE) is both a privilege and pleasure. The task includes rer...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 13

Exploring the effect of COVID-19 restrictions on the Social Functioning Scale in a clinical trial of Antipsychotic Reduction: using multiple imputation to target a hypothetical estimand - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Exploring the effect of COVID-19 restrictions on the Social Functioning Scale in a clinical trial of Antipsychotic Reduction: using multiple imputation to target a hypothetical estimand

Many trials are affected by unforeseen events after recruitment has commenced. The aim of this study is to explore a hypothetical strategy for dealing with an intercurrent event that occurred during t...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 17

A scoping review identifies comments suggesting modifications to PRISMA-P 2015 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

A scoping review identifies comments suggesting modifications to PRISMA-P 2015

To identify, summarise, and analyse published comments relevant to the PRISMA-P (Preferred Items for Reporting Systematic reviews and Meta-Analyses Protocols) 2015 reporting guideline for systematic r...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 17

Methods resources for authors new to conducting systematic reviews with network meta-analysis: A Scoping Review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Methods resources for authors new to conducting systematic reviews with network meta-analysis: A Scoping Review

To support systematic reviewers new to network meta-analysis (NMA), we (i) identified and described published methods resources for conducting systematic reviews (SRs) with NMA of randomized controlle...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 17

Calculating Follow-Up Completeness: a comparison of multiple methods under different simulated scenarios and a use-case - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Calculating Follow-Up Completeness: a comparison of multiple methods under different simulated scenarios and a use-case

Completeness of follow-up is a crucial aspect of data quality in cohort studies and clinical trials. This study aims to provide an overview of different methods to calculate follow-up completeness. Ad...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 17

#keyconcepts Statistical strategies to analyze local control after radiotherapy - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Statistical strategies to analyze local control after radiotherapy

Historically, local progression, an outcome of effectiveness in curative radiotherapy, has not always been statistically analyzed with the same method. This article aims to elucidate the validity and ...

www.jclinepi.com

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David Tovey @davidit.bsky.social · Feb 22

Great to see journals based in the US and elsewhere standing up for scientific integrity.

PLOS Biology @plosbiology.org · Feb 21

PLOS has issued a statement on recent US Executive Orders and scientific integrity.

We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.

plos.io/3D4O8cH

PLOS statement on recent US Executive Orders and scientific integrity - The Official PLOS Blog

Since its founding over twenty five years ago PLOS has been dedicated to advancing open science, ensuring that knowledge is accessible to…

plos.io

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PLOS Biology @plosbiology.org · Feb 21

PLOS has issued a statement on recent US Executive Orders and scientific integrity.

We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.

plos.io/3D4O8cH

PLOS statement on recent US Executive Orders and scientific integrity - The Official PLOS Blog

Since its founding over twenty five years ago PLOS has been dedicated to advancing open science, ensuring that knowledge is accessible to…

plos.io

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Feb 21

Corrigendum to ʻMethodological systematic review recommends improvements to conduct and reporting when meta-analyzing interrupted time series studies’. Journal of Clinical Epidemiology 145 (2022) 55–69 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Corrigendum to ʻMethodological systematic review recommends improvements to conduct and reporting when meta-analyzing interrupted time series studies’. Journal of Clinical Epidemiology 145 (2022) 55–6...

In the original article, the supplementary file included our revisions as tracked changes arising from the peer-review process. Attached is an updated supplementary file where the tracked-changes have...

www.jclinepi.com

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David Tovey @davidit.bsky.social · Feb 14

So sorry to read this Richard. All best wishes to you and your family

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David Tovey @davidit.bsky.social · Feb 13

Thanks for this notifcation Florian but I feel obliged to point out that @jdwilko.bsky.social was very much the first and lead author!

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David Tovey @davidit.bsky.social · Feb 13

Delighted to see our @jclinepi.bsky.social commentary on redundant publication and potential research waste in the field of reporting guidelines is now fully online and accessible for 50 days via this link: authors.elsevier.com/c/1kbcJ3BcJQ...

authors.elsevier.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Feb 5

Massive covidization and subsequent decovidization of the scientific literature involved 2 million authors - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Massive covidization and subsequent decovidization of the scientific literature involved 2 million authors

We aimed to examine the growth trajectory and impact of COVID-19-related papers in the scientific literature and how the scientific workforce engaged in this work.

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Feb 5

Supplementary databases increased literature search coverage beyond PubMed and Embase - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Supplementary databases increased literature search coverage beyond PubMed and Embase

In health sciences, comprehensive literature searches are crucial for ensuring the accuracy and completeness of systematic reviews. Relying on only a few databases can lead to the omission of relevant...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Feb 5

Meta-analysis of individual participant data and informed consent: A small step, but important and neglected - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Meta-analysis of individual participant data and informed consent: A small step, but important and neglected

•Data sharing needs to be considered at the very beginning of planning trials and drafting informed consent forms.•De-identified individual participant data meta-analyses (IPD-MA) conduct and reportin...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Feb 5

Pain and Physical Function are common core domains across 40 core outcome sets of musculoskeletal conditions: A systematic review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Pain and Physical Function are common core domains across 40 core outcome sets of musculoskeletal conditions: A systematic review

To determine common domains across existing musculoskeletal COSs. Secondary aims were to assess the development quality of existing musculoskeletal COSs and whether development quality and patient par...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Feb 5

Visualizing the Value of Diagnostic Tests and Prediction Models, Part III. Numerical Example with Discrete Risk Groups and Miscalibration - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Visualizing the Value of Diagnostic Tests and Prediction Models, Part III. Numerical Example with Discrete Risk Groups and Miscalibration

Calculating net benefit (NB) is a logical approach to quantifying the value of a diagnostic test or risk prediction model. The harm of the test and of treating unnecessarily because of the test is sub...

www.jclinepi.com

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Journal of Clinical Epidemiology @jclinepi.bsky.social · Feb 5

Visualizing the Value of Diagnostic Tests and Prediction Models, Part II. Net Benefit Graphs: Net Benefit as a Function of the Exchange Rate - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Visualizing the Value of Diagnostic Tests and Prediction Models, Part II. Net Benefit Graphs: Net Benefit as a Function of the Exchange Rate

Net benefit (NB) calculations and NB graphs are used to evaluate diagnostic tests and risk prediction models. NB is the expected gain or loss in utility of treating or testing relative to not treating...

www.jclinepi.com

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