Brian Glancy
@brianglancylab.bsky.social
We study how muscles are built to sustain power with a focus on mitochondrial energy metabolism.
Reposted by Brian Glancy
We are hiring!
Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches.
Please share!
More about us: martinottlab.com
Apply here:
web103.reachmee.com/ext/I005/103...
Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches.
Please share!
More about us: martinottlab.com
Apply here:
web103.reachmee.com/ext/I005/103...
January 28, 2026 at 1:35 PM
We are hiring!
Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches.
Please share!
More about us: martinottlab.com
Apply here:
web103.reachmee.com/ext/I005/103...
Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches.
Please share!
More about us: martinottlab.com
Apply here:
web103.reachmee.com/ext/I005/103...
Reposted by Brian Glancy
Reposted by Brian Glancy
New #NatureComms paper: CHAMP1 is an essential regulator for human myoblast fusion and muscle development. #Myoblue tinyurl.com/2wyu39fr
https://www.nature.com/articles/s41467-025-67584-w
tinyurl.com
January 16, 2026 at 1:01 PM
New #NatureComms paper: CHAMP1 is an essential regulator for human myoblast fusion and muscle development. #Myoblue tinyurl.com/2wyu39fr
Reposted by Brian Glancy
High carotid blood flow velocity and pulsatility correlate with lower hippocampal mito oxygen consumption, while both low and high flow increase mito fusion protein expression compared to control. Thanks to Drs. J. Carson Smith and Gabriel Pena for the collaboration! ahajrnls.org/3YmmdMj
January 5, 2026 at 5:50 PM
High carotid blood flow velocity and pulsatility correlate with lower hippocampal mito oxygen consumption, while both low and high flow increase mito fusion protein expression compared to control. Thanks to Drs. J. Carson Smith and Gabriel Pena for the collaboration! ahajrnls.org/3YmmdMj
Reposted by Brian Glancy
Mitochondrial Reticulum in Skeletal Muscles: Proven and Hypothetical Functions
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Mitochondrial Reticulum in Skeletal Muscles: Proven and Hypothetical Functions - Biochemistry (Moscow)
Abstract The mitochondrial reticulum of skeletal muscles has been characterized in the 1970-80s. It has been suggested and then proven its role is delivering energy in a form of transmembrane potentia...
link.springer.com
December 27, 2025 at 6:30 PM
Mitochondrial Reticulum in Skeletal Muscles: Proven and Hypothetical Functions
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Brian Glancy
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
December 22, 2025 at 2:57 PM
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
Reposted by Brian Glancy
📄 New preprint
Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans.
👇 Link in first comment
#Physiology #Diabetes #Mitochondria #Metabolism
Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans.
👇 Link in first comment
#Physiology #Diabetes #Mitochondria #Metabolism
December 22, 2025 at 8:55 AM
📄 New preprint
Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans.
👇 Link in first comment
#Physiology #Diabetes #Mitochondria #Metabolism
Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans.
👇 Link in first comment
#Physiology #Diabetes #Mitochondria #Metabolism
Reposted by Brian Glancy
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Self-renewal of neuronal mitochondria through asymmetric division
Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...
www.biorxiv.org
December 18, 2025 at 8:36 PM
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Reposted by Brian Glancy
Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy.
doi.org/10.1038/s441...
doi.org/10.1038/s441...
Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia - Nature Cardiovascular Research
Giles et al. developed a method for noninvasive absorbance measurement of mitochondrial hemes to monitor the mitochondrial membrane potential in the perfused heart. They then applied this approach to ...
doi.org
December 15, 2025 at 11:07 AM
Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy.
doi.org/10.1038/s441...
doi.org/10.1038/s441...
Reposted by Brian Glancy
Excited to share our new paper on high-throughput #optogenetic #exercise assays for tissue engineered skeletal muscle! We leverage a multi-well stimulation apparatus to study how exercise regimen of various durations + frequencies impact muscle gene expression:
doi.org/10.1002/btm2...
#myoblue
doi.org/10.1002/btm2...
#myoblue
December 16, 2025 at 3:18 PM
Excited to share our new paper on high-throughput #optogenetic #exercise assays for tissue engineered skeletal muscle! We leverage a multi-well stimulation apparatus to study how exercise regimen of various durations + frequencies impact muscle gene expression:
doi.org/10.1002/btm2...
