Fabian Fröhlich
@frohlichlab.com
Dynamics of Living Systems (https://www.frohlichlab.com) group leader @thecrick.bsky.social Understanding signalling & cell state dynamics through mathematical modelling and machine learning.
Reposted by Fabian Fröhlich
We are recruiting a Postdoc in computational biology, together with @mariasecrier.bsky.social
4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence
Applications open now: www.imperial.ac.uk/jobs/search-...
4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence
Applications open now: www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
January 21, 2026 at 12:58 PM
We are recruiting a Postdoc in computational biology, together with @mariasecrier.bsky.social
4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence
Applications open now: www.imperial.ac.uk/jobs/search-...
4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence
Applications open now: www.imperial.ac.uk/jobs/search-...
Reposted by Fabian Fröhlich
Apply for the Ascona workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems", 28 Jun-3 Jul 2026 on Monte Verità, Lago Maggiore at the foot of the Swiss Alps.
ascona2026.sciencesconf.org
ascona2026.sciencesconf.org
January 15, 2026 at 4:16 PM
Apply for the Ascona workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems", 28 Jun-3 Jul 2026 on Monte Verità, Lago Maggiore at the foot of the Swiss Alps.
ascona2026.sciencesconf.org
ascona2026.sciencesconf.org
Reposted by Fabian Fröhlich
🚀 New preprint! Meet ORIGAMI: Mapping cancer cell state heterogeneity and plasticity, predicting and steering therapy-induced trajectories to rationalize genotype-agnostic combination strategies with only two physical metrics (cell surface area and volume)
www.researchsquare.com/article/rs-8...
www.researchsquare.com/article/rs-8...
Simple cell geometry metrics reveal cancer cell diversity and plasticity and guide combination therapy
Intra-tumour heterogeneity (ITH) and cellular plasticity contribute to therapy resistance. Single-cell transcriptomics is the gold standard for assessing ITH, but this approach remains costly and slow...
www.researchsquare.com
January 9, 2026 at 4:40 PM
🚀 New preprint! Meet ORIGAMI: Mapping cancer cell state heterogeneity and plasticity, predicting and steering therapy-induced trajectories to rationalize genotype-agnostic combination strategies with only two physical metrics (cell surface area and volume)
www.researchsquare.com/article/rs-8...
www.researchsquare.com/article/rs-8...
Reposted by Fabian Fröhlich
Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Group Leader - Generative Biology and AI
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
tinyurl.com
January 1, 2026 at 12:08 PM
Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Reposted by Fabian Fröhlich
Announcing the Ascona Workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems" on 28 June - 3 July 2026 in Ascona, CH
www.huber.embl.de/group/events...
Reserve the dates!
www.huber.embl.de/group/events...
Reserve the dates!
December 22, 2025 at 11:10 AM
Announcing the Ascona Workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems" on 28 June - 3 July 2026 in Ascona, CH
www.huber.embl.de/group/events...
Reserve the dates!
www.huber.embl.de/group/events...
Reserve the dates!
Reposted by Fabian Fröhlich
Enjoyed reading
“AI for chemistry in 2025 is like AI for images in 2010”
leashbio.substack.com/p/ai-for-che...
“AI for chemistry in 2025 is like AI for images in 2010”
leashbio.substack.com/p/ai-for-che...
December 18, 2025 at 9:39 PM
Enjoyed reading
“AI for chemistry in 2025 is like AI for images in 2010”
leashbio.substack.com/p/ai-for-che...
“AI for chemistry in 2025 is like AI for images in 2010”
leashbio.substack.com/p/ai-for-che...
Reposted by Fabian Fröhlich
We can know more than we can tell, but now Al can capture it. Our multimodal agent analyzes lab videos to generate protocols & catch common lab errors. Preserving tacit knowledge in proteomics. Now in @molsystbiol.org @patiskowronek.bsky.social #Google
link.springer.com/10.1038/s443...
link.springer.com/10.1038/s443...
December 16, 2025 at 9:29 AM
We can know more than we can tell, but now Al can capture it. Our multimodal agent analyzes lab videos to generate protocols & catch common lab errors. Preserving tacit knowledge in proteomics. Now in @molsystbiol.org @patiskowronek.bsky.social #Google
link.springer.com/10.1038/s443...
link.springer.com/10.1038/s443...
Reposted by Fabian Fröhlich
Funny how LLM companies are spending millions to discover what students learn in the first year of business school. At least the employees are having lolz.
