Anand Vaidya
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anandvaidya17.bsky.social
Anand Vaidya
@anandvaidya17.bsky.social
210 followers 280 following 27 posts
Adrenal physiology and medicine
vaidya.bwh.harvard.edu
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anandvaidya17.bsky.social
Anand Vaidya @anandvaidya17.bsky.social · Jan 23
Primary Aldosteronism is very common

This interactive case reviews how to recognize it, avoid pitfalls, and effectively help your patients @nejm.org

www.nejm.org/doi/full/10....

(free access with login)
Reposted by Anand Vaidya
amjhypertension.bsky.social
#WeekendReads from the Advance Articles section

Time to retire Aldosterone Suppression Testing?

academic.oup.com/ajh/advance-...
Is It Time to Retire Aldosterone Suppression Testing?
Abstract. Primary aldosteronism (PA) is the most common endocrine hypertension. For decades, PA diagnosis has required proving nonsuppressibility of aldost
academic.oup.com
October 4, 2025 at 2:15 PM
anandvaidya17.bsky.social
Confirmatory testing (aldosterone suppression testing) for primary aldosteronism: not reliable, or reproducible, for diagnosis or predicting lateralization. Sensitivity at the expense of specificity, and vice-versa. Time to simplify the process

academic.oup.com/ejendo/artic...
Discordance and shortcomings of aldosterone suppression tests in primary aldosteronism
AbstractBackground. The saline suppression test (SST) and the captopril challenge test (CCT) have traditionally been used to confirm or exclude primary ald
academic.oup.com
September 7, 2025 at 1:16 AM
anandvaidya17.bsky.social
To accompany the new ACC/AHA BP guidelines, a practical guide on how to test for Primary Aldosteronism: now recommended for most people with hypertension.

www.jacc.org/doi/10.1016/...
September 7, 2025 at 1:04 AM
Reposted by Anand Vaidya
jama.com
Adrenal insufficiency is a syndrome of cortisol deficiency.

This Review summarizes the pathophysiology of adrenal insufficiency and approaches to diagnosis, treatment, and prevention of adrenal crisis.

ja.ma/3HKk9Jr
An illustration from JAMA's review on adrenal insufficiency, dated June 16, 2025, showing normal and impaired hypothalamic-pituitary-adrenal axis physiology with mechanisms leading to adrenal insufficiency.
September 1, 2025 at 11:00 AM
anandvaidya17.bsky.social
Yes!
September 1, 2025 at 12:45 PM
Reposted by Anand Vaidya
ertrunnell.bsky.social
Don't miss the preprint from:
@alice.soragnilab.com
@michaelyehmd.bsky.social
@anandvaidya17.bsky.social
@nicolebechmann.bsky.social

🏥
@uthealthsa.bsky.social
@dgsomucla.bsky.social
@harvardmed.bsky.social
@mdanderson.bsky.social
@tudresden.bsky.social

www.biorxiv.org/content/10.1...
Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas
Pheochromocytomas and paragangliomas (PPGLs) are rare chromaffin cell-derived neuroendocrine tumors of sympathetic (catecholamine-producing) or parasympathetic (nonsecretory) origin, frequently driven...
www.biorxiv.org
August 29, 2025 at 12:28 PM
Reposted by Anand Vaidya
jia-luo.bsky.social
🩺 In NEJM, our interactive case on a common CC - evaluation of a patient with new pulmonary symptoms www.nejm.org/doi/full/10....

Congrats to star fellow Dr Joanne I. Hsu for leading & wonderful to learn from expert multi-D colleagues @anandvaidya17.bsky.social @harvardmed.bsky.social @nejm.org
nejm.org NEJM.org @nejm.org · Jul 28
A 59-year-old woman presented to the emergency department with a 1-week history of profound fatigue, nonproductive cough, confusion, and decreased oral intake. The night before presentation, she began to have chills and night sweats. Learn more and test your skills: nej.md/4mcUHuL
Interactive Medical Case A Case of Crackles An illustration of the patient coughing in bed and her husband caring for her
August 8, 2025 at 2:08 PM
Reposted by Anand Vaidya
nejm.org
A 59-year-old woman presented to the emergency department with a 1-week history of profound fatigue, nonproductive cough, confusion, and decreased oral intake. The night before presentation, she began to have chills and night sweats. Learn more and test your skills: nej.md/4mcUHuL
Interactive Medical Case A Case of Crackles An illustration of the patient coughing in bed and her husband caring for her
July 28, 2025 at 6:58 PM
Reposted by Anand Vaidya
adinaturcu.bsky.social
#ENDO2026 Welcomes Your Ideas | Our annual meeting will take place in Chicago, IL, June 13–16, and I’m inviting YOU to shape the program💡Submit your symposium proposal or session suggestion by Tuesday, September 2: bit.ly/4flCMjl
#endocrinology @TheEndoSociety
ENDO 2026 Session Submissions
ENDO wouldn’t be possible without the insight and expertise of the Endocrine community. Your ideas are essential to building a dynamic, forward-thinking program that reflects the full breadth of our f...
bit.ly
August 28, 2025 at 4:35 PM
Reposted by Anand Vaidya
joshleisring.bsky.social
1/ Even outside of AVS the intra-individual variability of plasma aldo is important. Another study with the same message. www.ahajournals.org/doi/10.1161/...
July 28, 2025 at 9:27 PM
Reposted by Anand Vaidya
amjhypertension.bsky.social
#ThrowbackThursday

Variability of Aldosterone concentration while performing AVS

academic.oup.com/ajh/article/...

