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Erik

@epikrisa.bsky.social

660 followers 1.6K following 1.5K posts

Associate professor, PI molecular psychiatry group at Gothenburg uni. (WCMTM fellow). Member of the Young Academy of Sweden. Resident psychiatrist. Physicist. Father of two. 🐈‍⬛🦮🧠⛵️🇸🇪 smedlerlab.org Founder of brainwest.org

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Erik @epikrisa.bsky.social · Nov 16

1) What are the molecular mechanisms behind severe mental illness? 2) what if glioma tumours crosstalk with the normal brain and affect how we think?

Zack Albert @zalbert.bsky.social · Nov 16

Bluesky academics… Quote this & tell me: 1) a project you are working on & 2) an odd idea/theory you aren’t working on but keep thinking about

1) who are small donors, who do they support, & what are likely effects of reform?
2) ppl always been poorly informed but it’s now much worse/more impactful

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Erik @epikrisa.bsky.social · 6h

Ett jäkla sätt.

Erik @epikrisa.bsky.social · 1d

De kommersiella gentesterna är rätt dåliga på att uppskatta ursprung.

Reposted by Erik

captain bleach @blainecapatch.bsky.social · 1d

can you imagine half-assing a last-minute ceasefire that won't last a week and still not getting the Nobel Peace Prize

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Reposted by Erik

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 1d

Decoding calcium oscillation frequency in transcriptional regulation https://www.biorxiv.org/content/10.1101/2025.10.10.676024v1

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Erik @epikrisa.bsky.social · 1d

6) These findings demonstrate that cells can decode Ca2+ oscillation frequency through a multi-kinase network that tunes transcription via NFkB and MYC, providing mechanistic insight into how temporal dynamics of second messengers shape cellular decision-making.

Erik @epikrisa.bsky.social · 1d

5) Label-free phosphoproteomics identified PRKDC, CHEK2 and ATM as the top upstream kinases, forming a network linking Ca2+ oscillations to cell cycle and stress signaling.

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Erik @epikrisa.bsky.social · 1d

4) Bulk RNA sequencing revealed a MYC-centered transcriptional response, with 116 of 215 differentially expressed genes predicted as MYC targets, despite unchanged MYC mRNA levels.

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Erik @epikrisa.bsky.social · 1d

3) We found that TNF and IL8 transcription via NFkB displayed sigmoidal frequency dependence, strictly requiring regular periodic stimulation, while random or low-frequency inputs with equal cumulative Ca2+ exposure were ineffective.

Erik @epikrisa.bsky.social · 1d

2) We use optogenetics to control calcium oscillations in non-excitable cells with the retinal protein melanipsin. We assess frequency decoding by comparing downstream activity between low and high frequency.

Erik @epikrisa.bsky.social · 1d

🧵New preprint from the lab! An old story finalized: Decoding calcium oscillation frequency in transcriptional regulation www.biorxiv.org/content/10.1...