Biswajit Pradhan
@bislightyear.bsky.social
Postdoc at MPI Biophysics.
DNA, SMC, Chromosome Organization, Nanoscience, Single-Molecule Biophysics.
https://www.biswajit.de/
DNA, SMC, Chromosome Organization, Nanoscience, Single-Molecule Biophysics.
https://www.biswajit.de/
Pinned
Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. π§¬π¬π§ͺ
Reposted by Biswajit Pradhan
The hinge bypass gate paper is finally out! doi.org/10.1038/s414...
We show how loop-extruding SMC complexes can maintain DNA entrapment while bypassing obstacles on DNA β including transcription machinery & potentially other SMCs.
A lucky convergence of 3 projects lead to the initial discovery!
We show how loop-extruding SMC complexes can maintain DNA entrapment while bypassing obstacles on DNA β including transcription machinery & potentially other SMCs.
A lucky convergence of 3 projects lead to the initial discovery!
The SMC Hinge is a Selective Gate for Obstacle Bypass - Nature Communications
SMC complexes are ring-shaped motors that fold DNA by extruding loops, but how they navigate large DNA obstacles is unclear. Here, Liu et al., show that SMC complexes bypass obstacles by threading obs...
doi.org
November 25, 2025 at 3:26 PM
The hinge bypass gate paper is finally out! doi.org/10.1038/s414...
We show how loop-extruding SMC complexes can maintain DNA entrapment while bypassing obstacles on DNA β including transcription machinery & potentially other SMCs.
A lucky convergence of 3 projects lead to the initial discovery!
We show how loop-extruding SMC complexes can maintain DNA entrapment while bypassing obstacles on DNA β including transcription machinery & potentially other SMCs.
A lucky convergence of 3 projects lead to the initial discovery!
Herzlichen GlΓΌckwunsch!
November 11, 2025 at 2:06 PM
Herzlichen GlΓΌckwunsch!
Congratulations! That's a amazing team on DNA-SMC!
November 6, 2025 at 4:40 PM
Congratulations! That's a amazing team on DNA-SMC!
Reposted by Biswajit Pradhan
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more β¬οΈ and β‘οΈ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social βs group identifies the SND3 protein as a new route for membrane protein insertion! π π Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more β¬οΈ and β‘οΈ rdcu.be/eNgIO
Reposted by Biswajit Pradhan
Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At @gruberlab.bsky.social, Dubochet Center for Imaging and BSI @igbmc.bsky.social
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
October 9, 2025 at 2:55 PM
Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At @gruberlab.bsky.social, Dubochet Center for Imaging and BSI @igbmc.bsky.social
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Amazing WadjetSMC-DNA gymnastics! fantastic data from @roisnehamelinf.bsky.social , @gruberlab.bsky.social and their team.
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics π€ΈββοΈπ€ΈββοΈπ€ΈββοΈ.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics π€ΈββοΈπ€ΈββοΈπ€ΈββοΈ.
Check out the new paper: www.cell.com/molecular-ce...
October 10, 2025 at 12:34 PM
Amazing WadjetSMC-DNA gymnastics! fantastic data from @roisnehamelinf.bsky.social , @gruberlab.bsky.social and their team.
Reposted by Biswajit Pradhan
Our Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu...
With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:
WadjetβKeeping a watchful eye on circular DNA.
www.cell.com/structure/fu...
With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:
WadjetβKeeping a watchful eye on circular DNA.
www.cell.com/structure/fu...
September 5, 2025 at 6:29 AM
Our Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu...
With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:
WadjetβKeeping a watchful eye on circular DNA.
www.cell.com/structure/fu...
With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:
WadjetβKeeping a watchful eye on circular DNA.
www.cell.com/structure/fu...
beautiful structures everywhere in the paper. the artistic rendition looks so cool π
July 22, 2025 at 7:46 AM
beautiful structures everywhere in the paper. the artistic rendition looks so cool π
Congratulations Anuj!
March 8, 2025 at 4:37 AM
Congratulations Anuj!
Reposted by Biswajit Pradhan
Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social
Exciting green news! π¦ Do you know how certain microorganisms make a living by transforming CO2 into useful molecules? Check out our new work on the molecular choreography behind acetyl-CoA synthesis in the CODH/ACS protein complex. π©βπ¬ π www.biophys.mpg.de/2844976/micr...
January 31, 2025 at 4:18 PM
Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social
madness. That's some next-level Eule obsession
January 24, 2025 at 4:16 PM
madness. That's some next-level Eule obsession
that's awesome. Congratulations!
January 16, 2025 at 1:17 PM
that's awesome. Congratulations!
Reposted by Biswajit Pradhan
Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with
βͺ@kraftlabfr.bsky.socialβ¬
www.nature.com/articles/s41...
Short teaser below πππ
βͺ@kraftlabfr.bsky.socialβ¬
www.nature.com/articles/s41...
Short teaser below πππ
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology
Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargoβreceptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...
www.nature.com
January 8, 2025 at 3:11 PM
Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with
βͺ@kraftlabfr.bsky.socialβ¬
www.nature.com/articles/s41...
Short teaser below πππ
βͺ@kraftlabfr.bsky.socialβ¬
www.nature.com/articles/s41...
Short teaser below πππ
Reposted by Biswajit Pradhan
What a great way to end the year! β¨
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long π§΅...
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long π§΅...
December 31, 2024 at 3:38 PM
What a great way to end the year! β¨
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long π§΅...
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long π§΅...
Reposted by Biswajit Pradhan
Hi all, I am very excited to share two positions (PhD and PostDoc) in my group on a EU-funded project ProAct.