#Free #EditorsCHoice
July 24, 2025 at 3:38 PM
anandvaidya17.bsky.social
Subclinical Primary Aldosteronism and MACE

www.ahajournals.org/doi/10.1161/...
Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study | Circulation
BACKGROUND: Primary aldosteronism (PA), an overt form of renin-independent aldosterone production, leads to a disproportionately high rate of major adverse cardiovascular events (MACEs). Mounting evid...
www.ahajournals.org
July 20, 2025 at 9:31 PM
anandvaidya17.bsky.social
New Primary Aldosteronism Guidelines - simpler, streamlined, and hopefully more pragmatic
academic.oup.com/jcem/advance...
July 15, 2025 at 1:06 PM
anandvaidya17.bsky.social
The Impact of Modern Industrialized Dietary Sodium Intake on the Plasma Proteome

academic.oup.com/ajh/advance-...
July 3, 2025 at 9:32 PM
anandvaidya17.bsky.social
A pragmatic approach to evaluate for ADRENAL INSUFFICIENCY

Thanks to @irinabancos.bsky.social and Jay Findling for lending their expertise!
June 21, 2025 at 11:52 PM
anandvaidya17.bsky.social
Adrenal Insufficiency
jama.com JAMA @jama.com · Jun 16
Adrenal insufficiency is a syndrome of cortisol deficiency.

This Review summarizes the pathophysiology of adrenal insufficiency and approaches to diagnosis, treatment, and prevention of adrenal crisis.

https://ja.ma/43Zy2ui
Figure 1. Pathophysiology of Adrenal Insufficiency
June 16, 2025 at 10:32 PM
anandvaidya17.bsky.social
Beautiful study. Stop the madness.
Low-renin hypertension is by far and away some manifestation of primary aldosteronism pathophysiology. Even if you get caught up in names and definitions and can't accept this, it responds beautifully to MR antagonist therapy, so just do the right thing.
May 6, 2025 at 9:40 PM
Reposted by Anand Vaidya
hswapnil.medsky.social
In the @annalsofim.bsky.social

www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team

Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management)

#NephSky #EndoSky
Confirmatory Testing for Primary Aldosteronism: A Study of Diagnostic Test Accuracy: Annals of Internal Medicine: Vol 0, No 0
Background: Confirmatory testing to verify the diagnosis of primary aldosteronism (PA) in patients who have an abnormal screening result is of uncertain benefit. Objective: To perform a blinded assess...
www.acpjournals.org
May 6, 2025 at 10:34 AM
anandvaidya17.bsky.social
Work smarter, not harder!

A low renin with concurrent use of ACEi/ARB is almost certainly some shade of Primary Aldosteronism.

Either way, aldosterone-directed therapy is very likely to provide major clinical benefits

www.ahajournals.org/eprint/TUS6C...
April 3, 2025 at 1:09 AM
anandvaidya17.bsky.social
Do patients want to be screened for primary aldosteronism: YES

How much PA can be identified with a direct-to-patient approach: A LOT

Can this approach be implemented nationwide: YES

@JeniferBrown

www.ahajournals.org/doi/10.1161/...
March 20, 2025 at 11:21 PM
anandvaidya17.bsky.social
Subclinical primary aldosteronism + Natriuretic peptide deficiency => HYPERTENSION

academic.oup.com/jcem/advance...
March 14, 2025 at 6:11 PM
Reposted by Anand Vaidya
joshleisring.bsky.social
Interesting study looking at a direct-to-patient approach to implement primary aldosteronism screening.

www.ahajournals.org/doi/10.1161/... (paywall)
@jenifermbr.bsky.social @anandvaidya17.bsky.social

#medsky #nephsky
Nationwide, Pragmatic, Direct-to-Patient Primary Aldosteronism Testing Program | Hypertension
BACKGROUND: Primary aldosteronism, an endocrinopathy present in ≥10% to 25% of patients with hypertension, confers excess cardiovascular risk that can be mitigated with aldosterone-directed therapy. H...
www.ahajournals.org
February 23, 2025 at 7:52 PM
Reposted by Anand Vaidya
eurojendo.bsky.social
Mild autonomous #cortisol secretion in patients with aldosterone-producing adenoma and risk for cardiac remodeling and diastolic dysfunction by Cheng-Hsuan Tsai et al

EJE Vol 192, Issue 1, January 2025
Full paper 👉 doi.org/10.1093/ejen...
ESE Members via 👉 my.ese-hormones.org
February 16, 2025 at 11:06 AM
Reposted by Anand Vaidya
nejm.org
A new interactive feature describes a 27-year-old woman who received a diagnosis of hypertension and preeclampsia. After giving birth, her blood pressure remained elevated. Test your diagnostic and therapeutic skills: nej.md/3Wsvi5L

#MedSky #CardioSky #OBGYN
Interactive Medical Case Targeting a Hormonal Cause of Hypertension Illustration of a medical professional taking a patient's blood pressure
January 27, 2025 at 5:32 PM
Reposted by Anand Vaidya
vascularimmuno.bsky.social
Interesting interactive case presentation on an under-recognized cause of hypertension. @anandvaidya17.bsky.social @nejm.org

www.nejm.org/doi/10.1056/...
Targeting a Hormonal Cause of Hypertension | NEJM
This interactive feature describes a woman who received a diagnosis of hypertension and preeclampsia at 27 years of age. After giving birth, her blood pressure remained elevated. Test your diagnost...
www.nejm.org
January 25, 2025 at 10:16 PM