#myoblue
doi.org/10.1002/btm2...
#myoblue
Reposted by Brian Glancy
Nice work and congrats @kevinmurachphd.bsky.social & colleagues for their new #SkeletalMuscle paper: Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle. #Myoblue tinyurl.com/3vhxwku4
Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle - Skeletal Muscle
Non-peripheral (displaced) myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to th...
tinyurl.com
December 5, 2025 at 1:32 PM
Nice work and congrats @kevinmurachphd.bsky.social & colleagues for their new #SkeletalMuscle paper: Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle. #Myoblue tinyurl.com/3vhxwku4
NCLX is a mitochondrial proton/calcium exchanger, not a sodium/calcium exchanger as previously thought
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structure and mechanism of the mitochondrial calcium transporter NCLX - Nature
Cryogenic electron microscopy structures and functional analyses reveal that NCLX functions as a H+/Ca2+ rather than a Na+/Ca2+ exchanger, and uncover its transport mechanism with implications for the...
www.nature.com
December 4, 2025 at 8:01 PM
NCLX is a mitochondrial proton/calcium exchanger, not a sodium/calcium exchanger as previously thought
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Brian Glancy
Happy to have contributed to this beautiful work led by @elenaberezhnaya.bsky.social and Dr. Gyorgy Hajnoczky, and thrilled to see it finally out! 👏🏽👏🏽👏🏽
MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...
MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...
MICU2 controls mitochondrial calcium signaling and migration in neurons during development
Berezhnaya et al. showed that MICU2 is present in the brain during development but
is replaced during maturation by MICU3. MICU2 loss during development results in neuronal
overmigration in the cortex...
www.cell.com
November 24, 2025 at 8:39 PM
Happy to have contributed to this beautiful work led by @elenaberezhnaya.bsky.social and Dr. Gyorgy Hajnoczky, and thrilled to see it finally out! 👏🏽👏🏽👏🏽
MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...
MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...
Reposted by Brian Glancy
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications
Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
www.nature.com
January 6, 2025 at 2:44 PM
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
Reposted by Brian Glancy
Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis | Nature Communications www.nature.com/articles/s41... @myoblue.bsky.social
Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis - Nature Communications
In mdx mouse fetuses, the lack of dystrophin markedly impairs secondary myogenesis due to reduced muscle stem cell polarity. AAK1 deletion restores polarity and rescues secondary myogenesis, revealing...
www.nature.com
November 18, 2025 at 1:35 PM
Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis | Nature Communications www.nature.com/articles/s41... @myoblue.bsky.social
Reposted by Brian Glancy
New @NatMetabolism paper: Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia. #Myoblue tinyurl.com/4adh7uy3
https://www.nature.com/articles/s42255-025-01397-5
tinyurl.com
November 17, 2025 at 10:04 PM
New @NatMetabolism paper: Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia. #Myoblue tinyurl.com/4adh7uy3
Reposted by Brian Glancy
If so, you might want to read our new preprint on @biorxivpreprint.bsky.social! We repeated this experiment (acute exercise in untrained and trained mice, analyzed at different time points, comparison of untrained and trained at rest) on the single nucleus level.
2/3
doi.org/10.1101/2025...
2/3
doi.org/10.1101/2025...
Muscle Fiber- and Cell Type-Specificity of Training Adaptation in Male Mice
Skeletal muscle possesses extraordinary plasticity of structure, metabolism, and function in response to repeated contractile activity. As a syncytium embedded within a complex microenvironment, muscl...
doi.org
November 14, 2025 at 2:34 PM
If so, you might want to read our new preprint on @biorxivpreprint.bsky.social! We repeated this experiment (acute exercise in untrained and trained mice, analyzed at different time points, comparison of untrained and trained at rest) on the single nucleus level.
2/3
doi.org/10.1101/2025...
2/3
doi.org/10.1101/2025...
