astrocyteNet
@astrocytenet.bsky.social
I am a female researcher in Computational Neuroscience and interested in neuron-astrocyte interaction. The person behind: Dr. Kerstin Lenk (she/her) @TUGraz
Pinned
Frontiers | Computational modeling of the relationship between morphological heterogeneity and functional responses in mouse hippocampal astrocytes
Recent studies indicate that astrocytes show heterogeneity in morphology and physiological function. They integrate synaptic signals and release calcium in r...
www.frontiersin.org
⭐️ Latest paper from my team: Anna Freund, Alexander Mayr, Peter Winkler, Rene Weber, Aapo Tervonen, Ron Refaeli, Kerstin Lenk: Computational modeling of the relationship between morphological heterogeneity and functional responses in mouse hippocampal astrocytes ⭐️ www.frontiersin.org/journals/cel...
Reposted by astrocyteNet
If you missed our Minisymposium at #SfN2025, you can still catch up with some of the topics by reading our new review:
www.jneurosci.org/content/45/4...
Also, got the printed version of this paper (and many more)🤩 @sfn.org
www.jneurosci.org/content/45/4...
Also, got the printed version of this paper (and many more)🤩 @sfn.org
November 19, 2025 at 1:59 PM
If you missed our Minisymposium at #SfN2025, you can still catch up with some of the topics by reading our new review:
www.jneurosci.org/content/45/4...
Also, got the printed version of this paper (and many more)🤩 @sfn.org
www.jneurosci.org/content/45/4...
Also, got the printed version of this paper (and many more)🤩 @sfn.org
Reposted by astrocyteNet
Astrocytic RNA degradation suppresses calcium signaling to support synapse function and restrain anxiety https://www.biorxiv.org/content/10.1101/2025.11.18.689044v1
November 19, 2025 at 2:16 AM
Astrocytic RNA degradation suppresses calcium signaling to support synapse function and restrain anxiety https://www.biorxiv.org/content/10.1101/2025.11.18.689044v1
Reposted by astrocyteNet
Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarrier
Dynamic modulation of the blood–brain barrier in the healthy brain - Nature Reviews Neuroscience
The blood–brain barrier was conventionally seen as a static protective structure, but a more complex, dynamic view of this barrier has now emerged. In this Review, Friedman et al. discuss the dynamic ...
www.nature.com
November 16, 2025 at 3:48 PM
Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarrier
Reposted by astrocyteNet
Four phases and temporal threshold of population calcium response during locomotion in cortical astrocytes https://www.biorxiv.org/content/10.1101/2025.11.15.688660v1
November 16, 2025 at 10:16 AM
Four phases and temporal threshold of population calcium response during locomotion in cortical astrocytes https://www.biorxiv.org/content/10.1101/2025.11.15.688660v1
Reposted by astrocyteNet
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks
Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...
onlinelibrary.wiley.com
November 13, 2025 at 8:17 PM
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by astrocyteNet
Reposted by astrocyteNet
Ever wondered if analyzing your images by using intensity Z-projections impacts your data?
Happy to announce my guest article in Microscopy & Analysis on that topic. It's a very short read but worth for everyone dealing with image analysis!
buff.ly/KJ147tI
#Microscopy #ZProjection #ImageAnalysis
Happy to announce my guest article in Microscopy & Analysis on that topic. It's a very short read but worth for everyone dealing with image analysis!
buff.ly/KJ147tI
#Microscopy #ZProjection #ImageAnalysis
November 10, 2025 at 4:05 PM
Ever wondered if analyzing your images by using intensity Z-projections impacts your data?
Happy to announce my guest article in Microscopy & Analysis on that topic. It's a very short read but worth for everyone dealing with image analysis!
buff.ly/KJ147tI
#Microscopy #ZProjection #ImageAnalysis
Happy to announce my guest article in Microscopy & Analysis on that topic. It's a very short read but worth for everyone dealing with image analysis!
buff.ly/KJ147tI
#Microscopy #ZProjection #ImageAnalysis
Reposted by astrocyteNet
#WissenschaftlicheIntegrität ganz grundsätzlich: Wie müssen Forschungseinrichtungen ihr Verfahren in Verdachtsfällen wissenschaftlichen Fehlverhaltens ausgestalten? Antwort und Orientierung gibt Leitlinie 19 des Kodex zur "Guten wissenschaftlichen Praxis":
sohub.io/zilv
sohub.io/zilv
Verfahren in Verdachtsfällen wissenschaftlichen Fehlverhaltens - Wissenschaftliche Integrität
Hochschulen und außerhochschulische Forschungseinrichtungen etablieren Verfahren zum Umgang mit Vorwürfen wissenschaftlichen Fehlverhaltens. Entsprechende Regelwerke erlassen sie auf Basis einer hin- ...
sohub.io
November 11, 2025 at 12:13 PM
#WissenschaftlicheIntegrität ganz grundsätzlich: Wie müssen Forschungseinrichtungen ihr Verfahren in Verdachtsfällen wissenschaftlichen Fehlverhaltens ausgestalten? Antwort und Orientierung gibt Leitlinie 19 des Kodex zur "Guten wissenschaftlichen Praxis":
sohub.io/zilv
sohub.io/zilv
Reposted by astrocyteNet
Call for Symposia: Göttingen Meeting 2027
Time to take the opportunity and help to shape the Scientific Program 2027 by submitting your proposal until:
17 February 2026
Further information can be found here: web.nwg-info.de/de/conferenc...
