The NCFG
LightNews LightNews
thencfg.bsky.social
The NCFG
@thencfg.bsky.social
350 followers 290 following 21 posts
The official bsky account of the National Center for Functional Glycomics. Re-posts ≠ Endorsement
Posts Media Videos Starter Packs
Pinned
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Nov 18
If you are in the #glycoscience field, share something with glycoscience or have some glyco term in your profile. Send us a DM or follow us and we will follow you back. If you are a glycoscientist and already a follower and we are not following you, send us a DM and we will follow you.
1 11
thencfg.bsky.social
The NCFG @thencfg.bsky.social · 29d
🤯 Did you know proteins inside cells can be glycosylated?! 🔬 Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in biology!
👉 research.bidmc.org/ncfg/blog/21...

#glycans #glycosylation #posttranslationalmodification #glycotime
21] Facts About: Intracellular Protein Glycosylation
research.bidmc.org
3
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Jul 15
Exciting virtual seminar by Dr. Maxence Noel (From Dr. Richard Cummings' Lab) - "Brain N and O glycosylation: Discoveries, Tools and Dysregulation in Disease", held by the BGDG.
Thursday July 17, 2025 at 12pm EDT.
Register: docs.google.com/forms/d/e/1F...
#glycotime #neuroglycobiology #neuroscience
1 3
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Jul 7
📢New article alert! 'Blood group O expression in normal tissues and tumors', just published in FEBS Journal, highlights findings using our lamprey-derived monoclonal antibodies towards specific H antigen epitopes.
Read at: febs.onlinelibrary.wiley.com/doi/10.1111/...
#glycotime #glycans #bloodgroups
FEBS Press
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4-31L and OmcFL3-...
febs.onlinelibrary.wiley.com
2 5
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Jun 13
Antifreeze glycoproteins: not just for fish! 🤔 They could revolutionize food preservation and organ cryopreservation. Read more about this exciting potential in our latest interesting fact: research.bidmc.org/ncfg/blog/19...

#glycotime #glycofacts #cryopreservation
19] Facts About: Antifreeze Glycoproteins (AFGPs)
research.bidmc.org
1 3 8
Reposted by The NCFG
glyco.me
Hiren Joshi @glyco.me · Jun 10
Well, it turns out that you can actually make PyMOL do quite a lot of stuff. Here's the full workflow, integrating the amazing ReGlyco into PyMOL to re-glycosylate the LDLA linker. There's some serious magic needed to get it running as fast as it is within PyMOL. @elisafadda.bsky.social
2 6 27
Reposted by The NCFG
cashwood.proteaglyco.com
Chris Ashwood @cashwood.proteaglyco.com · Jun 10
By deep characterisation of 186 N-glycan standards, we @thencfg.bsky.social have made the most comprehensive targeted LC-MS glycomic assay to date.
Non-reduced native glycan analysis is key.
We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.
186 pure glycan structures used to construct a targeted glycomic assay
4 20 56
thencfg.bsky.social
The NCFG @thencfg.bsky.social · May 19
Explosions, allergies, & more! 🤯 Polysaccharides are more surprising than you think!

Read our latest interesting facts about Dangerous Carbohydrates:
research.bidmc.org/ncfg/blog/18...

#science #carbs #glycotime #glycofacts
18] Facts About: Dangerous Carbohydrates?
research.bidmc.org
2
Reposted by The NCFG
carolynbertozzi.bskyverified.social
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Apr 25
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!

www.nature.com/articles/s41...
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
www.nature.com
1 34 120
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Apr 24
📢 Our latest work describing a new versatile click chemistry glycan linker which enabled us to create glycan derivatives for use in microarrays, Luminex (bead based arrays) and ELISA assays.

Check it out in @acs.org ACS Central Science doi.org/10.1021/acsc...

#glycotime #clickchemistry #luminex
Novel Click Coupling Chemistry to Explore Glycan Recognition
Specific recognition of glycans by proteins is important in many biological processes and immune responses. Here we present a general approach for derivatizing free glycans with a novel linker MTZ (3-...
doi.org
5 9
Reposted by The NCFG
carolynbertozzi.bskyverified.social
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Apr 18
Woefully missing from this review is any mention of #glycotime, when there are now so many publications and biopharma companies active in this space.
1 1 25
Reposted by The NCFG
akulmehta.bsky.social
Akul Mehta @akulmehta.bsky.social · Apr 19
#glycotime
1 2
Reposted by The NCFG
glygen.bsky.social
GlyGen @glygen.bsky.social · Mar 20
Dr. Hudson Freeze and Dr. Michael Tiemeyer @flyglyco.bsky.social on Capitol Hill Day organized by @faseborg.bsky.social and @sfglycobiology.bsky.social , advocating for federal funding in the glyco domain and beyond!

