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Reposted by Allegra Angeloni

Ozren Bogdanovic @obog.bsky.social · 5d

We’re looking for a Research Assistant / Lab Manager to join the 🧬 Developmental Epigenomics lab at the Andalusian Centre for Developmental Biology (CABD, Seville 🇪🇸)!
🐟 Work with zebrafish, CRISPR–Cas9, and genomics technologies
💫 3-year fully funded position
Details 👉 www.bogdanoviclab.org

Bogdanovic Lab

www.bogdanoviclab.org

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Reposted by Allegra Angeloni

Virtual Gastrulation Zoom Talks @vgzt2021.bsky.social · 5d

Dear VGZT enthusiasts,
Do you—or someone in your lab—work on exciting developmental biology research? Showcase it at VGZT, a global online seminar series connecting developmental biologists across all career stages. Apply here: www.tinyurl.com/VGZT-Nomination

VGZT Season 7 - Nomination

Virtual Gastrulation Zoom Talks (VGZT) is an opportunity to share your science with an engaged, international audience of developmental biologists. Running from October 2025 to July 2026, this online ...

www.tinyurl.com

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Reposted by Allegra Angeloni

Raquel Fueyo @fueyoraquel.bsky.social · 10d

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

A human-specific regulatory mechanism revealed in a pre-implantation model

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

rdcu.be

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Reposted by Allegra Angeloni

Virtual Gastrulation Zoom Talks @vgzt2021.bsky.social · 16d

We are excited to announce the first Western VGZT of Season 7! 🎉

🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET

Our speakers:

👉 Antonia Weberling (@a-weberling.bsky.social)

👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)

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Allegra Angeloni @angeloniallegra.bsky.social · 22d

Big thanks to our amazing committee @pmasamsetti.bsky.social, @giuliaxin.bsky.social, @osvaldoics.bsky.social, @heisler-lab.bsky.social, James Burchfield, Peter Su, Gregory Redpath, Jonathan Scavuzzo, Nicole Green and Jacqueline Tearle

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Allegra Angeloni @angeloniallegra.bsky.social · 22d

SAVE THE DATE! Join us for the 2025 @anzscdb.bsky.social
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫

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Reposted by Allegra Angeloni

Aurelie Hintermann @aurhin.bsky.social · 24d

Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust

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Reposted by Allegra Angeloni

Maxim Greenberg @maxvcg.bsky.social · 26d

Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...

Epigenetic relay: Polycomb-directed DNA methylation in mammalian development

In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...

journals.plos.org

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Reposted by Allegra Angeloni

Merlin Crossley @merlincrossley.bsky.social · 28d

www.nature.com/articles/s41...
Our latest paper in collaboration with Mitch Weiss’s lab. We showed DNA methylation turns off fetal globin expression. I’m still not sure how important methylation is in regulating individual human genes but it represses this one.#sicklecelldisease #crispr #epigenetics

Removal of promoter CpG methylation by epigenome editing reverses HBG silencing - Nature Communications

DNA methylation is a critical component for repression of fetal haemoglobin in adult blood cells. Removing DNA methylation from the fetal haemoglobin promoter effectively upregulates the gene, opening...

www.nature.com

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Reposted by Allegra Angeloni

Alex de Mendoza @alexdemendoza.bsky.social · Sep 11

Very happy to have contributed to this review on "non-CG" #methylation in animals now out in @natgenet.nature.com. Working again with @obog.bsky.social and Tirsa is always a pleasure. We think this not so well studied form of methylation should be more widely considered, please read: rdcu.be/eFAEk

Non-CG DNA methylation in animal genomes

Nature Genetics - This Review discusses noncanonical DNA methylation (mCH) in animal genomes and highlights the remaining need to clarify whether mCH represents a conserved regulatory layer or a...

rdcu.be

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Reposted by Allegra Angeloni

FMI science @fmiscience.bsky.social · Sep 2

In a new study, FMI researchers show that two enzymes—KDM2A and KDM2B—act as safeguards in eggs, preventing excessive DNA methylation at gene regions. Without them, abnormal methylation is passed to embryos, repressing genes needed for early development. www.cell.com/developmenta...

Preventing CpG hypermethylation in oocytes safeguards mouse development

Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b knockout embryos die dur...

www.cell.com

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Reposted by Allegra Angeloni

Osvaldo Contreras @osvaldoics.bsky.social · Sep 2

Thrilled to share our new paper: "OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics"!

We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.

www.cell.com/iscience/ful...

OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics

Biochemistry; Cell biology; Developmental biology; Computational bioinformatics

www.cell.com

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Reposted by Allegra Angeloni

Leon Hilgers @leonhilgers.bsky.social · Jul 24

You link #phenotype 🦜 to #genotype 🧬 with #comparative #genomics 💻?

This #review is for you 📜: authors.elsevier.com/sd/article/S...

We review new #methods, remaining #challenges and #future directions and highlight recent key studies.

Thanks @hillermich.bsky.social!