Time to take the opportunity and help to shape the Scientific Program 2027 by submitting your proposal until:
17 February 2026
Further information can be found here: web.nwg-info.de/de/conferenc...
October 8, 2025 at 7:57 AM
Call for Symposia: Göttingen Meeting 2027
Time to take the opportunity and help to shape the Scientific Program 2027 by submitting your proposal until:
17 February 2026
Further information can be found here: web.nwg-info.de/de/conferenc...
Time to take the opportunity and help to shape the Scientific Program 2027 by submitting your proposal until:
17 February 2026
Further information can be found here: web.nwg-info.de/de/conferenc...
Reposted by astrocyteNet
When the stars of glial scar borders and stroke recovery “have a baby”, it gives this 😅 #astrocytes #stroke #cerebrovascular
Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…
www.sciencedirect.com
November 8, 2025 at 7:39 AM
When the stars of glial scar borders and stroke recovery “have a baby”, it gives this 😅 #astrocytes #stroke #cerebrovascular
Reposted by astrocyteNet
Just published in Nat. Neurosci.
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience
Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphory...
www.nature.com
November 7, 2025 at 10:16 AM
Just published in Nat. Neurosci.
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Reposted by astrocyteNet
Reposted by astrocyteNet
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
November 5, 2025 at 6:53 PM
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
Reposted by astrocyteNet
I’m proud to have helped launch the #PITraining survey of FKNE @fkne-scholars.bsky.social
We ask PIs to share what really matters for effective research leadership. Your feedback = better support, better science.
Take part or share:
fenskavlinetwork.org/fkne-pi-surv...
Deadline: 29 Dec 2025
We ask PIs to share what really matters for effective research leadership. Your feedback = better support, better science.
Take part or share:
fenskavlinetwork.org/fkne-pi-surv...
Deadline: 29 Dec 2025
November 5, 2025 at 4:28 PM
I’m proud to have helped launch the #PITraining survey of FKNE @fkne-scholars.bsky.social
We ask PIs to share what really matters for effective research leadership. Your feedback = better support, better science.
Take part or share:
fenskavlinetwork.org/fkne-pi-surv...
Deadline: 29 Dec 2025
We ask PIs to share what really matters for effective research leadership. Your feedback = better support, better science.
Take part or share:
fenskavlinetwork.org/fkne-pi-surv...
Deadline: 29 Dec 2025
Reposted by astrocyteNet
Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease - Nature Communications
The role of astrocytes in Alzheimer’s disease pathology remains insufficiently characterized. Here, the authors show that aggravated astrocyte response to Aβ causes brain inflammation, and amyloid and...
www.nature.com
November 5, 2025 at 12:42 PM
Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by astrocyteNet
📢 June 8th-9th 2026 Bristol University 📢
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
UK Glia 2026
UK Glia 2026 meeting will highlight the pivotal role of glia in brain physiology, offering invaluable insights for those investigating glia function in both health and disease. Find out more about the...
www.physoc.org
October 20, 2025 at 12:54 PM
📢 June 8th-9th 2026 Bristol University 📢
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
Reposted by astrocyteNet
Glia gang, this is for you!
In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC).
🧠📈 http://microns-explorer.org
In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC).
🧠📈 http://microns-explorer.org
November 3, 2025 at 3:47 PM
Glia gang, this is for you!
In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC).
🧠📈 http://microns-explorer.org
In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC).
🧠📈 http://microns-explorer.org
Reposted by astrocyteNet
We are doing it again!!!!
Save the date for the next in-person #AstrocyteCafe next June 3-5 (2026) in Pamplona (Spain)!
We can’t wait to see many of you in person again, thanks so much to the main local organizer @maitesolas.bsky.social ♥️
Save the date for the next in-person #AstrocyteCafe next June 3-5 (2026) in Pamplona (Spain)!
We can’t wait to see many of you in person again, thanks so much to the main local organizer @maitesolas.bsky.social ♥️
November 2, 2025 at 11:26 AM
We are doing it again!!!!
Save the date for the next in-person #AstrocyteCafe next June 3-5 (2026) in Pamplona (Spain)!