#glycotime
5 12
Reposted by The NCFG
rommieamaro.bsky.social
Rommie Amaro @rommieamaro.bsky.social · Mar 28
✨✨ It's #glycotime for #HIV Env ✨✨

N-linked glycans modulate flexibility & MPER epitope exposure #glycotime

Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪

Would love feedback!

www.biorxiv.org/content/10.1...
6 31 150
Reposted by The NCFG
rachelhevey.bsky.social
Rachel Hevey @rachelhevey.bsky.social · Apr 3
🚀 Exciting News! 🚀

Our project developing therapeutic carbohydrate-based molecules to reduce risk of organ transplant rejection has been 🌟 awarded ca. 1 million CHF 🌟 from @snsf-ch.bsky.social 🎉 🥂

We are so excited to embark on this journey over the next 4 years!

@unibas.ch #GlycoTime
2 14
Reposted by The NCFG
carolynbertozzi.bskyverified.social
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Mar 26
Check out our new review on induced proximity modalities (#TPD and a lot more!) aimed cell surface targets @naturebiotech.bsky.social, spearheaded by postdocs Nick Till and "Rahm" Ramanathan

www.nature.com/articles/s41...
Induced proximity at the cell surface - Nature Biotechnology
Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.
www.nature.com
22 79
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Mar 26
In the latest interesting facts about #glycans, we take a look at two tiny #glycolipids which are critical for life.

Read the full post at: research.bidmc.org/ncfg/blog/17...

For more interesting facts: research.bidmc.org/ncfg/interes...

#glycotime #glycofacts
17] Facts About: Two Tiny Glycolipids – Essential to Life
research.bidmc.org
2
Reposted by The NCFG
carolynbertozzi.bskyverified.social
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Feb 26
Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!

www.nature.com/articles/s41...
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature
Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.
www.nature.com
2 59 220
Reposted by The NCFG
cashwood.proteaglyco.com
Chris Ashwood @cashwood.proteaglyco.com · Feb 25
A POGase is a huge advance in the glycomics field, which has typically relied on chemical or incomplete enzymatic releases (no Sia).
Expect a lot of multi-omic studies enabled by this (N-glycomics, O-glycomics, and proteomics) since the peptide backbone is left intact.
www.nature.com/articles/s41...
1 7 17
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Feb 13
We have an opening! If you are looking for a great postdoc fellowship in Boston - then check out this opportunity to work on antibody production against glycan antigens:
research.bidmc.org/ncfg/careers...

Please re-share to spread the word
#glycotime #glycocareers #postdoc
Postdoctoral Research Fellowship in Immunology and Glycoscience - Cummings Lab, BIDMC
research.bidmc.org
4 4
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Feb 3
In our latest interesting fact about #glycans we take a look at the most abundant #glycoprotein found in #urine, and how its glycosylation and function varies under different genetic physiological conditions.

Read more at: research.bidmc.org/ncfg/blog/16...

#glycotime #uromodulin
16] Facts About: Major Glycoprotein in Urine – Uromodulin/Tamm-Horsfall Protein (THP)
research.bidmc.org
2 1
Reposted by The NCFG
cashwood.proteaglyco.com
Chris Ashwood @cashwood.proteaglyco.com · Jan 27
How could you not want to study glycans and polysaccharides when we’re surrounded by them?
Mushrooms growing out of leaf litter in a subtropical rainforest. Each of these have biomasses majorly composed of polysaccharides.
2 2 14
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Jan 26
Would you like to see more #XSharing posts where we reshare #glycotime content from other platforms here?

Example 👇
1 2
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Jan 26
Original tweet
3
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Jan 26
#XSharing from Sriram Neelamegham
The paper highlights that #Glycotime is critical for all tested beta-CoVs, not just #SARS-CoV-2!

www.nature.com/articles/s44...
Conserved role of spike S2 domain N-glycosylation across betacoronaviruses - npj Viruses
npj Viruses - Conserved role of spike S2 domain N-glycosylation across betacoronaviruses
www.nature.com
1 1
thencfg.bsky.social
The NCFG @thencfg.bsky.social · Jan 13
Our latest blog on interesting facts about glycans we dig deeper into the UDP-glucuronic acid and glucuronyltransferases in the endoplasmic reticulum - which can be critical in drug metabolism.

Read at: research.bidmc.org/ncfg/blog/fa...

#glycotime #glycoblog #glycoenzymes #cazyme #metabolism
Facts About: UDP-Glucuronic Acid and Glucuronosyltransferases in the ER
research.bidmc.org
2 3