Boris Lenhard
@borislenhard.bsky.social
Professor of Computational Biology, Imperial College London
MRC Investigator, Computational Regulatory Genomics, MRC Laboratory of Medical Sciences
Interested in eukaryotic promoters, enhancers and long-range developmental regulation
MRC Investigator, Computational Regulatory Genomics, MRC Laboratory of Medical Sciences
Interested in eukaryotic promoters, enhancers and long-range developmental regulation
I am delighted that my group will be a part of this.
1. We start a major consortium programme funded by the sLoLa of BBSRC (shorturl.at/aUbnt) to decipher the semantic rules of enhancer arrangements driving regulator genes of development (shorturl.at/6qcjW).
shorturl.at
November 18, 2025 at 1:20 PM
I am delighted that my group will be a part of this.
Reposted by Boris Lenhard
Good to see the peer reviewed version of this in print
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program operates across the vertebrate nervous system to control neural cell diversity
www.cell.com/developmenta...
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program operates across the vertebrate nervous system to control neural cell diversity
www.cell.com/developmenta...
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
Zhang et al. identify a global temporal chromatin program that operates across the
developing vertebrate nervous system to control neural cell diversity. This mechanism,
which involves Nr6a1 and NFIA/...
www.cell.com
November 18, 2025 at 8:59 AM
Good to see the peer reviewed version of this in print
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program operates across the vertebrate nervous system to control neural cell diversity
www.cell.com/developmenta...
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program operates across the vertebrate nervous system to control neural cell diversity
www.cell.com/developmenta...
Reposted by Boris Lenhard
Our study on mdka transcriptional regulation during zebrafish brain regeneration has been accepted in FEBS Journal and will be online soon! 🚀 A related review from our group on immunity & inflammation in zebrafish brain regeneration is also available in FEBS Journal: doi.org/10.1111/febs...
doi.org
November 17, 2025 at 9:37 PM
Our study on mdka transcriptional regulation during zebrafish brain regeneration has been accepted in FEBS Journal and will be online soon! 🚀 A related review from our group on immunity & inflammation in zebrafish brain regeneration is also available in FEBS Journal: doi.org/10.1111/febs...
Reposted by Boris Lenhard
@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS.
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
November 4, 2025 at 5:33 PM
@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS.
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
Reposted by Boris Lenhard
Why far from being a disadvantage, hostility to people from different races and cultures has now become an active requirement for career advancement on the right of British politics
www.adambienkov.co.uk/p/the-racism...
www.adambienkov.co.uk/p/the-racism...
The Racism Premium
Far from being a disadvantage, hostility to people from different races and cultures has now become an active requirement for career advancement on the right of British politics
www.adambienkov.co.uk
November 1, 2025 at 12:18 PM
Why far from being a disadvantage, hostility to people from different races and cultures has now become an active requirement for career advancement on the right of British politics
www.adambienkov.co.uk/p/the-racism...
www.adambienkov.co.uk/p/the-racism...
Reposted by Boris Lenhard
Tl;dr: The first sentence.
October 21, 2025 at 6:03 PM
Tl;dr: The first sentence.
This is the state in which waste collectors have left the bins at 14-19 Lichfield Gardens this morning. It has been like that for the past several weeks, after years of (mostly) no issues.
This is not haste. This is passive aggression.
@richmondcouncil.bsky.social Please report to Serco.
This is not haste. This is passive aggression.
@richmondcouncil.bsky.social Please report to Serco.
October 21, 2025 at 11:05 AM
This is the state in which waste collectors have left the bins at 14-19 Lichfield Gardens this morning. It has been like that for the past several weeks, after years of (mostly) no issues.
This is not haste. This is passive aggression.
@richmondcouncil.bsky.social Please report to Serco.
This is not haste. This is passive aggression.
@richmondcouncil.bsky.social Please report to Serco.
It turns out that "Idiocracy" was way too optimistic.
Trump posts AI video showing him literally dumping shit on America
October 19, 2025 at 1:12 PM
It turns out that "Idiocracy" was way too optimistic.
Reposted by Boris Lenhard
new lab preprint 👇
Ever wondered how sperm are formed? Spermatogenesis is a microscopic marathon that starts in the testes and ends with fully functional sperm! Our new preprint bitly.cx/jC4Qg takes a deep dive into zebrafish spermatogenesis, mapping out every fascinating step. 🧵👇 1/7
A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formation
Spermatogenesis is the biological process by which male sperm cells (spermatozoa) are produced in the testes. Beyond facilitating the transmission of genetic information, spermatogenesis also provides...
bitly.cx
March 13, 2025 at 12:47 PM
new lab preprint 👇
Reposted by Boris Lenhard
First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1
September 28, 2025 at 10:33 AM
First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)
Reposted by Boris Lenhard
“Let’s call it for what it is: bullshit. The truth is, politicians have talked about little else but immigration for decades and in the most dehumanising ways.
