Alexander Stein
@alexsteinresearch.bsky.social
Cancer Genomics | Somatic Evolution | Math Bio
DE -> CH -> UK -> BE
Always happy to chat about science!
DE -> CH -> UK -> BE
Always happy to chat about science!
Pinned
Very happy that @alexsteinresearch.bsky.social manuscript on the patterns of genetic heterogeneity before and after treatment is out now:
academic.oup.com/genetics/adv...
We build on and expand the population genetics theory of gITH.
Very worth a read if you are interested in somatic evolution.
academic.oup.com/genetics/adv...
We build on and expand the population genetics theory of gITH.
Very worth a read if you are interested in somatic evolution.
On the patterns of genetic intra-tumour heterogeneity before and after treatment
Abstract. Genetic intra-tumour heterogeneity (gITH) is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumu
academic.oup.com
Interested in population genetics of cancer?
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
Reposted by Alexander Stein
Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems?
Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
September 29, 2025 at 7:03 AM
Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems?
Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Alexander Stein
Excited to announce that registration for the 13th
@mathonco.bsky.social workshop on Treatment Revolution is now open. Held onsite @moffittnews.bsky.social Nov 2-Nov 7 #MoffittIMO more details: imo13.eventbrite.com. Deluxe travel awards are available on a competitive basis, apply by 10/03!
@mathonco.bsky.social workshop on Treatment Revolution is now open. Held onsite @moffittnews.bsky.social Nov 2-Nov 7 #MoffittIMO more details: imo13.eventbrite.com. Deluxe travel awards are available on a competitive basis, apply by 10/03!
September 24, 2025 at 3:32 AM
Excited to announce that registration for the 13th
@mathonco.bsky.social workshop on Treatment Revolution is now open. Held onsite @moffittnews.bsky.social Nov 2-Nov 7 #MoffittIMO more details: imo13.eventbrite.com. Deluxe travel awards are available on a competitive basis, apply by 10/03!
@mathonco.bsky.social workshop on Treatment Revolution is now open. Held onsite @moffittnews.bsky.social Nov 2-Nov 7 #MoffittIMO more details: imo13.eventbrite.com. Deluxe travel awards are available on a competitive basis, apply by 10/03!
Reposted by Alexander Stein
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Reposted by Alexander Stein
Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes. https://www.biorxiv.org/content/10.1101/2025.09.08.674950v1
September 9, 2025 at 7:35 AM
Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes. https://www.biorxiv.org/content/10.1101/2025.09.08.674950v1
Reposted by Alexander Stein
New preprint! Let me tell you a story about trees, caterpillars, brooms, entropy, and getting scooped by 50 years.
Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14
arxiv.org/abs/2507.08615
Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14
arxiv.org/abs/2507.08615
July 14, 2025 at 9:43 AM
New preprint! Let me tell you a story about trees, caterpillars, brooms, entropy, and getting scooped by 50 years.
Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14
arxiv.org/abs/2507.08615
Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14
arxiv.org/abs/2507.08615
Reposted by Alexander Stein
In #GENETICS, @alexsteinresearch.bsky.social and @benjaminwerner.bsky.social present a new study about the population genetics of cancer. Learn about their theoretical assessment of the genetic makeup of cancers before and after treatment: buff.ly/AE4sLUH
July 15, 2025 at 8:02 PM
In #GENETICS, @alexsteinresearch.bsky.social and @benjaminwerner.bsky.social present a new study about the population genetics of cancer. Learn about their theoretical assessment of the genetic makeup of cancers before and after treatment: buff.ly/AE4sLUH
Interested in population genetics of cancer?
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
Very happy that @alexsteinresearch.bsky.social manuscript on the patterns of genetic heterogeneity before and after treatment is out now:
academic.oup.com/genetics/adv...
We build on and expand the population genetics theory of gITH.
Very worth a read if you are interested in somatic evolution.
academic.oup.com/genetics/adv...
We build on and expand the population genetics theory of gITH.
Very worth a read if you are interested in somatic evolution.
On the patterns of genetic intra-tumour heterogeneity before and after treatment
Abstract. Genetic intra-tumour heterogeneity (gITH) is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumu
academic.oup.com
May 29, 2025 at 3:22 PM
Interested in population genetics of cancer?
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
Reposted by Alexander Stein
My department is hiring! Permanent faculty job (research + teaching) in applied maths. Mathematical biology would be highly appropriate. We're a friendly department in a large university in central London, recently merged with a big medical school. Apply by 1st June. www.jobs.ac.uk/job/DMY889/l...
