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epikrisa.bsky.social
Erik
@epikrisa.bsky.social
660 followers 1.6K following 1.5K posts
Associate professor, PI molecular psychiatry group at Gothenburg uni. (WCMTM fellow). Member of the Young Academy of Sweden. Resident psychiatrist. Physicist. Father of two. 🐈‍⬛🦮🧠⛵️🇸🇪 smedlerlab.org Founder of brainwest.org
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · Nov 16
1) What are the molecular mechanisms behind severe mental illness? 2) what if glioma tumours crosstalk with the normal brain and affect how we think?
zalbert.bsky.social
Zack Albert @zalbert.bsky.social · Nov 16
Bluesky academics… Quote this & tell me: 1) a project you are working on & 2) an odd idea/theory you aren’t working on but keep thinking about

1) who are small donors, who do they support, & what are likely effects of reform?
2) ppl always been poorly informed but it’s now much worse/more impactful
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 15h
De kommersiella gentesterna är rätt dåliga på att uppskatta ursprung.
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Reposted by Erik
blainecapatch.bsky.social
captain bleach @blainecapatch.bsky.social · 1d
can you imagine half-assing a last-minute ceasefire that won't last a week and still not getting the Nobel Peace Prize
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Reposted by Erik
biorxiv-cellbio.bsky.social
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 1d
Decoding calcium oscillation frequency in transcriptional regulation https://www.biorxiv.org/content/10.1101/2025.10.10.676024v1
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 1d
6) These findings demonstrate that cells can decode Ca2+ oscillation frequency through a multi-kinase network that tunes transcription via NFkB and MYC, providing mechanistic insight into how temporal dynamics of second messengers shape cellular decision-making.
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 1d
5) Label-free phosphoproteomics identified PRKDC, CHEK2 and ATM as the top upstream kinases, forming a network linking Ca2+ oscillations to cell cycle and stress signaling.
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 1d
4) Bulk RNA sequencing revealed a MYC-centered transcriptional response, with 116 of 215 differentially expressed genes predicted as MYC targets, despite unchanged MYC mRNA levels.
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 1d
3) We found that TNF and IL8 transcription via NFkB displayed sigmoidal frequency dependence, strictly requiring regular periodic stimulation, while random or low-frequency inputs with equal cumulative Ca2+ exposure were ineffective.
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 1d
2) We use optogenetics to control calcium oscillations in non-excitable cells with the retinal protein melanipsin. We assess frequency decoding by comparing downstream activity between low and high frequency.
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 1d
🧵New preprint from the lab! An old story finalized: Decoding calcium oscillation frequency in transcriptional regulation www.biorxiv.org/content/10.1...
Decoding calcium oscillation frequency in transcriptional regulation
Cells continuously experience fluctuating intracellular calcium (Ca2+) signals that orchestrate diverse processes such as transcription, proliferation, and apoptosis. Temporal features of Ca2+ dynamic...
www.biorxiv.org
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 1d
Cool man kände sig när man rondade hamnen och båtklubben en fredag kväll. Imorgon är det jour på psykakuten istället.
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 1d
Nu har nästan 100 anmälda till BRAINWEST-mötet i december och ca 200 000 kr i spons!
Reposted by Erik
beyerstein.bsky.social
Lindsay Beyerstein @beyerstein.bsky.social · 2d
Of all the clerics they could have popped, those ICE idiots had to hit Hot Priest.
Presbyterian minister David Black on CNN, who was shot with pepper balls while praying outside an ICE facility.
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Reposted by Erik
cosmicrami.com
CosmicRami 🏳️‍🌈🏳️‍⚧️ @cosmicrami.com · 2d
Accurate.
howiehua.bsky.social
Howie Hua @howiehua.bsky.social · 2d
My best explanation of parallel lines
Two parallel lines going up. Top line says "The age I consider 'old'" and the bottom line says "My age".
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 2d
Hörde några tonåringar på vagnen som sa att de ville ha en mammakorv idag för att de frös. Kontaktar genast EU.
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 2d
Något min gudfar berättade om; används istället för toapapper. Men när jag googlar ser jag att det finns alternativa betydelser…
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 2d
Önskar dig en skön ledighet!
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 2d
Ja och en rövslev
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Reposted by Erik
haoyin.bsky.social
Hao Yin @haoyin.bsky.social · 2d
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 2d
Är det det som kallas shabby chic?
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 2d
Vad händer då?
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Reposted by Erik
bastorpentonit.bsky.social
Butternut Sasquatch @bastorpentonit.bsky.social · 2d
Snel hest.
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 2d
Ja kul med barn för omväxlings skull!
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 2d
Nej alltså jag behöver bara fixa ett annat intyg.
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epikrisa.bsky.social
Erik @epikrisa.bsky.social · 2d
Bra aw med labbet
epikrisa.bsky.social
Erik @epikrisa.bsky.social · 2d
Pysslar lite med några intyg inför specialistansökan (som förvisso är mer än 1,5 år bort). Allt ska fan ha speciella intyg. Räcker inte med intyg på psykoterapiutbildning från kursgivaren utan det ska skrivas på särskild blankett. Etc etc
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