Reposted by Brian Glancy
📰🧵📰 REGISTRATION ANNOUNCEMENT!! 💻🧵💻
1/ #IBEC2026 Conference dates are from June 1-3 in #RoanokeVA. Early registration will open January 1, 2026. Early registration/ eligibility for awards through March 1. Preliminary schedule available here: t.co/D2buRVHKGb
1/ #IBEC2026 Conference dates are from June 1-3 in #RoanokeVA. Early registration will open January 1, 2026. Early registration/ eligibility for awards through March 1. Preliminary schedule available here: t.co/D2buRVHKGb
https://fbri.vtc.vt.edu/research/research-centers/center-for-exercise-medicine-research/IBEC-2026/conference-schedule.html
t.co
November 3, 2025 at 4:34 PM
📰🧵📰 REGISTRATION ANNOUNCEMENT!! 💻🧵💻
1/ #IBEC2026 Conference dates are from June 1-3 in #RoanokeVA. Early registration will open January 1, 2026. Early registration/ eligibility for awards through March 1. Preliminary schedule available here: t.co/D2buRVHKGb
1/ #IBEC2026 Conference dates are from June 1-3 in #RoanokeVA. Early registration will open January 1, 2026. Early registration/ eligibility for awards through March 1. Preliminary schedule available here: t.co/D2buRVHKGb
Reposted by Brian Glancy
Some interesting data from postdoc Nate Serrano: “Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle” www.biorxiv.org/content/10.1...
Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle
Non-peripheral myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to the activity o...
www.biorxiv.org
October 12, 2025 at 11:50 AM
Some interesting data from postdoc Nate Serrano: “Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle” www.biorxiv.org/content/10.1...
Reposted by Brian Glancy
Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Paternal exercise confers endurance capacity to offspring through sperm microRNAs
Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic
health via sperm microRNAs that reprogram gene expression in early embryos, revealing
how exercise benefits c...
www.cell.com
October 6, 2025 at 3:17 PM
Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Reposted by Brian Glancy
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme
employment.ku.dk
September 29, 2025 at 11:11 AM
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
Reposted by Brian Glancy
Our new preprint!
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Mitochondrial cristae density is increased following high-intensity interval training in patients with type 2 diabetes
Aims/hypothesis: Mitochondrial cristae architecture is a key determinant of oxidative capacity in skeletal muscle. While mitochondrial dysfunction is common in type 2 diabetes, it remains unclear whet...
www.biorxiv.org
September 30, 2025 at 2:00 PM
Our new preprint!
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Reposted by Brian Glancy
Title: Professor in Exercise and Sport Science or Exercise Physiology
📍Place: @newcastle 🇦🇺
💰Salary: $222,734 plus 17% superannuation plus annual leave loading
📅Deadline: 12/10/25
ℹ For more details👇 www.livehire.com/careers/univ...
📍Place: @newcastle 🇦🇺
💰Salary: $222,734 plus 17% superannuation plus annual leave loading
📅Deadline: 12/10/25
ℹ For more details👇 www.livehire.com/careers/univ...
Professor in Exercise and Sport Science or Exercise Physiology - University of Newcastle
FullTimePermanent • Callaghan, NSW 2308 • Salary: $222,734 plus 17% superannuation plus annual leave loading Position: Full-time, Continuing Location: Callaghan Campus, Newcastle, NSW Australia About ...
www.livehire.com
September 26, 2025 at 4:12 AM
Title: Professor in Exercise and Sport Science or Exercise Physiology
📍Place: @newcastle 🇦🇺
💰Salary: $222,734 plus 17% superannuation plus annual leave loading
📅Deadline: 12/10/25
ℹ For more details👇 www.livehire.com/careers/univ...
📍Place: @newcastle 🇦🇺
💰Salary: $222,734 plus 17% superannuation plus annual leave loading
📅Deadline: 12/10/25
ℹ For more details👇 www.livehire.com/careers/univ...
Reposted by Brian Glancy
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
www.kcl.ac.uk
September 25, 2025 at 5:01 PM
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Reposted by Brian Glancy
Kinesiology and Applied Physiology at UD is hiring a biomechanist! We invite applications for a tenure-track assistant professor position with a preferred research focus in musuloskeletal modeling.
careers.udel.edu/cw/en-us/job...
careers.udel.edu/cw/en-us/job...
University of Delaware - Details - Kinesiology and Applied Physiology, Tenure-Track Assistant Professor
careers.udel.edu
September 23, 2025 at 1:50 PM
Kinesiology and Applied Physiology at UD is hiring a biomechanist! We invite applications for a tenure-track assistant professor position with a preferred research focus in musuloskeletal modeling.
careers.udel.edu/cw/en-us/job...
careers.udel.edu/cw/en-us/job...