Lecturer in Applied Mathematics at City St George’s, University of London
Apply for the Lecturer in Applied Mathematics role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
www.jobs.ac.uk
May 6, 2025 at 9:42 AM
My department is hiring! Permanent faculty job (research + teaching) in applied maths. Mathematical biology would be highly appropriate. We're a friendly department in a large university in central London, recently merged with a big medical school. Apply by 1st June. www.jobs.ac.uk/job/DMY889/l...
Thank you David @cancerevo.org and Simone @zaccasimo.bsky.social for building my PhD viva panel! I enjoyed the discussions and appreciate your time and effort to assess my PhD.
And heartfelt thank you Ben @benjaminwerner.bsky.social and Katerina for guiding me through this PhD journey!
And heartfelt thank you Ben @benjaminwerner.bsky.social and Katerina for guiding me through this PhD journey!
Congrats Dr. @alexsteinresearch.bsky.social and also Alex's PhD supervisor @benjaminwerner.bsky.social for an excellent body of doctoral work pushing the frontiers of #mathonco and #cancerevo
March 21, 2025 at 10:44 AM
Thank you David @cancerevo.org and Simone @zaccasimo.bsky.social for building my PhD viva panel! I enjoyed the discussions and appreciate your time and effort to assess my PhD.
And heartfelt thank you Ben @benjaminwerner.bsky.social and Katerina for guiding me through this PhD journey!
And heartfelt thank you Ben @benjaminwerner.bsky.social and Katerina for guiding me through this PhD journey!
Reposted by Alexander Stein
Congratulations to a successful viva Dr. @alexsteinresearch.bsky.social
Many thanks to @cancerevo.org and @zaccasimo.bsky.social to be examiners!
Many thanks to @cancerevo.org and @zaccasimo.bsky.social to be examiners!
March 20, 2025 at 10:22 PM
Congratulations to a successful viva Dr. @alexsteinresearch.bsky.social
Many thanks to @cancerevo.org and @zaccasimo.bsky.social to be examiners!
Many thanks to @cancerevo.org and @zaccasimo.bsky.social to be examiners!
Reposted by Alexander Stein
The University of Bern is looking for a Tenure Track Assistant Professor in Mathematical or Computational Biology: www.nature.com/naturecareer...
Tenure-Track Assistant Professor for Mathematical or Computational Ecology (80-100%) - Bern, Canton of Bern (CH) job with Institut für Ökologie und Evolution | 12834542
The Department of Biology at the University of Bern announces a vacancy for a Tenure-Track Assistant Professor to lead a new Division of Mathematic...
www.nature.com
January 3, 2025 at 1:26 PM
The University of Bern is looking for a Tenure Track Assistant Professor in Mathematical or Computational Biology: www.nature.com/naturecareer...
Reposted by Alexander Stein
We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded
www.findaphd.com
November 28, 2024 at 9:40 AM
We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded
Reposted by Alexander Stein
📝New Author's summary about
"Complexity-stability relationships in competitive disordered dynamical system" O Mazzarisi, M Smerlak
and
"Diversity begets stability: Sublinear growth and competitive coexistence across ecosystems" I Hatton, O Mazzarisi, A Altieri, M Smerlak
"Complexity-stability relationships in competitive disordered dynamical system" O Mazzarisi, M Smerlak
and
"Diversity begets stability: Sublinear growth and competitive coexistence across ecosystems" I Hatton, O Mazzarisi, A Altieri, M Smerlak
November 27, 2024 at 8:43 AM
📝New Author's summary about
"Complexity-stability relationships in competitive disordered dynamical system" O Mazzarisi, M Smerlak
and
"Diversity begets stability: Sublinear growth and competitive coexistence across ecosystems" I Hatton, O Mazzarisi, A Altieri, M Smerlak
"Complexity-stability relationships in competitive disordered dynamical system" O Mazzarisi, M Smerlak
and
"Diversity begets stability: Sublinear growth and competitive coexistence across ecosystems" I Hatton, O Mazzarisi, A Altieri, M Smerlak
Reposted by Alexander Stein
Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...
Somatic mutation and selection at epidemiological scale
As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...
www.medrxiv.org
November 20, 2024 at 2:28 PM
Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...
Reposted by Alexander Stein