Polanski added: “Stop the boats’ is all we hear. Well, today I'm saying ‘stop the bullshit’.”
www.independent.co.uk/news/uk/home...
Polanski added: “Stop the boats’ is all we hear. Well, today I'm saying ‘stop the bullshit’.”
www.independent.co.uk/news/uk/home...
UK faces ‘battle for the soul’ of the country, says Starmer amid Reform threat
In a rallying cry to progressives around the world, the Prime Minister said allies must stop the ‘politics of predatory grievance’.
www.independent.co.uk
September 26, 2025 at 1:34 PM
“Let’s call it for what it is: bullshit. The truth is, politicians have talked about little else but immigration for decades and in the most dehumanising ways.
Polanski added: “Stop the boats’ is all we hear. Well, today I'm saying ‘stop the bullshit’.”
www.independent.co.uk/news/uk/home...
Polanski added: “Stop the boats’ is all we hear. Well, today I'm saying ‘stop the bullshit’.”
www.independent.co.uk/news/uk/home...
Reposted by Boris Lenhard
Vichy Labour. Deliberately and repeatedly affirming and amplifying the inflammatory far right *lie* of "uncontrolled migration".
“The belief that uncontrolled legal migration was nothing but good news for an economy should never have been accepted on the Left,” writes Starmer “fighting” populism. What does even mean “uncontrolled” in the case of legal migration? www.telegraph.co.uk/gift/f9444c6...
The Left ignored immigration fears for too long. It’s time to give communities back control
Only a plan for patriotic national renewal led by Labour will counter the rise of the populist Right
www.telegraph.co.uk
September 26, 2025 at 6:56 AM
Vichy Labour. Deliberately and repeatedly affirming and amplifying the inflammatory far right *lie* of "uncontrolled migration".
Reposted by Boris Lenhard
Useful reminder from Peter Kellner on the problems we refuse to acknowledge are getting better, and the politics of hopelessness that this breeds
open.substack.com/pub/kellnerp...
open.substack.com/pub/kellnerp...
September 23, 2025 at 6:29 AM
Useful reminder from Peter Kellner on the problems we refuse to acknowledge are getting better, and the politics of hopelessness that this breeds
open.substack.com/pub/kellnerp...
open.substack.com/pub/kellnerp...
Reposted by Boris Lenhard
Retrospectively removing indefinite leave to remain would be immoral and economically damaging. It would tear families apart.
Attacking it as ‘potentially illegal’ is completely beside the point.
Argue with the (awful) idea. Don’t try ’well, actually you can’t do that’.
Attacking it as ‘potentially illegal’ is completely beside the point.
Argue with the (awful) idea. Don’t try ’well, actually you can’t do that’.
September 22, 2025 at 7:10 AM
Retrospectively removing indefinite leave to remain would be immoral and economically damaging. It would tear families apart.
Attacking it as ‘potentially illegal’ is completely beside the point.
Argue with the (awful) idea. Don’t try ’well, actually you can’t do that’.
Attacking it as ‘potentially illegal’ is completely beside the point.
Argue with the (awful) idea. Don’t try ’well, actually you can’t do that’.
Reposted by Boris Lenhard
mRNA vaccines are one of if not the most studied human inventions in history at this point. It's madness to say that they are somehow not well-understood!
September 2, 2025 at 11:03 PM
mRNA vaccines are one of if not the most studied human inventions in history at this point. It's madness to say that they are somehow not well-understood!
Reposted by Boris Lenhard
Interested in a sabbatical in Lyon? The Collegium de Lyon provides accommodation and attractive interdisciplinary environment for 1 or 2 semesters. Open to all disciplines. You can be affiliated with any local department/lab. Apply now for 2026-27. collegium.universite-lyon.fr/2026-2027-un...
September 2, 2025 at 8:45 AM
Interested in a sabbatical in Lyon? The Collegium de Lyon provides accommodation and attractive interdisciplinary environment for 1 or 2 semesters. Open to all disciplines. You can be affiliated with any local department/lab. Apply now for 2026-27. collegium.universite-lyon.fr/2026-2027-un...
Reposted by Boris Lenhard
And now government doctors got my entire channel removed.
Don’t worry.
I won’t base my entire identity around this or claim it is worse than covid. 😂
Don’t worry.
I won’t base my entire identity around this or claim it is worse than covid. 😂
August 29, 2025 at 9:49 PM
And now government doctors got my entire channel removed.
Don’t worry.
I won’t base my entire identity around this or claim it is worse than covid. 😂
Don’t worry.
I won’t base my entire identity around this or claim it is worse than covid. 😂
If anybody needs advice on good fountain pens, I’d be happy to help.
So far, the main businesses that have been financially benefited from AI have been the producers of blue books
www.wsj.com/business/cha...
www.wsj.com/business/cha...
They Were Every Student’s Worst Nightmare. Now Blue Books Are Back.
Cheating with ChatGPT has become a huge problem for colleges. The solution is painfully old-school.
www.wsj.com
August 26, 2025 at 9:07 PM
If anybody needs advice on good fountain pens, I’d be happy to help.
