John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews

Rest in peace Jane Goodall, a true giant among scientists. Your breakthroughs into the secret lives of chimpanzees viewed through an anthropomorphic lens – without yet knowing that science had forbidden it – changed science forever, and with it how we see ourselves.

Elegant work to unveil the etiology behind the ubiquitous SBS5 mutational signature. Glad to be in the audience to see this work presented and I have already put it on my reading list.

We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...

If you don’t have time to take a walk, then you don’t have time to do science. Charles Darwin would take two walks every day on his "thinking path", not as a break from science, but as a crucial part of it.

Excited for the talks on the amazing biology of ecDNA! Interested in ecDNA in esophageal cancers and long read sequencing? Always happy to chat!

#CancerGrandChallenges #CGCecDNA

Attending BRCA Symposium 2025 and enjoying a master class from Ralph Scilly on HRD. I will also start calling SBS3 bland from now on.

Interesting work from Khi Pin Chua, PhD on precise characterization of complex repeat regions in cancer genomes at #AACR25. Catch him at poster 2 in section 46 (#6288) until 5 PM! #PacBio

“If left unchallenged, a rising wave of white nationalism in many parts of the globe could threaten the progress that has been made in science — and broader society — towards a more equitable world,” writes Genevieve Wojcik in a Comment article for Nature. 🧬 🧪

We should catch up! Was looking around to see if you were here!

Maybe I need to look at some head and neck cancer to study both DNA repair and ecDNAs. Come look for me at #AACR25 if you like to chat!

Maybe I need to look at some head and neck cancer to study both DNA repair and ecDNAs. Come look for me at #AACR25 if you like to chat!

Yes! - we are hiring @yale.edu - links below...

Highlights of day 1 of #MITS : @steverozen.bsky.social on Aristolochic Acids their effects on carcinogeneis
, @nlbigas.bsky.social on driver mutations in small clones in the bladder. Sir Mike Stratton on signatures stem of the colorectum @mollyprz.bsky.social elegantly solving the etiology of a Sig

A wonderful reminder that my time spent comparing all the ecDNAs in organoids from the @RFitzgerald_lab added new insight to how we can use tumour organoids as a model to study ecDNA.
The future of tumor organoids in precision therapy: Trends in Cancer www.cell.com/trends/cance...

And so it begins. I have been working in genomics / sequencing for more than 30 years but today is a particularly exciting day as I begin training on using the @nanopore MK1D sequencer which we will be using soon for student projects (and other things) at @ucdavis.bsky.social

The first Singapore Long-Reads Symposium was a success! A massive thanks to the speakers: Keynote Heng Li, Ken Sung @jonathangoeke.bsky.social , @msikic.bsky.social & industrial partners @nanoporetech.com , @pacbio.bsky.social , @awscloud.bsky.social MGI_Technology Next Level Genomics & NovogeneAIT

I'm happy to announce that my project to use @nanoporetech.com sequencing to study Early Onset Colorectal Cancer has been funded!

Our 2024 Wrapped! 🧪

- £173m awarded to our Cambridge Institute, @cruk-ci.bsky.social
- £58.7m to train clinician scientists
- 120,000+ people being recruited for the capsule sponge screening trial
- 3 cancer prevention vaccine projects

Read more about our progress this year 👇 cruk.ink/4iLz3ws

SPECIAL ISSUE! This month Genome Research publishes a diverse collection of research and review articles in a special issue highlighting advances in long-read sequencing applications in biology and medicine. Full issue links here: tinyurl.com/Genome-Res-3....