Please share! 🙂

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Reposted by Allegra Angeloni

ANZSCDB @anzscdb.bsky.social · Aug 21

ANZSCDB is pleased to launch our Zoom seminar series!

Our first seminar kicks off on Thursday August 28th, 2025 at 12pm AEST with Professor Jose Polo and Dr Melanie White.

Please register and attend to ensure the success and long-term sustainability of this initiative.

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Reposted by Allegra Angeloni

Aurora Ruiz-Herrera @aruizherrera.bsky.social · Aug 19

🎉 Another exciting contribution from our lab this summer!

🧬 Nearly complete, gapless genome of the sex-changing central bearded dragon (Pogona vitticeps) shed new light on the mystery of reptile sex determination.

Proud to be part of this collaborative effort!

academic.oup.com/gigascience/...

A near telomere-to-telomere phased genome assembly and annotation for the Australian central bearded dragon Pogona vitticeps

AbstractBackground. The central bearded dragon (Pogona vitticeps) is widely distributed in central eastern Australia and adapts readily to captivity. Among

academic.oup.com

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Reposted by Allegra Angeloni

kasitc.bsky.social @kasitc.bsky.social · Aug 18

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

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Reposted by Allegra Angeloni

Yi-Jyun Luo @yjluo.bsky.social · Aug 18

Delighted to share the peer-reviewed version of our study led by @tomlewin.bsky.social now out in Genome Biology @bmc.springernature.com! We analyzed 64 chromosome-level genomes across 15 animal phyla and found that extensive genome rearrangements are the norm in bilaterians.
doi.org/10.1186/s130...

Conservation of bilaterian genome structure is the exception, not the rule - Genome Biology

Species from diverse animal lineages have conserved groups of orthologous genes together on the same chromosome for over half a billion years since the last common ancestor of bilaterians. Although no...

doi.org

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Reposted by Allegra Angeloni

Nature Reviews Genetics @natrevgenet.nature.com · Aug 18

Our featured article:
Epigenome dynamics in early mammalian embryogenesis by Adam Burton & Maria-Elena Torres-Padilla go.nature.com/45UA8Ob

Epigenome dynamics in early mammalian embryogenesis - Nature Reviews Genetics

Upon fertilization and during early mammalian development, major changes in cellular plasticity occur. This is accompanied by large-scale epigenome remodelling, as has been recently highlighted by the...

go.nature.com

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Reposted by Allegra Angeloni

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · Aug 14

🥂Congrats to Gao, Li & co for their new @natcellbio.nature.com study: they derive #trophectoderm stem cells from 32-cell mouse #embryos. These cells represent an early trophectoderm state, develop into #placenta cells and organoids and contribute to blastoid generation.
rdcu.be/eAKzp

bit.ly/4fyZ9Sg

Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state - Nature Cell Biology

Gao, Li and colleagues derive trophectoderm stem cells from 32-cell mouse embryos. These cells represent an early trophectoderm state and are capable of developing into placenta cells, forming placent...

bit.ly

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Reposted by Allegra Angeloni

Heather Lee @heatherjlee.bsky.social · Jul 28

I'm pleased to share that Leukemia have published our analysis of heterogeneous responses to hypomethylating agents #HMAs in Acute Myeloid Leukaemia #AML
www.nature.com/articles/s41...

Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal - Leukemia

Leukemia - Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal

www.nature.com

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Reposted by Allegra Angeloni

Alex de Mendoza @alexdemendoza.bsky.social · Jul 28

Happy to see our latest work out in @molbioevol.bsky.social. We revisit the evolution of 5-methylcytosine across neglected eukaryotic supergroups, establishing an ancestral repressive role silencing genome invaders, both transposons and viral elements👾: academic.oup.com/mbe/advance-... 🧵 1/7

Repressive cytosine methylation is a marker of viral gene transfer across divergent eukaryotes

Abstract. Cytosine DNA methylation patterns vary widely across eukaryotes, with its ancestral roles being understood to have included both transposable ele

academic.oup.com

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Reposted by Allegra Angeloni

Sergio Menchero @sermenchero.bsky.social · Jul 24

Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...

Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs

Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show rapid progression of transcriptional programs in specific tissues relative to morphological landmarks. This shift in...

www.cell.com

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Reposted by Allegra Angeloni

Stefan Schoenfelder @stefanschoenfelder.bsky.social · Jul 22

🚨 New paper alert 🚨
I am excited to share our new work on epigenetic enhancer priming in early mammalian development
genomebiology.biomedcentral.com/articles/10....
Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd.
Short 🧵

Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks - Genome Biology

Background Embryonic development requires the accurate spatiotemporal execution of cell lineage-specific gene expression programs, which are controlled by transcriptional enhancers. Developmental enha...

genomebiology.biomedcentral.com

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Reposted by Allegra Angeloni

Guillaume Andrey @guandrey.bsky.social · Jul 9

Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...

Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells - Nature Communications

Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also ...

www.nature.com

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