Akul Mehta
akulmehta.bsky.social
Akul Mehta
@akulmehta.bsky.social
310 followers 430 following 49 posts
Glycoscientist @theNCFG BIDMC-Harvard Medical School πŸ‘¨β€πŸ’»πŸ‘¨β€πŸ”¬βš½πŸ“· (Views are my own)
Posts Media Videos Starter Packs
Reposted by Akul Mehta
The @nuxt.com team is highly underrated πŸ’―

I'm working with Nuxt Content, and this product blows my mind 🀯

It's easy, flexible, and fast. Open sourcing Nuxt UI was a solid move too.

You know you're crushing it when a SERVER GUY compliments JavaScript πŸ€“
Reposted by Akul Mehta
Reposted by Akul Mehta
You're kidding me!? πŸ‘€

TIL about "post_start" in Docker Compose 🐳

You can run commands as a privileged user on startup, but still run your services as an unprivileged user.

This dramatically simplifies bootstrapping an app! 🀩
Reposted by Akul Mehta
serversideup/php v4.0-beta1 is now available!!!

It's a next level Docker image:

🐘 FrankenPHP now available
❀️ Improved native health checks
πŸ€– Advanced Laravel automations
🀩 12 new contributors

Our biggest open source release yet. LET'S GO PHP!! πŸš€
Reposted by Akul Mehta
πŸ§‘β€πŸ’» New GitHub integration is here!
Connect your GitHub account, choose an existing markdown repo (or create a new one), and hosted.md will build your site automatically.
Push to GitHub, rebuild instantly ⚑

Full update πŸ‘‰ https://link.hosted.md/kDSFq
The Best Markdown Site Generator for Blogs, Docs, and More - Hosted.MD
With hosted.md, you can publish Markdown online without setting up servers, configuring a CMS, or dealing with complicated tools.
link.hosted.md
To be honest all places are quite awful right now, for different reasons.
Reposted by Akul Mehta
If there was a certain vendor developing a brand new ion mobility instrument and is in the process of choosing a file format, this is timed incredibly well for them to catch the wave.
I'm a huge fan of this proposal!

If we can get vendor buy-in to an open, common format, it could bring more computational folks into the field. How can these folks be excited about #proteomics when its hard to even read the already complicated data?

pubs.acs.org/doi/10.1021/...
mzPeak: Designing a Scalable, Interoperable, and Future-Ready Mass Spectrometry Data Format
Advances in mass spectrometry (MS) instrumentation, including higher resolution, faster scan speeds, and improved sensitivity, have dramatically increased the data volume and complexity. The adoption of imaging and ion mobility further amplifies these challenges in proteomics, metabolomics, and lipidomics. Current open formats such as mzML and imzML struggle to keep pace due to large file sizes, slow data access, and limited metadata support. Vendor-specific formats offer faster access but lack interoperability and long-term archival guarantees. We here lay the groundwork for mzPeak, a next-generation community data format designed to address these challenges and support high-throughput, multidimensional MS workflows. By adopting a hybrid model that combines efficient binary storage for numerical data and both human- and machine-readable metadata storage, mzPeak will reduce file sizes, accelerate data access, and offer a scalable, adaptable solution for evolving MS technologies. For researchers, mzPeak will support complex workflows and regulatory compliance through faster access, improved metadata, and interoperability. For vendors, it offers a streamlined, open alternative to proprietary formats. mzPeak aims to become a cornerstone of MS data management, enabling sustainable, high-performance solutions for future data types and fostering collaboration across the mass spectrometry community.
pubs.acs.org
Reposted by Akul Mehta
employment.ku.dk/faculty/?sho...

Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Postdoc at the Copenhagen Center for Glycocalyx Research at the Department of Cellular and Molecular Medicine
employment.ku.dk
This is remarkable and obviously fantastic science. I have always wondered though, wouldn't the transplanted organ just start expressing the blood group antigens eventually in the recipient? And therefore making this a temporary solution rather than a permanent one.
Most people think that #glycosylation is only extracellular. But there is increasing evidence for the existence of intracellular proteins also being glycosylated. Check out this blog post to learn more about this topic!
🀯 Did you know proteins inside cells can be glycosylated?! πŸ”¬ Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in biology!
πŸ‘‰ research.bidmc.org/ncfg/blog/21...

#glycans #glycosylation #posttranslationalmodification #glycotime
21] Facts About: Intracellular Protein Glycosylation
research.bidmc.org
Reposted by Akul Mehta
5. Abrupt end of the review as the AI probably ran out of tokens.
4. Slowly over the course of the review, AI starts to want to rewrite your entire manuscript for you "I moved the statistical significance sentence up because it is a natural follow-up of the sentence …" The current state of AI, it likes to generate text not to be critical of it.
Example:
"-line XX: … Whats does it mean to study well? Properly? Using right methods? Comprehensively, covering a wide range of possible candidates?"
For context, several of the authors on that paper were native English speakers and all of them had proof-read the paper. But AI used this as an excuse to improve the language, even where it wasn't needed. 40% of the review was just this.
3. AI assumes you are a non-native English speaker even if you are. It will try to rephrase everything you say just to make it sound better. In my colleagues review it stated "…. (obviously not proof-read by a native speaker) …"
Another example it cites Wikipedia "Elution - Wikipedia Please be aware of the difference between an eluate and an eluent" or other web-based resources often instead of actual journal articles. This is because LLMs have access to web-based resources for training but not as much pay-walled articles.
2. AI cites very strange evidences for their statements. In my colleagues review they stated the following "As I checked in Scopus, the authors have an expertise on the biology and biochemistry of … , so I expected to read a sound work."
Another example from the review "I have checked the Supplemental table in excel and I saw XXXXX and XXXXX in rows XX and XX, respectively." Newer reasoning models like to β€œshow their work” and hence blurt out such text.
In the review which my colleague had, it stated in bold "Now I am going to list suggestions for authors to improve the manuscript." No reviewer needs to put this as a bold-title in their review.
1. AI is known to generate very lengthy text. All LLMs so far are trained to output more than what is required and, in an attempt to show their "thinking" they state what they will do next.