Need to start from the original - this is episode 2 where @anthropic.com enlisted @wsj.com to help test www.anthropic.com/research/pro... (link to episode 1 inside). @matt-levine.bsky.social has covered well
Project Vend: Phase two
How Claude turned around its failing vending machine business
www.anthropic.com
December 19, 2025 at 5:54 AM
Funny how LLM companies are spending millions to discover what students learn in the first year of business school. At least the employees are having lolz.
Reposted by Fabian Fröhlich
🎄 We’re hiring in Health AI at @HelmholtzMunich!
🔹 PIs in Health AI/AI Foundations
🔹 Health AI Fellows
🔹 Clinical AI Consultants
Apply👇
PIs: jobs.helmholtz-muenchen.de/jobposting/8...
Fellows: jobs.helmholtz-muenchen.de/jobposting/7...
Consult: jobs.helmholtz-muenchen.de/jobposting/c...
🔹 PIs in Health AI/AI Foundations
🔹 Health AI Fellows
🔹 Clinical AI Consultants
Apply👇
PIs: jobs.helmholtz-muenchen.de/jobposting/8...
Fellows: jobs.helmholtz-muenchen.de/jobposting/7...
Consult: jobs.helmholtz-muenchen.de/jobposting/c...
Principal Investigators (f/m/x) for (i) AI in Biomedicine and (ii) AI Foundations
At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we…
jobs.helmholtz-muenchen.de
December 19, 2025 at 3:49 PM
🎄 We’re hiring in Health AI at @HelmholtzMunich!
🔹 PIs in Health AI/AI Foundations
🔹 Health AI Fellows
🔹 Clinical AI Consultants
Apply👇
PIs: jobs.helmholtz-muenchen.de/jobposting/8...
Fellows: jobs.helmholtz-muenchen.de/jobposting/7...
Consult: jobs.helmholtz-muenchen.de/jobposting/c...
🔹 PIs in Health AI/AI Foundations
🔹 Health AI Fellows
🔹 Clinical AI Consultants
Apply👇
PIs: jobs.helmholtz-muenchen.de/jobposting/8...
Fellows: jobs.helmholtz-muenchen.de/jobposting/7...
Consult: jobs.helmholtz-muenchen.de/jobposting/c...
Reposted by Fabian Fröhlich
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
December 16, 2025 at 12:05 PM
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Reposted by Fabian Fröhlich
🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social.
www.biorxiv.org/content/10.6...
👇
www.biorxiv.org/content/10.6...
👇
December 17, 2025 at 3:10 PM
🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social.
www.biorxiv.org/content/10.6...
👇
www.biorxiv.org/content/10.6...
👇
Reposted by Fabian Fröhlich
Here's another exciting doctoral project led by Research Group Leader Beatrice Ramm at the Friedrich Miescher Laboratory.
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
December 9, 2025 at 9:22 AM
Here's another exciting doctoral project led by Research Group Leader Beatrice Ramm at the Friedrich Miescher Laboratory.
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
Reposted by Fabian Fröhlich
Very excited to announce that MSc computational cancer is now open for applications! A new joint programme from UCL engineering & cancer institute.
Teaching #cancer through a computational lens, integrating cutting edge research with taught components.
Apply below!
www.ucl.ac.uk/prospective-...
Teaching #cancer through a computational lens, integrating cutting edge research with taught components.
Apply below!
www.ucl.ac.uk/prospective-...
Computational Cancer MSc
Be part of the revolution in cancer research and computational science with this interdisciplinary Master’s at UCL. Delivered jointly by UCL Medical Physics and Biomedical Engineering and the UCL Cancer Institute, this programme equips you with cutting-edge skills at the forefront of healthcare innovation.
www.ucl.ac.uk
December 8, 2025 at 12:03 PM
Very excited to announce that MSc computational cancer is now open for applications! A new joint programme from UCL engineering & cancer institute.
Teaching #cancer through a computational lens, integrating cutting edge research with taught components.
Apply below!
www.ucl.ac.uk/prospective-...
Teaching #cancer through a computational lens, integrating cutting edge research with taught components.
Apply below!
www.ucl.ac.uk/prospective-...
Reposted by Fabian Fröhlich
Great to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Reconstructing Waddington’s landscape from data | PNAS
The development of a zygote into a functional organism requires that this single progenitor
cell gives rise to numerous distinct cell types. Attemp...
www.pnas.org
December 4, 2025 at 6:29 AM
Great to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Reposted by Fabian Fröhlich
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
November 27, 2025 at 1:02 PM
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
Reposted by Fabian Fröhlich
🧬 Kinase Inhibitors can do more than block their targets!
A study by @cemm.oeaw.ac.at[email protected] and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.
Out in @nature.com
➡️ bit.ly/43SD9xj
A study by @cemm.oeaw.ac.at[email protected] and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.
