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geddescc.bsky.social @geddescc.bsky.social · Jul 3

Great paper from UK RaDaR dataset on outcomes in adult and childhood nephrotic syndrome

journals.lww.com/jasn/fulltex...

Long-Term Outcomes in Nephrotic Syndrome by Kidney Biopsy... : Journal of the American Society of Nephrology

sociated with good kidney outcomes at 10 years.Monogenic nephrotic syndrome cases had very high proteinuria and rapid progression to kidney failure with little response to current treatments. Backgro...

journals.lww.com

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Edgar V. Lerma 🇵🇭 @edgarvlermamd.bsky.social · Jun 8

A stylized representation of the unmet need in a typical adult patient with IgA Nephropathy #IgAN ca. 2024
#ERA25 🇦🇹 #Nephpearls #NephSky

👉 pubmed.ncbi.nlm.nih.gov/39211339/

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Jayana Devathasan @jyndvthsn.bsky.social · Jun 5

10 years of SGLT2i trials shared by Dr Kaitlyn Mayne at #era25!

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Kate Stevens @kateisabelle24.bsky.social · Jun 3

Disease-modifying anti-nephropathic drugs ‘DMANDs’ in NDT this month

@ndt-era.bsky.social

The right drug for the right patient…that’s how we keep changing the story for patients with kidney disease

academic.oup.com/ndt/article/...

Disease-modifying anti-nephropathic drugs (DMANDs)—a definition proposed by the Immunonephrology Working Group (IWG) of the European Renal Association (ERA)

ABSTRACT. A definition of ‘disease modification’ for kidney disease is long overdue. Here, we propose three key criteria for disease modification in immune

academic.oup.com

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Jun 2

Foundational therapies in ESRD for heart failure

Dr Matt Graham-Brown from Leicester presents at #NephGR

www.youtube.com/watch?v=Ar11...

(Rounds from Feb, late share!)

Foundation therapies for heart failure in end stage kidney disease with Dr Matt Graham-Brown

YouTube video by Ottawa Nephrology

www.youtube.com

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geddescc.bsky.social @geddescc.bsky.social · May 29

KFRE underestimates risk in people with CKD and frailty

journals.lww.com/cjasn/abstra...

Frailty in Adults with Chronic Kidney Disease and... : Clinical Journal of the American Society of Nephrology

aim was to validate KFRE by frailty status and assess whether model performance could be improved by using cystatin based estimated glomerular filtration rate (eGFR) equations and to assess the impact...

journals.lww.com

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geddescc.bsky.social @geddescc.bsky.social · May 28

The remaining challenge is measuring BP by standardized method. Very few clinics can do it in Scotland. Is the same true in Canada? pubmed.ncbi.nlm.nih.gov/39638870/

Blood pressure measurement technique in clinical practice in the NHS Greater Glasgow and Clyde - PubMed

Blood pressure (BP) measurement is a common procedure conducted in various disciplines and is widely available on clinical reports. The diagnosis and management of hypertension require reliable measur...

pubmed.ncbi.nlm.nih.gov

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Rémi Goupil @goupilremi.bsky.social · May 27

That’s what we just did in Canada! Target is SBP < 130 mmHg for all

www.cmaj.ca/content/197/...

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geddescc.bsky.social @geddescc.bsky.social · May 27

So we should remove diastolic targets from guidelines no? @hswapnil.medsky.social

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Kidney International @kidneyint.bsky.social · May 27

A randomized controlled trial of intravenous immunoglobulin vs standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients

doi.org/10.1016/j.kint.2025.04.023

#NephSky #MedSky @dialysisbloke.bsky.social #kidneytransplant #KTx

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geddescc.bsky.social @geddescc.bsky.social · May 15

It is not lack of capacity driving this in Scotland. It is patient choice.

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STITCHES Medicine - the Best of Medical Research @medicine.stitches.today · May 6

Discontinuing aspirin during surgery for chronic subdural hematoma did not lower recurrence rates compared to continuous treatment.

by Kamenova M, Pacan L (...) Soleman J et 9 al. in JAMA Neurol #MedSky

👉 get more here

📖 read the article:

Aspirin Continuation or Discontinuation in Surgically Treated Chronic Subdural Hematoma

The SECA randomized clinical trial assesses the risk of recurrence of chronic subdural hematoma (cSDH) and cardiovascular events in patients undergoing surgical treatment for cSDH with continuous vs discontinuous low-dose acetylsalicylic acid treatment.

jamanetwork.com

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geddescc.bsky.social @geddescc.bsky.social · Apr 24

Come to #ERA2026 in Glasgow @hswapnil.medsky.social . It will be a great meeting and we will make you very welcome.

