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Reposted by Fabian Fröhlich

Tina Perica @glukozica.bsky.social · 1d

Skeetorial on our BRAF preprint!
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer

The RAF/MEK/ERK signaling cascade regulates cell proliferation and differentiation and is frequently dysregulated in cancer. Approximately 90% of RAF-mutant cancers harbour mutations in B-type of Rapi...

tinyurl.com

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Reposted by Fabian Fröhlich

SPARC @sparcopen.bsky.social · 5d

We just posted an impact story on policies at HHMI, Gates & Astera promoting #OpenAccess #OpenScience #OpenData. Powerful signals to other funders to accelerate discovery in science. Well done @madubs.bsky.social @openaccessmaven.bsky.social @pracheeac.bsky.social! sparcopen.org/impact-story...

Funders Roll Out Next Gen Open Policies - SPARC

sparcopen.org

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Reposted by Fabian Fröhlich

The Francis Crick Institute @crick.ac.uk · 6d

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

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Fabian Fröhlich @frohlichlab.com · 6d

Opening my lab @crick.ac.uk two years ago has been a privilege, a delight and ultimately the most transformative experience of my sciencific career. Discovery science without boundaries, inspiring colleagues and infinite possibilities. Come join us!

The Francis Crick Institute @crick.ac.uk · 6d

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

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Reposted by Fabian Fröhlich

The Francis Crick Institute @crick.ac.uk · 13d

Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme.

Apply by 05 November 2025

www.crick.ac.uk/careers-and-...

PhD students

Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.

www.crick.ac.uk

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Reposted by Fabian Fröhlich

Julia Sero @cellmorphosero.bsky.social · 6d

Omg nature is so weird and amazing

Rebecca R Helm @rebeccarhelm.bsky.social · 6d

Many sea stars begin life as young fairy-like creature (called a brachiolaria) that float through the open ocean. Eventually, a small star forms within them (here in yellow). The fairy-like brachiolaria sinks under the star’s weight, and the star pops out!
🎥@the_story_of_a_biologist (on Insta)

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Reposted by Fabian Fröhlich

Patrick Kidger @patrickkidger.bsky.social · 8d

🚀 New talk!

"Automated ML-guided lead optimization: surpassing human-level performance at protein engineering"

▶️ www.youtube.com/watch?v=mEhB...

✨🧪 This was a talk I gave at the recent AIxBIO conference in Cambridge UK. A 10-minute pitch for what we do at Cradle!

Automated ML-guided lead optimization: surpassing human-level performance at protein engineering

YouTube video by Patrick Kidger

www.youtube.com

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Fabian Fröhlich @frohlichlab.com · 8d

🌊 Signals intertwine,
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.

Come do a PhD with us www.crick.ac.uk/careers-stud...

Fröhlich Lab | Scientific Machine Learning for Signal Transduction

www.crick.ac.uk

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Reposted by Fabian Fröhlich

Chris Tape @christophertape.bsky.social · 13d

Applications are now open for the @cruk-cityoflondon.bsky.social Black Leaders in Cancer PhD Programme.

If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!

www.colcc.ac.uk/2026-blic-ph...

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Reposted by Fabian Fröhlich

Tina Perica @glukozica.bsky.social · 17d

First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)

bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 18d

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1

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Reposted by Fabian Fröhlich

Zena Hadjivasiliou @zenahadjivasiliou.bsky.social · 23d

🚨New Preprint🚨

How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness?

We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Reposted by Fabian Fröhlich

David Balchin @davidbalchin.bsky.social · 26d

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology

By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...

www.nature.com

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Reposted by Fabian Fröhlich

Mathew Garnett @mgarnett.bsky.social · 25d

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.

Start mining data now: dataminer.depmap.sanger.ac.uk

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Reposted by Fabian Fröhlich

Zena Hadjivasiliou @zenahadjivasiliou.bsky.social · 28d

Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...

Gene Network Organization, Mutation, and Selection Collectively Drive Developmental Pattern Evolvability and Predictability

The historical order in which mutations appear during evolution determine the evolutionary trajectory of gene regulatory networks and influence how developmental patterns change and diversify over tim...

journals.aps.org

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Reposted by Fabian Fröhlich

Alexis Barr @alexisbarr.bsky.social · 26d

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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Reposted by Fabian Fröhlich

Saez-Rodriguez Group @saezlab.bsky.social · 28d

🥁 Check out our new preprint on OmniPath, the prior knowledge resource for #SystemsBiology, and its brand-new OmniPath Explorer web app! 🥳

📖 Preprint: www.biorxiv.org/content/10.1...
🔍 Explorer: explore.omnipathdb.org

OmniPath integrates 160+ resources for multi-omics analysis & modeling.