Out in @nature.com
➡️ bit.ly/43SD9xj
November 26, 2025 at 4:05 PM
🧬 Kinase Inhibitors can do more than block their targets!
A study by @cemm.oeaw.ac.at[email protected] and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.
Out in @nature.com
➡️ bit.ly/43SD9xj
A study by @cemm.oeaw.ac.at[email protected] and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.
Out in @nature.com
➡️ bit.ly/43SD9xj
Reposted by Fabian Fröhlich
Great post. “mentoring should be criteria for hiring tenure-track faculty! But alas, it rarely is.”
Also how to measure? Everyone can write about how to be a good mentor on an application form but how can you assess if they actually are?
Also how to measure? Everyone can write about how to be a good mentor on an application form but how can you assess if they actually are?
You know those labs that keep harming students, again and again? Some reflections on why it's so hard to stop this from happening and where our responsibilities lie.
scienceforeveryone.science/bad-mentors-... 🧪
scienceforeveryone.science/bad-mentors-... 🧪
Bad mentors hurt people
What to do about bad mentors?
scienceforeveryone.science
November 26, 2025 at 6:37 AM
Great post. “mentoring should be criteria for hiring tenure-track faculty! But alas, it rarely is.”
Also how to measure? Everyone can write about how to be a good mentor on an application form but how can you assess if they actually are?
Also how to measure? Everyone can write about how to be a good mentor on an application form but how can you assess if they actually are?
Reposted by Fabian Fröhlich
[so AI may be bad but probably no worse than your average pundit and definitely not as bad as WSJ 😆] 3/n
November 22, 2025 at 5:59 PM
[so AI may be bad but probably no worse than your average pundit and definitely not as bad as WSJ 😆] 3/n
Reposted by Fabian Fröhlich
I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes
November 21, 2025 at 1:14 PM
I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes
Reposted by Fabian Fröhlich
I think almost all scientific projects should be planned carefully. And I think an app can dramatically improve that. So I wrote an app for that (free for now, if you can fund this let me know). I tested it quite a bit (>8000 users in beta so far). try it: planyourscience.com
November 20, 2025 at 3:33 PM
I think almost all scientific projects should be planned carefully. And I think an app can dramatically improve that. So I wrote an app for that (free for now, if you can fund this let me know). I tested it quite a bit (>8000 users in beta so far). try it: planyourscience.com
Reposted by Fabian Fröhlich
This is wild - an open challenge on 'virtual cell' perturbation prediction falls on its face due to flawed metrics:
gmdbioinformatics.substack.com/p/arc-virtua...
Benchmarking is important. It's also difficult. It's not just an engineering challenge. Figuring out what "good performance"...
⬇️
gmdbioinformatics.substack.com/p/arc-virtua...
Benchmarking is important. It's also difficult. It's not just an engineering challenge. Figuring out what "good performance"...
⬇️
November 19, 2025 at 2:42 PM
This is wild - an open challenge on 'virtual cell' perturbation prediction falls on its face due to flawed metrics:
gmdbioinformatics.substack.com/p/arc-virtua...
Benchmarking is important. It's also difficult. It's not just an engineering challenge. Figuring out what "good performance"...
⬇️
gmdbioinformatics.substack.com/p/arc-virtua...
Benchmarking is important. It's also difficult. It's not just an engineering challenge. Figuring out what "good performance"...
⬇️
Reposted by Fabian Fröhlich
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
November 18, 2025 at 11:03 PM
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
Reposted by Fabian Fröhlich
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Reposted by Fabian Fröhlich
New essay out today by me and @acjsissons.bsky.social - ‘Getting Britain out of the hole: a plan for the economy’. You can read the whole thing here getting-out-of-the-hole.uk
A chart mega-thread follows 🧵
A chart mega-thread follows 🧵
Getting Britain out of the hole
A plan for the UK economy
getting-out-of-the-hole.uk
November 17, 2025 at 8:00 AM
New essay out today by me and @acjsissons.bsky.social - ‘Getting Britain out of the hole: a plan for the economy’. You can read the whole thing here getting-out-of-the-hole.uk
A chart mega-thread follows 🧵
A chart mega-thread follows 🧵
To the consumers of LLM tools and of their outputs: Is it really that hard to see that ideation/conception and implementation are distinct skills in writing (of text and code), and that while LLMs are strong at implementation, they continue to fall short on ideation?
November 15, 2025 at 5:17 PM
To the consumers of LLM tools and of their outputs: Is it really that hard to see that ideation/conception and implementation are distinct skills in writing (of text and code), and that while LLMs are strong at implementation, they continue to fall short on ideation?