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Friends of Glasgow Royal Infirmary @friendsofgri.bsky.social · Apr 24

#archive30 #day24

It's very hard to choose 😵‍💫

But this is a pretty #popularitem - an original X ray tube

Plus the man who set up the world's very first X ray department in 1896 at #glasgowroyalinfirmary our medical electrician Dr John McIntyre ❤️

@arascot.bsky.social

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Apr 16

This seems like a - let us write more guidelines that will get heavily cited and boost my h-index - piece

I will argue we need less guidelines

They should be like wars - waged only when absolutely necessary (stealing from @cardiobrief.bsky.social Larry Husten www.forbes.com/sites/larryh...)

Why Health Guidelines Should Be Waged Like War

Updated Here's a modest proposal: we need fewer and shorter guidelines. In fact, I'd like to propose that guidelines, like war, should be waged only when there is absolute consensus and overwhelming e...

www.forbes.com

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Science Magazine @science.org · Apr 11

Exclusive: Towana Looney, a 53-year-old woman who received a kidney from a gene-edited pig on 25 November 2024, had it removed last week after the organ suddenly stopped functioning, Science has learned. scim.ag/3EiaJmM

Longest human transplant of pig kidney fails

In latest xenotransplant test, Towana Looney’s body rejects gene-edited organ after more than 4 months

scim.ag

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Apr 10

Overall they sleep poorly
Median ~ 6.5 hours - and look at the spread
2/

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Apr 10

Very interesting pilot trial from @bhanu24.bsky.social and colleagues in @ajkd.bsky.social

Renal Denervation in .....loin pain hematuria syndrome!

www.ajkd.org/article/S027...

#NephSky

Renal Denervation in Loin Pain Hematuria Syndrome: A Pilot Randomized Controlled Trial

Loin pain hematuria syndrome (LPHS) is a rare disease characterized by severe, unrelenting unilateral or bilateral loin pain localized to the kidney but not caused by any identifiable urinary tract di...

www.ajkd.org

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Heather Badenoch 🇨🇦 @heatherbadenoch.bsky.social · Apr 8

Nearly all patient representatives on the Organ Procurement and Transplantation Network board have resigned. #MedSky

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Screaming Pectoriloquy @caulimovirus.bsky.social · Apr 5

hyponatremia: serum sodium tells us where you are and urine osm/lytes tell us how you got there

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geddescc.bsky.social @geddescc.bsky.social · Apr 5

👏👏

geddescc.bsky.social @geddescc.bsky.social · Apr 3

Contrary to other studies we observed highest incidence of thrombotic events in min change but we analysed events per month of NS. So maybe nothing special about membranous other than NS is sustained for longer than other causes? pubmed.ncbi.nlm.nih.gov/27669572/

Venous Thromboembolism in Primary Nephrotic Syndrome - Is the Risk High Enough to Justify Prophylactic Anticoagulation? - PubMed

Patients with primary NS are at an increased risk of VTE. The timing of VTE means that only half of episodes would be targeted by prophylactic anticoagulation. Given the low frequency of events, a wel...

pubmed.ncbi.nlm.nih.gov

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geddescc.bsky.social @geddescc.bsky.social · Apr 3

Could it be that higher incidence of thrombotic events in the first 6m is because some NS scenarios involve imbalance of protein loss in favour of thrombosis and some don’t? So what remains after a few months is latter (who by implication will be harmed by anticoag because they never needed it)

geddescc.bsky.social @geddescc.bsky.social · Apr 3

We’re no further forward after 30 years of debate. Producing detailed treatment algorithms based on flawed observational evidence makes the RCTs the authors cry out for less likely to happen. Recommending a “Highly personalised” approach is code for “we don’t know”.

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Friends of Glasgow Royal Infirmary @friendsofgri.bsky.social · Apr 3

#archive30 #day3 #soundandvision

#musicinthegri our concert series, a wonderful project instigated & led by Arthur Doyle, a man who definitely has vision & makes some wonderful sounds on his violin.

The last concert in GRI was in1883; recitals were a common means of raising £ in the days pre #nhs

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