More about the positions below.
Please share with your colleagues! This will be a great project to work on and also we offer a great environment at the BIOS group
More about the positions below.
Please share with your colleagues! This will be a great project to work on and also we offer a great environment at the BIOS group
December 20, 2024 at 10:45 AM
Hi all, I am very excited to share two positions (PhD and PostDoc) in my group on a EU-funded project ProAct.
More about the positions below.
Please share with your colleagues! This will be a great project to work on and also we offer a great environment at the BIOS group
More about the positions below.
Please share with your colleagues! This will be a great project to work on and also we offer a great environment at the BIOS group
Reposted by Biswajit Pradhan
Chromokinesin KIF4A activation of human condensin I involves a SLiM interfering with auto-inhibitory intramolecular interactions in the condensin complex, exemplifying a conserved mechanism for regulating diverse SMC complexes
@eecutts.bsky.social, Luis Aragon et al
www.embopress.org/doi/full/10....
@eecutts.bsky.social, Luis Aragon et al
www.embopress.org/doi/full/10....
December 18, 2024 at 11:20 AM
Chromokinesin KIF4A activation of human condensin I involves a SLiM interfering with auto-inhibitory intramolecular interactions in the condensin complex, exemplifying a conserved mechanism for regulating diverse SMC complexes
@eecutts.bsky.social, Luis Aragon et al
www.embopress.org/doi/full/10....
@eecutts.bsky.social, Luis Aragon et al
www.embopress.org/doi/full/10....
Reposted by Biswajit Pradhan
Please share: Still plenty of time to apply for PhD projects in my lab using single-molecule methods to look at disordered regions and condensin complexes!
Contact me at [email protected]
For details on how to apply: www.findaphd.com/phds/project...
Contact me at [email protected]
For details on how to apply: www.findaphd.com/phds/project...
Developing Imaging Solutions to Study the Dynamics of Human Condensin I at University of Sheffield on FindAPhD.com
PhD Project - Developing Imaging Solutions to Study the Dynamics of Human Condensin I at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
December 16, 2024 at 3:37 PM
Please share: Still plenty of time to apply for PhD projects in my lab using single-molecule methods to look at disordered regions and condensin complexes!
Contact me at [email protected]
For details on how to apply: www.findaphd.com/phds/project...
Contact me at [email protected]
For details on how to apply: www.findaphd.com/phds/project...
Reposted by Biswajit Pradhan
Heartbeat of an early zebrafish embryo. Credit to Drs. Fengzhu Xiong & Sean Megason @harvardmed.bsky.social. #ZebrafishZunday π§ͺ
December 15, 2024 at 10:22 AM
Heartbeat of an early zebrafish embryo. Credit to Drs. Fengzhu Xiong & Sean Megason @harvardmed.bsky.social. #ZebrafishZunday π§ͺ
Reposted by Biswajit Pradhan
We have an opening for a 4 yr PhD interested in membrane remodelling and cryo-EM/ET of a minimal cell division machinery: edu.nl/bukan
You will be part of the EVOLF consortium in which 30 leading biochemists/biophysicists work together to explore if and how we can build autonomous synthetic cells.
You will be part of the EVOLF consortium in which 30 leading biochemists/biophysicists work together to explore if and how we can build autonomous synthetic cells.
December 10, 2024 at 2:53 PM
We have an opening for a 4 yr PhD interested in membrane remodelling and cryo-EM/ET of a minimal cell division machinery: edu.nl/bukan
You will be part of the EVOLF consortium in which 30 leading biochemists/biophysicists work together to explore if and how we can build autonomous synthetic cells.
You will be part of the EVOLF consortium in which 30 leading biochemists/biophysicists work together to explore if and how we can build autonomous synthetic cells.
Welcome! π€π½ for more of those atomic-level awesome REELs! ππ¬
December 6, 2024 at 10:00 AM
Welcome! π€π½ for more of those atomic-level awesome REELs! ππ¬
Reposted by Biswajit Pradhan
topology sensing, very cool! another job for loop extrusion!
Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. π§¬π¬π§ͺ
December 4, 2024 at 10:09 PM
topology sensing, very cool! another job for loop extrusion!
Reposted by Biswajit Pradhan
Delighted to publish my new molecular animation:
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv
YouTube video by WEHImovies
youtu.be
December 4, 2024 at 12:07 AM
Delighted to publish my new molecular animation:
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
Reposted by Biswajit Pradhan
Excited to share this work, now out in Molecular Cell.
This was a fun collaboration between the Corbett lab and Kim lab.
This was a fun collaboration between the Corbett lab and Kim lab.
It's awesome that most of the coauthors are on Bluesky! π€©
I had so much fun learning, collaborating with @amardeeep.bsky.social from @kevincorbett.bsky.social lab.
Thanks to @jessicakoenig.bsky.social and Martin Baaske from @eugenekimlab.bsky.social
I had so much fun learning, collaborating with @amardeeep.bsky.social from @kevincorbett.bsky.social lab.
Thanks to @jessicakoenig.bsky.social and Martin Baaske from @eugenekimlab.bsky.social
Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. π§¬π¬π§ͺ
December 3, 2024 at 10:30 AM
Excited to share this work, now out in Molecular Cell.
This was a fun collaboration between the Corbett lab and Kim lab.
This was a fun collaboration between the Corbett lab and Kim lab.
Thanks, Olivia!
December 3, 2024 at 12:25 PM
Thanks, Olivia!
Thanks, Victor!
December 3, 2024 at 12:16 PM
Thanks, Victor!