ALT: a white cat is sitting on a box with the words where written on it .

USAID antimalarial and HIV supplies valued at nearly $140 million were delayed in the first half of the year or not delivered at all due to the Trump administration’s foreign aid pause, The Post found...

This cross-sectional study investigates population-level effectiveness and herd protection in the first 17 years after human papillomavirus (HPV) vaccination among adolescent girls and young women at ...

This decision analytical model study estimates the number of avertable COVID-19 hospitalizations in US infants younger than 6 months and pregnant persons with vaccinations during pregnancy.

Malaria remains a major cause of childhood death in sub-Saharan Africa. We leveraged the traditional practice of mothers carrying children on their backs in cloth wraps to assess whether treating t...

The Gates Foundation will give $912 million to the Global Fund to Fight AIDS, Tuberculosis and Malaria, philanthropist Bill Gates announced on Monday as he urged governments to reverse global health funding cuts.

Move deals potentially major blow to US tech industry, which relies heavily on workers from India and China

Post-artesunate delayed hemolysis (PADH) occurs in 7%–25% of adults with severe imported malaria. Whether it exists in African children is controversial.MethodsIn total, 351 children treated with artesunate were enrolled in a prospective severe malaria study in Benin. Clinical, epidemiological and biological data, plasma concentrations of antimalarials were captured or determined on admission then at 3, 5, 14, 21, and 28 days after starting treatment. PADH was defined by a >10% drop in hemoglobin level and/or a >10% rise in LDH concentrations beyond Day 5.ResultsFourteen children (4%) died before D14. Although 10% of guardians declared administration of anti-malarial drugs before admission, 316/350 (90%) of children had measurable plasma levels of lumefantrine (n = 279), quinine (n = 104), sulfadoxine (n = 67), artemisinin (n = 28), chloroquine (n = 16), or other antimalarials (n = 9). PADH occurred in 76/332 children (22.9%). Levels of pitted red blood cells (RBC) were higher and recovery from anemia was slower in these children. Severe anemia and transfusion were more frequent between D14 and D28 in children with PADH compared to children without PADH (10.6% vs 0.4%, 9.8% vs 0%). During follow-up, children with PADH were more frequently hospitalized (11.1% vs 1.6%) and had more frequent infectious events (6.9% vs 0.4%) than children without PADH. Children who received 2 transfusions within 3 days post-admission had a lower incidence of PADH than untransfused children (12.5% vs 26.8%, P = .015).ConclusionsDespite widespread self-medication with antimalarials, PADH affects 23% of African children treated with artesunate for severe malaria, of whom more than 15% suffer from severe anemia and/or infectious events. Liberal early transfusion may be protective against PADH.

The American Academy of Pediatrics recommends 5-day amoxicillin monotherapy as first-line treatment for pediatric uncomplicated community-acquired pne…

Agony and death are not all that shots prevent.