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Journal of Clinical Investigation @jci.org · 3h

ICYMI: Gut complement system: a new frontier in microbiota-host communication and intestinal homeostasis

As part of JCI’s ongoing Review series on complement biology and therapeutics, Xianbin Tian et al. discuss the unique adaptations of intestinal complement: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 23h

Endothelial gateways for brain lipid uptake and metabolism: www.jci.org/articles/vie...

A. Dushani Ranasinghe & Timothy Hla Comment on Wenxin Song et al: www.jci.org/articles/vie...

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Reposted by Journal of Clinical Investigation

tharaux-lenoir-lab.bsky.social @tharaux-lenoir-lab.bsky.social · 2d

Enthusiastic about this emerging field. Perhaps a key to understanding and treating the multiorgan complications of #diabetes and #metabolic syndrome?

Journal of Clinical Investigation @jci.org · 2d

Perturbation of the circadian clock in chronic diseases involving organ fibrosis

This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...

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Reposted by Journal of Clinical Investigation

Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · 2d

Impressive work by Sylvanus Toikumo revealing cell-type-specific genetic architecture of human chronic pain across central and peripheral nervous system. The C2 DRG from our patients with neck pain undergoing surgery at @uwmedicine.bsky.social displayed enrichment of pain-specific genes.

Ted Price @tedpricethepainguy.bsky.social · 3d

Huge congrats to Sylvanus Toikumo for this outstanding work just published online preview in JCI: www.jci.org/articles/vie... We were happy to be able to play a small role in this paper, and I have been happy to be an informal co-mentor to Sylvanus... he is on the job market!

JCI - The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia

www.jci.org

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Journal of Clinical Investigation @jci.org · 1d

SIRT2 puts the brakes on human beta cell proliferation: Therapeutic opportunities and next challenges: www.jci.org/articles/vie...

Liora S. Katz @likatz.bsky.social, Donald K. Scott, & Andrew F. Stewart provide a Commentary on Katz et al.: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 1d

A promising drug target for regenerating functional β-cell mass in diabetes!

@worthamlab.bsky.social, @sanderlaberlin.bsky.social & team discover the deacetylase SIRT2 restrains proliferation of pancreatic β-cells in a glucose-dependent manner: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 2d

Genomic adjusted radiation dose stratifies radiotherapy dosing based on tumor-specific sensitivity in HPV-positive oropharyngeal cancer: www.jci.org/articles/vie...

Sandip K. Rath & David S. Yu comment on Emily Ho et al.: www.jci.org/articles/vie...

JCI - Genomic adjusted radiation dose stratifies radiotherapy dosing based on tumor-specific sensitivity in HPV+ oropharyngeal cancer

www.jci.org

Journal of Clinical Investigation @jci.org · 2d

Personalized treatment in HPV+ oropharynx cancer using genomic adjusted radiation dose

@cancerconnector.bsky.social & team analyze gene expression profiles in patients with HPV+ OSCC & provide a model that outperforms standard measures for predicting OS:
www.jci.org/articles/vie...

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Reposted by Journal of Clinical Investigation

Ted Price @tedpricethepainguy.bsky.social · 3d

Huge congrats to Sylvanus Toikumo for this outstanding work just published online preview in JCI: www.jci.org/articles/vie... We were happy to be able to play a small role in this paper, and I have been happy to be an informal co-mentor to Sylvanus... he is on the job market!

JCI - The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia

www.jci.org

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Journal of Clinical Investigation @jci.org · 2d

We thought the brain couldn’t use fatty acids or metabolize triglyceride-rich lipoproteins.

Stephen G. Young & team now provide convincing evidence for lipoprotein lipase-mediated intravascular triglyceride processing in the CNS:
www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 2d

Perturbation of the circadian clock in chronic diseases involving organ fibrosis

This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 3d

Resistance to endocrine therapy in HR+ early breast cancer remains a challenge

Clarissa Gerhauser & team identify epi-/genetic features associated with primary resistance to tamoxifen and aromatase inhibitors in HR+/HER2- breast cancer & develop predictors: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 3d

The reno-protective effects of SGLT2 inhibitors cannot be fully explained by their glucose-lowering actions.