The guest is David Collum, a rabid conspiracy theorist who is still a professor of chemistry and chemical biology at Cornell.
Tenure should probably not be able to protect academics against the consequences of lunacy such as this.
Tenure should probably not be able to protect academics against the consequences of lunacy such as this.
Tucker Carlson agrees with a guest on his show who says, “It turns out I think the story we got about World War II is all wrong… one can make the argument that we should have sided with Hitler.”
Not even trying to hide it.
Not even trying to hide it.
August 22, 2025 at 12:24 PM
The guest is David Collum, a rabid conspiracy theorist who is still a professor of chemistry and chemical biology at Cornell.
Tenure should probably not be able to protect academics against the consequences of lunacy such as this.
Tenure should probably not be able to protect academics against the consequences of lunacy such as this.
Reposted by Boris Lenhard
Archaea are often surrounded by bacteria. But is there ever active conflict between the two? Can archaea kill bacteria? If so, how do they do it?
Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...
Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...
Archaea produce peptidoglycan hydrolases that kill bacteria
Archaea regularly interact with bacteria but reports of archaea killing bacteria are very rare. This study shows that many archaea encode peptidoglycan hydrolases, which specifically target bacterial ...
journals.plos.org
August 14, 2025 at 6:50 PM
Archaea are often surrounded by bacteria. But is there ever active conflict between the two? Can archaea kill bacteria? If so, how do they do it?
Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...
Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...
Reposted by Boris Lenhard
After nearly twenty years in the making, our attempt at understanding what makes the chaetognath phylum so unique has finally been published! www.nature.com/articles/s41...
with #LauraPiovani @dariagavr.bsky.social @alexdemendoza.bsky.social @chemamd.bsky.social and others /1
with #LauraPiovani @dariagavr.bsky.social @alexdemendoza.bsky.social @chemamd.bsky.social and others /1
The genomic origin of the unique chaetognath body plan - Nature
Genomic, single-cell transcriptomic and epigenetic analyses show that chaetognaths, following extensive gene loss in the gnathiferan lineage, relied on newly evolved genes and lineage-specific tandem ...
www.nature.com
August 13, 2025 at 4:38 PM
After nearly twenty years in the making, our attempt at understanding what makes the chaetognath phylum so unique has finally been published! www.nature.com/articles/s41...
with #LauraPiovani @dariagavr.bsky.social @alexdemendoza.bsky.social @chemamd.bsky.social and others /1
with #LauraPiovani @dariagavr.bsky.social @alexdemendoza.bsky.social @chemamd.bsky.social and others /1
Reposted by Boris Lenhard
Wrote a big review with my friend and colleague @varshneylab.social on the state-of-the-art in CRISPR used experimentally in vivo. We wanted to focus on their use in experimental vertebrate animals (apparently passé now but we persist).
CRISPR-based functional genomics tools in vertebrate models - Experimental & Molecular Medicine
Recent advances in DNA sequencing have allowed scientists to gather vast amounts of genetic data, but understanding what those sequences actually do requires additional tools that allow scientists to ...
www.nature.com
July 31, 2025 at 4:08 PM
Wrote a big review with my friend and colleague @varshneylab.social on the state-of-the-art in CRISPR used experimentally in vivo. We wanted to focus on their use in experimental vertebrate animals (apparently passé now but we persist).
Reposted by Boris Lenhard
Of all the bullshit positions, the one I loathe most is "yOu LiBz mAdE tEh fAsCiSmZ hAppEn" as if fascism is not a cyclical political phenomenon that always has behind it the same violent insecure inadequate men who yearn to dominate and those that support it have no agency or moral responsibility.
July 31, 2025 at 9:07 PM
Of all the bullshit positions, the one I loathe most is "yOu LiBz mAdE tEh fAsCiSmZ hAppEn" as if fascism is not a cyclical political phenomenon that always has behind it the same violent insecure inadequate men who yearn to dominate and those that support it have no agency or moral responsibility.
Reposted by Boris Lenhard
There is a growing violent movement which senior politicians and media organisations are now not only seeking to justify, but actively encouraging.
Why it's time for politicians to instead start standing up to the wholly illegitimate concerns of the far right
www.adambienkov.co.uk/p/illegitima...
Why it's time for politicians to instead start standing up to the wholly illegitimate concerns of the far right
www.adambienkov.co.uk/p/illegitima...
Illegitimate Concerns
There is a growing violent far-right movement in the UK which senior politicians and media organisations are now not only seeking to justify, but are actively encouraging
www.adambienkov.co.uk
July 26, 2025 at 11:33 AM
There is a growing violent movement which senior politicians and media organisations are now not only seeking to justify, but actively encouraging.
Why it's time for politicians to instead start standing up to the wholly illegitimate concerns of the far right
www.adambienkov.co.uk/p/illegitima...
Why it's time for politicians to instead start standing up to the wholly illegitimate concerns of the far right
www.adambienkov.co.uk/p/illegitima...