🧶⬇️

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Reposted by Fabian Fröhlich

Patrick Kidger @patrickkidger.bsky.social · Sep 12

💥 We are *also* organizing Machine Learning for Structural Biology @ EurIPS, Copenhagen!!

Topics include anything in the ML+bio intersection.

Submit your ML+bio short papers! Authors can even present in both locations if they have people in both locations 🚀

MLSB (in San Diego + Copenhagen) @workshopmlsb.bsky.social · Sep 12

You asked and we listened... @workshopmlsb.bsky.social is excited to be expanding to Copenhagen, DK at @euripsconf.bsky.social 🎉

Two workshops (San Diego & Copenhagen) will run concurrently to support broader attendance. You can indicate your location preference(s) in the submission portal💫

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Reposted by Fabian Fröhlich

Trevor Graham @trevorgraham.bsky.social · Sep 10

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature

Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

www.nature.com

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Reposted by Fabian Fröhlich

Alex Fedorec @ajfedorec.bsky.social · Sep 11

The advert for the first of these positions (computational/mathematical synbio) is live!

www.ucl.ac.uk/work-at-ucl/...

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Reposted by Fabian Fröhlich

The Francis Crick Institute @crick.ac.uk · Sep 10

Edith Heard our new CEO shares ten lessons from her life in science, from curiosity, courage and coffee to the secrets of our genetic code.

www.crick.ac.uk/news/2025-09...

Edith Heard life lessons

Edith Heard, the Crick’s new Director and CEO, shares ten lessons from a life in science, spanning curiosity, courage, coffee, and the secrets of our genetic code.

www.crick.ac.uk

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Reposted by Fabian Fröhlich

Ollie Inge @oliveringe.bsky.social · Sep 9

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation

Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

www.cell.com

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Reposted by Fabian Fröhlich

The Francis Crick Institute @crick.ac.uk · Sep 4

Congratulations to @gregfindlay.bsky.social on being awarded a €1.5 million Starting Grant from the @erc.europa.eu to take a closer look at possible disease variants hiding in the dark genome.

www.crick.ac.uk/news/2025-09...

€1.5 million to uncover disease risk hiding in non-coding DNA

Greg Findlay, Group Leader of the Genome Function Laboratory at the Francis Crick Institute, has been awarded a Starting Grant from the European Research Council for €1.5 million to take a deep dive i...

www.crick.ac.uk

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Reposted by Fabian Fröhlich

Alexis Barr @alexisbarr.bsky.social · Sep 3

Feeling very fortunate to be awarded a Programme Foundation Award from CRUK @cruk-si.bsky.social

This is a new area for the lab & lets us team up with @mariasecrier.bsky.social to tackle a big problem of how different cancers lose control of proliferation

MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · Sep 3

Congratulations to @alexisbarr.bsky.social and Jesus Gil who have received funding awards, together totalling around £3M, from @cancerresearchuk.org!

They will lead two exciting projects that could result in discoveries that make a real difference to the lives of people with cancer in the future.

LMS scientists receive funding to boost cancer research

Cancer Research UK has awarded significant funding to researchers at the MRC Laboratory of Medical Sciences (LMS) to lead two exciting new projects that could result in discoveries that make a real di...

lms.mrc.ac.uk

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Reposted by Fabian Fröhlich

Julia Sero @cellmorphosero.bsky.social · Sep 2

I like how the QWERTY keyboard mirrors evolution. Proteins and pathways adapted to a situation persist, even when the situation changes. So we end up with mysteriously complex Rube Goldberg machines across biology that only make sense if you know about clashing type bars in Victorian machines.

Marcin Wichary @aresluna.org · Aug 29

I just put online the chapter from my book that talks about all the myths and mysteries about QWERTY and Dvorak.

You can read it here: aresluna.org/the-primitiv...

The primitive tortureboard

Untangling the myths and mysteries of Dvorak and QWERTY

aresluna.org

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Reposted by Fabian Fröhlich

James Briscoe @jamesbriscoe.bsky.social · Sep 1

Exciting day for @crick.ac.uk today: Edith Heard takes over as Director

We're looking forward to this new chapter in the story

www.crick.ac.uk/about-us/lea...

Edith Heard

www.crick.ac.uk

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