Quaggin & team now show SGLT2 inhibition increases tissue levels of SAM, resulting in enhanced H3K27 trimethylation & repression of inflammatory genes: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 4d

Genetic and environmental factors converge in congenital craniofacial birth defects

Paul A. Trainor @aussiebiologist.bsky.social & team explore a mouse model of Treacher Collins syndrome, reporting on ROS & genomic instability involved in phenotype variability:
www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 4d

Gut complement system: a new frontier in microbiota-host communication and intestinal homeostasis

As part of JCI’s ongoing Review series on complement biology and therapeutics, Xianbin Tian et al. discuss the unique adaptations of intestinal complement: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 5d

Progress towards enhancing #cancer immunotherapies in the context of solid tumors!

William E. Carson III & team show BRD4 inhibition can reduce suppressive immune cells in murine cancer models: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 6d

ICYMI: This issue’s cover art represents the potential for improving pain relief by restoring #circadian rhythmicity.

@ghasemloulab.bsky.social & team link daily pain rhythmicity with neutrophil activation, better biopsychosocial profiles, & reduced opioid use: jci.org/articles/vie...

Reposted by Journal of Clinical Investigation

TRAstonDrs @castltrastondrs.bsky.social · 9d

#Medsky🧪 #immunosky #publichealth This study found circadian rhythms & biopsychosocial characteristics significantly influence opioid use in patients with chronic low back pain (CLBP). Poor circadian rhythmicity is associated with worse pain outcomes & higher opioid use,

Journal of Clinical Investigation @jci.org · 9d

This issue’s cover art represents the potential for improving pain relief by restoring circadian rhythmicity

@ghasemloulab.bsky.social & team link daily pain rhythmicity with neutrophil activation, better biopsychosocial profiles, & reduced opioid use: buff.ly/GR3SOAK

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Journal of Clinical Investigation @jci.org · 7d

From earlier this week: Another installment in JCI’s Review series on complement biology and therapeutics:

Carsten Krieg & Silvia Guglietta highlight the complement system in intestinal inflammation and cancer: www.jci.org/articles/vie...

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Reposted by Journal of Clinical Investigation

mariejeansson.bsky.social @mariejeansson.bsky.social · 25d

Super happy about our new publication! JCI - TIE2 activation by antibody-clustered endogenous angiopoietin-2 prevents capillary loss and fibrosis in experimental kidney disease www.jci.org/articles/vie...

JCI - TIE2 activation by antibody-clustered endogenous angiopoietin-2 prevents capillary loss and fibrosis in experimental kidney disease

www.jci.org

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Journal of Clinical Investigation @jci.org · 7d

Ruling In, Ruling Out: The Clinical Utility of Plasma Biomarkers in Alzheimer’s Diagnosis

This Viewpoint by Julie K Wisch & Beau M Ances frames first FDA-approved test for amyloid pathology in a historical context and highlights implications for practice: www.jci.org/articles/vie...

Journal of Clinical Investigation @jci.org · 7d

A die is cast: Autologous neutralizing antibody resistance shapes the HIV reservoir during uninterrupted ART: www.jci.org/articles/vie...

Nancie M. Archin comments on Natalie F. McMyn et al.: www.jci.org/articles/vie...

Journal of Clinical Investigation @jci.org · 7d

A major barrier to HIV cure is a population of T cells that harbors replication-competent proviruses

Here, Robert F. Siliciano & team report most viruses in the latent HIV-1 reservoir are resistant to autologous neutralizing antibodies: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 8d

T cell engagers are effective in treating myeloma, but dosing schedules have not been defined.

In this research letter, Madhav V. Dhodapkar & team find in vivo CD4+ T cell fitness within 48 hours following TCE therapy correlates with outcomes: www.jci.org/articles/vie...

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Reposted by Journal of Clinical Investigation

Eric Topol @erictopol.bsky.social · 9d

The role of perturbation of our circadian clock plays in promoting the fibrosis (scarring) of organs
www.jci.org/articles/vie...

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