We can’t wait to see many of you in person again, thanks so much to the main local organizer @maitesolas.bsky.social ♥️
Save the date for the next in-person #AstrocyteCafe next June 3-5 (2026) in Pamplona (Spain)!
We can’t wait to see many of you in person again, thanks so much to the main local organizer @maitesolas.bsky.social ♥️
Reposted by astrocyteNet
Senescent astrocytic deposits drive cognitive decline by disrupting tripartite synapse in the aging brain https://www.biorxiv.org/content/10.1101/2025.10.31.685958v1
November 2, 2025 at 10:15 AM
Senescent astrocytic deposits drive cognitive decline by disrupting tripartite synapse in the aging brain https://www.biorxiv.org/content/10.1101/2025.10.31.685958v1
The next International Astrocyte School is coming. A wonderful and insightful week about astrocytes sprinkled with Italian food and drinks ⭐️ Highly recommend! More info: ias2026.azuleon.org
#IAS2026
#IAS2026
October 31, 2025 at 2:20 PM
The next International Astrocyte School is coming. A wonderful and insightful week about astrocytes sprinkled with Italian food and drinks ⭐️ Highly recommend! More info: ias2026.azuleon.org
#IAS2026
#IAS2026
Reposted by astrocyteNet
Towards the ethical development of functional genomics research
www.cell.com/trends/biote...
www.cell.com/trends/biote...
October 31, 2025 at 1:44 AM
Towards the ethical development of functional genomics research
www.cell.com/trends/biote...
www.cell.com/trends/biote...
Reposted by astrocyteNet
Our latest paper is out! While the circadian photoentrainment circuit has been extensively studied, the mechanisms regulating its development remain poorly understood. Here we show that retinal Müller glia play a key role in this process. Check it out! www.sciencedirect.com/science/arti...
Retinal glia regulate development of the circadian photoentrainment circuit
Circadian photoentrainment depends on intrinsically photosensitive retinal ganglion cells (ipRGCs), which convey environmental light information to th…
www.sciencedirect.com
October 29, 2025 at 2:27 PM
Our latest paper is out! While the circadian photoentrainment circuit has been extensively studied, the mechanisms regulating its development remain poorly understood. Here we show that retinal Müller glia play a key role in this process. Check it out! www.sciencedirect.com/science/arti...
Reposted by astrocyteNet
Excited to share our Current Biology Primer written with Dr. Audrey Chagnot in the Brain-Body Interactions special issue!
We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health.
@ukdri.ac.uk @thebhf.bsky.social
shorturl.at/NNc57
We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health.
@ukdri.ac.uk @thebhf.bsky.social
shorturl.at/NNc57
The blood–brain barrier
In animals, the central nervous system (CNS) plays a crucial role as the primary organ responsible for integrating environmental information and coord…
shorturl.at
October 20, 2025 at 7:26 PM
Excited to share our Current Biology Primer written with Dr. Audrey Chagnot in the Brain-Body Interactions special issue!
We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health.
@ukdri.ac.uk @thebhf.bsky.social
shorturl.at/NNc57
We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health.
@ukdri.ac.uk @thebhf.bsky.social
shorturl.at/NNc57
Reposted by astrocyteNet
APOE3 astrocytes can rescue lipid abnormalities and dystrophic neurites of APOE4 human neurons #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.24.684364v1
https://www.biorxiv.org/content/10.1101/2025.10.24.684364v1
October 25, 2025 at 4:02 PM
APOE3 astrocytes can rescue lipid abnormalities and dystrophic neurites of APOE4 human neurons #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.10.24.684364v1
https://www.biorxiv.org/content/10.1101/2025.10.24.684364v1
Reposted by astrocyteNet
💡 Research Spotlight: Primary cilia in astrocytes are key for their development, metabolism & synaptic regulation. Defects lead to neuronal and behavioral issues in mice, offering new insights into neurodevelopment & ciliopathies.
🔗 https://www.nature.com/articles/s41593-024-01726-z
🔗 https://www.nature.com/articles/s41593-024-01726-z
Primary cilia signaling in astrocytes mediates development and regional-specific functional specification - Nature Neuroscience
Astrocyte diversity is greatly influenced by local environmental modulation. Wang et al. report a critical role for astrocytic primary cilia in transmitting local cues that drive the region-specific diversification of astrocytes within the developing mouse brain.
www.nature.com
October 23, 2025 at 10:49 AM
💡 Research Spotlight: Primary cilia in astrocytes are key for their development, metabolism & synaptic regulation. Defects lead to neuronal and behavioral issues in mice, offering new insights into neurodevelopment & ciliopathies.
🔗 https://www.nature.com/articles/s41593-024-01726-z
🔗 https://www.nature.com/articles/s41593-024-01726-z